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... such interaction stimulating each other activity (ATPase for HerA and nuclease for NurA). In all of the Thermus spp. so far sequenced, an archaeal HerA homologue is encoded in the chromosome. We will call this protein helicase protein A (HepA) hereafter to avoid confusion with the extensively studie ...
... such interaction stimulating each other activity (ATPase for HerA and nuclease for NurA). In all of the Thermus spp. so far sequenced, an archaeal HerA homologue is encoded in the chromosome. We will call this protein helicase protein A (HepA) hereafter to avoid confusion with the extensively studie ...
Molecular assembly of the period-cryptochrome circadian
... Mammalian CRY1 and CRY2 paralogs contain a highly similar photolyase-homology region (PHR) and a more diverse Cryptochrome C-terminal Extension (CCE) sequence (Figure 1—figure supplement 1). Their PER-binding activity has previously been mapped to the PHR, which is made of an α/β photolyase domain a ...
... Mammalian CRY1 and CRY2 paralogs contain a highly similar photolyase-homology region (PHR) and a more diverse Cryptochrome C-terminal Extension (CCE) sequence (Figure 1—figure supplement 1). Their PER-binding activity has previously been mapped to the PHR, which is made of an α/β photolyase domain a ...
The Shwachman-Diamond SBDS protein localizes to the nucleolus
... contains deletions and nucleotide changes that prevent the generation of a functional protein.9 The majority of patients (nearly 75%) with Shwachman-Diamond syndrome were found to harbor SBDS mutations arising from a gene conversion event with this pseudogene.9 The SBDS gene is predicted to encode a ...
... contains deletions and nucleotide changes that prevent the generation of a functional protein.9 The majority of patients (nearly 75%) with Shwachman-Diamond syndrome were found to harbor SBDS mutations arising from a gene conversion event with this pseudogene.9 The SBDS gene is predicted to encode a ...
After Bath Body Moisturizer After Bath Body Moisturizer offers instant
... This luxurious exfoliant leaves skin appearing silky-smooth and flawlessly refined. Available in 2.5oz ...
... This luxurious exfoliant leaves skin appearing silky-smooth and flawlessly refined. Available in 2.5oz ...
REVIEWS - Haseloff Lab
... activates the ubiquitin moiety by forming a high energy thioester bond between an E1 Cys residue and the carboxy-terminal Gly of ubiquitin (see the figure, part a). This activated ubiquitin is then donated to a Cys on an E2 (or ubiquitin-conjugating enzyme) by trans-esterification. In most cases, th ...
... activates the ubiquitin moiety by forming a high energy thioester bond between an E1 Cys residue and the carboxy-terminal Gly of ubiquitin (see the figure, part a). This activated ubiquitin is then donated to a Cys on an E2 (or ubiquitin-conjugating enzyme) by trans-esterification. In most cases, th ...
Resistance of Helicoverpa armigera to Cry1Ac toxin from Bacillus
... populations resistant to Cry1Ac have been isolated [8]. Since insects have developed resistance to all the different chemical insecticides used today, diverse resistance management strategies have been recommended the world over to contain the resistance development risk, which includes use of B. th ...
... populations resistant to Cry1Ac have been isolated [8]. Since insects have developed resistance to all the different chemical insecticides used today, diverse resistance management strategies have been recommended the world over to contain the resistance development risk, which includes use of B. th ...
Combining docking and molecular dynamic simulations in drug design
... The three dimensional (3-D) structure of both ligand and protein are necessary for the application of docking techniques. While the manifold of conformational structures of small molecules may be relatively easy to predict, the lowest energy conformation obtained may not correspond to that of the bo ...
... The three dimensional (3-D) structure of both ligand and protein are necessary for the application of docking techniques. While the manifold of conformational structures of small molecules may be relatively easy to predict, the lowest energy conformation obtained may not correspond to that of the bo ...
Xdbx inhibits neurogenesis - Development
... Regionalized X-Ngnr1 expression defines domains of early neurogenesis. Are there negative effectors that similarly define neural progenitor domains in the embryo? The homeodomaincontaining gene Xiro3 is expressed at highest levels in neural progenitors and when overexpressed, Xiro3 inhibits neuronal ...
... Regionalized X-Ngnr1 expression defines domains of early neurogenesis. Are there negative effectors that similarly define neural progenitor domains in the embryo? The homeodomaincontaining gene Xiro3 is expressed at highest levels in neural progenitors and when overexpressed, Xiro3 inhibits neuronal ...
fulltext - DiVA portal
... addition, upon screening of several different Salmonella enterica serovars, functional homologues to the clyA gene were identified in the typhoid Salmonella serovars Typhi and Paratyphi A [9]. The presence of the clyA gene in wild-type isolates of Salmonella suggests a conserved function of the gene ...
