Initiation of Innate Immune Responses in the
... cuticle proPOs of the silkworm, Bombyx mori have been characterized and one of them is shown to be transported from the hemolymph proPO to the cuticle. The transported cuticle proPO has different molecular mass from the hemolymph proPO because of the modification of one up to six methionine residue( ...
... cuticle proPOs of the silkworm, Bombyx mori have been characterized and one of them is shown to be transported from the hemolymph proPO to the cuticle. The transported cuticle proPO has different molecular mass from the hemolymph proPO because of the modification of one up to six methionine residue( ...
Leukaemia Section t(10;11)(q22;q23) KMT2A/TET1 Atlas of Genetics and Cytogenetics in Oncology and Haematology
... TET1 is also called LCX (leukemia-associated protein with a CXXC domain) or CXXC6 (CXXC finger 6). DNA/RNA 8497 bp representing the whole coding sequence. Contains 12 exons. Contains 3 bipartite nuclear localization sites, 1 alpha helice coiled-coil region and 1 cysteine rich domain with high level ...
... TET1 is also called LCX (leukemia-associated protein with a CXXC domain) or CXXC6 (CXXC finger 6). DNA/RNA 8497 bp representing the whole coding sequence. Contains 12 exons. Contains 3 bipartite nuclear localization sites, 1 alpha helice coiled-coil region and 1 cysteine rich domain with high level ...
Fe Sparing and Fe Recycling Contribute to
... was subsequently maintained at a new steady state level, consistent with its essential role in plastid metabolism. The abundance of the cyclase increased over the first 24 h, while the cells continued to divide (although not to the same extent as in the +Fe controls), but then decreased markedly rela ...
... was subsequently maintained at a new steady state level, consistent with its essential role in plastid metabolism. The abundance of the cyclase increased over the first 24 h, while the cells continued to divide (although not to the same extent as in the +Fe controls), but then decreased markedly rela ...
Neisseria conserved hypothetical protein DMP12
... protein dimer. DMP12 also protects HU protein from limited digestion by trypsin and enhances the growth rate Escherichia coli. Functionally, HU proteins participate in bacterial nucleoid formation, as well as recombination, gene regulation and DNA replication. The interaction between DMP12 and HU pr ...
... protein dimer. DMP12 also protects HU protein from limited digestion by trypsin and enhances the growth rate Escherichia coli. Functionally, HU proteins participate in bacterial nucleoid formation, as well as recombination, gene regulation and DNA replication. The interaction between DMP12 and HU pr ...
Supplemental Text
... Donachie & Blakely, 2003] and cell division. The model further captures optimal regulation of ribosome synthesis in different nutrient environments as a function of the intracellular level of resources like amino acids or ATP – a mechanism that is widely accepted as the means by which E. coli and ot ...
... Donachie & Blakely, 2003] and cell division. The model further captures optimal regulation of ribosome synthesis in different nutrient environments as a function of the intracellular level of resources like amino acids or ATP – a mechanism that is widely accepted as the means by which E. coli and ot ...
Plant mitochondria contain the protein translocase subunits TatB
... Journal of Cell Science • Advance article ...
... Journal of Cell Science • Advance article ...
Biocatalytic potential of thermophilic bacteria and actinomycetes
... 51]. Their unique characteristics include substrate specificity, stereospecificity, regioselectivity and ability to catalyze a heterogeneous reaction at the interface of water soluble and water insoluble systems [52]. The esters produced play a significant role in the food industry as flavor and aro ...
... 51]. Their unique characteristics include substrate specificity, stereospecificity, regioselectivity and ability to catalyze a heterogeneous reaction at the interface of water soluble and water insoluble systems [52]. The esters produced play a significant role in the food industry as flavor and aro ...
Characterization of the pscC
... bioRxiv preprint first posted online Aug. 26, 2016; doi: http://dx.doi.org/10.1101/071720. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license. ...
... bioRxiv preprint first posted online Aug. 26, 2016; doi: http://dx.doi.org/10.1101/071720. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license. ...
Protein import into the nucleus - Universitätsklinikum des Saarlandes
... Ran-GTP. Names of S. cerevisiae homologues are in parentheses. the import substrate from NRc~. By one model, release could be achieved by NRc~ modification, e.g. dephosphorylation. This idea is supported by the observation that only phosphorylated NRe~ bound NLSs in a blot binding assay [40] and by ...
