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... dAgo1, and dAgo2 have been implicated in RNAi-like silencing phenomena. dAgo1 was shown to be required for efficient RNAi in Drosophila embryos, with its particular function lying downstream of Dicer in the pathway (Williams and Rubin 2002). piwi has been shown to be necessary for PTGS and some aspe ...
... dAgo1, and dAgo2 have been implicated in RNAi-like silencing phenomena. dAgo1 was shown to be required for efficient RNAi in Drosophila embryos, with its particular function lying downstream of Dicer in the pathway (Williams and Rubin 2002). piwi has been shown to be necessary for PTGS and some aspe ...
The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on
... Another quantitatively highly relevant case concerns chemical modification of enzymatic coenzymes, such as NADH or FADH. Hydration of NADH or NADPH is common, occurring either non-enzymatically [63] or as a side reaction of promiscuous enzymes such as glyceraldehyde 3-phosphate dehydrogenase [64]. T ...
... Another quantitatively highly relevant case concerns chemical modification of enzymatic coenzymes, such as NADH or FADH. Hydration of NADH or NADPH is common, occurring either non-enzymatically [63] or as a side reaction of promiscuous enzymes such as glyceraldehyde 3-phosphate dehydrogenase [64]. T ...
suppression of the ras1 mutant phenotype. encoding a protein
... carboxyl terminus of the byr2 product had significant homology to a large number of proteins, all of them known or suspected to be protein kinases. In fact, all of the conserved amino acid residues deduced from 65 protein kinases (10) are present in the byr2 product. The serine at position 566 sugge ...
... carboxyl terminus of the byr2 product had significant homology to a large number of proteins, all of them known or suspected to be protein kinases. In fact, all of the conserved amino acid residues deduced from 65 protein kinases (10) are present in the byr2 product. The serine at position 566 sugge ...
669 Salmonella typhimurium - Journal of General Virology
... Immediately after binding, the tail proteins begin to cleave the O antigen. As the rhamnosylgalactose linkages are cleaved, the proteins apparently migrate down the chain. This is based on the fact that when unattached tail protein is bound to ceils, it is not found free in the medium until some tim ...
... Immediately after binding, the tail proteins begin to cleave the O antigen. As the rhamnosylgalactose linkages are cleaved, the proteins apparently migrate down the chain. This is based on the fact that when unattached tail protein is bound to ceils, it is not found free in the medium until some tim ...
ClgR regulation of chaperone and protease systems is essential for
... Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence. Bacteria have evolved accurate regulatory systems to con ...
... Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence. Bacteria have evolved accurate regulatory systems to con ...
PHM 142 UNIT 9B Mitochondrial function in neurodegenerative
... patients. Often, the prediction of the pathogenicity of unknown genetic variants is not possible on the basis of sequence information alone. Usually, the level of heteroplasmy of the mtDNA variant is checked in different tissues of the patient and, in addition, in family members in the maternal line ...
... patients. Often, the prediction of the pathogenicity of unknown genetic variants is not possible on the basis of sequence information alone. Usually, the level of heteroplasmy of the mtDNA variant is checked in different tissues of the patient and, in addition, in family members in the maternal line ...
Hemoglobin
... These modifications occur following the synthesis (translation) of proteins and are, therefore, termed post-translational modifications. These forms of modification impart specialized functions upon the resultant proteins. Proteins covalently associated with carbohydrates are termed glycoproteins. G ...
... These modifications occur following the synthesis (translation) of proteins and are, therefore, termed post-translational modifications. These forms of modification impart specialized functions upon the resultant proteins. Proteins covalently associated with carbohydrates are termed glycoproteins. G ...
Super secondary structure (Motif)
... arrangements known as motifs Since motifs contain more than one secondary structural element, these are referred to as super secondary structures Simple motifs can combine to form more complex motifs Recognizing motifs helps decompose complex protein structures into simpler units that can be readily ...
... arrangements known as motifs Since motifs contain more than one secondary structural element, these are referred to as super secondary structures Simple motifs can combine to form more complex motifs Recognizing motifs helps decompose complex protein structures into simpler units that can be readily ...
