Peroxiredoxin-controlled G-CSF signalling at the endoplasmic
... of H2O2 for the so-called oxidative burst, a major weapon in host defence against bacteria. In non-phagocytic cells, H2O2 has long been considered as an unwanted by-product of cell metabolism, potentially hazardous because of the damaging effects on proteins, lipids, carbohydrates and nucleic acids ...
... of H2O2 for the so-called oxidative burst, a major weapon in host defence against bacteria. In non-phagocytic cells, H2O2 has long been considered as an unwanted by-product of cell metabolism, potentially hazardous because of the damaging effects on proteins, lipids, carbohydrates and nucleic acids ...
Cellular Internalization of Fluorescent Proteins via Arginine
... polyhistidine or polyornithine (Futaki 2002). Various chain lengths of polyarginine were examined for cellular internalization. The highest translocation efficiency was reached by using octa-arginine or nona-arginine (R9) peptides (Futaki 2002). In addition, the arginine residues do not necessarily ...
... polyhistidine or polyornithine (Futaki 2002). Various chain lengths of polyarginine were examined for cellular internalization. The highest translocation efficiency was reached by using octa-arginine or nona-arginine (R9) peptides (Futaki 2002). In addition, the arginine residues do not necessarily ...
Role of plectin in cytoskeleton organization and dynamics
... Role of plectin in cytoskeleton organization and dynamics 2479 of the highly conserved repeat 5 domain core region which, like all other carboxy-terminal repeat domains comprises multiple copies of a tandemly repeated 19 (38) amino acid residue-long sequence motif, plectin’s IF binding site is part ...
... Role of plectin in cytoskeleton organization and dynamics 2479 of the highly conserved repeat 5 domain core region which, like all other carboxy-terminal repeat domains comprises multiple copies of a tandemly repeated 19 (38) amino acid residue-long sequence motif, plectin’s IF binding site is part ...
Detecting and characterizing specialized ribosomes translating
... It has long been known that ribosome architecture and the basic mechanism of protein synthesis are highly conserved in evolution. For this reason, ribosomes have been traditionally regarded as a static factory that passively carry out translation, while the mechanisms controlling translation have be ...
... It has long been known that ribosome architecture and the basic mechanism of protein synthesis are highly conserved in evolution. For this reason, ribosomes have been traditionally regarded as a static factory that passively carry out translation, while the mechanisms controlling translation have be ...
a study of intelligent techniques for protein secondary structure
... Qian and Terrence [Qian et al, 1988] introduced one of the first Neural Networks used for secondary structure prediction. They worked on a network with 17 input groups having 21 units per group, 40 hidden units and three output units. The usage of Neural Networks then started evolving and different ...
... Qian and Terrence [Qian et al, 1988] introduced one of the first Neural Networks used for secondary structure prediction. They worked on a network with 17 input groups having 21 units per group, 40 hidden units and three output units. The usage of Neural Networks then started evolving and different ...
ASH1 by Puf6p–Fun12p/eIF5B interaction and released by CK2 phosphorylation Yingfeng Deng,
... al. 2000), which contains putative Puf6p-binding sites at the 3⬘UTR (Gu et al. 2004). IST2 mRNA was found diffusely distributed within the bud in both fun12 and puf6 mutants (Supplemental Fig. 4), similar to the pattern observed for ASH1 mRNA. Both the N-terminal region and PUF domain of Puf6p are r ...
... al. 2000), which contains putative Puf6p-binding sites at the 3⬘UTR (Gu et al. 2004). IST2 mRNA was found diffusely distributed within the bud in both fun12 and puf6 mutants (Supplemental Fig. 4), similar to the pattern observed for ASH1 mRNA. Both the N-terminal region and PUF domain of Puf6p are r ...
PDF - International Journal of Biological Sciences
... reduced transpiration rate in pine can stimulate population growth of B. xylophilus [8]. In addition to abiotic factors, such as temperature and water stress, biotic factors also play a prominent role in the infection and distribution of this plant pathogenic nematode. A better understanding of thes ...
... reduced transpiration rate in pine can stimulate population growth of B. xylophilus [8]. In addition to abiotic factors, such as temperature and water stress, biotic factors also play a prominent role in the infection and distribution of this plant pathogenic nematode. A better understanding of thes ...
Ch 7 Slides - people.iup.edu
... Concept 7.1: Cellular membranes are consist of lipids and proteins in a fluid mosaic arrangement. • Phospholipids are the primary lipids in most membranes. • amphipathic molecules • The fluid mosaic model states that a membrane is a fluid structure with a “mosaic” of various proteins embedded in it ...
