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... an institution of its own. The school prides itself on offering not only productive educational content but also an opportunity for the young researchers to form a global network. We are committed to continuing contributions to scientific advances through immunology research and education and the ev ...
... an institution of its own. The school prides itself on offering not only productive educational content but also an opportunity for the young researchers to form a global network. We are committed to continuing contributions to scientific advances through immunology research and education and the ev ...
Yeasts as a model for human diseases
... fact that fewer and fewer genes are of unknown function, it serves as a reference genome for the annotation of new ones. For all these reasons, several ‘omics’ approaches were developed using S. cerevisiae. This provided an immense wealth of information that has been used to study more complex organ ...
... fact that fewer and fewer genes are of unknown function, it serves as a reference genome for the annotation of new ones. For all these reasons, several ‘omics’ approaches were developed using S. cerevisiae. This provided an immense wealth of information that has been used to study more complex organ ...
COMPOUND-INDUCED HOST CELL RESPONSES AND EFFECTS ON WHOLE VIRUS CHAPTER 4
... The study of drug-like properties of new chemicals early in drug discovery has gained significant importance over the last decade due to the high rate of late drug failures during clinical trials (Hamid et al., 2004) with toxicity and adverse effects being some of the reasons for the failures. While ...
... The study of drug-like properties of new chemicals early in drug discovery has gained significant importance over the last decade due to the high rate of late drug failures during clinical trials (Hamid et al., 2004) with toxicity and adverse effects being some of the reasons for the failures. While ...
Centromere dynamics
... basis for epigenetic specification of centromere. A study from the pathogenic yeast reveals that pre-existing centromeres remain functional, but if they are isolated as naked DNA and reintroduced back into the cell, functional centromeres do not form [15]. These and other studies might force us to ...
... basis for epigenetic specification of centromere. A study from the pathogenic yeast reveals that pre-existing centromeres remain functional, but if they are isolated as naked DNA and reintroduced back into the cell, functional centromeres do not form [15]. These and other studies might force us to ...
Taxol-stabilized Microtubules Can Position the
... chromosomes formed stable interactions with the cell cortex at the site of furrowing (Canman et al., 2003). This led to a model in which microtubule dynamics contribute to furrow positioning, with a subpopulation of relatively stable microtubules interacting with the equatorial cortex to promote fur ...
... chromosomes formed stable interactions with the cell cortex at the site of furrowing (Canman et al., 2003). This led to a model in which microtubule dynamics contribute to furrow positioning, with a subpopulation of relatively stable microtubules interacting with the equatorial cortex to promote fur ...
Apical constriction: A cell shape change that can
... In certain species of sea urchin, a ring of cells along the edges of the vegetal plate has been recognized to undergo more pronounced apical constriction, as judged by scanning electron micrographs (Nakajima and Burke, 1996, Kimberly and Hardin, 1998, Fig. 2). Cells in this ring have been referred t ...
... In certain species of sea urchin, a ring of cells along the edges of the vegetal plate has been recognized to undergo more pronounced apical constriction, as judged by scanning electron micrographs (Nakajima and Burke, 1996, Kimberly and Hardin, 1998, Fig. 2). Cells in this ring have been referred t ...
Leaf epidermal studies of three species of Acalypha Linn.
... headache and colds in Nigeria, the cold extracts of the leaves is used to bath babies with skin infection (Adesina et al., 2000). The leaf poultice is deam good for headache, swellings and cold in trinidad. Its leaf extract is active against Gram +ve bacteria, the extracts of seed have Immunomodulat ...
... headache and colds in Nigeria, the cold extracts of the leaves is used to bath babies with skin infection (Adesina et al., 2000). The leaf poultice is deam good for headache, swellings and cold in trinidad. Its leaf extract is active against Gram +ve bacteria, the extracts of seed have Immunomodulat ...
Wnt signaling
... (Dvl), a family of cytosolic signal transducer molecules. • Activation of Dvl ultimately leads to phosphorylation and consequently inhibition of GSK-3 • Inhibition of GSK-3 results in stabilisation and consequent cytosolic accumulation of -catenin, which then translocates into the nucleus, • -ca ...
... (Dvl), a family of cytosolic signal transducer molecules. • Activation of Dvl ultimately leads to phosphorylation and consequently inhibition of GSK-3 • Inhibition of GSK-3 results in stabilisation and consequent cytosolic accumulation of -catenin, which then translocates into the nucleus, • -ca ...
Microtubule Associated Protein 1b (MAP1B) Is a Marker of the
... Constitutive MAP1B knock-out mouse. To obtain sufficient numbers of MAP1B-/- mice and aged matched wild-type controls, females heterozygous for the MAP1B deletion allele [16] on an inbred C57BL/6 background (backcrossed to C57BL/6OlaHsd for >11 generations) were mated to males heterozygous for the M ...