... addition, upon screening of several different Salmonella enterica serovars, functional homologues to the clyA gene were identified in the typhoid Salmonella serovars Typhi and Paratyphi A [9]. The presence of the clyA gene in wild-type isolates of Salmonella suggests a conserved function of the gene ...
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... exists post-zygotically (28). The supportive evidence is that full mutation carriers are found to be somatic mosaicisms of CGG repeats (28,29). However, the length of CGG repeats on a particular allele in a differentiated cell derived from these carriers is generally mitotically stable although rece ...
... exists post-zygotically (28). The supportive evidence is that full mutation carriers are found to be somatic mosaicisms of CGG repeats (28,29). However, the length of CGG repeats on a particular allele in a differentiated cell derived from these carriers is generally mitotically stable although rece ...
Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP
... protein of 40 kDa, released from the mitochondria. Structural and binding studies show that SmacDIABLO binds to the XIAP-BIR3 domain through a specific IAP binding motif (IBM), built by its Nterminal tetrapeptide Ala-Val-Pro-Ile (AVPI).24 Smac AVPI competes directly with a similar tetrapeptide (ATPF ...
... protein of 40 kDa, released from the mitochondria. Structural and binding studies show that SmacDIABLO binds to the XIAP-BIR3 domain through a specific IAP binding motif (IBM), built by its Nterminal tetrapeptide Ala-Val-Pro-Ile (AVPI).24 Smac AVPI competes directly with a similar tetrapeptide (ATPF ...
dravhandling-hafte - DUO
... site of the Golgi apparatus, from where further transport is mediated by specialized apical and basolateral transport containers. Some data obtained from studies of the soluble proteoglycan (PG) serglycin (Tveit et al. 2005; Vuong et al. 2006) and N-linked glycoproteins (Alfalah et al. 2005), howeve ...
... site of the Golgi apparatus, from where further transport is mediated by specialized apical and basolateral transport containers. Some data obtained from studies of the soluble proteoglycan (PG) serglycin (Tveit et al. 2005; Vuong et al. 2006) and N-linked glycoproteins (Alfalah et al. 2005), howeve ...
Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the
... been generated, and ubiquitous homologs of SV proteins have been identified, leading to the notion that similar sets of proteins are involved in all membrane trafficking events in eukaryotes (Südhof, 2004). A large number of molecular interactions have been shown to occur in vitro among proteins in ...
... been generated, and ubiquitous homologs of SV proteins have been identified, leading to the notion that similar sets of proteins are involved in all membrane trafficking events in eukaryotes (Südhof, 2004). A large number of molecular interactions have been shown to occur in vitro among proteins in ...
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... importance of such phenomena lies partly in the fact that physically associated enzymes or transient multi-enzyme complexes have the potential to exhibit unique catalytic properties in contrast to isolated enzymes [25,26]. Compartmentalization may include both metabolites and enzymes. The enzymes ca ...
... importance of such phenomena lies partly in the fact that physically associated enzymes or transient multi-enzyme complexes have the potential to exhibit unique catalytic properties in contrast to isolated enzymes [25,26]. Compartmentalization may include both metabolites and enzymes. The enzymes ca ...
Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the
... been generated, and ubiquitous homologs of SV proteins have been identified, leading to the notion that similar sets of proteins are involved in all membrane trafficking events in eukaryotes (Südhof, 2004). A large number of molecular interactions have been shown to occur in vitro among proteins in ...
... been generated, and ubiquitous homologs of SV proteins have been identified, leading to the notion that similar sets of proteins are involved in all membrane trafficking events in eukaryotes (Südhof, 2004). A large number of molecular interactions have been shown to occur in vitro among proteins in ...
Hereditary spastic paraplegia: clinical features and pathogenetic
... HSP associated with mutations in the gene for heat shock protein 60 (HSPD1; formerly SPG13) typically has a late onset without additional features.26 A Gly563Ala missense variant was recently reported to be associated with an earlier age of onset in patients carrying SPAST mutations, although this w ...
... HSP associated with mutations in the gene for heat shock protein 60 (HSPD1; formerly SPG13) typically has a late onset without additional features.26 A Gly563Ala missense variant was recently reported to be associated with an earlier age of onset in patients carrying SPAST mutations, although this w ...
Diverse roles of the Mediator complex in plants
... localize to the endoplasmic reticulum. Here we summarize some of these functions and discuss their inclusion as subunits of the Mediator complex. Backstrom et al., (2007) found the Arabidopsis gene, At1g44910, in two Mediator purifications and thus annotated it as a putative plant specific MED35 su ...
... localize to the endoplasmic reticulum. Here we summarize some of these functions and discuss their inclusion as subunits of the Mediator complex. Backstrom et al., (2007) found the Arabidopsis gene, At1g44910, in two Mediator purifications and thus annotated it as a putative plant specific MED35 su ...
