CitA (citrate) and DcuS (C 4 -dicarboxylate) sensor kinases in
... were tested for growth on C4-dicarboxylates. For identification as CitA or DcuS-type systems, ...
... were tested for growth on C4-dicarboxylates. For identification as CitA or DcuS-type systems, ...
KAT6A Syndrome - Rarechromo.org
... What does the KAT6A gene/protein do? The KAT6A protein (made from the KAT6A gene) is involved in controlling the production of proteins from other genes. It does this in several ways. One way in which it does this is by controlling the shape of the chromosome. The 23 chromosomes contain 3 billion ‘l ...
... What does the KAT6A gene/protein do? The KAT6A protein (made from the KAT6A gene) is involved in controlling the production of proteins from other genes. It does this in several ways. One way in which it does this is by controlling the shape of the chromosome. The 23 chromosomes contain 3 billion ‘l ...
KAT6A Syndrome - Rarechromo.org
... muscles of the face and mouth, including the tongue). Several children have been noted to have markedly better receptive language than expressive language. This means their understanding is much better than their ability to use worlds. Children who have relatively good understanding but are unable t ...
... muscles of the face and mouth, including the tongue). Several children have been noted to have markedly better receptive language than expressive language. This means their understanding is much better than their ability to use worlds. Children who have relatively good understanding but are unable t ...
Thermo Scientific Solutions for Quantitative
... and their place in complex biological systems, it is often necessary to measure changes in protein abundance relative to changes in the state of the system. As such, modern proteomics has evolved from an almost exclusively qualitative technique into one that spans a continuum of qualitative and quan ...
... and their place in complex biological systems, it is often necessary to measure changes in protein abundance relative to changes in the state of the system. As such, modern proteomics has evolved from an almost exclusively qualitative technique into one that spans a continuum of qualitative and quan ...
The Plant Cell - Semantic Scholar
... present, and their potential for compensation should be considered as well. In this study, we show that nine FtsH proteins, including VAR1 and VAR2, are targeted to chloroplasts, whereas three are mitochondrial. Inactivation of homologous genes that are highly related to VAR1 and VAR2 did not lead t ...
... present, and their potential for compensation should be considered as well. In this study, we show that nine FtsH proteins, including VAR1 and VAR2, are targeted to chloroplasts, whereas three are mitochondrial. Inactivation of homologous genes that are highly related to VAR1 and VAR2 did not lead t ...
ABSTRACT Title of Document:
... The first anti-apoptotic gene that was identified by our lab, nuoG, is a part of the nuo operon and codes for a protein NDH-1. NDH-1 is a proton-pumping NADH ubiquinone reductase, and is also called respiratory complex 1. It is the first enzyme of the bacterial and mitochondrial respiratory chain. I ...
... The first anti-apoptotic gene that was identified by our lab, nuoG, is a part of the nuo operon and codes for a protein NDH-1. NDH-1 is a proton-pumping NADH ubiquinone reductase, and is also called respiratory complex 1. It is the first enzyme of the bacterial and mitochondrial respiratory chain. I ...
Copyright Information of the Article Published Online
... the C terminal domain of the protein. It is mostly used by proteins located in the peroxisomal matrix[14]. PTS1-containing proteins are recognized by Pex5 protein, whose C-terminal domain (and in rare cases its N-terminal domain) interacts with the PTS1 sequence[15,16]. This is a method of peroxisom ...
... the C terminal domain of the protein. It is mostly used by proteins located in the peroxisomal matrix[14]. PTS1-containing proteins are recognized by Pex5 protein, whose C-terminal domain (and in rare cases its N-terminal domain) interacts with the PTS1 sequence[15,16]. This is a method of peroxisom ...
A novel C. elegans zinc finger transcription factor, lsy
... proteins can also bind RNA, the vast majority of these proteins are DNA-binding transcription factors (Iuchi, 2001). ...
... proteins can also bind RNA, the vast majority of these proteins are DNA-binding transcription factors (Iuchi, 2001). ...
Tumor metastasis-associated human MTA1 gene and its MTA1
... (NuRD complex), which is involved in chromatin remodeling, contains MTA1 protein or a MTA1-related protein (MTA2) [16, 17]. Thus, a possible function for the MTA1 protein has been reported; however, the exact role of the MTA1 protein in tumor progression and metastasis must still be determined. Here ...
... (NuRD complex), which is involved in chromatin remodeling, contains MTA1 protein or a MTA1-related protein (MTA2) [16, 17]. Thus, a possible function for the MTA1 protein has been reported; however, the exact role of the MTA1 protein in tumor progression and metastasis must still be determined. Here ...
