CAJANUS CAJAN INDUCED LIVER DAMAGE Research Article
... hepatoprotective study is CCl412. The active radical of this compound is CCl3 which bind to the macromolecules and induce peroxidative degradation of membrane lipids of Endoplasmic reticulum. This results in the formation of lipid peroxides whose product malondialdehyde ...
... hepatoprotective study is CCl412. The active radical of this compound is CCl3 which bind to the macromolecules and induce peroxidative degradation of membrane lipids of Endoplasmic reticulum. This results in the formation of lipid peroxides whose product malondialdehyde ...
Molecular Machinery Regulating Exocytosis
... despite there being less than 10% sequence identity between the individual proteins. These C-terminal domains consist of multiple rod-like helical bundles, which appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins (Sivaram, et a ...
... despite there being less than 10% sequence identity between the individual proteins. These C-terminal domains consist of multiple rod-like helical bundles, which appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins (Sivaram, et a ...
MAPK-mediated Phosphorylation of GATA-1 Promotes Expression and Cell Survival* Bcl-X □
... pathway of apoptosis is highly conserved throughout evolution from nematodes to humans (25). Within the regulatory pyramid of this pathway, E4BP4 acts as one of the initial responses to extracellular stimulation, suppresses the suicidal reaction, and prevents cells from disintegration. We previously ...
... pathway of apoptosis is highly conserved throughout evolution from nematodes to humans (25). Within the regulatory pyramid of this pathway, E4BP4 acts as one of the initial responses to extracellular stimulation, suppresses the suicidal reaction, and prevents cells from disintegration. We previously ...
The structural biology of the amyloid precursor protein
... Phosphorylation and glycosylation sites are shown as P and empty circles, respectively. (B) The two folded domains E1 and E2 of APP as well as the transmembrane segment connecting the JMR with the AICD are shown as surface representation based on their respective crystal or NMR structures [PDB-ID: 3 ...
... Phosphorylation and glycosylation sites are shown as P and empty circles, respectively. (B) The two folded domains E1 and E2 of APP as well as the transmembrane segment connecting the JMR with the AICD are shown as surface representation based on their respective crystal or NMR structures [PDB-ID: 3 ...
Similarities and Differences in the Glycosylation Mechanisms in
... The first bacterial N-OST gene was identified about a decade ago. This is the pglB gene of Campylobacter jejuni which was found to be highly homologous to the catalytic subunit (called Stt3) of eukaryotic N-OSTs. A similar degree of homology was found in archaeal N-OST genes (which are ...
... The first bacterial N-OST gene was identified about a decade ago. This is the pglB gene of Campylobacter jejuni which was found to be highly homologous to the catalytic subunit (called Stt3) of eukaryotic N-OSTs. A similar degree of homology was found in archaeal N-OST genes (which are ...
The study of cell cycle control is entering a new and exciting phase
... they are identical at 62% of their amino acid positions. This suggests that the two genes are related by common descent. The two yeasts are not closely related: sequence comparisons suggest that they may have diverged as much as 1000 million years ago, close to the origin of eukaryotic life (Huysman ...
... they are identical at 62% of their amino acid positions. This suggests that the two genes are related by common descent. The two yeasts are not closely related: sequence comparisons suggest that they may have diverged as much as 1000 million years ago, close to the origin of eukaryotic life (Huysman ...
Endoplasmic Reticulum Stress and Pancreatic Cancer
... these three ER stress sensors (8). However, in an ER stress condition, GRP 78 dissociates from IRE1, PERK, and ATF-6, and results in the activation of stress response (1). IRE1 is a type 1 ER transmembrane kinase and has two isoforms, IRE1α and IRE1β (9). After induction of UPR, IRE1 dimerizes and a ...
... these three ER stress sensors (8). However, in an ER stress condition, GRP 78 dissociates from IRE1, PERK, and ATF-6, and results in the activation of stress response (1). IRE1 is a type 1 ER transmembrane kinase and has two isoforms, IRE1α and IRE1β (9). After induction of UPR, IRE1 dimerizes and a ...