The Heat-Shock Proteins
... of high negative-charge density toward the carboxy terminus. The carboxyterminal regions of these proteins are generally the most divergent, but the four most-terminalaminoacids, glu-glu-val-asp, are the samein all eukaryotic hsp90s (in trypanosmes the second glu is replaced by gin; 56). It is remar ...
... of high negative-charge density toward the carboxy terminus. The carboxyterminal regions of these proteins are generally the most divergent, but the four most-terminalaminoacids, glu-glu-val-asp, are the samein all eukaryotic hsp90s (in trypanosmes the second glu is replaced by gin; 56). It is remar ...
The molecular basis for selective assembly of the UBAP1
... for several cellular functions, such as cell division and retroviral budding. ESCRT-I has four subunits; TSG101, VPS28, VPS37 and MVB12. There are several members of VPS37 and MVB12 families in mammalian cells, and their differential incorporation into ESCRT-I could provide function-specific variant ...
... for several cellular functions, such as cell division and retroviral budding. ESCRT-I has four subunits; TSG101, VPS28, VPS37 and MVB12. There are several members of VPS37 and MVB12 families in mammalian cells, and their differential incorporation into ESCRT-I could provide function-specific variant ...
Molecular biology of brain aging and neurodegenerative disorders
... 1995). This gene has also been cloned and is named STM2 (the second seven transmembrane gene associated with AD) (Levy-Lahad et al. 1995) or E5-1 (Rogaev et al. 1995). STM2 encodes for a protein predicted to have 554 amino acids. At the primary structure level STM2 and S182 are 67% identical over al ...
... 1995). This gene has also been cloned and is named STM2 (the second seven transmembrane gene associated with AD) (Levy-Lahad et al. 1995) or E5-1 (Rogaev et al. 1995). STM2 encodes for a protein predicted to have 554 amino acids. At the primary structure level STM2 and S182 are 67% identical over al ...
Annotated Bibliography "Primary Information of P53 Gene
... Annotated Bibliography "Primary Information of P53 Gene." Bioinformatics Organization. Bioinformatics Organization, Inc. Web. 1 Oct. 2015. The people that wrote this article are a group or bioinformatics researches that conduct many research projects. The intended audience is people who would like t ...
... Annotated Bibliography "Primary Information of P53 Gene." Bioinformatics Organization. Bioinformatics Organization, Inc. Web. 1 Oct. 2015. The people that wrote this article are a group or bioinformatics researches that conduct many research projects. The intended audience is people who would like t ...
An in silico analysis of the mitochondrial protein import apparatus of
... respiratory chain [17]. Although fungi contain alternative NAD(P)H dehydrogenases and an alternative oxidase, these are usually only expressed under conditions where the cytochrome chain is inhibited [17]. In contrast, plant mitochondria contain components of the alternative respiratory pathways whi ...
... respiratory chain [17]. Although fungi contain alternative NAD(P)H dehydrogenases and an alternative oxidase, these are usually only expressed under conditions where the cytochrome chain is inhibited [17]. In contrast, plant mitochondria contain components of the alternative respiratory pathways whi ...
BLAST Tips - Boston University
... Search sequences that have gene expression profiles (GEO) Search immunoglobulins (IgBLAST) Search for SNPs (snp) Screen sequence for vector contamination (vecscreen) Align two (or more) sequences using BLAST (bl2seq) Search protein or nucleotide targets in PubChem BioAssay Search SRA transcript libr ...
... Search sequences that have gene expression profiles (GEO) Search immunoglobulins (IgBLAST) Search for SNPs (snp) Screen sequence for vector contamination (vecscreen) Align two (or more) sequences using BLAST (bl2seq) Search protein or nucleotide targets in PubChem BioAssay Search SRA transcript libr ...
The Electrophoretic Movement of Proteins from Various
... strains. For example, f, i, k, m and p occurred in all five strains and g , h, j, n and q in four strains. For any named band, the frequency of occurrence and the intensity of staining (dark or light) was not the same for all isolates. The frequency of band k was low, only 18% for PD 04833,and high ...
