SASAI 1 pm
... Several types of transcription factors mediating early neuralizing signals have been identified. They can be categorized into two classes. The first class consists of primary neuron-specific transcriptional regulators (Lee, 1997), such as Xngnr-1 (neurogeninrelated), an HLH factor expressed in the p ...
... Several types of transcription factors mediating early neuralizing signals have been identified. They can be categorized into two classes. The first class consists of primary neuron-specific transcriptional regulators (Lee, 1997), such as Xngnr-1 (neurogeninrelated), an HLH factor expressed in the p ...
REVIEWS - Brandeis Life Sciences
... that have led to new approaches, in elucidating the principles of neural development. I will define cutting, pasting and painting rather broadly to include not only tissue ablation, transplantation and marking, respectively, ...
... that have led to new approaches, in elucidating the principles of neural development. I will define cutting, pasting and painting rather broadly to include not only tissue ablation, transplantation and marking, respectively, ...
DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN
... factor antagonists is secreted by the Spemann organizer and further patterns the embryo. A ventral gastrula signaling center opposes the actions of the dorsal organizer, and another set of secreted antagonists is produced ventrally under the control of BMP4. The early dorsal β-Catenin signal inhibit ...
... factor antagonists is secreted by the Spemann organizer and further patterns the embryo. A ventral gastrula signaling center opposes the actions of the dorsal organizer, and another set of secreted antagonists is produced ventrally under the control of BMP4. The early dorsal β-Catenin signal inhibit ...
- ScienceCentral
... Cyp26 genes have been previously characterized in various species, but their function in Xenopus leavis have not yet been fully identified. The role of Cyp26 during RA utilization and the anteriorization of the neuroectoderm during the early embryonic stages of Xenopus is also unclear. Wnt and FGF a ...
... Cyp26 genes have been previously characterized in various species, but their function in Xenopus leavis have not yet been fully identified. The role of Cyp26 during RA utilization and the anteriorization of the neuroectoderm during the early embryonic stages of Xenopus is also unclear. Wnt and FGF a ...
Geminin, a neuralizing molecule that demarcates the future neural
... 1997; Yamashita et al., 1995; Harland and Gerhart, 1997). As this inhibition of BMP signaling neuralizes ectodermal explants, it is likely to initiate neural induction in vivo. The cell signaling and transcriptional events occurring between mesodermal signaling and the earliest expression of neural ...
... 1997; Yamashita et al., 1995; Harland and Gerhart, 1997). As this inhibition of BMP signaling neuralizes ectodermal explants, it is likely to initiate neural induction in vivo. The cell signaling and transcriptional events occurring between mesodermal signaling and the earliest expression of neural ...
Gene regulatory networks for development
... Fig. 1. GRN for endomesoderm specification in sea urchin embryos. (A) GRN for period from initiation of zygotic regulatory control shortly after fertilization to just before gastrulation (⬇4 –30 h). The short horizontal lines represent relevant cis-regulatory modules of indicated genes on which the ...
... Fig. 1. GRN for endomesoderm specification in sea urchin embryos. (A) GRN for period from initiation of zygotic regulatory control shortly after fertilization to just before gastrulation (⬇4 –30 h). The short horizontal lines represent relevant cis-regulatory modules of indicated genes on which the ...
Gene regulatory networks for development
... Fig. 1. GRN for endomesoderm specification in sea urchin embryos. (A) GRN for period from initiation of zygotic regulatory control shortly after fertilization to just before gastrulation (⬇4 –30 h). The short horizontal lines represent relevant cis-regulatory modules of indicated genes on which the ...
... Fig. 1. GRN for endomesoderm specification in sea urchin embryos. (A) GRN for period from initiation of zygotic regulatory control shortly after fertilization to just before gastrulation (⬇4 –30 h). The short horizontal lines represent relevant cis-regulatory modules of indicated genes on which the ...
Activation of Hedgehog signaling by loss of GNAS causes
... Hedgehog target genes Ptch1, Gli1 and Hhip (which encodes Hedgehog interacting protein) was higher in the Prrx1-cre; Gnasfl/− limb at E14.5 as compared to control embryos, including in the interdigital areas, before heterotopic ossification appearance at E17.5, indicating that Hedgehog signaling was ...