A Novel Plant Kinesin-Related Protein Specifically
... (GenBank accession number Z97336). After being sequenced, however, the OAO358 clone did not show a fulllength open reading frame. To determine the 5 end of the coding sequence, 5 rapid amplification of cDNA ends (RACE) experiments were performed. We predicted that the full-length open reading fra ...
... (GenBank accession number Z97336). After being sequenced, however, the OAO358 clone did not show a fulllength open reading frame. To determine the 5 end of the coding sequence, 5 rapid amplification of cDNA ends (RACE) experiments were performed. We predicted that the full-length open reading fra ...
The Arabidopsis TRM1-TON1 interaction reveals a recruitment
... To get further insights into TON1 function, we searched for TON1 protein partners. Here, we describe the characterization of a new superfamily of 34 Arabidopsis proteins that are able to interact with TON1 and are found only in plants. The TON1 Recruiting Motif (TRM) superfamily is defined by the pr ...
... To get further insights into TON1 function, we searched for TON1 protein partners. Here, we describe the characterization of a new superfamily of 34 Arabidopsis proteins that are able to interact with TON1 and are found only in plants. The TON1 Recruiting Motif (TRM) superfamily is defined by the pr ...
The Arabidopsis TRM1-TON1 interaction reveals a recruitment
... To get further insights into TON1 function, we searched for TON1 protein partners. Here, we describe the characterization of a new superfamily of 34 Arabidopsis proteins that are able to interact with TON1 and are found only in plants. The TON1 Recruiting Motif (TRM) superfamily is defined by the pr ...
... To get further insights into TON1 function, we searched for TON1 protein partners. Here, we describe the characterization of a new superfamily of 34 Arabidopsis proteins that are able to interact with TON1 and are found only in plants. The TON1 Recruiting Motif (TRM) superfamily is defined by the pr ...
PDF
... C02H-terminal parts can be incorporated into this membrane in vivo [Bremer et al. (1982) Eur. J. Biochem. 222, 223 - 2311. The possibility that these fragments can be used, via gene fusions, as vehicles to transport other proteins to the outer membrane has been investigated. To test whether fragment ...
... C02H-terminal parts can be incorporated into this membrane in vivo [Bremer et al. (1982) Eur. J. Biochem. 222, 223 - 2311. The possibility that these fragments can be used, via gene fusions, as vehicles to transport other proteins to the outer membrane has been investigated. To test whether fragment ...
the RbDe web service - Oxford Academic
... Residue-based diagrams are a special kind of representation of a protein where residues are laid out on a page with conventions that highlight the relations between a given sequence, secondary structure information and residue-level annotations. For transmembrane proteins, where the representation i ...
... Residue-based diagrams are a special kind of representation of a protein where residues are laid out on a page with conventions that highlight the relations between a given sequence, secondary structure information and residue-level annotations. For transmembrane proteins, where the representation i ...
Architecture of the trypanosome RNA editing accessory complex
... governing the sites and numbers of uridines to be inserted and deleted is provided by the mostly (with two exceptions) minicircle-encoded guide RNAs (gRNAs). RNA editing is catalyzed by the multiprotein RNA editing core complex (RECC), also known as the editosome. Pre-mRNA and cognate gRNA form an a ...
... governing the sites and numbers of uridines to be inserted and deleted is provided by the mostly (with two exceptions) minicircle-encoded guide RNAs (gRNAs). RNA editing is catalyzed by the multiprotein RNA editing core complex (RECC), also known as the editosome. Pre-mRNA and cognate gRNA form an a ...
Ceman, S, O Donnell, WT, Reed, M, Patton, S, Pohl, J and Warren, ST: Phosphorylation regulates translation state of FMRP-associated polyribosomes. Human Molecular Genetics 12:3295-3305 (2003).
