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Biological Membrane Structure By Solid-State NMR
... study the structure and dynamics of lipid membranes in the liquid-crystalline phase (17-19). As mentioned above, it is the orientation dependence of the electric quadrupolar interaction that permits the study of molecular orientational order, structure and dynamics of lipid membranes by 2H NMR. On o ...
... study the structure and dynamics of lipid membranes in the liquid-crystalline phase (17-19). As mentioned above, it is the orientation dependence of the electric quadrupolar interaction that permits the study of molecular orientational order, structure and dynamics of lipid membranes by 2H NMR. On o ...
Gene Section SRSF1 (serine/arginine rich splicing factor 1) -
... modular structure with two RNA recognition motifs (RRM) that provide RNA-binding specificity and one arginine/serine-rich domain (RS), involved in protein-protein interactions that facilitate recruitment of the spliceosome. The RS domain acts also as a nuclear localization signal, controlling the su ...
... modular structure with two RNA recognition motifs (RRM) that provide RNA-binding specificity and one arginine/serine-rich domain (RS), involved in protein-protein interactions that facilitate recruitment of the spliceosome. The RS domain acts also as a nuclear localization signal, controlling the su ...
Chemistry 433 BIOCHEMISTRY LABORATORY MANUAL
... This course is intended to introduce you to some of the most widely used experimental procedures in biochemistry, including protein purification and characterization, enzyme assays and kinetics, and DNA isolation and manipulation. You will also gain some familiarity with some of the types of equipme ...
... This course is intended to introduce you to some of the most widely used experimental procedures in biochemistry, including protein purification and characterization, enzyme assays and kinetics, and DNA isolation and manipulation. You will also gain some familiarity with some of the types of equipme ...
Draft: set up of conference
... Different whey sources (with cheese production based on cows, sheep, goats or buffalo milk), with casein production (rennet, acid), with Greek Yoghurt production, from ultafiltration of milk, etc ) ...
... Different whey sources (with cheese production based on cows, sheep, goats or buffalo milk), with casein production (rennet, acid), with Greek Yoghurt production, from ultafiltration of milk, etc ) ...
PDF
... Analysis of acidic proteins by two-dimensional gel electrophoresis The patterns of polypeptide synthesis of oocytes labelled from either 0 to 3 h or from 18 to 21 h (i.e. after culture) are shown in Figs 3 and 4 respectively. These profiles confirm that maturation is accompanied by major changes in ...
... Analysis of acidic proteins by two-dimensional gel electrophoresis The patterns of polypeptide synthesis of oocytes labelled from either 0 to 3 h or from 18 to 21 h (i.e. after culture) are shown in Figs 3 and 4 respectively. These profiles confirm that maturation is accompanied by major changes in ...
Arabidopsis RTM1 and RTM2 Genes Function in Phloem to Restrict
... Similar results were obtained using anti-RTM1 produced in each of four chickens (data not shown). The lack of detection of RTM1 in various tissues, ecotypes, and rtm1 mutant lines may be due to several factors. For instance, RTM1 may be present but in concentrations below the level of detection usin ...
... Similar results were obtained using anti-RTM1 produced in each of four chickens (data not shown). The lack of detection of RTM1 in various tissues, ecotypes, and rtm1 mutant lines may be due to several factors. For instance, RTM1 may be present but in concentrations below the level of detection usin ...
Anterior PAR proteins function during cytokinesis and
... absence of Arp2/3 complex [Shivas and Skop, 2012]. Endocytic recycling mechanisms appear to be an important step in maintaining PAR proteins in the plasma membrane throughout development. Overall, the importance of PAR proteins in the generation of cell asymmetry is obvious in the C. elegans embryo ...
... absence of Arp2/3 complex [Shivas and Skop, 2012]. Endocytic recycling mechanisms appear to be an important step in maintaining PAR proteins in the plasma membrane throughout development. Overall, the importance of PAR proteins in the generation of cell asymmetry is obvious in the C. elegans embryo ...
Self-Referential Encoding on Modules of Anticodon Pairs—Roots of
... other aspects of the life process—the entire set of activities (from ontogenesis to evolution) instantiated by living beings—as evolutionary additions to the basic biomolecular. The constitutive functions in the terrestrial life process are: propulsion through the plasticity properties, which is mos ...
... other aspects of the life process—the entire set of activities (from ontogenesis to evolution) instantiated by living beings—as evolutionary additions to the basic biomolecular. The constitutive functions in the terrestrial life process are: propulsion through the plasticity properties, which is mos ...
Functional analysis of polar amino
... family shares a conserved structure, with a membraneassociated N-terminus of approximately 500 amino acids, and a large, regulatory, cytoplasmic domain of approximately 300 amino acids. The primary structure of the membrane-associated domain is more conserved than the cytosolic domain [6]. Surprisin ...
... family shares a conserved structure, with a membraneassociated N-terminus of approximately 500 amino acids, and a large, regulatory, cytoplasmic domain of approximately 300 amino acids. The primary structure of the membrane-associated domain is more conserved than the cytosolic domain [6]. Surprisin ...
