The Proteomic Code: a molecular recognition code for proteins
... found that these specially coded amino acid pairs are statistically overrepresented in those proteins known to interact with each other. In addition, I was able to find short complementary amino acid sequences within the same protein sequences and inferred that these might play a role in the formati ...
... found that these specially coded amino acid pairs are statistically overrepresented in those proteins known to interact with each other. In addition, I was able to find short complementary amino acid sequences within the same protein sequences and inferred that these might play a role in the formati ...
Brassinosteroid Signal Transduction from Receptor Kinases to
... and its homologs (SERK1 and SERK4) confirmed their essential roles in BR signaling, as well as in additional pathways (3, 28). The kinase domains of BRI1 and BAK1 interact with and trans-phosphorylate each other in vitro and in yeast (52, 60), and their in vivo interaction has been detected by coimmu ...
... and its homologs (SERK1 and SERK4) confirmed their essential roles in BR signaling, as well as in additional pathways (3, 28). The kinase domains of BRI1 and BAK1 interact with and trans-phosphorylate each other in vitro and in yeast (52, 60), and their in vivo interaction has been detected by coimmu ...
Bluetongue virus: dissection of the polymerase complex
... and see reviews by Roy et al., 1990a; Roy, 1995). Core enzymes transcribe the ten viral genome segments, as well as cap and methylate full-length mRNA copies of each segment (Van Dijk & Huismans, 1982). The mRNAs are not polyadenylated. In the current model of replication, the mRNA molecules synthes ...
... and see reviews by Roy et al., 1990a; Roy, 1995). Core enzymes transcribe the ten viral genome segments, as well as cap and methylate full-length mRNA copies of each segment (Van Dijk & Huismans, 1982). The mRNAs are not polyadenylated. In the current model of replication, the mRNA molecules synthes ...
Structural Requirements of Simple Organic
... relationship between lipophilicity and recognition by P-glycoprotein-mediated MDR. In addition, since the guanidiniums each of the compounds tested are presented in Table 1. It is did not contain an aromatic moiety but the pyridiniums did, we apparent that for alkylGu"1" and alkylPy"1", toxicity in ...
... relationship between lipophilicity and recognition by P-glycoprotein-mediated MDR. In addition, since the guanidiniums each of the compounds tested are presented in Table 1. It is did not contain an aromatic moiety but the pyridiniums did, we apparent that for alkylGu"1" and alkylPy"1", toxicity in ...
Commentary on “Research on Mitotic Mechanisms”
... Mitosis is the process by which eukaryotic cells segregate their already duplicated chromosomes and move them to opposite ends of the cell in preparation for cell division. Its biological importance is seen in the facts that accurate chromosome segregation is essential for successful cell division a ...
... Mitosis is the process by which eukaryotic cells segregate their already duplicated chromosomes and move them to opposite ends of the cell in preparation for cell division. Its biological importance is seen in the facts that accurate chromosome segregation is essential for successful cell division a ...
Extracellular Trapping of Soil Contaminants by Root Border Cells
... control, and, as such, presents an ongoing global threat to sustainable agriculture and human health. Efforts to remove contaminants by plant-mediated pathways, or “phytoremediation”, though widely studied, have failed to yield consistent, predictable removal of biological and chemical contaminants. ...
... control, and, as such, presents an ongoing global threat to sustainable agriculture and human health. Efforts to remove contaminants by plant-mediated pathways, or “phytoremediation”, though widely studied, have failed to yield consistent, predictable removal of biological and chemical contaminants. ...
Elg1 forms an alternative RFC complex important for DNA
... in elg1D cells (Figure 4). ELG1 was not required for Rad53 activation following HU arrest, as we observed wild-type levels of Rad53 phosphorylation in the elg1D mutant (Figure 4A). The ctf18D rad24D mutant displayed a clear defect in Rad53 activation, as previously reported (Naiki et al., 2001) and ...
... in elg1D cells (Figure 4). ELG1 was not required for Rad53 activation following HU arrest, as we observed wild-type levels of Rad53 phosphorylation in the elg1D mutant (Figure 4A). The ctf18D rad24D mutant displayed a clear defect in Rad53 activation, as previously reported (Naiki et al., 2001) and ...
Bactericidal activity of the organo
... when the inhibition zone of the drug was tested on a rich medium (BHA). No susceptibility to AS101 was shown when bacteria were grown on a poorer medium (NA), except for a slight and insignificant inhibition diameter (8 mm) seen with 1.5 mg (Figure 2). The MIC and MBC of AS101 were found to be 9.4 m ...
... when the inhibition zone of the drug was tested on a rich medium (BHA). No susceptibility to AS101 was shown when bacteria were grown on a poorer medium (NA), except for a slight and insignificant inhibition diameter (8 mm) seen with 1.5 mg (Figure 2). The MIC and MBC of AS101 were found to be 9.4 m ...
Activation of the Cell Wall Degrading Protease, Lysin, during Sexual
... and Weiss (22) and Matsuda et al. (20) have presented evidence that the enzyme is stored outside of the plasma membrane, possibly in the periplasm. These workers showed that cells without walls do not contain lysin. Other studies on the enzyme indicate that the enzyme is a metaUoendoprotease that ac ...