... we metabolically-labeled cells with [32P]orthophosphoric acid and isolated Flag-tagged FMRP by immunoprecipitation with an anti-Flag antibody as described previously (10). We observed an 80 kDa phosphoprotein in the Flag-FMRPexpressing transfectant that was not present in the empty vector cell line ...
... we metabolically-labeled cells with [32P]orthophosphoric acid and isolated Flag-tagged FMRP by immunoprecipitation with an anti-Flag antibody as described previously (10). We observed an 80 kDa phosphoprotein in the Flag-FMRPexpressing transfectant that was not present in the empty vector cell line ...
chromatography - Bio-Rad
... different amounts of this support was also examined. The chromatograms obtained following separation on a 40 ml Affi-Gel Blue column coupled with either a 10 ml or 5 ml Affi-Gel protein A column, as plotted by BioLogic DuoFlow software, are shown in Figure 2. SDS-PAGE analysis of the peak-containing ...
... different amounts of this support was also examined. The chromatograms obtained following separation on a 40 ml Affi-Gel Blue column coupled with either a 10 ml or 5 ml Affi-Gel protein A column, as plotted by BioLogic DuoFlow software, are shown in Figure 2. SDS-PAGE analysis of the peak-containing ...
The archaeal origins of the eukaryotic translational system
... segmental structure associated uniquely to one, two or all three of the phylodomains (Vishwanath et al. 2004) (Figure 3). Critically, the current analyses show that eukaryotic homologous proteins contain only the archaeal-specific blocks and no bacterial-specific blocks, with the possible but unclea ...
... segmental structure associated uniquely to one, two or all three of the phylodomains (Vishwanath et al. 2004) (Figure 3). Critically, the current analyses show that eukaryotic homologous proteins contain only the archaeal-specific blocks and no bacterial-specific blocks, with the possible but unclea ...
fulltekst
... SR proteins from adenovirus infected nuclear extract SR proteins purified from HeLa nuclear extract small nuclear ribonucleoprotein particle splice site transcription factor IIIa repressor element ...
... SR proteins from adenovirus infected nuclear extract SR proteins purified from HeLa nuclear extract small nuclear ribonucleoprotein particle splice site transcription factor IIIa repressor element ...
The Psp system of Mycobacterium tuberculosis integrates envelope
... downstream genes (Fig. S1). This result strongly suggests the presence of one or more multicistronic mRNA(s) encoded by the four-gene region. To further explore the regulatory structure of the region, we used promoterprobe technology and constructed lacZ reporter fusions with DNA sequences upstream ...
... downstream genes (Fig. S1). This result strongly suggests the presence of one or more multicistronic mRNA(s) encoded by the four-gene region. To further explore the regulatory structure of the region, we used promoterprobe technology and constructed lacZ reporter fusions with DNA sequences upstream ...
Transcriptional activation by the Antennapedia and fushi tarazu proteins in cultured Drosophila cells. Cell 57, 1017-30. pdf
... The An@ and ftz genes are both members of the Antennapedia Complex (ANT-C), a cluster of regulatory genes that includes at least nine homeobox-containing genes (Kaufman et al., 1980; Mahaffey and Kaufman, 1989) while Ubx is a member of the Bithorax Complex (Duncan, 1987). The An@, ftz, and Ubx prote ...
... The An@ and ftz genes are both members of the Antennapedia Complex (ANT-C), a cluster of regulatory genes that includes at least nine homeobox-containing genes (Kaufman et al., 1980; Mahaffey and Kaufman, 1989) while Ubx is a member of the Bithorax Complex (Duncan, 1987). The An@, ftz, and Ubx prote ...
Using intrinsically fluorescent proteins for plant cell
... are unique in that their fluorophore is composed of modified amino acid residues within the polypeptide chain (Figure 1; Tsien, 1998). Although these proteins are naturally formed in jellyfish and corals, the fluorophore is capable of forming in the plant cell. The use of IFPs has therefore become w ...