... strains. For example, f, i, k, m and p occurred in all five strains and g , h, j, n and q in four strains. For any named band, the frequency of occurrence and the intensity of staining (dark or light) was not the same for all isolates. The frequency of band k was low, only 18% for PD 04833,and high ...
Gene Section BRD4 (bromodomain containing 4) Atlas of Genetics and Cytogenetics
... bromodomains and a conserved ET-domain. The open reading frame encodes a 1362 amino acid protein with a molecular weight of 200 kDa. ...
... bromodomains and a conserved ET-domain. The open reading frame encodes a 1362 amino acid protein with a molecular weight of 200 kDa. ...
ppt
... The analysis of the FPs indicates that they often involve texts that describe general consensus sequence or predicted sites of protein phosphorylation. These FPs may result from a condition used in the system that focuses on finding all potential phosphorylation site information. The system missed o ...
... The analysis of the FPs indicates that they often involve texts that describe general consensus sequence or predicted sites of protein phosphorylation. These FPs may result from a condition used in the system that focuses on finding all potential phosphorylation site information. The system missed o ...
Phytopathogen type III effector weaponry and their plant targets
... Plant innate immunity controls the activation of innate immune responses using mitogen-activated protein kinase (MAPK) cascades and hormones such as salicylic acid (SA). These defences include the deposition of lignin and callose in the cell wall, transcription of pathogenesis-related (PR) genes, an ...
... Plant innate immunity controls the activation of innate immune responses using mitogen-activated protein kinase (MAPK) cascades and hormones such as salicylic acid (SA). These defences include the deposition of lignin and callose in the cell wall, transcription of pathogenesis-related (PR) genes, an ...
Hydrolytic Enzymes
... Microbial enzymes are produced by methods which can be scaled up easily. Recombinant DNA technology now provides the means to produce many different enzymes, including those not normally synthesized by microorganisms or permanent cell lines, in bacteria, yeast and cultured cells. ...
... Microbial enzymes are produced by methods which can be scaled up easily. Recombinant DNA technology now provides the means to produce many different enzymes, including those not normally synthesized by microorganisms or permanent cell lines, in bacteria, yeast and cultured cells. ...
Chapter 5 The Structure and Function of Large Biological Molecules
... Alterations in pH, salt concentration, temperature, or other environmental factors can cause a protein to unravel This loss of a protein’s native structure is called denaturation ...
... Alterations in pH, salt concentration, temperature, or other environmental factors can cause a protein to unravel This loss of a protein’s native structure is called denaturation ...
Expressing_CENH3_Orthologs
... kinetochore (1). The main protein that recruits other kinetochore proteins and assembles a functional centromere is the centromere-specific histone H3 (CENH3) which replaces the canonical histone H3 in centromeric chromatin (2). Conventional histone H3 is highly conserved due to its importance in DN ...
... kinetochore (1). The main protein that recruits other kinetochore proteins and assembles a functional centromere is the centromere-specific histone H3 (CENH3) which replaces the canonical histone H3 in centromeric chromatin (2). Conventional histone H3 is highly conserved due to its importance in DN ...
Amyloid deposits - Lindquist Lab
... characteristics independent of the proteins’ primary amino acid sequences and may share a common mechanism of toxicity.5 Indeed even proteins completely unrelated to disease, such as PI3 kinase and the E. Coli protein HypF-N, can be induced to form such prefibrillar structures in vitro and, when the ...
... characteristics independent of the proteins’ primary amino acid sequences and may share a common mechanism of toxicity.5 Indeed even proteins completely unrelated to disease, such as PI3 kinase and the E. Coli protein HypF-N, can be induced to form such prefibrillar structures in vitro and, when the ...
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... into the extracellular space. Multiple rounds of sequential budding and fusion of vesicular carriers mediate protein secretion among compartments [2]. Membrane proteins, for example integral PM proteins, are also delivered to their target membrane through this secretory pathway, referred to as conve ...
... into the extracellular space. Multiple rounds of sequential budding and fusion of vesicular carriers mediate protein secretion among compartments [2]. Membrane proteins, for example integral PM proteins, are also delivered to their target membrane through this secretory pathway, referred to as conve ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.