... and Weiss (22) and Matsuda et al. (20) have presented evidence that the enzyme is stored outside of the plasma membrane, possibly in the periplasm. These workers showed that cells without walls do not contain lysin. Other studies on the enzyme indicate that the enzyme is a metaUoendoprotease that ac ...
Autocrine Effects of Fibroblast Growth Factor in Repair of Radiation
... cGy/min. Single doses ranging from 200 to 600 cGy were delivered. Immediately after irradiation the cells were seeded for colony formation assays in 35-mm dishes (300-3000 cells/dish) coated with either the Cell Cultures. Cloned populations of BAEC were established from HR9/ECM or the HR9-bFGF/ECM. ...
... cGy/min. Single doses ranging from 200 to 600 cGy were delivered. Immediately after irradiation the cells were seeded for colony formation assays in 35-mm dishes (300-3000 cells/dish) coated with either the Cell Cultures. Cloned populations of BAEC were established from HR9/ECM or the HR9-bFGF/ECM. ...
Degradation by bacteria of membrane and soluble protein in seawater
... level (1.5 X 107 cells ml-l). After 50 h, bacterial abundance decreased while flagellate abundance increased. The flagellate abundance was as high as 8 X 103 cells ml-l. A similar general pattern of changes in abundance of bacteria and flagellates was observed in Expt 5 (data not shown). No data of ...
... level (1.5 X 107 cells ml-l). After 50 h, bacterial abundance decreased while flagellate abundance increased. The flagellate abundance was as high as 8 X 103 cells ml-l. A similar general pattern of changes in abundance of bacteria and flagellates was observed in Expt 5 (data not shown). No data of ...
Where in the Cell Are You? Probing HIV
... endocytosed virions can often be shuttled back to the cell surface. While early seminal studies utilized transmission electron microscopy (TEM) to identify HIV-1 fusion at the cell surface [3], the advent of dually fluorescent HIV-1 virions and pH-sensing reporters have demonstrated that as much as ...
... endocytosed virions can often be shuttled back to the cell surface. While early seminal studies utilized transmission electron microscopy (TEM) to identify HIV-1 fusion at the cell surface [3], the advent of dually fluorescent HIV-1 virions and pH-sensing reporters have demonstrated that as much as ...
T Cells + Lymphotropic Virus (MTLV) Destroying CD4 Autoimmune
... To determine the role of the MTLV-induced T cell deficiency in the autoimmune development, the deficiency was sustained by removal of the thymus 3 wk after neonatal infection, and the mice were examined at 3 mo of age for the development of autoimmune disease (Table I, Fig. 5). The virus-infected an ...
... To determine the role of the MTLV-induced T cell deficiency in the autoimmune development, the deficiency was sustained by removal of the thymus 3 wk after neonatal infection, and the mice were examined at 3 mo of age for the development of autoimmune disease (Table I, Fig. 5). The virus-infected an ...
Allelic variation in normal human FBN1 expression in a family with
... FBN1 mutations cause Marfan syndrome (MFS), an autosomal dominant disorder of connective tissue. One of the unexplained features of MFS is the pathogenic mechanism that leads to marked inter- and intra-familial clinical variability, despite complete disease penetrance. An FBN1 deletion patient [46,X ...
... FBN1 mutations cause Marfan syndrome (MFS), an autosomal dominant disorder of connective tissue. One of the unexplained features of MFS is the pathogenic mechanism that leads to marked inter- and intra-familial clinical variability, despite complete disease penetrance. An FBN1 deletion patient [46,X ...
Role of Phospholipase D in the cAMP Signal Transduction Pathway
... 1994; Simpson et al., 1994; Reinhart, 1994). From an evolutionary perspective, the capacity of cells to recognize mechanical stimuli may have developed first as a requirement for unicellular organisms to control cell volume in changing osmotic environments (Hamill and McBride, ...
... 1994; Simpson et al., 1994; Reinhart, 1994). From an evolutionary perspective, the capacity of cells to recognize mechanical stimuli may have developed first as a requirement for unicellular organisms to control cell volume in changing osmotic environments (Hamill and McBride, ...
Expression Sequences and Distribution of Two Primary Cell
... as shown by immunoblot analysis. The functional reactivity of this antibody in Xenopus was established by its ability (Gallin et al., 1983) to inhibit the aggregation of tadpole skin ceils in the presence of calcium. Skin cells were prepared by immersing stage 32 or 38 tadpoles in Hepes-buffered, Ca ...
... as shown by immunoblot analysis. The functional reactivity of this antibody in Xenopus was established by its ability (Gallin et al., 1983) to inhibit the aggregation of tadpole skin ceils in the presence of calcium. Skin cells were prepared by immersing stage 32 or 38 tadpoles in Hepes-buffered, Ca ...