... are unique in that their fluorophore is composed of modified amino acid residues within the polypeptide chain (Figure 1; Tsien, 1998). Although these proteins are naturally formed in jellyfish and corals, the fluorophore is capable of forming in the plant cell. The use of IFPs has therefore become w ...
Engineered tRNA suppression of a CFTR nonsense mutation
... PTC diseases. Further, redundant experimental efforts on multiple fronts may be a successful strategy for the rescue of CFTR nonsense codons and other such diseases, given that each mutation may yield novel phenotypes based on the position within the gene or other complicating factors. A general app ...
... PTC diseases. Further, redundant experimental efforts on multiple fronts may be a successful strategy for the rescue of CFTR nonsense codons and other such diseases, given that each mutation may yield novel phenotypes based on the position within the gene or other complicating factors. A general app ...
to the complete text
... two types of protein are known that fulfill these criteria. One is typified by the KDEL receptor — a multispanning membrane-protein that recognizes a carboxy-terminal KDEL tetrapeptide (Lys–Asp–Glu–Leu) of lumenal soluble proteins of the ER and retrieves from the Golgi those KDEL proteins that have ...
... two types of protein are known that fulfill these criteria. One is typified by the KDEL receptor — a multispanning membrane-protein that recognizes a carboxy-terminal KDEL tetrapeptide (Lys–Asp–Glu–Leu) of lumenal soluble proteins of the ER and retrieves from the Golgi those KDEL proteins that have ...
Arbonne-Protein-Shake-Label-Avery
... Arbonne Protein Shake (Chocolate – Vanilla) Add contents to 9 oz. of cold water or almond milk and shake vigorously (add ice and use a blender for a thicker shake). ...
... Arbonne Protein Shake (Chocolate – Vanilla) Add contents to 9 oz. of cold water or almond milk and shake vigorously (add ice and use a blender for a thicker shake). ...
The plant formin AtFH4 interacts with both actin and microtubules
... 6⫻His-tagged AtFH4D1. Coated and uncoated beads were exposed to a polymerisation solution containing 2 mM of rhodamine-labelled actin. Rhodamine fluorescence accumulated in a growing corona around the coated beads before reaching a steady state approximately 10 minutes after initial exposure (Fig. 3 ...
... 6⫻His-tagged AtFH4D1. Coated and uncoated beads were exposed to a polymerisation solution containing 2 mM of rhodamine-labelled actin. Rhodamine fluorescence accumulated in a growing corona around the coated beads before reaching a steady state approximately 10 minutes after initial exposure (Fig. 3 ...
Vacuolar protein sorting mechanisms in plants
... In plants, the secretory and biosynthetic trafficking pathways are involved in a series of vital mechanisms, such as gravitropism, autophagy, hormone transport, cytokinesis and abiotic/biotic stress responses [6,7], as well as in ion secretion by salt glands, nectar production, and the secretion of ...
... In plants, the secretory and biosynthetic trafficking pathways are involved in a series of vital mechanisms, such as gravitropism, autophagy, hormone transport, cytokinesis and abiotic/biotic stress responses [6,7], as well as in ion secretion by salt glands, nectar production, and the secretion of ...
Protein phosphorylation
Protein phosphorylation is a post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or modifying its function. The reverse reaction of phosphorylation is called dephosphorylation, and is catalyzed by protein phosphatases. Protein kinases and phosphatases work independently and in a balance to regulate the function of proteins. The amino acids most commonly phosphorylated are serine, threonine, and tyrosine in eukaryotes, and histidine in prokaryotes, which play important and well-characterized roles in signaling pathways and metabolism. However, many other amino acids can also be phosphorylated, including arginine, lysine, and cysteine. Protein phosphorylation was first reported in 1906 by Phoebus Levene at the Rockefeller Institute for Medical Research with the discovery of phosphorylated vitellin. However, it was nearly 50 years until the enzymatic phosphorylation of proteins by protein kinases was discovered.