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The location and type of mutation predict
... intellectual disability only (3). Lissencephaly is one component of the contiguous gene deletion disorder known as Miller– Dieker syndrome (MDS) or may occur as an isolated brain malformation in patients with isolated lissencephaly sequence (ILS) (2). The clinical severity generally correlates with ...
... intellectual disability only (3). Lissencephaly is one component of the contiguous gene deletion disorder known as Miller– Dieker syndrome (MDS) or may occur as an isolated brain malformation in patients with isolated lissencephaly sequence (ILS) (2). The clinical severity generally correlates with ...
A Single Arabidopsis Gene Encodes Two
... precursors have been extensively studied in Arabidopsis (Arabidopsis thaliana; Fig. 1). All the MEP pathway enzymes are encoded by nuclear genes and imported into plastids, whereas cytosolic, endoplasmic reticulum (ER), and peroxisomal-associated locations have been found for MVA enzymes (Pulido et ...
... precursors have been extensively studied in Arabidopsis (Arabidopsis thaliana; Fig. 1). All the MEP pathway enzymes are encoded by nuclear genes and imported into plastids, whereas cytosolic, endoplasmic reticulum (ER), and peroxisomal-associated locations have been found for MVA enzymes (Pulido et ...
Touring Ensembl: A practical guide to genome browsing Open Access
... at the 5' end of the IL2 transcript and flanking sequence [12-14]. Within only 200 bp upstream of the translational start site, binding sites for proteins such as NF-κB, AP-1, and NFAT (nuclear factor of activated T-cells), DNase I hypersensitive sites and a TATA box can all be found. These regions ...
... at the 5' end of the IL2 transcript and flanking sequence [12-14]. Within only 200 bp upstream of the translational start site, binding sites for proteins such as NF-κB, AP-1, and NFAT (nuclear factor of activated T-cells), DNase I hypersensitive sites and a TATA box can all be found. These regions ...
(9E10): sc-40 - Santa Cruz Biotechnology
... Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibits appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad 1 and Mxi1, and Mad 1-Max dimers have been shown to repress transcription through int ...
... Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibits appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad 1 and Mxi1, and Mad 1-Max dimers have been shown to repress transcription through int ...
MiRNA_GO_Meeting_August2015
... When annotating a miRNA we should minimally aim to capture the following: 1. The miRNA’s main role in gene silencing and its target(s); gene silencing by miRNA negative regulation of gene expression mRNA binding involved in post-transcriptional gene silencing by miRNA target mRNA indicated in the an ...
... When annotating a miRNA we should minimally aim to capture the following: 1. The miRNA’s main role in gene silencing and its target(s); gene silencing by miRNA negative regulation of gene expression mRNA binding involved in post-transcriptional gene silencing by miRNA target mRNA indicated in the an ...
Get cached
... Arabidopsis genes are rhythmically expressed, with expression peaks at all phases throughout the day and night (Harmer et al., 2000; Schaffer et al., 2001). This circadian gene expression produces the rhythms that pervade plant physiology, some of which are obvious (such as the “sleep movements” of ...
... Arabidopsis genes are rhythmically expressed, with expression peaks at all phases throughout the day and night (Harmer et al., 2000; Schaffer et al., 2001). This circadian gene expression produces the rhythms that pervade plant physiology, some of which are obvious (such as the “sleep movements” of ...
The Antagonist Function of Arabidopsis WRKY53 and
... Crosstalk between salicylic acid (SA) and jasmonic acid (JA) signaling is well-studied but not during leaf senescence. We found that the senescence-specific WRKY53 transcription factor interacts with the JA-inducible protein EPITHIOSPECIFYING SENESCENCE REGULATOR (ESR/ESP). The expression of these g ...
... Crosstalk between salicylic acid (SA) and jasmonic acid (JA) signaling is well-studied but not during leaf senescence. We found that the senescence-specific WRKY53 transcription factor interacts with the JA-inducible protein EPITHIOSPECIFYING SENESCENCE REGULATOR (ESR/ESP). The expression of these g ...
The proposed channel-enzyme transient receptor potential
... eLife digest Ion channels are proteins that allow specific charged particles to move across the membranes of cells – for example to travel in or out of a cell, or between different parts of the same cell. Almost all ion channels are gated, meaning that they can open and close in response to differen ...
... eLife digest Ion channels are proteins that allow specific charged particles to move across the membranes of cells – for example to travel in or out of a cell, or between different parts of the same cell. Almost all ion channels are gated, meaning that they can open and close in response to differen ...