... Ran-GTP. Names of S. cerevisiae homologues are in parentheses. the import substrate from NRc~. By one model, release could be achieved by NRc~ modification, e.g. dephosphorylation. This idea is supported by the observation that only phosphorylated NRe~ bound NLSs in a blot binding assay [40] and by ...
The possibilities of practical application of transgenic mammalian
... also detected in the brain, kidneys and testis of some transgenic mouse lines and murine cell lines (Lin et al. 1995, Kerr et al. 1998, Zhang et al. 2002, Zhu et al. 2004, Kwon et al. 2006). Kwon et al. (2006) cloned an 8.8 kb pig UPII (pUPII) promoter region and investigated which cells within the ...
... also detected in the brain, kidneys and testis of some transgenic mouse lines and murine cell lines (Lin et al. 1995, Kerr et al. 1998, Zhang et al. 2002, Zhu et al. 2004, Kwon et al. 2006). Kwon et al. (2006) cloned an 8.8 kb pig UPII (pUPII) promoter region and investigated which cells within the ...
Systemic Delivery of siRNA by a Plant PHLOEM SMALL RNA
... (a) and (b) Total proteins were extracted from infected tissues (A) and phloem exudate (B) of pumpkin plants in which c-Myc4-His8 tagged rbcS, GFP, CmPSRP1 WT, Qm and ∆C were expressed using a ZYMV vector. Total proteins extracted from infected tissues (10 µg) and phloem exudate (40 µg) were separa ...
... (a) and (b) Total proteins were extracted from infected tissues (A) and phloem exudate (B) of pumpkin plants in which c-Myc4-His8 tagged rbcS, GFP, CmPSRP1 WT, Qm and ∆C were expressed using a ZYMV vector. Total proteins extracted from infected tissues (10 µg) and phloem exudate (40 µg) were separa ...
Ribosome stalls at trp codons, allowing 2+3 pairing Transcription
... Enzymes acting in pathway to produce tryptophan. Gene order correlates with order of reactions in pathway. ...
... Enzymes acting in pathway to produce tryptophan. Gene order correlates with order of reactions in pathway. ...
Disparate proteins use similar architectures to damage membranes
... physiological conditions. This group of proteins includes enzymes, transporters, small domains of signalling proteins, polypeptide toxins, antibacterial peptides, etc. The peripheral proteins attach to the lipid membranes through various mechanisms (Figure I). The amino acids that participate in pro ...
... physiological conditions. This group of proteins includes enzymes, transporters, small domains of signalling proteins, polypeptide toxins, antibacterial peptides, etc. The peripheral proteins attach to the lipid membranes through various mechanisms (Figure I). The amino acids that participate in pro ...
Genotype–phenotype associations and human eye color
... transporter protein, it transports melanosomes, but additionally, it controls their pH.3,13 Therefore, the P protein encoded by OCA2 affects the amount and quality of melanin that deposits in melanocytes. In mice and humans where the P protein is nonfunctional, albinism occurs, indicating its crucia ...
... transporter protein, it transports melanosomes, but additionally, it controls their pH.3,13 Therefore, the P protein encoded by OCA2 affects the amount and quality of melanin that deposits in melanocytes. In mice and humans where the P protein is nonfunctional, albinism occurs, indicating its crucia ...
A Sunflower Helianthinin Gene Upstream Sequence
... DNA fragment of the sunflower helianthinin gene HaG3D, located 322 base pairs from the transcriptional start site, enhanced pglucuronidase expression in transgenic tobacco embryos. Sequences within this fragment were found to bind nuclear proteins present in both sunflower embryo and hypocotyl nucle ...
... DNA fragment of the sunflower helianthinin gene HaG3D, located 322 base pairs from the transcriptional start site, enhanced pglucuronidase expression in transgenic tobacco embryos. Sequences within this fragment were found to bind nuclear proteins present in both sunflower embryo and hypocotyl nucle ...
Genome Analysis Excerpt from Chapter 11
... These gene sequences and the amino acid sequences of the encoded proteins may be used to predict the evolutionary history of genomes. Genes frequently occur in families resulting from repeated duplication and subsequent diversification of the biological function of these genes through sequence varia ...
... These gene sequences and the amino acid sequences of the encoded proteins may be used to predict the evolutionary history of genomes. Genes frequently occur in families resulting from repeated duplication and subsequent diversification of the biological function of these genes through sequence varia ...
