2004 Lec 42-43: Nucleotide Metabolism
... No part of this presentation may be reproduced by any mechanical, photographic, or electronic process, or in the form of a phonographic recording, nor may it be stored in a retrieval system, transmitted, or otherwise copied for public or private use, without written permission from the publisher. ...
... No part of this presentation may be reproduced by any mechanical, photographic, or electronic process, or in the form of a phonographic recording, nor may it be stored in a retrieval system, transmitted, or otherwise copied for public or private use, without written permission from the publisher. ...
ppt
... of AAs. All common 20 AAs are converted to only 7 compounds: • pyruvate • acetyl-CoA • acetoacetyl-CoA • α-ketoglutarate • succinyl-CoA • fumarate • oxaloacetate ...
... of AAs. All common 20 AAs are converted to only 7 compounds: • pyruvate • acetyl-CoA • acetoacetyl-CoA • α-ketoglutarate • succinyl-CoA • fumarate • oxaloacetate ...
Synthesis and elongation of fatty acids
... • Essential in all organisms except archaea • Constituents of membranes • Posttranslational protein modification (myristoylation, palmitoylation) • Storage of chemical energy (TAG, sterolesters) ...
... • Essential in all organisms except archaea • Constituents of membranes • Posttranslational protein modification (myristoylation, palmitoylation) • Storage of chemical energy (TAG, sterolesters) ...
Nitrogen Anabolism
... groups for synthesis of most other nitrogen-containing molecules (e.g., nucleotides) ...
... groups for synthesis of most other nitrogen-containing molecules (e.g., nucleotides) ...
Universal Bioanalyte Signal Amplification for Electrochemical
... ~1014 glucose molecules associated with 1.1 mmol/L glucose in blood. However, most clinical and environmental bioanalyte applications require much lower quantities to be measured such as ~106 guanine molecules associated with 5,000 copies/mL of HIV RNA. This is below the detection limit of electroch ...
... ~1014 glucose molecules associated with 1.1 mmol/L glucose in blood. However, most clinical and environmental bioanalyte applications require much lower quantities to be measured such as ~106 guanine molecules associated with 5,000 copies/mL of HIV RNA. This is below the detection limit of electroch ...
Lecture_12
... 1. Feedback inhibition and activation: If two pathways have an initial common step, one pathway is inhibited by its own product and stimulated by the product of the other pathway. Threonine deaminase illustrates this type of regulation. 2. Enzyme multiplicity: The committed step is catalyzed by two ...
... 1. Feedback inhibition and activation: If two pathways have an initial common step, one pathway is inhibited by its own product and stimulated by the product of the other pathway. Threonine deaminase illustrates this type of regulation. 2. Enzyme multiplicity: The committed step is catalyzed by two ...
Hormones in intermediary metabolism
... • Mobilization of energy reserves and increase of energy expenditure (uncoupling proteins) • Increase of hepatic glycogenolysis and gluconeogenesis – α1 and β2 rec. (mild glycogenolysis in muscle – β2 rec., main activator is influx of Ca2+) decrease of glycolysis in liver ...
... • Mobilization of energy reserves and increase of energy expenditure (uncoupling proteins) • Increase of hepatic glycogenolysis and gluconeogenesis – α1 and β2 rec. (mild glycogenolysis in muscle – β2 rec., main activator is influx of Ca2+) decrease of glycolysis in liver ...
Ahmed Fazary_Click Chemistry
... identifies a class of chemical transformations with a number of attaractive features including excellent functional-group tolerance, high yields and good selectivity under mild experimental conditions. As defined by K. B. Sharpless – “‘Click’ chemistry…a set of powerful, virtually 100% reliable, sel ...
... identifies a class of chemical transformations with a number of attaractive features including excellent functional-group tolerance, high yields and good selectivity under mild experimental conditions. As defined by K. B. Sharpless – “‘Click’ chemistry…a set of powerful, virtually 100% reliable, sel ...
Peptidomimetic building blocks for drug discovery: An overview
... of methanesulfonamide proceeds smoothly to give diol6 (Scheme 2) with excellent optical purity (>98% ee). The diol6 is converted to its 2.3-cyclic sulfite 7 with SOC12 and oxidized to cyclic sulfate 8 in a onepot fashion. Nucleophilic substitution then occurs at the a-C of 8 with clean inversion of ...