... Constitutive MAP1B knock-out mouse. To obtain sufficient numbers of MAP1B-/- mice and aged matched wild-type controls, females heterozygous for the MAP1B deletion allele [16] on an inbred C57BL/6 background (backcrossed to C57BL/6OlaHsd for >11 generations) were mated to males heterozygous for the M ...
as a PDF
... fusion proteins (n = 33 cells, 4.1min average duration at 3.85sec intervals) revealed discrete sites of apparent microtubule initiation at the cell cortex (Fig. 1A,B). Microtubules that depolymerized to visible completion rarely showed recovery (48 of 50 events with >2min of imaging after depolymeri ...
... fusion proteins (n = 33 cells, 4.1min average duration at 3.85sec intervals) revealed discrete sites of apparent microtubule initiation at the cell cortex (Fig. 1A,B). Microtubules that depolymerized to visible completion rarely showed recovery (48 of 50 events with >2min of imaging after depolymeri ...
The allocation of early blastomeres to the ectoderm and endoderm
... demonstrating that the sixth cleavage does not segregate the ectoderm from the endoderm and eliminating the possibility that signaling between veg1 and veg2 cells at this cleavage allocates them to separate lineages. In addition, some of the same endodermal cell types made by veg1 progeny are also m ...
... demonstrating that the sixth cleavage does not segregate the ectoderm from the endoderm and eliminating the possibility that signaling between veg1 and veg2 cells at this cleavage allocates them to separate lineages. In addition, some of the same endodermal cell types made by veg1 progeny are also m ...
zjawisko oddzia*ywania allelopatycznego sinic i glonów w
... submarina compared to control cultures that grew on mineral medium f/2. Similar results were presented by Valdor & Aboal (2007), where morphological changes under the influence of an extract of cyanobacteria Geitlerinema sp., Oscillatoria sp. and Phormidium sp. were observed under light and electron ...
... submarina compared to control cultures that grew on mineral medium f/2. Similar results were presented by Valdor & Aboal (2007), where morphological changes under the influence of an extract of cyanobacteria Geitlerinema sp., Oscillatoria sp. and Phormidium sp. were observed under light and electron ...
during Drosophila melanogaster Embryogenesis
... (Zalokar and Erk, 1976). This allows us to examine a twodimensional array of genetically identical nuclei at defined mitotic stages, facilitating the analysis of chromosome structure. We have previously analyzed the three-dimensional paths of embryonic chromosomes during mitosis from prophase throug ...
... (Zalokar and Erk, 1976). This allows us to examine a twodimensional array of genetically identical nuclei at defined mitotic stages, facilitating the analysis of chromosome structure. We have previously analyzed the three-dimensional paths of embryonic chromosomes during mitosis from prophase throug ...
The roles of microtubules in tropisms
... organize their microtubules into parallel arrays, but instead of a transverse alignment, the arrays form shallow helices with either a right- or a left-handed orientation. Theoretically, twisted growth occurs because cells are expanding perpendicularly to microtubules that have a helical rather than ...
... organize their microtubules into parallel arrays, but instead of a transverse alignment, the arrays form shallow helices with either a right- or a left-handed orientation. Theoretically, twisted growth occurs because cells are expanding perpendicularly to microtubules that have a helical rather than ...
Article - Columbia University
... to bias introduced by sectioning or counting methodology (West, 1993). However, we have taken precautions to reduce the possibility that our conclusions could be compromised by such bias. For example, bias may be introduced if the objects being counted are larger than the section width; in this case ...
... to bias introduced by sectioning or counting methodology (West, 1993). However, we have taken precautions to reduce the possibility that our conclusions could be compromised by such bias. For example, bias may be introduced if the objects being counted are larger than the section width; in this case ...
How to Study and Exploit microRNAs for Gene Therapy Bernhard Gentner, M.D.
... microRNA: an abundant class of non-coding RNA • >700 miRNA species known in human, most are highly conserved in mammals • negatively regulate HALF of ALL mRNA transcripts by • directing mRNA destruction • inhibiting translation • extent of regulation of single targets may seem minor (in general 2-3 ...
... microRNA: an abundant class of non-coding RNA • >700 miRNA species known in human, most are highly conserved in mammals • negatively regulate HALF of ALL mRNA transcripts by • directing mRNA destruction • inhibiting translation • extent of regulation of single targets may seem minor (in general 2-3 ...
Cunningham_etal_2012_Experimental
... Nonetheless, there are inherent problems with the giant-sulphur-bacteria interpretation. There is no structure in Thiomargarita comparable with the multi-layered ornate envelope observed in the fossils [10], though Bailey et al. [11] compared the ornamentation of the fossil envelope walls with the s ...