Structure based hypothesis of a mitochondrial
... colored red. The switch loop is highlighted in green. The conformation of the universally conserved ribosome decoding site nucleotides A-1492 and A-1493 is shown (C) in case of an empty A-site with both bases stacked (from PDB entry 1J5E [11]), (D) with mRNA and a cognate tRNA present in the A-site ...
... colored red. The switch loop is highlighted in green. The conformation of the universally conserved ribosome decoding site nucleotides A-1492 and A-1493 is shown (C) in case of an empty A-site with both bases stacked (from PDB entry 1J5E [11]), (D) with mRNA and a cognate tRNA present in the A-site ...
Role of hsp90 and the hsp90-binding immunophilins in signalling
... binding of Hop to hsp90 dimer [16] and cross-linking of hsp90 FKBP52 complexes [7] are consistent with one TPR binding site per dimer. In contrast, isothermal titration calorimetry studies are consistent with binding of two molecules of TPR protein to an hsp90 dimer [27,28]. In cross-linking studies ...
... binding of Hop to hsp90 dimer [16] and cross-linking of hsp90 FKBP52 complexes [7] are consistent with one TPR binding site per dimer. In contrast, isothermal titration calorimetry studies are consistent with binding of two molecules of TPR protein to an hsp90 dimer [27,28]. In cross-linking studies ...
Translocation of Structural P Proteins in the Phloem
... Phloem-specific proteins (P proteins) are particularly useful markers to investigate long-distance trafficking of macromolecules in plants. In this study, genus-specific molecular probes were used in combination with intergeneric grafts to reveal the presence of a pool of translocatable P protein su ...
... Phloem-specific proteins (P proteins) are particularly useful markers to investigate long-distance trafficking of macromolecules in plants. In this study, genus-specific molecular probes were used in combination with intergeneric grafts to reveal the presence of a pool of translocatable P protein su ...
Protein stabilization: a common consequence of mutations
... Myc is overexpressed in many cancers as a result of gene rearrangement or ampli®cation, but coding sequence changes which cluster in the N-terminal transactivation domain also appear to play a role in tumour progression. The prototypic v-Myc gene of MC29 virus diers from avian c-Myc by a series of ...
... Myc is overexpressed in many cancers as a result of gene rearrangement or ampli®cation, but coding sequence changes which cluster in the N-terminal transactivation domain also appear to play a role in tumour progression. The prototypic v-Myc gene of MC29 virus diers from avian c-Myc by a series of ...
as a PDF - CiteSeerX
... CD34 antibodies, confirming the association between CrkL and CD34. CD34 peptide inhibition assays demonstrated that CrkL interacts at a membrane-proximal region of the CD34 tail. To identify the CrkL domain responsible for interaction with CD34, we generated GST-fusion constructs of adapter proteins ...
... CD34 antibodies, confirming the association between CrkL and CD34. CD34 peptide inhibition assays demonstrated that CrkL interacts at a membrane-proximal region of the CD34 tail. To identify the CrkL domain responsible for interaction with CD34, we generated GST-fusion constructs of adapter proteins ...
doc
... This will be further addressed by deciphering the phase of NF-B and IRF activation in TANK-deficient macrophages treated with various stimuli, by identifying TANK-dependent genes in LPS-treated macrophages through micro-array analyses, and by functionally characterizing the role of novel TANKintera ...
... This will be further addressed by deciphering the phase of NF-B and IRF activation in TANK-deficient macrophages treated with various stimuli, by identifying TANK-dependent genes in LPS-treated macrophages through micro-array analyses, and by functionally characterizing the role of novel TANKintera ...
A Genome-Wide Survey of the NAC Transcription
... meristem (Kim et al., 2007b), fiber development (Ko et al., 2007), leaf senescence (Guo et al., 2005a), and cell division (Kim et al., 2006). Additionally, AtNAC1 gene expression is induced by lateral root development, which in turn is regulated by the hormone auxin (Xie et al., 2000). Many proteins ...
... meristem (Kim et al., 2007b), fiber development (Ko et al., 2007), leaf senescence (Guo et al., 2005a), and cell division (Kim et al., 2006). Additionally, AtNAC1 gene expression is induced by lateral root development, which in turn is regulated by the hormone auxin (Xie et al., 2000). Many proteins ...
File - Catecholaminergic Polymorphic Ventricular
... ventricular arrhythmia disorder caused by mutation in the RYR2 gene. It has been classified as one of the most dangerous heart arrhythmias since 30% of individuals with CPVT die before the age of thirty (Leenhardt et al., 2012; Ylanen et al., 2010). CPVT's high lethality rate can be attributed to RY ...
... ventricular arrhythmia disorder caused by mutation in the RYR2 gene. It has been classified as one of the most dangerous heart arrhythmias since 30% of individuals with CPVT die before the age of thirty (Leenhardt et al., 2012; Ylanen et al., 2010). CPVT's high lethality rate can be attributed to RY ...