... of methanesulfonamide proceeds smoothly to give diol6 (Scheme 2) with excellent optical purity (>98% ee). The diol6 is converted to its 2.3-cyclic sulfite 7 with SOC12 and oxidized to cyclic sulfate 8 in a onepot fashion. Nucleophilic substitution then occurs at the a-C of 8 with clean inversion of ...
Lipid Synthesis 1. Fatty acid synthesis
... Fatty acids are a more efficient form of energy storage than carbohydrates because they are less hydrated, as result of fewer hydroxyl groups being available for hydrogen bonding. The energy content of fat tissue is 38 kJ/gm compared to 17 kJ/gm for carbohydrates. The processes of fatty acid degrada ...
... Fatty acids are a more efficient form of energy storage than carbohydrates because they are less hydrated, as result of fewer hydroxyl groups being available for hydrogen bonding. The energy content of fat tissue is 38 kJ/gm compared to 17 kJ/gm for carbohydrates. The processes of fatty acid degrada ...
Lecture 27
... Pyrimidines are simpler to synthesize than purines. N1, C4, C5, C6 are from Asp. C2 from bicarbonate N3 from Gln ...
... Pyrimidines are simpler to synthesize than purines. N1, C4, C5, C6 are from Asp. C2 from bicarbonate N3 from Gln ...
Triacylglycerol Metabolism Gone Bad: A major cause of disease
... • Apolipoprotein B-100 synthesis is required for the transport of lipid out of the liver – If protein synthesis is reduced (e.g. by malnutrition) fat droplets accumulate in the liver. – If the rate of lipid synthesis is greatly elevated with respect to protein synthesis (e.g. in type I diabetes or ...
... • Apolipoprotein B-100 synthesis is required for the transport of lipid out of the liver – If protein synthesis is reduced (e.g. by malnutrition) fat droplets accumulate in the liver. – If the rate of lipid synthesis is greatly elevated with respect to protein synthesis (e.g. in type I diabetes or ...
Chapter 21
... • The biosynthesis of other di-, oligo-, and polysaccharides also uses this common activation step to form an appropriate UDP derivative. ...
... • The biosynthesis of other di-, oligo-, and polysaccharides also uses this common activation step to form an appropriate UDP derivative. ...
Regulation of fatty acid synthesis and degradation by the AMP
... Please refer t o abstract number 20. This abstract was originally submitted as a poster, and on the basis of its scientific interest and merit, was chosen by the colloquium organizers to be presented as an oral communication, as well as a poster. ...
... Please refer t o abstract number 20. This abstract was originally submitted as a poster, and on the basis of its scientific interest and merit, was chosen by the colloquium organizers to be presented as an oral communication, as well as a poster. ...
Third Lecture - LSU School of Medicine
... Melatonin is derived from serotonin within the pineal gland and the retina that contain Nacetyltransferase enzyme Melatonin Synthesis * Synthesis and secretion of melatonin increases during the dark period of the day and is maintained at a low level during daylight ...
... Melatonin is derived from serotonin within the pineal gland and the retina that contain Nacetyltransferase enzyme Melatonin Synthesis * Synthesis and secretion of melatonin increases during the dark period of the day and is maintained at a low level during daylight ...
other nitrogen-containing compounds
... • Serotonin is synthesized from tryptophan, which is hydroxyllated by tryptophan hydroxylase. The product, 5-hydroxytryptophan, is decarboxylated to serotonin. Serotonin has multiple physiologic roles, including pain perception, affective disorders, and regulation of ...
... • Serotonin is synthesized from tryptophan, which is hydroxyllated by tryptophan hydroxylase. The product, 5-hydroxytryptophan, is decarboxylated to serotonin. Serotonin has multiple physiologic roles, including pain perception, affective disorders, and regulation of ...
Allessan® CAP - Corden Pharma
... Allessan®CAP as a water scavenger agent: Allessan®CAP is a pH neutral dehydration reagent, similar in strenghth to the highly reactive and hazardous phosphorous pentoxid and polyphosphoric acid, alternative to molecular sieves for water removal from organic solvents and providing Lewis acid catalys ...
... Allessan®CAP as a water scavenger agent: Allessan®CAP is a pH neutral dehydration reagent, similar in strenghth to the highly reactive and hazardous phosphorous pentoxid and polyphosphoric acid, alternative to molecular sieves for water removal from organic solvents and providing Lewis acid catalys ...