Frequency of dipeptides and antidipeptides
... computed with sets of different sizes, one would conclude that the amount of information is insufficient and that no reliable and significant values of C190 can be computed. On the contrary, if the C190 values were constant and independent of the dimension of the subsets, one would conclude that the ...
... computed with sets of different sizes, one would conclude that the amount of information is insufficient and that no reliable and significant values of C190 can be computed. On the contrary, if the C190 values were constant and independent of the dimension of the subsets, one would conclude that the ...
PowerPoint-Präsentation - European Bioinformatics Institute
... • To contribute to the advancement of biology through basic investigator-driven research in bioinformatics ...
... • To contribute to the advancement of biology through basic investigator-driven research in bioinformatics ...
Landscape_Evoles Physics
... • DNA pieces that encode distinct protein modules become organized and concatenated in the course of evolution • Evolution of E(Pc)-like protein in yeast (Y), fly (F), and vertebrate (V) to peregrin protein in fly and ...
... • DNA pieces that encode distinct protein modules become organized and concatenated in the course of evolution • Evolution of E(Pc)-like protein in yeast (Y), fly (F), and vertebrate (V) to peregrin protein in fly and ...
Gene Section SIL (SCL/TAL1 interrupting locus) Atlas of Genetics and Cytogenetics
... holopresencephaly, randomized left/right asymmetry and marked apoptosis of the neural folds. Genetic evidence showed that SIL is required for the Sonic Hedgehog response pathway. SIL phosphorylation and interactions with PIN1 is required for maintenance of the mitotic checkpoint. ...
... holopresencephaly, randomized left/right asymmetry and marked apoptosis of the neural folds. Genetic evidence showed that SIL is required for the Sonic Hedgehog response pathway. SIL phosphorylation and interactions with PIN1 is required for maintenance of the mitotic checkpoint. ...
Mucolipin 1 channel activity is regulated by protein kinase A
... characterized by mental and psychomotor retardation, diminished muscle tone or hypotonia, achlorhydria and visual problems, including corneal clouding, retinal degeneration, sensitivity to light and strabismus [1–3]. This disorder is found at a relatively high frequency among Ashkenazi Jews, with 1: ...
... characterized by mental and psychomotor retardation, diminished muscle tone or hypotonia, achlorhydria and visual problems, including corneal clouding, retinal degeneration, sensitivity to light and strabismus [1–3]. This disorder is found at a relatively high frequency among Ashkenazi Jews, with 1: ...
Word - The Open University
... actin; in humans there are six principal isoforms, four of which are found in different types of muscle and the other two (β and γ) in all non-muscle cells. (The term ‘isoform’ describes variants of a protein. These may be produced by different genes, or by differential splicing of the mRNA, or be g ...
... actin; in humans there are six principal isoforms, four of which are found in different types of muscle and the other two (β and γ) in all non-muscle cells. (The term ‘isoform’ describes variants of a protein. These may be produced by different genes, or by differential splicing of the mRNA, or be g ...
immunology - USF Health
... reported by other groups including our own (1, 4, 5). CIAS1 contains an amino-terminal pyrin domain, a centrally located predicted NBD, and numerous LRR motifs at its carboxyl terminus. The function of each domain is largely unknown. The pyrin domain of CIAS1 is highly homologous to its namesake, th ...
... reported by other groups including our own (1, 4, 5). CIAS1 contains an amino-terminal pyrin domain, a centrally located predicted NBD, and numerous LRR motifs at its carboxyl terminus. The function of each domain is largely unknown. The pyrin domain of CIAS1 is highly homologous to its namesake, th ...
The Gene Ontology
... – Biologists currently waste a lot of time and effort in searching for all of the available information about each small area of research. ...
... – Biologists currently waste a lot of time and effort in searching for all of the available information about each small area of research. ...
Bacteriophages and Their Structural Organisation
... 1. Introduction Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants, insects and bacteria. All viruses have a ...
... 1. Introduction Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants, insects and bacteria. All viruses have a ...
to get the file - Oxford Brookes University
... families controlling endomembrane traf®c can be predicted from their similarity to known yeast proteins and some can be readily modi®ed to generate dominant inhibitory forms. These include some of the most important families such as the Rab GTPases and SNAREs. In Arabidopsis, these protein families ...
... families controlling endomembrane traf®c can be predicted from their similarity to known yeast proteins and some can be readily modi®ed to generate dominant inhibitory forms. These include some of the most important families such as the Rab GTPases and SNAREs. In Arabidopsis, these protein families ...