The glycocalyx of the sperm surface
... use of specific lectins, which bind to different types of sugar side-chain (Cummings, 1994), and thus together provide a picture of the sugar moieties forming the sperm surface. Whereas the majority of authors have looked at lectin-binding to ejaculated spermatozoa, some have used this technique to ...
... use of specific lectins, which bind to different types of sugar side-chain (Cummings, 1994), and thus together provide a picture of the sugar moieties forming the sperm surface. Whereas the majority of authors have looked at lectin-binding to ejaculated spermatozoa, some have used this technique to ...
The OBO Foundry Project
... A molecular function is a propensity of a gene product instance to perform actions on the molecular level of granularity. Hypothesis 1: these actions must be reliably such as to contribute to biological processes. Hypothesis 2: these actions must be reliably such as to contribute to the organism’s r ...
... A molecular function is a propensity of a gene product instance to perform actions on the molecular level of granularity. Hypothesis 1: these actions must be reliably such as to contribute to biological processes. Hypothesis 2: these actions must be reliably such as to contribute to the organism’s r ...
Maternal and Zygotic Control of Zebrafish Dorsoventral Axial
... each division. Prior to the 16-cell stage, all cells of the embryo undergo incomplete cytokinesis, such that cell membranes are not complete at the yolk cell interface (59). In subsequent divisions, the central-most blastomeres undergo complete cytokinesis and only the peripheral blastomeres adjacen ...
... each division. Prior to the 16-cell stage, all cells of the embryo undergo incomplete cytokinesis, such that cell membranes are not complete at the yolk cell interface (59). In subsequent divisions, the central-most blastomeres undergo complete cytokinesis and only the peripheral blastomeres adjacen ...
Pax proteins and eye development Rachel Macdonald 1 and
... Expression of pax-6 and pax-2 in the developing eye. Dorsal views of 18-somite zebrafish embryos labelled with antibodies that recognize (a) Pax-6 and (b) Pax-2. (a) Within the optic cup, Pax-6 is present in cells of the neural retina (nr) and pigment epithelium (pe), (b) whereas Pax-2 expression is ...
... Expression of pax-6 and pax-2 in the developing eye. Dorsal views of 18-somite zebrafish embryos labelled with antibodies that recognize (a) Pax-6 and (b) Pax-2. (a) Within the optic cup, Pax-6 is present in cells of the neural retina (nr) and pigment epithelium (pe), (b) whereas Pax-2 expression is ...
NF-kB as a primary regulator of the stress response
... receptors. A number of signal transduction proteins have been identi®ed as associated with these receptors, including TNF-receptor associated factors 2 and 6 [TRAF2 and 6], death domain-containing proteins [TRADD and FADD], kinases associated with the IL1 receptor [IRAK1 and 2, and MYD88]. Other pro ...
... receptors. A number of signal transduction proteins have been identi®ed as associated with these receptors, including TNF-receptor associated factors 2 and 6 [TRAF2 and 6], death domain-containing proteins [TRADD and FADD], kinases associated with the IL1 receptor [IRAK1 and 2, and MYD88]. Other pro ...
Term Identification in the Biomedical Literature*
... The current growth of biomedical knowledge has spurred interest in natural language processing (NLP) and information technologies such as information retrieval (IR) and information extraction (IE), which are helpful to cope with an increasingly large body of biomedical articles. These applications d ...
... The current growth of biomedical knowledge has spurred interest in natural language processing (NLP) and information technologies such as information retrieval (IR) and information extraction (IE), which are helpful to cope with an increasingly large body of biomedical articles. These applications d ...
T1 transgenic tobacco plants
... is an urgent issue in order to protect the world’s food safety nowadays. Current preserving method such as drying, mixing with inert dust, or stirring are time-consuming and inefficient, while chemical treatment may cause risks of environmental pollution and poisoning for humans and animals. Plant d ...
... is an urgent issue in order to protect the world’s food safety nowadays. Current preserving method such as drying, mixing with inert dust, or stirring are time-consuming and inefficient, while chemical treatment may cause risks of environmental pollution and poisoning for humans and animals. Plant d ...
from dicp.ac.cn
... five sites are located in the MSK1 C-terminus, close to Thr700, which is conserved in MAPK-integrating kinase 1 and 2 (MNK1 and MNK2) (6). According to a recent activation model of MSK1, phosphorylation of Thr700 relieves inhibition of MSK1 by a C-terminal autoinhibitory helix, and helps induce a co ...
... five sites are located in the MSK1 C-terminus, close to Thr700, which is conserved in MAPK-integrating kinase 1 and 2 (MNK1 and MNK2) (6). According to a recent activation model of MSK1, phosphorylation of Thr700 relieves inhibition of MSK1 by a C-terminal autoinhibitory helix, and helps induce a co ...
Protein moonlighting
![](https://commons.wikimedia.org/wiki/Special:FilePath/3EL3.png?width=300)
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.