... Concept 7.1: Cellular membranes are consist of lipids and proteins in a fluid mosaic arrangement. • Phospholipids are the primary lipids in most membranes. • amphipathic molecules • The fluid mosaic model states that a membrane is a fluid structure with a “mosaic” of various proteins embedded in it ...
video slide
... Concept 7.1: Cellular membranes are consist of lipids and proteins in a fluid mosaic arrangement. • Phospholipids are the primary lipids in most membranes. • amphipathic molecules • The fluid mosaic model states that a membrane is a fluid structure with a “mosaic” of various proteins embedded in it ...
... Concept 7.1: Cellular membranes are consist of lipids and proteins in a fluid mosaic arrangement. • Phospholipids are the primary lipids in most membranes. • amphipathic molecules • The fluid mosaic model states that a membrane is a fluid structure with a “mosaic” of various proteins embedded in it ...
Association of CAD, a multifunctional protein involved in pyrimidine
... Conclusion: The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8. Keywords: mLST8, CAD, mTOR, Amino acids, Pyrimidine synthesis ...
... Conclusion: The results obtained indicate that mLST8 bridges between CAD and mTOR, and plays a role in the signaling mechanism where CAD is regulated in the mTOR pathway through the association with mLST8. Keywords: mLST8, CAD, mTOR, Amino acids, Pyrimidine synthesis ...
Boronophenyl analogs of phospholyrosines
... protein complexes that relay signals throughout the cell. The structural nature of these protein interactions is emerging through the identi?cation of the individual pro teins that participate in each signal transduction pathway. the elucidation of the temporal order in which these proteins ...
... protein complexes that relay signals throughout the cell. The structural nature of these protein interactions is emerging through the identi?cation of the individual pro teins that participate in each signal transduction pathway. the elucidation of the temporal order in which these proteins ...
Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar
... Recombinant DNA manipulations employed in the construction of plasmids were performed as described previously (Maniatis et al., 1989), with the exception of DNA fragment isolations carried out by the glass bead method of Vogelstein and Gillespie (1979). The CENbased plasmid pVPS45-10 was generated b ...
... Recombinant DNA manipulations employed in the construction of plasmids were performed as described previously (Maniatis et al., 1989), with the exception of DNA fragment isolations carried out by the glass bead method of Vogelstein and Gillespie (1979). The CENbased plasmid pVPS45-10 was generated b ...
D0 You Know About Amino Acids?
... D0 You Know About Amino Acids? What on Earth is an Amino Acid? Simply put, they are organic compounds that are created when protein is digested. But it doesn’t end there. Your body needs a variety of amino acids to function properly. Your body makes some of these amino acids by itself, but a lot of ...
... D0 You Know About Amino Acids? What on Earth is an Amino Acid? Simply put, they are organic compounds that are created when protein is digested. But it doesn’t end there. Your body needs a variety of amino acids to function properly. Your body makes some of these amino acids by itself, but a lot of ...
AP Biology Unit 2 Exam Study Guide 1. Explain the requirements for
... the Endosymbiotic Theory. 16. Explain what occurs at each of the checkpoints in the cell cycle and the consequences if a flaw is not detected. 17. Describe the structure and function of cyclins. 18. Have the ability to analyze and explain a graph of enzyme concentration vs. reaction rate. 19. Explai ...
... the Endosymbiotic Theory. 16. Explain what occurs at each of the checkpoints in the cell cycle and the consequences if a flaw is not detected. 17. Describe the structure and function of cyclins. 18. Have the ability to analyze and explain a graph of enzyme concentration vs. reaction rate. 19. Explai ...
Conserved functions of retinoblastoma proteins: From purple retina
... and a PP1 phosphatase containing a slightly modified version of the LxCxE motif [27]. The importance of this region was underlined by the fact that most of the RB mutations detected in tumors affect at least either one of the A or B domains. A specific characteristic of the structure of these domain ...
... and a PP1 phosphatase containing a slightly modified version of the LxCxE motif [27]. The importance of this region was underlined by the fact that most of the RB mutations detected in tumors affect at least either one of the A or B domains. A specific characteristic of the structure of these domain ...
Protein Prenylation: Genes, Enzymes, Targets, and Functions
... Annu. Rev. Genet. 1992.26:209-237. Downloaded from arjournals.annualreviews.org by Medical Research Council-Cambridge UK on 11/21/06. For personal use only. ...
... Annu. Rev. Genet. 1992.26:209-237. Downloaded from arjournals.annualreviews.org by Medical Research Council-Cambridge UK on 11/21/06. For personal use only. ...
Molecular Mechanisms of Transforming Growth Factor
... a variety of biological processes, and loss of TGF-b responsiveness as an important correlate of certain diseases, a tremendous effort has been undertaken in the last decade to elucidate the mechanisms by which TGF-b propagates its signal. An important step in understanding TGF-b signaling came with ...