... Hedgehog target genes Ptch1, Gli1 and Hhip (which encodes Hedgehog interacting protein) was higher in the Prrx1-cre; Gnasfl/− limb at E14.5 as compared to control embryos, including in the interdigital areas, before heterotopic ossification appearance at E17.5, indicating that Hedgehog signaling was ...
Combinatorial signals from the neural tube, floor plate and
... markers (i.e. myoblast fusion or myosin heavy chain synthesis) were not activated unless the somites were co-cultivated with cells from the adjacent neural tube. In contrast, developmentally more mature somites could differentiate into muscle when explanted and cultured in the absence of neural tube ...
... markers (i.e. myoblast fusion or myosin heavy chain synthesis) were not activated unless the somites were co-cultivated with cells from the adjacent neural tube. In contrast, developmentally more mature somites could differentiate into muscle when explanted and cultured in the absence of neural tube ...
- University of East Anglia
... suggests an interaction between Pitx2 and -catenin/Lef1 dependent Wnt signaling and an effect on the proliferation of early myoblasts. Wnt signaling is essential for the induction of Pax3 and Pax7 expression in myogenic progenitors and in the dorsal neural tube (Alvarez-Medina et al., 2008). Pax3 c ...
... suggests an interaction between Pitx2 and -catenin/Lef1 dependent Wnt signaling and an effect on the proliferation of early myoblasts. Wnt signaling is essential for the induction of Pax3 and Pax7 expression in myogenic progenitors and in the dorsal neural tube (Alvarez-Medina et al., 2008). Pax3 c ...
+ BMP-4
... Morphogenic Protein-4 (BMP-4), made by neuroectodermal cells. 4. BMP-4 inhibits neuralization and promotes the epidermal fate in neighboring cells. 5. Mesodermal cells secrete proteins (Chordin, Noggin, Follistatin) which directly bind and antagonizes BMP-4 activity. 6. Neuroectodermal cells become ...
... Morphogenic Protein-4 (BMP-4), made by neuroectodermal cells. 4. BMP-4 inhibits neuralization and promotes the epidermal fate in neighboring cells. 5. Mesodermal cells secrete proteins (Chordin, Noggin, Follistatin) which directly bind and antagonizes BMP-4 activity. 6. Neuroectodermal cells become ...
Intraflagellar transport protein 172 is essential for primary cilia
... observed ventral neural tube defect. In the study presented here we show that the Ift172 gene plays a crucial role in forebrain growth and patterning and in the maintenance of the isthmic organizer, a signaling center essential for the anterior–posterior patterning of the mid- and hindbrain regions. ...
... observed ventral neural tube defect. In the study presented here we show that the Ift172 gene plays a crucial role in forebrain growth and patterning and in the maintenance of the isthmic organizer, a signaling center essential for the anterior–posterior patterning of the mid- and hindbrain regions. ...
RFX2 is broadly required for ciliogenesis during
... The RFX transcription factor (called Daf19 in Caenorhabditis elegans) has been identified as an essential regulator of ciliogenesis in C. elegans and Drosophila (Dubruille et al., 2002; Swoboda et al., 2000). In vertebrates, seven distinct RFX genes (RFX 1–7) have been identified based on the highly c ...
... The RFX transcription factor (called Daf19 in Caenorhabditis elegans) has been identified as an essential regulator of ciliogenesis in C. elegans and Drosophila (Dubruille et al., 2002; Swoboda et al., 2000). In vertebrates, seven distinct RFX genes (RFX 1–7) have been identified based on the highly c ...
Tissue interactions in the developing chick diencephalon
... flanking regions, the Pth anteriorly and the Th posteriorly [21-23,26-28]. The differential response of Pth and Th to ZLI signalling is regulated by a prepattern of transcription factors – most notably Irx3, which is expressed posterior to the ZLI and directs Th identity upon receipt of the Shh sign ...
... flanking regions, the Pth anteriorly and the Th posteriorly [21-23,26-28]. The differential response of Pth and Th to ZLI signalling is regulated by a prepattern of transcription factors – most notably Irx3, which is expressed posterior to the ZLI and directs Th identity upon receipt of the Shh sign ...
