![A Patch of Surface-Exposed Residues Mediates](http://s1.studyres.com/store/data/021077197_1-514974b341d580d55d4e66f98707a553-300x300.png)
A Patch of Surface-Exposed Residues Mediates
... PtiI and Pti4 are substrates of Pto in vitro (Gu et al., 2000), although it is unknown whether these proteins interact with Pto in vivo. Protein kinases are frequent points of control in diverse signaling pathways, and their structure and enzymology are well understood (Huse and Kuriyan, 2002). Ther ...
... PtiI and Pti4 are substrates of Pto in vitro (Gu et al., 2000), although it is unknown whether these proteins interact with Pto in vivo. Protein kinases are frequent points of control in diverse signaling pathways, and their structure and enzymology are well understood (Huse and Kuriyan, 2002). Ther ...
Complement Levels and Activity in the Normal and LPS - AJP-Lung
... has a role in lung host defense, its activity in the normal lung is reduced compared to serum even at same total protein concentrations (17-40% of serum activity) (Watford, et al. 2000), which may be due in part to complement inhibition by Surfactant Protein A (SP-A), a lung specific immune molecule ...
... has a role in lung host defense, its activity in the normal lung is reduced compared to serum even at same total protein concentrations (17-40% of serum activity) (Watford, et al. 2000), which may be due in part to complement inhibition by Surfactant Protein A (SP-A), a lung specific immune molecule ...
Role of the distal convoluted tubule in renal Mg handling: molecular
... Mg2+ replacement helps to determine whether the hypomagnesmic state results from renal or extra-renal causes. Moreover, hypomagnesemia can be secondary to treatment with therapeutic agents [10-12] or to other medical conditions [13]. In recent years, several, rare, inherited forms of hypomagnesemia ...
... Mg2+ replacement helps to determine whether the hypomagnesmic state results from renal or extra-renal causes. Moreover, hypomagnesemia can be secondary to treatment with therapeutic agents [10-12] or to other medical conditions [13]. In recent years, several, rare, inherited forms of hypomagnesemia ...
The evolution of silicon transporters in diatoms
... gene clades in natural communities that were attributed to nutrient availability and community composition. However, the limited reference phylogeny could not resolve the species-specific responses. Here, current knowledge about SIT proteins is placed within an evolutionary context to better charact ...
... gene clades in natural communities that were attributed to nutrient availability and community composition. However, the limited reference phylogeny could not resolve the species-specific responses. Here, current knowledge about SIT proteins is placed within an evolutionary context to better charact ...
Repression by RAZ of Epstein-Barr virus bZIP transcription factor
... Rta) (Hardwick et al., 1988) (Fig. la). Indeed, when EB1 and R expression vectors are transfected into latently infected B cells, both factors are able to activate all the EBV early genes (Buisson et al., 1989; Chevallier-Greco et al., 1986; Countryman & Miller, 1985; Flemington & Speck, 1990b; Roon ...
... Rta) (Hardwick et al., 1988) (Fig. la). Indeed, when EB1 and R expression vectors are transfected into latently infected B cells, both factors are able to activate all the EBV early genes (Buisson et al., 1989; Chevallier-Greco et al., 1986; Countryman & Miller, 1985; Flemington & Speck, 1990b; Roon ...
PDF
... difference among cells along the PSM. Anterior PSM cells are retarded in the oscillator phase relative to posterior PSM cells; the further anterior the cells are located, the greater the retardation is. This phase difference results in the formation of traveling wave-like gene expression patterns al ...
... difference among cells along the PSM. Anterior PSM cells are retarded in the oscillator phase relative to posterior PSM cells; the further anterior the cells are located, the greater the retardation is. This phase difference results in the formation of traveling wave-like gene expression patterns al ...
Maternal-Effect Genes That Alter the Fate Map of the Drosophila
... wild-type embryo at the cellular blastoderm stage (3 hr) exhibits seven stripes offtz protein. (b) A wild-type embryo at the end of embryogenesis (22 hr). Some segments are indicated. T, thoracic; A, abdominal; tl, telson. (c) vdpD/vc&? The broad region offtz staining that occurs in place of stripes ...
... wild-type embryo at the cellular blastoderm stage (3 hr) exhibits seven stripes offtz protein. (b) A wild-type embryo at the end of embryogenesis (22 hr). Some segments are indicated. T, thoracic; A, abdominal; tl, telson. (c) vdpD/vc&? The broad region offtz staining that occurs in place of stripes ...
The Multiple Personalities of the Regulatory Subunit of Protein
... proliferation and survival [3, 4]. Genetic studies in organisms such as yeast and slime mould have revealed that CK2 is essential for viability [5, 6]. Recent studies of molecular clock machinery in Drosophila and Arabidopsis have also provided evidence for the involvement of CK2 in circadian oscill ...
