Integrative Analysis of multiple large
... •This method is an approximation, but the best possible approximation. •It minimizes the error between the original dataset and the dataset obtained by the product of the three matrices. •It has been tried on the three datasets under study and the results look promising. • Please read the paper for ...
... •This method is an approximation, but the best possible approximation. •It minimizes the error between the original dataset and the dataset obtained by the product of the three matrices. •It has been tried on the three datasets under study and the results look promising. • Please read the paper for ...
Chemotherapy Targets the Hair-Follicle Vascular
... after chemotherapy. These results suggest that doxorubicin causes inhibition of hair-follicle-associated angiogenesis and that this inhibition may play a major role in chemotherapy-induced dystrophy and alopecia. On the other hand, the hair-follicle-derived blood vessels also vascularize tumors impl ...
... after chemotherapy. These results suggest that doxorubicin causes inhibition of hair-follicle-associated angiogenesis and that this inhibition may play a major role in chemotherapy-induced dystrophy and alopecia. On the other hand, the hair-follicle-derived blood vessels also vascularize tumors impl ...
Morphological classification of plant cell deaths
... School of Biosciences, College of Life and Environmental and Life Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; 5Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK; 6Department of Biological Science, Graduate School of Science, Kyoto University, Sakyo ...
... School of Biosciences, College of Life and Environmental and Life Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK; 5Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK; 6Department of Biological Science, Graduate School of Science, Kyoto University, Sakyo ...
The Interleukin-1 Family: Back to the Future
... (IL-1Ra, IL-36Ra, and IL-38), and an anti-inflammatory cytokine (IL-37). The IL-1R family members include 11 molecules. A simplified nomenclature for IL-1R members is proposed here: IL-1R1 (IL-1RI), IL-1R2 (IL-1RII), IL-1R3 (IL-1RAcP), IL-1R4 (ST2), IL-1R5 (IL-18Ra), IL-1R6 (IL-1Rrp2, IL-36R), IL-1R ...
... (IL-1Ra, IL-36Ra, and IL-38), and an anti-inflammatory cytokine (IL-37). The IL-1R family members include 11 molecules. A simplified nomenclature for IL-1R members is proposed here: IL-1R1 (IL-1RI), IL-1R2 (IL-1RII), IL-1R3 (IL-1RAcP), IL-1R4 (ST2), IL-1R5 (IL-18Ra), IL-1R6 (IL-1Rrp2, IL-36R), IL-1R ...
A missense mutation in Caenorhabditis elegans prohibitin 2 confers
... microtubule assembly in vitro (3), and mutations in ␣- or -tubulin that increase microtubule stability confer resistance to HTI-286 in ovarian carcinoma cells (4). Because HTI-286 is in clinical development as a promising cancer chemotherapeutic (5), we initiated genetic experiments to identify add ...
... microtubule assembly in vitro (3), and mutations in ␣- or -tubulin that increase microtubule stability confer resistance to HTI-286 in ovarian carcinoma cells (4). Because HTI-286 is in clinical development as a promising cancer chemotherapeutic (5), we initiated genetic experiments to identify add ...
MEK kinase activity is not necessary for Raf
... survive to adulthood, are fertile and have an apparently normal phenotype. In cells derived from both the raf-1±/± and raf-1FF/FF mice, ERK activation is normal. These results strongly argue that MEK kinase activity of Raf-1 is not essential for normal mouse development and that Raf-1 plays a key ro ...
... survive to adulthood, are fertile and have an apparently normal phenotype. In cells derived from both the raf-1±/± and raf-1FF/FF mice, ERK activation is normal. These results strongly argue that MEK kinase activity of Raf-1 is not essential for normal mouse development and that Raf-1 plays a key ro ...
The metabolism and functions of inositol pentakisphosphate and
... metabolism in cells, but progress in this arena is likely to be crucial to any understanding of the functions of Ins/’, and Ins/-’,. Nature has clearly used inositol phosphates as a means of signalling information in at least one case, namely Ins( 1,4,S)P,. Vallejo et al. ( 1987) considered the intr ...
... metabolism in cells, but progress in this arena is likely to be crucial to any understanding of the functions of Ins/’, and Ins/-’,. Nature has clearly used inositol phosphates as a means of signalling information in at least one case, namely Ins( 1,4,S)P,. Vallejo et al. ( 1987) considered the intr ...
Cancer-Initiating Cells from Colorectal Cancer Patients Escape from
... these cells was assessed by phenotype analysis and by in vitro stimulation of PBMCs with CICs as a source of Ags. CICs, compared with non-CIC counterparts, showed weak immunogenicity. This feature correlated with the expression of high levels of immunomodulatory molecules, such as IL-4, and with CIC ...
... these cells was assessed by phenotype analysis and by in vitro stimulation of PBMCs with CICs as a source of Ags. CICs, compared with non-CIC counterparts, showed weak immunogenicity. This feature correlated with the expression of high levels of immunomodulatory molecules, such as IL-4, and with CIC ...