Agrobacterium tumefaciens and Plant Cell Interactions and Activities
... A commonality, therefore, of both the phenol and sugar signaling is the diversity of plant compounds recognized. This likely plays a role in achieving the broad host range exhibited by Agrobacterium. The phenols, which are absolutely required for vir gene activation, may be especially important in t ...
... A commonality, therefore, of both the phenol and sugar signaling is the diversity of plant compounds recognized. This likely plays a role in achieving the broad host range exhibited by Agrobacterium. The phenols, which are absolutely required for vir gene activation, may be especially important in t ...
Physical and chemical interactions between aphids and plants
... most likely candidates for fast plugging events. There is a variety of protein forms in the sieve tubes. Presumably most of the phloem-specific proteins are in a soluble form in the phloem sap, a few are present as insoluble deposits along the SE plasma membrane of dicotyledons, while again others a ...
... most likely candidates for fast plugging events. There is a variety of protein forms in the sieve tubes. Presumably most of the phloem-specific proteins are in a soluble form in the phloem sap, a few are present as insoluble deposits along the SE plasma membrane of dicotyledons, while again others a ...
Systematic profiling of Caenorhabditis elegans locomotive
... chn-1 encodes an ortholog of mammalian carboxyl-terminus of Hsc70 interacting protein (CHIP), an E4 ubiquitin-chain elongation factor; chn-1 is ubiquitously expressed; chn-1(by155) mutants are viable and superficially normal, but have reduced fertility and arrest as larvae if subjected to heat shock ...
... chn-1 encodes an ortholog of mammalian carboxyl-terminus of Hsc70 interacting protein (CHIP), an E4 ubiquitin-chain elongation factor; chn-1 is ubiquitously expressed; chn-1(by155) mutants are viable and superficially normal, but have reduced fertility and arrest as larvae if subjected to heat shock ...
Agrobacterium tumefaciens and Plant Cell - igem
... A commonality, therefore, of both the phenol and sugar signaling is the diversity of plant compounds recognized. This likely plays a role in achieving the broad host range exhibited by Agrobacterium. The phenols, which are absolutely required for vir gene activation, may be especially important in t ...
... A commonality, therefore, of both the phenol and sugar signaling is the diversity of plant compounds recognized. This likely plays a role in achieving the broad host range exhibited by Agrobacterium. The phenols, which are absolutely required for vir gene activation, may be especially important in t ...
WW Domains Provide a Platform for the
... anti-Myc 9E10 MAb, antibody to the large subunit of RNA polymerase II (anti-RNA Pol II LS), antihemagglutinin (anti-HA), and anti-EWSR1 (antiEWS) polyclonal antisera (Santa Cruz, Santa Cruz, CA); anti-CA150 polyclonal antisera (Abcam, Cambridge, MA); and anti-Pin1 polyclonal antisera (Upstate Biotec ...
... anti-Myc 9E10 MAb, antibody to the large subunit of RNA polymerase II (anti-RNA Pol II LS), antihemagglutinin (anti-HA), and anti-EWSR1 (antiEWS) polyclonal antisera (Santa Cruz, Santa Cruz, CA); anti-CA150 polyclonal antisera (Abcam, Cambridge, MA); and anti-Pin1 polyclonal antisera (Upstate Biotec ...
Early germline development in Caenorhabditis elegans
... germ cell specification may involve molecular processes fundamentally different from those used by somatic cells. For example, examination of germ cell development across species has shown that primordial germ cells are often formed in locations and/or at times that appear to exclude them from the i ...
... germ cell specification may involve molecular processes fundamentally different from those used by somatic cells. For example, examination of germ cell development across species has shown that primordial germ cells are often formed in locations and/or at times that appear to exclude them from the i ...
Session 381 Lens physiology and biomechanics II
... Purpose: It is known, that human cortical or cuneiform opacities are accompanied by changes in lens fiber structure and architecture mainly in the equatorial border zone between the lens nucleus and cortex. Because the lens cortex and nucleus have different viscoelastic properties in young and old l ...
... Purpose: It is known, that human cortical or cuneiform opacities are accompanied by changes in lens fiber structure and architecture mainly in the equatorial border zone between the lens nucleus and cortex. Because the lens cortex and nucleus have different viscoelastic properties in young and old l ...
Protein moonlighting
![](https://commons.wikimedia.org/wiki/Special:FilePath/3EL3.png?width=300)
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.