... proliferation and survival [3, 4]. Genetic studies in organisms such as yeast and slime mould have revealed that CK2 is essential for viability [5, 6]. Recent studies of molecular clock machinery in Drosophila and Arabidopsis have also provided evidence for the involvement of CK2 in circadian oscill ...
Dysfunction of Wild-Type Huntingtin in Huntington
... factors (2). Various authors demonstrated that transcription factors such as CBP [cAMP-response element binding protein (CREB) binding protein], TATA binding protein, and Sin3A can be recruited into the intranuclear aggregates, thus reinforcing the hypothesis of a role for transcriptional dysregulat ...
... factors (2). Various authors demonstrated that transcription factors such as CBP [cAMP-response element binding protein (CREB) binding protein], TATA binding protein, and Sin3A can be recruited into the intranuclear aggregates, thus reinforcing the hypothesis of a role for transcriptional dysregulat ...
The Case of Protein Kinase CK2
... clustering of kinases that share functional features, such as preferred sites of phosphorylation, the mode of regulation and cellular localization. The similarity in the amino acid sequence of the catalytic domains of protein kinases has proven to be a good indicator of other features held in common ...
... clustering of kinases that share functional features, such as preferred sites of phosphorylation, the mode of regulation and cellular localization. The similarity in the amino acid sequence of the catalytic domains of protein kinases has proven to be a good indicator of other features held in common ...
The Vps13p–Cdc31p complex is directly required for TGN late
... Yeast VPS13 is the founding member of a eukaryotic gene family of growing interest in cell biology and medicine. Mutations in three of four human VPS13 genes cause autosomal recessive neurodegenerative or neurodevelopmental disease, making yeast Vps13p an important structural and functional model. U ...
... Yeast VPS13 is the founding member of a eukaryotic gene family of growing interest in cell biology and medicine. Mutations in three of four human VPS13 genes cause autosomal recessive neurodegenerative or neurodevelopmental disease, making yeast Vps13p an important structural and functional model. U ...
The PadR-like transcriptional regulator LftR ensures efficient
... Invasion of the bacterial pathogen Listeria monocytogenes into human host cells requires specialized surface molecules for attachment and induction of phagocytosis. However, efficient invasion is also dependent on factors with house-keeping functions, such as SecA2-dependent secretion of autolysins ...
... Invasion of the bacterial pathogen Listeria monocytogenes into human host cells requires specialized surface molecules for attachment and induction of phagocytosis. However, efficient invasion is also dependent on factors with house-keeping functions, such as SecA2-dependent secretion of autolysins ...
Document
... Milton (Drosophila GRIF-1 analog) required for kinesin-mediated axonal transport of mitochondria to Synapses (Neuron 36, 1063 (Schwarz). ...
... Milton (Drosophila GRIF-1 analog) required for kinesin-mediated axonal transport of mitochondria to Synapses (Neuron 36, 1063 (Schwarz). ...
Gene Section ALK (anaplastic lymphoma kinase) Atlas of Genetics and Cytogenetics
... NPM1 fused to the 562 C-term aminoacids of ALK (i.e. composed of the oligomerization domain and the metal binding site of NPM1, and the entire cytoplasmic portion of ALK); no apparent expres-sion of the ALK/NPM1 counterpart. Characteristic localisation both in the cytoplasm and in the nucleus, due t ...
... NPM1 fused to the 562 C-term aminoacids of ALK (i.e. composed of the oligomerization domain and the metal binding site of NPM1, and the entire cytoplasmic portion of ALK); no apparent expres-sion of the ALK/NPM1 counterpart. Characteristic localisation both in the cytoplasm and in the nucleus, due t ...
Chapter 4
... a DNA sequence that is consequently translated into a protein by encoding each triplet of nucleotides into an amino acid. The key to introducing frameshift lies in this triplet-based structure also known as the reading frame. Any insertion of deletion with a length not divisible by three introduces ...
... a DNA sequence that is consequently translated into a protein by encoding each triplet of nucleotides into an amino acid. The key to introducing frameshift lies in this triplet-based structure also known as the reading frame. Any insertion of deletion with a length not divisible by three introduces ...
assembly of integral membrane proteins from the periplasm into the
... was observed in such htrM (rfaD) mutants (Missiakas et al., 1996). Searches for folding factors in the periplasm resulted in the discovery of several interesting proteins that function as chaperones or peptidyl-prolyl cis/trans isomerases (PPIases), which are discussed in the following sections. For ...
... was observed in such htrM (rfaD) mutants (Missiakas et al., 1996). Searches for folding factors in the periplasm resulted in the discovery of several interesting proteins that function as chaperones or peptidyl-prolyl cis/trans isomerases (PPIases), which are discussed in the following sections. For ...