... a variety of biological processes, and loss of TGF-b responsiveness as an important correlate of certain diseases, a tremendous effort has been undertaken in the last decade to elucidate the mechanisms by which TGF-b propagates its signal. An important step in understanding TGF-b signaling came with ...
Golgi Apparatus
... The basic function of the Golgi apparatus is the transport of proteins within the cell. The Golgi receives materials for transportation through the cis face and sends the materials through to the trans face once they are packaged and modified into the vesicles. It functions in the collection, packa ...
... The basic function of the Golgi apparatus is the transport of proteins within the cell. The Golgi receives materials for transportation through the cis face and sends the materials through to the trans face once they are packaged and modified into the vesicles. It functions in the collection, packa ...
Digestion
... the pancreatic cells as proenzymes or inactive zymsgen gromules. • Trypsin is formed by removal of a hexapeptide from the trypisinogen molecule as a result of the hydrolysis of a lysineisoleucine bond. • Trypsin is an endopeptidase with optimal action at pH of about 7. • . Trypsinogen or trypsin, ha ...
... the pancreatic cells as proenzymes or inactive zymsgen gromules. • Trypsin is formed by removal of a hexapeptide from the trypisinogen molecule as a result of the hydrolysis of a lysineisoleucine bond. • Trypsin is an endopeptidase with optimal action at pH of about 7. • . Trypsinogen or trypsin, ha ...
Surface Plasmon Resonance Imaging of Transcription Factor Proteins
... offer the possibility of directly studying proteins from a sample without the need for protein modification (i.e., fluorescent tagging) or prior knowledge of the protein’s structure or function. In this paper, we report the use of DNA arrays and SPR imaging to study the sequence-specific binding of ...
... offer the possibility of directly studying proteins from a sample without the need for protein modification (i.e., fluorescent tagging) or prior knowledge of the protein’s structure or function. In this paper, we report the use of DNA arrays and SPR imaging to study the sequence-specific binding of ...
C9orf72 binds SMCR8, localizes to lysosomes and regulates
... Loewith, 2015; Kim et al., 2002), altered mTORC1 signaling could also contribute to the increased size of SMCR8 KO cells. We therefore measured mTORC1 signaling under basal cell growth conditions by assessing the phosphorylation state of ribosomal protein S6 (S235/S236 phosphorylation sites), a down ...
... Loewith, 2015; Kim et al., 2002), altered mTORC1 signaling could also contribute to the increased size of SMCR8 KO cells. We therefore measured mTORC1 signaling under basal cell growth conditions by assessing the phosphorylation state of ribosomal protein S6 (S235/S236 phosphorylation sites), a down ...
Proteomic analyses of the time course responses of mice infected
... using MALDI-TOF MS. The results of the protein identification analysis are shown in Table 3. These data revealed that multiple immunogenic proteins at different locations on 2DE-immunoblotting showed diverse Mr and pI values and were correlated with theoretical values. Evidence of the subcellular lo ...
... using MALDI-TOF MS. The results of the protein identification analysis are shown in Table 3. These data revealed that multiple immunogenic proteins at different locations on 2DE-immunoblotting showed diverse Mr and pI values and were correlated with theoretical values. Evidence of the subcellular lo ...
Regulation of Lung Fibrosis: the impact of Smad3 post
... some patients fibrotic scar tissues persist several weeks to several months. While most patients recover without significant complications, some develop permanent nonfunctional scar tissues (fibrosis). The molecular mechanism underlying this discrepancy remains to be elucidated. Transforming growth ...
... some patients fibrotic scar tissues persist several weeks to several months. While most patients recover without significant complications, some develop permanent nonfunctional scar tissues (fibrosis). The molecular mechanism underlying this discrepancy remains to be elucidated. Transforming growth ...
Protein phosphorylation
Protein phosphorylation is a post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or modifying its function. The reverse reaction of phosphorylation is called dephosphorylation, and is catalyzed by protein phosphatases. Protein kinases and phosphatases work independently and in a balance to regulate the function of proteins. The amino acids most commonly phosphorylated are serine, threonine, and tyrosine in eukaryotes, and histidine in prokaryotes, which play important and well-characterized roles in signaling pathways and metabolism. However, many other amino acids can also be phosphorylated, including arginine, lysine, and cysteine. Protein phosphorylation was first reported in 1906 by Phoebus Levene at the Rockefeller Institute for Medical Research with the discovery of phosphorylated vitellin. However, it was nearly 50 years until the enzymatic phosphorylation of proteins by protein kinases was discovered.