Chemical approaches to study metabolic networks
... metabolic network consists of enzymes converting substrate metabolites to products (e.g., hexokinase converts glucose to glucose-6-phosphate), a series of enzymes may catalyze the conversion of one metabolite, through a series of interconversions, to form a penultimate product (e.g., glucose to pyru ...
... metabolic network consists of enzymes converting substrate metabolites to products (e.g., hexokinase converts glucose to glucose-6-phosphate), a series of enzymes may catalyze the conversion of one metabolite, through a series of interconversions, to form a penultimate product (e.g., glucose to pyru ...
Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
... models [34], it is likely that the SMAD4 status defines two subclasses of pancreatic carcinoma with very distinct behavior. In tumors with functional SMAD4, the cytostatic effects of TGF have to be prevented by other mechanisms (e.g., hyperactive Ras signaling, overexpression of Ski, etc.), and thu ...
... models [34], it is likely that the SMAD4 status defines two subclasses of pancreatic carcinoma with very distinct behavior. In tumors with functional SMAD4, the cytostatic effects of TGF have to be prevented by other mechanisms (e.g., hyperactive Ras signaling, overexpression of Ski, etc.), and thu ...
Are viruses a source of new protein folds for organisms? Virosphere
... domains in the virosphere which are evolutionarily distinct from anything seen in cellular life. This shows that viruses have the capability to generate new protein folds de novo. The SUPERFAMILY database contains the genomic assignment of SCOP protein domains at the SCOP SF level for all completely ...
... domains in the virosphere which are evolutionarily distinct from anything seen in cellular life. This shows that viruses have the capability to generate new protein folds de novo. The SUPERFAMILY database contains the genomic assignment of SCOP protein domains at the SCOP SF level for all completely ...
Roles for Rice Membrane Dynamics and Plasmodesmata during
... Understanding the nature of the interface between blast IH and rice is critical for future studies to understand how pathogen effectors are secreted inside plant cells. The current literature contains contradictory reports on the nature of the IH–plant cytoplasm interface in rice blast disease. One ...
... Understanding the nature of the interface between blast IH and rice is critical for future studies to understand how pathogen effectors are secreted inside plant cells. The current literature contains contradictory reports on the nature of the IH–plant cytoplasm interface in rice blast disease. One ...
Cell-wall carbohydrates and their modification as a resource for
... 2006). Despite this emerging outline of how cellulose is deposited, many important issues remain unresolved. Genetic experiments provide evidence that additional proteins are involved in cellulose deposition (Lane et al., 2001; Pagant et al., 2002). One of these proteins has been shown to be a membr ...
... 2006). Despite this emerging outline of how cellulose is deposited, many important issues remain unresolved. Genetic experiments provide evidence that additional proteins are involved in cellulose deposition (Lane et al., 2001; Pagant et al., 2002). One of these proteins has been shown to be a membr ...
Dynamic Localization of Rop GTPases to the
... However, the molecular machinery for vacuole biogenesis remain poorly characterized, and it is unknown how the machinery is linked to developmental signals that control vacuole biogenesis and development. Studies in mammalian cells suggest that the biogenesis and dynamics of endosomes and lysosomes, ...
... However, the molecular machinery for vacuole biogenesis remain poorly characterized, and it is unknown how the machinery is linked to developmental signals that control vacuole biogenesis and development. Studies in mammalian cells suggest that the biogenesis and dynamics of endosomes and lysosomes, ...
Publication : Exercise: Putting Action into Our Epigenome
... RNA (mRNAs) and negatively regulate protein abundance by posttranscriptional regulation of mRNA stability or through the degradation of mRNA molecules. The binding of 50 UTRs is also possible, leading to either up- or down-regulation of mRNA levels (not shown in figure) ...
... RNA (mRNAs) and negatively regulate protein abundance by posttranscriptional regulation of mRNA stability or through the degradation of mRNA molecules. The binding of 50 UTRs is also possible, leading to either up- or down-regulation of mRNA levels (not shown in figure) ...
Heterokaryosis in Nectria haematococca
... of protein or nucleic acid synthesis, fragmentation or sporulation (Bouvier & Laville, 1970). The new mycelial morphologies are interpreted as differentiated forms which succeed a juvenile form (Chevaugeon, 1968). Using mutants, we have shown that the expression of the two differentiated states is c ...
... of protein or nucleic acid synthesis, fragmentation or sporulation (Bouvier & Laville, 1970). The new mycelial morphologies are interpreted as differentiated forms which succeed a juvenile form (Chevaugeon, 1968). Using mutants, we have shown that the expression of the two differentiated states is c ...
Microtechnologies for Cell Microenvironment Control and
... The term “cell microenvironment” involves those factors that directly or indirectly affect cell behavior, by biophysical, biochemical or other pathways. As previously stated, those factors can be classified in: ECM, cells surrounding a single cell, soluble factors, topography or physical properties ...