GTPase domains ofras p21 oncogene protein and elongation factor
... Communicated by H. A. Scheraga, December 13, 1990 ...
... Communicated by H. A. Scheraga, December 13, 1990 ...
delivery of proteins using biodegradable polymers
... • Biotechnology offers better product-targeting for specific diseases and patient groups, through the use of innovative technologies, in particular, genetics. Examples include, amongst others, treatment for rare diseases and cancers. • Some products are not naturally created in sufficient quantities ...
... • Biotechnology offers better product-targeting for specific diseases and patient groups, through the use of innovative technologies, in particular, genetics. Examples include, amongst others, treatment for rare diseases and cancers. • Some products are not naturally created in sufficient quantities ...
asense is a Drosophila neural precursor gene and is
... proneural genes such as those of the achaete-scute complex (AS-C), which encode members of the basic helix-loophelix (bHLH) group of transcriptional factors. The proneural genes of the AS-C are expressed in small groups of cells in the epithelium, called proneural clusters, prior to the generation o ...
... proneural genes such as those of the achaete-scute complex (AS-C), which encode members of the basic helix-loophelix (bHLH) group of transcriptional factors. The proneural genes of the AS-C are expressed in small groups of cells in the epithelium, called proneural clusters, prior to the generation o ...
Distinct roles of doublecortin modulating the microtubule cytoskeleton.
... that the doublecortin might protrude from the grooves between protofilaments and that it might therefore impede kinesin movement along the microtubules. Moores and co-workers therefore examined kinesin motion along doublecortinstabilised tracks and found, surprisingly, that doublecortin binding did ...
... that the doublecortin might protrude from the grooves between protofilaments and that it might therefore impede kinesin movement along the microtubules. Moores and co-workers therefore examined kinesin motion along doublecortinstabilised tracks and found, surprisingly, that doublecortin binding did ...
UB_GO_Apr_2004 - Buffalo Ontology Site
... continuants (= they endure through time while undergoing changes of various sorts) ...
... continuants (= they endure through time while undergoing changes of various sorts) ...
Gene Section USP1 (ubiquitin specific peptidase 1) Atlas of Genetics and Cytogenetics
... et al., 1998). USP1 belongs to the ubiquitin specific protease (USP) family of human deubiquitinases (DUBs). Like other members of its family, it harbours a highly conserved USP domain organization comprising a N-terminal Cys box and a C-terminal His box, which contain the catalytic residues (C90, H ...
... et al., 1998). USP1 belongs to the ubiquitin specific protease (USP) family of human deubiquitinases (DUBs). Like other members of its family, it harbours a highly conserved USP domain organization comprising a N-terminal Cys box and a C-terminal His box, which contain the catalytic residues (C90, H ...
Organization in the mechanisms of Protein synthesis and Natural
... and intricate organization of living things. To explain means to identify a mechanism that causes evolution and to demonstrate the consequences of its operation.‟ (Bell 2008 p1.) 5 If natural selection and protein synthesis are both explanatory mechanisms, one might assume they have something in com ...
... and intricate organization of living things. To explain means to identify a mechanism that causes evolution and to demonstrate the consequences of its operation.‟ (Bell 2008 p1.) 5 If natural selection and protein synthesis are both explanatory mechanisms, one might assume they have something in com ...
Full Article - PDF - Journal of Biotech Research
... Folic acids are essential cofactors for synthesis of DNA, RNA, membrane lipids, methionine metabolism and neurotransmitter synthesis. P. falciparum is capable of synthesizing folate de novo or obtaining it through salvage, whereas humans can only obtain folate from their diet, making the folate path ...
... Folic acids are essential cofactors for synthesis of DNA, RNA, membrane lipids, methionine metabolism and neurotransmitter synthesis. P. falciparum is capable of synthesizing folate de novo or obtaining it through salvage, whereas humans can only obtain folate from their diet, making the folate path ...
Intraflagellar transport and the generation of dynamic, structurally
... olfactory epithelia, oviduct, respiratory tissue, and in rod or cone photoreceptors [24–29]. A bipartite axoneme consisting of microtubule doublets followed by singlets therefore represents an evolutionarily conserved feature of motile and non-motile cilia. Diversity in cilia morphologies and ultras ...
... olfactory epithelia, oviduct, respiratory tissue, and in rod or cone photoreceptors [24–29]. A bipartite axoneme consisting of microtubule doublets followed by singlets therefore represents an evolutionarily conserved feature of motile and non-motile cilia. Diversity in cilia morphologies and ultras ...
Protein moonlighting
![](https://commons.wikimedia.org/wiki/Special:FilePath/3EL3.png?width=300)
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.