Lehninger Principles of Biochemistry
... catalyze transfer of amino groups of amino acids to a-ketoglutarate ...
... catalyze transfer of amino groups of amino acids to a-ketoglutarate ...
1. The carbon atoms of cysteine are derived from: A. Methionine B
... are synthesized in the lumen of the Golgi and endoplasmic reticulum. Synthesis of the carbohydrate component occurs in both the endoplasmic reticulum and the Golgi. The synthesis of the common oligosaccharide requires dolichol phosphate and takes place associated with the endoplasmic reticulum membr ...
... are synthesized in the lumen of the Golgi and endoplasmic reticulum. Synthesis of the carbohydrate component occurs in both the endoplasmic reticulum and the Golgi. The synthesis of the common oligosaccharide requires dolichol phosphate and takes place associated with the endoplasmic reticulum membr ...
Synthesis characterization and pharmacological
... (Including sampling procedure if any) a) Synthetic methodology Synthetic strategy for target molecules involves followings procedure. The reaction of salicylaldehyde with Ethylacetoacetate in presence of piperidine give yellow solid mass of Acetyl-Coumarin21-23, which was fused with substituted thio ...
... (Including sampling procedure if any) a) Synthetic methodology Synthetic strategy for target molecules involves followings procedure. The reaction of salicylaldehyde with Ethylacetoacetate in presence of piperidine give yellow solid mass of Acetyl-Coumarin21-23, which was fused with substituted thio ...
chm 434f/1206f solid state materials chemistry
... • Fundamental aspect of solid state chemistry • Chemical reactivity of solid state materials depends on form and physical dimensions as well as structure and imperfections of reactants and products • Factors governing solid state reactivity underpin concepts and methods for the synthesis of new soli ...
... • Fundamental aspect of solid state chemistry • Chemical reactivity of solid state materials depends on form and physical dimensions as well as structure and imperfections of reactants and products • Factors governing solid state reactivity underpin concepts and methods for the synthesis of new soli ...
6-Catabolism of Pyrimidine Nucleotides
... The pyrimidine ring can be completely degraded in humans. ...
... The pyrimidine ring can be completely degraded in humans. ...
Total Synthesis of Spiculoic Acid A
... Spiculoic Acid A, a polyketide natural product, was recently isolated from the marine sponge Plakortis angulospiculatus. The specific objective of our research is to investigate the mode of action of dehydratase (DH) domains in polyketide biosynthesis. Two conceivable routes may be hypothesized conc ...
... Spiculoic Acid A, a polyketide natural product, was recently isolated from the marine sponge Plakortis angulospiculatus. The specific objective of our research is to investigate the mode of action of dehydratase (DH) domains in polyketide biosynthesis. Two conceivable routes may be hypothesized conc ...
Oligonucleotide synthesis
Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure (sequence). The technique is extremely useful in current laboratory practice because it provides a rapid and inexpensive access to custom-made oligonucleotides of the desired sequence. Whereas enzymes synthesize DNA and RNA only in a 5' to 3' direction, chemical oligonucleotide synthesis does not suffer from this limitation, although it is, most often, carried out in the opposite, 3' to 5' direction. Currently, the process is implemented as solid-phase synthesis using phosphoramidite method and phosphoramidite building blocks derived from protected 2'-deoxynucleosides (dA, dC, dG, and T), ribonucleosides (A, C, G, and U), or chemically modified nucleosides, e.g. LNA, BNA.To obtain the desired oligonucleotide, the building blocks are sequentially coupled to the growing oligonucleotide chain in the order required by the sequence of the product (see Synthetic cycle below). The process has been fully automated since the late 1970s. Upon the completion of the chain assembly, the product is released from the solid phase to solution, deprotected, and collected. The occurrence of side reactions sets practical limits for the length of synthetic oligonucleotides (up to about 200 nucleotide residues) because the number of errors accumulates with the length of the oligonucleotide being synthesized. Products are often isolated by high-performance liquid chromatography (HPLC) to obtain the desired oligonucleotides in high purity. Typically, synthetic oligonucleotides are single-stranded DNA or RNA molecules around 15–25 bases in length.Oligonucleotides find a variety of applications in molecular biology and medicine. They are most commonly used as antisense oligonucleotides, small interfering RNA, primers for DNA sequencing and amplification, probes for detecting complementary DNA or RNA via molecular hybridization, tools for the targeted introduction of mutations and restriction sites, and for the synthesis of artificial genes.