Epididymis, Epithelium – Degeneration
... Epididymis, Duct - Exfoliated Germ Cell), where the epididymal epithelium remains normal and intact. If there is a breach of the epithelial lining, it is generally accompanied by an inflammatory infiltrate due to breakdown in the blood-epididymal barrier resulting in exposure of immune cells to the ...
... Epididymis, Duct - Exfoliated Germ Cell), where the epididymal epithelium remains normal and intact. If there is a breach of the epithelial lining, it is generally accompanied by an inflammatory infiltrate due to breakdown in the blood-epididymal barrier resulting in exposure of immune cells to the ...
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... nuclear lamina [56]. This autophagic degradation of lamin B1 results in oncogene-induced senescence and subsequent tumor suppression [56]. A recent study also demonstrated that selective autophagy, which specifically degrades GATA4, a key regulator of the SASP and cellular senescence during aging, p ...
... nuclear lamina [56]. This autophagic degradation of lamin B1 results in oncogene-induced senescence and subsequent tumor suppression [56]. A recent study also demonstrated that selective autophagy, which specifically degrades GATA4, a key regulator of the SASP and cellular senescence during aging, p ...
Questions - Biochemistry | UW
... damage in one of the template strands. Unfortunately, these photos provide too apt a summary of the current understanding of the structure of forks following these encounters. There are multiple questions here, including the DNA structures present and the status of the replication enzymes. There are ...
... damage in one of the template strands. Unfortunately, these photos provide too apt a summary of the current understanding of the structure of forks following these encounters. There are multiple questions here, including the DNA structures present and the status of the replication enzymes. There are ...
Root Systems Biology: integrative modeling
... individual genes or mechanisms that control root system architecture (reviewed in Benfey et al., 2010). However, as our knowledge of biological systems has increased, researchers have realized that the underlying components (e.g. gene products, cells, tissues and organs) function in highly complex, ...
... individual genes or mechanisms that control root system architecture (reviewed in Benfey et al., 2010). However, as our knowledge of biological systems has increased, researchers have realized that the underlying components (e.g. gene products, cells, tissues and organs) function in highly complex, ...
PAR Proteins Regulate Microtubule Dynamics at
... during the event of spindle positioning, as opposed to spindle rocking or rotation of the nuclear/centrosome complex, for the following reasons. First, microtubuledependent cellular processes are associated with much intracellular movement, and spindle positioning displays the least movement among t ...
... during the event of spindle positioning, as opposed to spindle rocking or rotation of the nuclear/centrosome complex, for the following reasons. First, microtubuledependent cellular processes are associated with much intracellular movement, and spindle positioning displays the least movement among t ...
The regulation and plasticity of root hair patterning
... the vasculature to tune the responses in roots (Lin et al., 2014). The morphological responses of roots are thought to be chiefly controlled by the local concentration of Pi (Ticconi et al., 2004; Thibaud et al., 2010), but it may be assumed that local and systemic signals are integrated and that lo ...
... the vasculature to tune the responses in roots (Lin et al., 2014). The morphological responses of roots are thought to be chiefly controlled by the local concentration of Pi (Ticconi et al., 2004; Thibaud et al., 2010), but it may be assumed that local and systemic signals are integrated and that lo ...
CHAPTER 23
... moving between protein complex sites. (3) The NADH and FAD2 formed during the CAC carry electrons and H+ ions to the ETC. a) All three statements are true. b) Two of the three statements are true. c) Only one of the statements is true. d) None of the statements is true. ...
... moving between protein complex sites. (3) The NADH and FAD2 formed during the CAC carry electrons and H+ ions to the ETC. a) All three statements are true. b) Two of the three statements are true. c) Only one of the statements is true. d) None of the statements is true. ...
Molecular Genetics of the RNA Polymerase II General
... Roeder that purified RNA pol II would selectively and accurately initiate transcription from template DNA when supplemented with a crude cell extract (529). This activity provided an assay for the fractionation and subsequent identification of the GTFs, defined as factors required for accurate, basa ...
... Roeder that purified RNA pol II would selectively and accurately initiate transcription from template DNA when supplemented with a crude cell extract (529). This activity provided an assay for the fractionation and subsequent identification of the GTFs, defined as factors required for accurate, basa ...
Mitochondrial dysfunction in Parkinson`s disease
... factors that are associated with PD contribute to mitochondrial dysfunction and PD pathogenesis. The induction of PD by neurotoxins that inhibit mitochondrial complex I provides direct evidence linking mitochondrial dysfunction to PD. Decrease of mitochondrial complex I activity is present in PD bra ...
... factors that are associated with PD contribute to mitochondrial dysfunction and PD pathogenesis. The induction of PD by neurotoxins that inhibit mitochondrial complex I provides direct evidence linking mitochondrial dysfunction to PD. Decrease of mitochondrial complex I activity is present in PD bra ...
Neural bHLH Genes Control the Neuronal versus Glial Fate
... et al., 1999; Morrison et al., 1999). Intermediate progenitors, such as the bipotential oligodendrocyte-type-2 astrocyte progenitor (O-2-A), and restricted neuronal progenitors have also been isolated and characterized in culture and by retroviral labeling studies. Moreover, a direct linear relation ...
... et al., 1999; Morrison et al., 1999). Intermediate progenitors, such as the bipotential oligodendrocyte-type-2 astrocyte progenitor (O-2-A), and restricted neuronal progenitors have also been isolated and characterized in culture and by retroviral labeling studies. Moreover, a direct linear relation ...