Blimp1 regulates development of the posterior forelimb, caudal
... blood pooling within the dorsal aortae. The primitive heart seems to function normally, but placental development is severely compromised. Blimp1 mutants fail to expand the labyrinthine region where the bulk of foetal and maternal exchange takes place leading to placental insufficiency. In the embry ...
... blood pooling within the dorsal aortae. The primitive heart seems to function normally, but placental development is severely compromised. Blimp1 mutants fail to expand the labyrinthine region where the bulk of foetal and maternal exchange takes place leading to placental insufficiency. In the embry ...
DV axis HT12
... 8. The activated Gd protein splits the Snake (Snk) protein, and activated Snk cleaves the Easter (Ea) protein. Gd, Snk and Ea are serine proteases 9. The activated Easter protein splits Spatzle; activated Spatzle binds to Toll receptor protein. 10. Toll activation activates Tube and Pelle, which pho ...
... 8. The activated Gd protein splits the Snake (Snk) protein, and activated Snk cleaves the Easter (Ea) protein. Gd, Snk and Ea are serine proteases 9. The activated Easter protein splits Spatzle; activated Spatzle binds to Toll receptor protein. 10. Toll activation activates Tube and Pelle, which pho ...
EMBRYOLOGY GASTROINTESTINAL DEVELOPMENT G.I.T
... Early liver also involved in blood formation, after the yolk sac and blood islands acting as a primary site. o ...
... Early liver also involved in blood formation, after the yolk sac and blood islands acting as a primary site. o ...
The generation and diversification of spinal motor neurons: signals
... Marti et al., 1995). Moreover, these experiments indicated that the induction of different cell types was controlled by different concentrations of amino terminal Shh—higher concentrations of Shh being necessary for the induction of floor plate cells, than for motor neuron differentiation (Roelink e ...
... Marti et al., 1995). Moreover, these experiments indicated that the induction of different cell types was controlled by different concentrations of amino terminal Shh—higher concentrations of Shh being necessary for the induction of floor plate cells, than for motor neuron differentiation (Roelink e ...
Hornstein, E. - Weizmann Institute of Science
... thousands of predicted targets on the other hand, is intriguing. One possible interpretation is that miRNAs may mainly play accessory role, being involved in enhancing the fidelity of primary gene expression programs. ...
... thousands of predicted targets on the other hand, is intriguing. One possible interpretation is that miRNAs may mainly play accessory role, being involved in enhancing the fidelity of primary gene expression programs. ...
African Pygmy Hedgehog Care Sheet
... African Pygmy Hedgehog Care Sheet Hibernation - APH cannot be allowed to hibernate, it will prove fatal to them! Signs of hibernation include - cool belly to the touch - unable to stand or hold head up - wobbliness slowed reactions - hedgehog being curled up into a tight ball and unable to uncurl - ...
... African Pygmy Hedgehog Care Sheet Hibernation - APH cannot be allowed to hibernate, it will prove fatal to them! Signs of hibernation include - cool belly to the touch - unable to stand or hold head up - wobbliness slowed reactions - hedgehog being curled up into a tight ball and unable to uncurl - ...
1998 warkany lecture: Signaling pathways in development
... emerges as an end product ready for incorporation into a macromolecule or complex lipid. But in a signal transduction pathway, carbon atoms and energy are not passed along. Only an impulse is relayed by way of successive reversible changes of state of switch-like intermediates. At the end of the pat ...
... emerges as an end product ready for incorporation into a macromolecule or complex lipid. But in a signal transduction pathway, carbon atoms and energy are not passed along. Only an impulse is relayed by way of successive reversible changes of state of switch-like intermediates. At the end of the pat ...
Germ disc differentiation
... 2.Understand the origin of the three embryonic “germ” layers that make up the trilaminar disk. 3.Describe the formation and derivatives of ectoderm, mesoderm and endoderm. ...
... 2.Understand the origin of the three embryonic “germ” layers that make up the trilaminar disk. 3.Describe the formation and derivatives of ectoderm, mesoderm and endoderm. ...
Origins of neural crest cells and cranial placodes at the edge of the
... Semaphorin is expressed on the posterior somite ...
... Semaphorin is expressed on the posterior somite ...
Sonic hedgehog
Sonic hedgehog is a protein that in humans is encoded by the SHH (""sonic hedgehog"") gene. Both the gene and the protein may also be found notated alternatively as ""Shh"".Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in the development of some cancers.