Oxalate decarboxylase of the white-rot fungus
... Dichomitus squalens, and cloned the corresponding Ds-odc gene. The primary structure of the Ds-ODC protein contains two conserved Mn-binding cupin motifs, but at the N-terminus, a unique, approximately 60 aa alanine-serine-rich region is found. Real-time quantitative RT-PCR analysis confirmed gene e ...
... Dichomitus squalens, and cloned the corresponding Ds-odc gene. The primary structure of the Ds-ODC protein contains two conserved Mn-binding cupin motifs, but at the N-terminus, a unique, approximately 60 aa alanine-serine-rich region is found. Real-time quantitative RT-PCR analysis confirmed gene e ...
... investigated whether differences could be observed in the inclusion bodies formed by the respective mutant AHSV-9 NS2 proteins. Transmission electron microscope analysis of recombinant baculovirus-infected Spodoptera frugiperda insect cells indicated that a mutant NS2 protein in which the serine re ...
Pdf - Text of NPTEL IIT Video Lectures
... subunit of nucleic acid. So, it consist of nitrogen containing base 5 carbon sugar and phosphate groups. The sugar and phosphate molecules play crucial role in forming the linear D N A sequence or a structure. So, the three dimensional structure illustrate a very close connection between the molecul ...
... subunit of nucleic acid. So, it consist of nitrogen containing base 5 carbon sugar and phosphate groups. The sugar and phosphate molecules play crucial role in forming the linear D N A sequence or a structure. So, the three dimensional structure illustrate a very close connection between the molecul ...
Architecture and Biosynthesis of the Saccharomyces cerevisiae Cell
... extent to which the wall is a barrier to export of soluble, secreted proteins to the medium. Some proteins can be retained by the wall outside the plasma membrane in the periplasmic space; in the case of Suc2, this is due to the ability of the protein to form large multimers (Orlean 1987). The barri ...
... extent to which the wall is a barrier to export of soluble, secreted proteins to the medium. Some proteins can be retained by the wall outside the plasma membrane in the periplasmic space; in the case of Suc2, this is due to the ability of the protein to form large multimers (Orlean 1987). The barri ...
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK
... sites whose phosphorylation is required for activation [36]. The other site is tyrosine-341, which is targeted by Src family kinases [37,38]. In addition, abl [39,40] and JAK (Janus kinase) [41,42] family tyrosine kinases also induce Raf-1 activation and tyrosine phosphorylation, but since the phosp ...
... sites whose phosphorylation is required for activation [36]. The other site is tyrosine-341, which is targeted by Src family kinases [37,38]. In addition, abl [39,40] and JAK (Janus kinase) [41,42] family tyrosine kinases also induce Raf-1 activation and tyrosine phosphorylation, but since the phosp ...
Yeast secretory expression of insulin precursors
... Secretory expression of heterologous proteins in S. cerevisiae Yeasts are unicellular eukaryotes which have a life cycle with certain stages where they divide by budding (Pha 1990). Yeasts belong to the fungi, lack photosynthetic abilities and are saprophytic or parasitic, being dependent on organi ...
... Secretory expression of heterologous proteins in S. cerevisiae Yeasts are unicellular eukaryotes which have a life cycle with certain stages where they divide by budding (Pha 1990). Yeasts belong to the fungi, lack photosynthetic abilities and are saprophytic or parasitic, being dependent on organi ...
letters - Centre for Social Evolution
... Sex determination in honeybees (Apis mellifera) is governed by heterozygosity at a single locus harbouring the complementary sex determiner (csd) gene1, in contrast to the well-studied sex chromosome system of Drosophila melanogaster2. Bees heterozygous at csd are females, whereas homozygotes and he ...
... Sex determination in honeybees (Apis mellifera) is governed by heterozygosity at a single locus harbouring the complementary sex determiner (csd) gene1, in contrast to the well-studied sex chromosome system of Drosophila melanogaster2. Bees heterozygous at csd are females, whereas homozygotes and he ...
Post-transcriptional regulation of auxin transport proteins: cellular
... levels of PGP1/ABCB1 in Arabidopsis were found to regulate hypocotyl elongation in a light-dependent manner (Sidler et al., 1998). ABCB1 was subsequently shown to function co-ordinately with PGP19/MDR1/ABCB19 in mediating polar auxin transport in Arabidopsis (Noh et al., 2001). The sequence of ABCB1 ...
... levels of PGP1/ABCB1 in Arabidopsis were found to regulate hypocotyl elongation in a light-dependent manner (Sidler et al., 1998). ABCB1 was subsequently shown to function co-ordinately with PGP19/MDR1/ABCB19 in mediating polar auxin transport in Arabidopsis (Noh et al., 2001). The sequence of ABCB1 ...
Protein moonlighting
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Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.