Prep1.1 has essential genetic functions in hindbrain development
... form a subgroup of Meinox proteins that share ~80% overall amino acid sequence identity. By contrast, the Meis and Prep proteins share high amino acid sequence conservation only in specific domains (Fognani et al., 2002). An additional difference between Prep and Meis might lie in Hox proteins bindi ...
... form a subgroup of Meinox proteins that share ~80% overall amino acid sequence identity. By contrast, the Meis and Prep proteins share high amino acid sequence conservation only in specific domains (Fognani et al., 2002). An additional difference between Prep and Meis might lie in Hox proteins bindi ...
Linköping University Post Print Histone Variants and Their Post-Translational
... strongly linked to obesity and a sedentary lifestyle, but there is also a well recognized genetic aspect. Around 30%–70% of the risk to get type 2 diabetes has been attributed to the individual genetic background and several recent genome-wide screens have identified a number of genetic variations t ...
... strongly linked to obesity and a sedentary lifestyle, but there is also a well recognized genetic aspect. Around 30%–70% of the risk to get type 2 diabetes has been attributed to the individual genetic background and several recent genome-wide screens have identified a number of genetic variations t ...
scf and cullin/ring h2-based
... inhibitor Sic1. Sic1 is normally destroyed as wild-type cells progress from G1 to S phase but persists indefinitely in the cdc mutants. Subsequently, it was shown that skp1ts mutants have a similar phenotype (Bai et al 1996). yCdc34 was a logical candidate for a Sic1 destabilizing factor because it ...
... inhibitor Sic1. Sic1 is normally destroyed as wild-type cells progress from G1 to S phase but persists indefinitely in the cdc mutants. Subsequently, it was shown that skp1ts mutants have a similar phenotype (Bai et al 1996). yCdc34 was a logical candidate for a Sic1 destabilizing factor because it ...
CoevolPaper2 - University of Illinois Archives
... There appear to be two general kinds of these signatures, the small scale, in which overall structure of a given locale does not appreciably change, but particular (constant and characteristic) sequence variations occur within the given structural element; and the large scale, in which one can (by d ...
... There appear to be two general kinds of these signatures, the small scale, in which overall structure of a given locale does not appreciably change, but particular (constant and characteristic) sequence variations occur within the given structural element; and the large scale, in which one can (by d ...
Prep1.1 has essential genetic functions in hindbrain development
... form a subgroup of Meinox proteins that share ~80% overall amino acid sequence identity. By contrast, the Meis and Prep proteins share high amino acid sequence conservation only in specific domains (Fognani et al., 2002). An additional difference between Prep and Meis might lie in Hox proteins bindi ...
... form a subgroup of Meinox proteins that share ~80% overall amino acid sequence identity. By contrast, the Meis and Prep proteins share high amino acid sequence conservation only in specific domains (Fognani et al., 2002). An additional difference between Prep and Meis might lie in Hox proteins bindi ...
PDF
... mouse spinal motoneurons. One family member, Nkx6.1, is expressed in the spinal cord pMN domain and is required for formation of a proportion of all spinal motoneuron subtypes (Sander et al., 2000). Another family member, Nkx6.2, is expressed dorsal to the pMN domain and is negatively regulated by N ...
... mouse spinal motoneurons. One family member, Nkx6.1, is expressed in the spinal cord pMN domain and is required for formation of a proportion of all spinal motoneuron subtypes (Sander et al., 2000). Another family member, Nkx6.2, is expressed dorsal to the pMN domain and is negatively regulated by N ...
Tracing the Archaeal Origins of Eukaryotic Membrane
... table S1, Supplementary Material online). Proteins with this domain comprise atypical members of the Ras superfamily functioning in target of rapamycin complex 1 (TORC1) signaling at the lysosome/vacuole (Sekiguchi et al. 2001; Kim et al. 2008). The 14 lokiarchaeal sequences selected for inclusion i ...
... table S1, Supplementary Material online). Proteins with this domain comprise atypical members of the Ras superfamily functioning in target of rapamycin complex 1 (TORC1) signaling at the lysosome/vacuole (Sekiguchi et al. 2001; Kim et al. 2008). The 14 lokiarchaeal sequences selected for inclusion i ...
Analysis of the paralysed trypanosome mutant snl-1
... retrograde transport systems operating in the flagellum. In this respect, the accumulation of unassembled PFR precursors in the flagellum shows interesting similarities with axonemal mutants in other systems, illustrating transport of components of a flagellar structure during both flagellum assembl ...