... Nonetheless, there are inherent problems with the giant-sulphur-bacteria interpretation. There is no structure in Thiomargarita comparable with the multi-layered ornate envelope observed in the fossils [10], though Bailey et al. [11] compared the ornamentation of the fossil envelope walls with the s ...
Compartmentalisation of Rho regulators directs cell
... INTRODUCTION Small GTPases of the Rho subfamily work as regulatory switches and play essential roles in Actin cytoskeleton organisation, cell:cell adhesion, cell:substrate adhesion, cell polarity, cytokinesis, cell cycle progression and cell migration. The Rho subfamily of genes is highly conserved ...
... INTRODUCTION Small GTPases of the Rho subfamily work as regulatory switches and play essential roles in Actin cytoskeleton organisation, cell:cell adhesion, cell:substrate adhesion, cell polarity, cytokinesis, cell cycle progression and cell migration. The Rho subfamily of genes is highly conserved ...
Cosuppression of Eukaryotic Release Factor 1-1
... this sequence similarity also translates into functional similarity. Xenopus eRF1 cDNA expressed in a yeast (Saccharomyces cerevisiae) mutant carrying a temperature-sensitive eRF1 allele, eRF1 (ts), rescued the conditional-lethal phenotype of the mutant at 36°C (Tassan et al., 1993). Other studies u ...
... this sequence similarity also translates into functional similarity. Xenopus eRF1 cDNA expressed in a yeast (Saccharomyces cerevisiae) mutant carrying a temperature-sensitive eRF1 allele, eRF1 (ts), rescued the conditional-lethal phenotype of the mutant at 36°C (Tassan et al., 1993). Other studies u ...
Understanding P53-Mdm2 Interactions: Future Prospect of Anti
... are composed of chromatin, and replicate in nucleus during cell division. They lodge in oncogenes and amplify them. The gene product of the MDM2is responsible for the cell transformation, inactivating P53 in the process of transformation, their by effectively inhibiting over production of P53. Some ...
... are composed of chromatin, and replicate in nucleus during cell division. They lodge in oncogenes and amplify them. The gene product of the MDM2is responsible for the cell transformation, inactivating P53 in the process of transformation, their by effectively inhibiting over production of P53. Some ...
Evo-engineering and the Cellular and Molecular Origins of
... cord and here we focus on this subject and recent developments. Comparing amniotes and anamniotes we address the question of whether the development of their nervous systems follow similar paths and suggest that in anamniotes the spinal cord is derived from a NMp population which, in contrast to tha ...
... cord and here we focus on this subject and recent developments. Comparing amniotes and anamniotes we address the question of whether the development of their nervous systems follow similar paths and suggest that in anamniotes the spinal cord is derived from a NMp population which, in contrast to tha ...
EFFECT OF ASCORBIC ACID CONCENTRATION ON
... Obtained results confirmed that ascorbic acid oxidizes to DHA after it is added to medium and then it is absorbed and reduced to ascorbate inside the cells [Potters et al. 2000]. The current results confirmed that activity of ascorbic acid oxidase could be found in cell wall and many cellular compar ...
... Obtained results confirmed that ascorbic acid oxidizes to DHA after it is added to medium and then it is absorbed and reduced to ascorbate inside the cells [Potters et al. 2000]. The current results confirmed that activity of ascorbic acid oxidase could be found in cell wall and many cellular compar ...
Signaling
... e) Janus family of non-receptor TK s also bind some receptors receptors i) growth hormone receptors ii) prola ctin receptors iii) some cytokine receptors ...
... e) Janus family of non-receptor TK s also bind some receptors receptors i) growth hormone receptors ii) prola ctin receptors iii) some cytokine receptors ...
Cell cycle
The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication (replication) that produces two daughter cells. In prokaryotes which lack a cell nucleus, the cell cycle occurs via a process termed binary fission. In cells with a nucleus, as in eukaryotes, the cell cycle can be divided into three periods: interphase, the mitotic (M) phase, and cytokinesis. During interphase, the cell grows, accumulating nutrients needed for mitosis, preparing it for cell division and duplicating its DNA. During the mitotic phase, the cell splits itself into two distinct daughter cells. During the final stage, cytokinesis, the new cell is completely divided. To ensure the proper division of the cell, there are control mechanisms known as cell cycle checkpoints.The cell-division cycle is a vital process by which a single-celled fertilized egg develops into a mature organism, as well as the process by which hair, skin, blood cells, and some internal organs are renewed. After cell division, each of the daughter cells begin the interphase of a new cycle. Although the various stages of interphase are not usually morphologically distinguishable, each phase of the cell cycle has a distinct set of specialized biochemical processes that prepare the cell for initiation of cell division.