Mycobacterium tuberculosis adhesins: potential
... the most common form of bacterial adhesins. They are elongated, multi-subunit protein structures that are able to interact with glycoprotein and glycolipid receptors found on host cells (Esko & Sharon, 2009). To be functional, adhesins must be anchored onto or displayed on the bacterial cell surface ...
... the most common form of bacterial adhesins. They are elongated, multi-subunit protein structures that are able to interact with glycoprotein and glycolipid receptors found on host cells (Esko & Sharon, 2009). To be functional, adhesins must be anchored onto or displayed on the bacterial cell surface ...
Microtubule
... referred to the plus end and the slower growing end is referred to the minus end. The minus end is usually located near the microtubule organizing center near the nucleus, while the plus end is spread out through the cell. (Figure 1) The αβ heterodimer is the basic structural unit of the microtubul ...
... referred to the plus end and the slower growing end is referred to the minus end. The minus end is usually located near the microtubule organizing center near the nucleus, while the plus end is spread out through the cell. (Figure 1) The αβ heterodimer is the basic structural unit of the microtubul ...
Identification of Plasmodium falciparum var1CSA
... Fig. 1A). No IgM binding was detected with any of the other domains including the highly expressed domain DBL5␥ (Table 1, Fig. 1B). Identical results were obtained with an affinity-purified goat polyclonal anti-human IgM reagent (Rockland, Gilbertsville, PA, USA, data not shown). For the var2CSA gen ...
... Fig. 1A). No IgM binding was detected with any of the other domains including the highly expressed domain DBL5␥ (Table 1, Fig. 1B). Identical results were obtained with an affinity-purified goat polyclonal anti-human IgM reagent (Rockland, Gilbertsville, PA, USA, data not shown). For the var2CSA gen ...
Aquaporin-Mediated Fluid Regulation in the Inner Ear
... expression during a lithium treatment may lead to polyuria. The physiological role of aquaporins in the kidney and other fluid controlling tissues seems rather straight forward. However, puzzling novel observations indicate additional functions for aquaporins apart from fluid regulation. For example ...
... expression during a lithium treatment may lead to polyuria. The physiological role of aquaporins in the kidney and other fluid controlling tissues seems rather straight forward. However, puzzling novel observations indicate additional functions for aquaporins apart from fluid regulation. For example ...
The presence of monoglucosylated N196
... hexamerins have been shown to suppress juvenile hormone-dependent worker differentiation into the soldier caste phenotype [17]. It has also been suggested that hexamerins function as ecdysteroid-carrier proteins in the haemolymph. This conclusion was based on the observation that spider (Eurypelma c ...
... hexamerins have been shown to suppress juvenile hormone-dependent worker differentiation into the soldier caste phenotype [17]. It has also been suggested that hexamerins function as ecdysteroid-carrier proteins in the haemolymph. This conclusion was based on the observation that spider (Eurypelma c ...
Operons - John Innes Centre
... same functional pathway. However, there are also examples of operons that contain genes with no obvious functional relationship. Genes within operons of this kind may be required under the same environmental conditions despite being involved in different pathways [9]. Although the lacI repressor gen ...
... same functional pathway. However, there are also examples of operons that contain genes with no obvious functional relationship. Genes within operons of this kind may be required under the same environmental conditions despite being involved in different pathways [9]. Although the lacI repressor gen ...
Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP
... receptor-mediated apoptosis,12,13 being able to interact with tumor necrosis factor receptor (TNFR) and tumor receptor-associated factors (TRAFs) through the first two α-helices of their BIR1 domains.14–16 Another important member of the IAP family, the X-linked IAP (XIAP), is highly expressed in ma ...
... receptor-mediated apoptosis,12,13 being able to interact with tumor necrosis factor receptor (TNFR) and tumor receptor-associated factors (TRAFs) through the first two α-helices of their BIR1 domains.14–16 Another important member of the IAP family, the X-linked IAP (XIAP), is highly expressed in ma ...
Cell Metabolism
... identity to HNF4a in its DBD and 61% identity in its LBD. Moreover, most of the basic metabolic pathways and regulatory interactions that maintain homeostasis are conserved in the fly, providing an ideal context for genetic and biological studies of HNF4 function (Baker and Thummel, 2007; Leopold an ...
... identity to HNF4a in its DBD and 61% identity in its LBD. Moreover, most of the basic metabolic pathways and regulatory interactions that maintain homeostasis are conserved in the fly, providing an ideal context for genetic and biological studies of HNF4 function (Baker and Thummel, 2007; Leopold an ...
Differential expression of genes under control of the
... Several MATAa loci of S. commune have been cloned and sequenced (Specht etal., 1992; Stankis e t al., 1992). These loci mostly contain allelic gene pairs with each of the two different genes in a pair containing a particular homeoboxlike sequence, HDI or HD2. It appears that in a heterokaryon with d ...
... Several MATAa loci of S. commune have been cloned and sequenced (Specht etal., 1992; Stankis e t al., 1992). These loci mostly contain allelic gene pairs with each of the two different genes in a pair containing a particular homeoboxlike sequence, HDI or HD2. It appears that in a heterokaryon with d ...