HIGH-INTENSITY ENDURANCE EXERCISE INCREASES MORE
... where the pressure during LI-ET+BFR was 80% of maximum restriction pressure. One biopsy was taken three hours (3hr) after each exercise session from vastus lateralis. Results: There were significant increases of PGC-1-α and VEGF mRNA expression to HI-EE. There were no changes in protein phosphorylat ...
... where the pressure during LI-ET+BFR was 80% of maximum restriction pressure. One biopsy was taken three hours (3hr) after each exercise session from vastus lateralis. Results: There were significant increases of PGC-1-α and VEGF mRNA expression to HI-EE. There were no changes in protein phosphorylat ...
operons operons operons
... • REPRESSABLE OPERONS Usually ON/repressor usually ACTIVE Can be turned off (repressed) Genes for enzymes that make product always needed EX: trp operon makes enzymes used in essential amino acid synthesis ...
... • REPRESSABLE OPERONS Usually ON/repressor usually ACTIVE Can be turned off (repressed) Genes for enzymes that make product always needed EX: trp operon makes enzymes used in essential amino acid synthesis ...
Protein S deficiency
... acquired protein S deficiency may provoke a hyperinflammatory response.26 Many authors have reported inhibition of APC anticoagulant activity in patients with lupus anticoagulants and thromboembolic manifestations. Optimal function of the APC-protein S complex requires the presence of phosphatidylet ...
... acquired protein S deficiency may provoke a hyperinflammatory response.26 Many authors have reported inhibition of APC anticoagulant activity in patients with lupus anticoagulants and thromboembolic manifestations. Optimal function of the APC-protein S complex requires the presence of phosphatidylet ...
BPM§1.2_Protein Struktur.key
... This describes the overall shape of the domain structure as determined by the orientations of the secondary structures but ignores the connectivity between the secondary structures. ...
... This describes the overall shape of the domain structure as determined by the orientations of the secondary structures but ignores the connectivity between the secondary structures. ...
The Evolutionary Accessibility of New Enzyme Functions: A Case
... [14,15]2. In another study, eleven base changes were used to convert a dehalogenase into a crotonase, with only 0.005% of wild-type crotonase activity achieved [16]. Somewhat better conversion, reaching 0.25% of wild-type activity, was accomplished between two hydroxysteroid dehydrogenases (HSDs), b ...
... [14,15]2. In another study, eleven base changes were used to convert a dehalogenase into a crotonase, with only 0.005% of wild-type crotonase activity achieved [16]. Somewhat better conversion, reaching 0.25% of wild-type activity, was accomplished between two hydroxysteroid dehydrogenases (HSDs), b ...
BrownCNA Thank you with the QC checking of this genome. It was
... Thank you with the QC checking of this genome. It was pretty straightforward and we had 2 different class sections work on the annotations that were compared for the final file. We had 2 genes that I would like help another opinion on. Larry’s class added one ORF, but it was not added by mine; both ...
... Thank you with the QC checking of this genome. It was pretty straightforward and we had 2 different class sections work on the annotations that were compared for the final file. We had 2 genes that I would like help another opinion on. Larry’s class added one ORF, but it was not added by mine; both ...
Review article - HAL
... The identification of the FBN1 gene has allowed the development of two types of diagnostic tests: either genetic family studies or mutation identification. Family studies can be performed with specific FBN1 polymorphic markers to identify the mutation-bearing haplotype (24). These studies are only r ...
... The identification of the FBN1 gene has allowed the development of two types of diagnostic tests: either genetic family studies or mutation identification. Family studies can be performed with specific FBN1 polymorphic markers to identify the mutation-bearing haplotype (24). These studies are only r ...
Leukaemia Section t(11;17)(q23;q21) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... 1- As a result of the alternative splicing of PLZF gene, two forms of PLZF-RARa protein can be detected: a) PLZF(A)-RARa (735 amino acids; 81 kDa) composed of the N-term part of PLZF including POZ domain and two of the nine zinc fingers, fused to the DNA and ligand binding domains of RARa. b) PLZF(B ...
... 1- As a result of the alternative splicing of PLZF gene, two forms of PLZF-RARa protein can be detected: a) PLZF(A)-RARa (735 amino acids; 81 kDa) composed of the N-term part of PLZF including POZ domain and two of the nine zinc fingers, fused to the DNA and ligand binding domains of RARa. b) PLZF(B ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.