... The term “cell microenvironment” involves those factors that directly or indirectly affect cell behavior, by biophysical, biochemical or other pathways. As previously stated, those factors can be classified in: ECM, cells surrounding a single cell, soluble factors, topography or physical properties ...
Targeted Stimuli-Responsive Dextran Conjugates for Doxorubicin Delivery to Hepatocytes
... drug delivery vehicle is being developed in our lab to help alleviate severe side-effects caused by narrow therapeutic window drugs. Targeting specific cell types or organs via proteins, specifically, lectinmediated targeting holds potential due to the high specificity and affinity of receptor-ligan ...
... drug delivery vehicle is being developed in our lab to help alleviate severe side-effects caused by narrow therapeutic window drugs. Targeting specific cell types or organs via proteins, specifically, lectinmediated targeting holds potential due to the high specificity and affinity of receptor-ligan ...
Fig. - Journal of Cell Science
... flagellar pocket (Fig. 2B) and kDNA segregation occurred (Fig. 1C3,C4). The volume of the mitochondrial DNA density of the kinetoplast increased significantly at stage 2 when kinetoplast S-phase occurred, reaching a maximum in stage 3 (these measurements included the nabelschnur in stage 3) (Fig. 3) ...
... flagellar pocket (Fig. 2B) and kDNA segregation occurred (Fig. 1C3,C4). The volume of the mitochondrial DNA density of the kinetoplast increased significantly at stage 2 when kinetoplast S-phase occurred, reaching a maximum in stage 3 (these measurements included the nabelschnur in stage 3) (Fig. 3) ...
Lysosomal biogenesis and function is critical for necrotic cell death
... possibility that the effects on neurodegeneration we observed were caused by unlinked spurious mutations in the genetic background of the cup-5(lf) allele. Furthermore, we used RNAi to specifically target cup-5. Both outcrossed cup-5(lf) derivatives and RNAi-mediated knockdown of cup-5 resulted in e ...
... possibility that the effects on neurodegeneration we observed were caused by unlinked spurious mutations in the genetic background of the cup-5(lf) allele. Furthermore, we used RNAi to specifically target cup-5. Both outcrossed cup-5(lf) derivatives and RNAi-mediated knockdown of cup-5 resulted in e ...
The Bacterial Nucleoid
... It is based on a contribution to the symposium on ‘Relations between Structure and Function in the Prokaryotic Cell’ at the Annual Meeting of the Society for General Microbiology in April 1978, but was not published in the Symposium Volume. One of the main features that distinguishes a prokaryotic c ...
... It is based on a contribution to the symposium on ‘Relations between Structure and Function in the Prokaryotic Cell’ at the Annual Meeting of the Society for General Microbiology in April 1978, but was not published in the Symposium Volume. One of the main features that distinguishes a prokaryotic c ...
Ultrastructural studies of the mouse blastocyst
... blastocyst staging and description are apparent in the light of several recent investigations. For example, Stern (1972) and Stern & Wilson (1972) found that mouse blastocyst cells are developmentally labile, and Gardner (1972) reported that the continued presence of the inner cell mass is necessary ...
... blastocyst staging and description are apparent in the light of several recent investigations. For example, Stern (1972) and Stern & Wilson (1972) found that mouse blastocyst cells are developmentally labile, and Gardner (1972) reported that the continued presence of the inner cell mass is necessary ...
GSDMD membrane pore formation constitutes
... proposed. The fractionation experiments are not fully conclusive. There is no clear protein marker for the P150 fraction, as the Na+K+ATPase is as much there as in P0.7, and it is most abundant in P15. Binding of GSDMD to the plasma membrane upon cleavage should be verified by additional methods, li ...
... proposed. The fractionation experiments are not fully conclusive. There is no clear protein marker for the P150 fraction, as the Na+K+ATPase is as much there as in P0.7, and it is most abundant in P15. Binding of GSDMD to the plasma membrane upon cleavage should be verified by additional methods, li ...
Bell Work: What is the fundamental unit of life?
... The nuclear size of the envelope is lined by the nuclear lamina, which is composed of proteins and maintains the shape of the nucleus ...
... The nuclear size of the envelope is lined by the nuclear lamina, which is composed of proteins and maintains the shape of the nucleus ...
Glucose Metabolism in T Cells and Monocytes: New Perspectives in
... (PEP) is important in sustaining T cell receptor-mediated Ca2 +-NFAT signaling and effector functions (Ho et al., 2015). Although studies suggest that Glut1 is required for metabolic reprogramming of CD4+ T cell activation, its significance in HIV infected individuals and the impact on disease progre ...
... (PEP) is important in sustaining T cell receptor-mediated Ca2 +-NFAT signaling and effector functions (Ho et al., 2015). Although studies suggest that Glut1 is required for metabolic reprogramming of CD4+ T cell activation, its significance in HIV infected individuals and the impact on disease progre ...