... retrograde transport systems operating in the flagellum. In this respect, the accumulation of unassembled PFR precursors in the flagellum shows interesting similarities with axonemal mutants in other systems, illustrating transport of components of a flagellar structure during both flagellum assembl ...
NeuroGeM, a knowledgebase of genetic modifiers
... Modifiers can be grouped into aggregation modifiers and toxicity modifiers depending on the quantification method: the primary effect of aggregation modifiers is to increase or decrease aggregates while the primary effect of toxicity modifiers is to change the phenotype eventually leading to cell de ...
... Modifiers can be grouped into aggregation modifiers and toxicity modifiers depending on the quantification method: the primary effect of aggregation modifiers is to increase or decrease aggregates while the primary effect of toxicity modifiers is to change the phenotype eventually leading to cell de ...
The nullo protein is a component of the actin
... 1990). Like its transcript, the sry-α protein is short-lived. The nullo gene is predicted to encode a 23 kDa protein lacking homology to known proteins, including the sry-α protein. Sequence analysis demonstrated that the nullo protein has an excess of basic amino acids (predicted pI is 11.4) and su ...
... 1990). Like its transcript, the sry-α protein is short-lived. The nullo gene is predicted to encode a 23 kDa protein lacking homology to known proteins, including the sry-α protein. Sequence analysis demonstrated that the nullo protein has an excess of basic amino acids (predicted pI is 11.4) and su ...
STING Millennium: a web-based suite of programs
... because any point on the structure/surface might be painted (colored) only once, following the color code designed for given amino acid characteristics. Amino acid sequence on the other hand, can be mapped by number of parameters, organized and displayed in underlying rows. Appropriate visualization ...
... because any point on the structure/surface might be painted (colored) only once, following the color code designed for given amino acid characteristics. Amino acid sequence on the other hand, can be mapped by number of parameters, organized and displayed in underlying rows. Appropriate visualization ...
Molecular function - SGD-Wiki - Saccharomyces Genome Database
... products, for example, fructose-bisphosphate aldolase activity or protein serine/threonine kinase activity. Biological process: the broad biological goals, such as mitosis or DNA replication, that are accomplished by ordered assemblies of molecular functions. Cellular component: subcellular structur ...
... products, for example, fructose-bisphosphate aldolase activity or protein serine/threonine kinase activity. Biological process: the broad biological goals, such as mitosis or DNA replication, that are accomplished by ordered assemblies of molecular functions. Cellular component: subcellular structur ...
Genes for two multicopper proteins required for Fe(III) oxide
... multicopper protein OmpB for Fe(III) oxide reduction. A homologue of OmpB, designated OmpC, which is 36 % similar to OmpB, has been discovered in the G. sulfurreducens genome. Deletion of ompC inhibited reduction of insoluble, but not soluble Fe(III). Analysis of multiple Geobacter and Pelobacter ge ...
... multicopper protein OmpB for Fe(III) oxide reduction. A homologue of OmpB, designated OmpC, which is 36 % similar to OmpB, has been discovered in the G. sulfurreducens genome. Deletion of ompC inhibited reduction of insoluble, but not soluble Fe(III). Analysis of multiple Geobacter and Pelobacter ge ...
Endomembrane proton pumps: connecting membrane and vesicle
... secretory pathways is critical for protein sorting and vesicle trafficking, and is achieved by the activity of the vacuolar H+-ATPase (V-ATPase). Plants have an additional endomembrane pump, the vacuolar H+-pyrophosphatase (V-PPase), and previous research was largely focused on the respective functi ...
... secretory pathways is critical for protein sorting and vesicle trafficking, and is achieved by the activity of the vacuolar H+-ATPase (V-ATPase). Plants have an additional endomembrane pump, the vacuolar H+-pyrophosphatase (V-PPase), and previous research was largely focused on the respective functi ...
Two-step and one-step secretion mechanisms in Gram
... machineries for transport of substrates across their cell membrane in response to various environmental cues. These machineries, known as secretion systems, are essential for bacterial virulence and are used by bacteria to acquire nutrients, transport various proteins, nucleic acids or toxins or ass ...
... machineries for transport of substrates across their cell membrane in response to various environmental cues. These machineries, known as secretion systems, are essential for bacterial virulence and are used by bacteria to acquire nutrients, transport various proteins, nucleic acids or toxins or ass ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.