Coagulation
... • The tissue factor and contact activation pathways both activate the "final common pathway" through factor X, thrombin and fibrin. • Activated Factor X (FXa), in the presence of factor V (FVa), calcium and platelet phospholipid ("prothrombinase complex") convert prothrombin to thrombin. • Thombin, ...
... • The tissue factor and contact activation pathways both activate the "final common pathway" through factor X, thrombin and fibrin. • Activated Factor X (FXa), in the presence of factor V (FVa), calcium and platelet phospholipid ("prothrombinase complex") convert prothrombin to thrombin. • Thombin, ...
The proposed channel-enzyme transient receptor potential
... In a previous attempt to purify and biochemically characterize the TRPM2 NUDT9H domain in isolation we found it to be essentially insoluble, unlike its mitochondrial homologue NUDT9 (Tóth et al., 2014). Because of this unexpected difference we further investigated the two proteins in an attempt to ...
... In a previous attempt to purify and biochemically characterize the TRPM2 NUDT9H domain in isolation we found it to be essentially insoluble, unlike its mitochondrial homologue NUDT9 (Tóth et al., 2014). Because of this unexpected difference we further investigated the two proteins in an attempt to ...
Chapter 4 - Neurasync
... (29). It will be interesting to decipher exactly how this compensatory activation occurs, and why it does not always operate. Of note, steady state levels of the prototypical CMA substrate GAPDH were not altered following Lamp2a downregulation in cultured cortical neurons, even though CMA-dependent ...
... (29). It will be interesting to decipher exactly how this compensatory activation occurs, and why it does not always operate. Of note, steady state levels of the prototypical CMA substrate GAPDH were not altered following Lamp2a downregulation in cultured cortical neurons, even though CMA-dependent ...
Effect of Colchicine on Human Tissues.
... There were also numerous colchicine figures in the large lymphocytes, or "lymphoblasts" of the lymph nodes, the epithelium of the fallopian tubes, endometrium, and the epithelium of the renal tubules. In the latter instance, an occasional multinucleated cell could be found (fig. 6). Diagnosis: Colch ...
... There were also numerous colchicine figures in the large lymphocytes, or "lymphoblasts" of the lymph nodes, the epithelium of the fallopian tubes, endometrium, and the epithelium of the renal tubules. In the latter instance, an occasional multinucleated cell could be found (fig. 6). Diagnosis: Colch ...
Full Text - The International Journal of Developmental Biology
... would shake its foundations. Indeed the radical shift of emphasis to the cellular and subcellular levels and, from the 1950’s on, to the molecular level, transformed experimental embryology to developmental biology”. The term “decline” of experimental embryology was falsely interpreted by some autho ...
... would shake its foundations. Indeed the radical shift of emphasis to the cellular and subcellular levels and, from the 1950’s on, to the molecular level, transformed experimental embryology to developmental biology”. The term “decline” of experimental embryology was falsely interpreted by some autho ...
Protected Cell Companies Act 1999
... “Articles" means the Articles of Association of a protected cell company as registered with the Registrar from time to time, and in the case of a protected cell company which is registered by way of continuation of a foreign company, means the Articles of Association as registered with the Registrar ...
... “Articles" means the Articles of Association of a protected cell company as registered with the Registrar from time to time, and in the case of a protected cell company which is registered by way of continuation of a foreign company, means the Articles of Association as registered with the Registrar ...
Article Opsin Clines in Butterflies Suggest Novel Roles for Insect
... the wingless and EF-1 alpha loci, and from neutral amplified fragment length polymorphisms, which show no evidence of significant locus-specific or genome-wide structure among populations. Using a combination of functional genetic and physiological approaches, including expression in cell culture, t ...
... the wingless and EF-1 alpha loci, and from neutral amplified fragment length polymorphisms, which show no evidence of significant locus-specific or genome-wide structure among populations. Using a combination of functional genetic and physiological approaches, including expression in cell culture, t ...
In the prevailing view Conducitn is usually considered to act as a
... conductin depends on the respective DIX-DIX domain interactions. A bioinformatical analysis predicted ten amino acids likely to be required for specificity of DIX domain interactions (Ehebauer and Arias, 2009). Four of these amino acids differ between axin and conductin and may mediate differential ...
... conductin depends on the respective DIX-DIX domain interactions. A bioinformatical analysis predicted ten amino acids likely to be required for specificity of DIX domain interactions (Ehebauer and Arias, 2009). Four of these amino acids differ between axin and conductin and may mediate differential ...
AP Bio Ch 4 Study Guide
... a. are shorter and more numerous than flagella. b. are composed of microfilaments. c. are composed of intermediate filaments. d. propel ribosomes through the cytoplasm. e. are needed for plasmodesmata to function. ____ 62. Which statement about the plant cell wall is false? a. Its principal chemical ...
... a. are shorter and more numerous than flagella. b. are composed of microfilaments. c. are composed of intermediate filaments. d. propel ribosomes through the cytoplasm. e. are needed for plasmodesmata to function. ____ 62. Which statement about the plant cell wall is false? a. Its principal chemical ...
Regeneration in the aging peripheral nervous system The Harvard
... Today, understanding "why we age" is most often seen through the lens of two interrelated theories: mutation accumulation theory and antagonistic pleiotropy. Articulated by Medawar in 1952, mutation accumulation theory proposes that aging results from a decline in selection power against deleterious ...
... Today, understanding "why we age" is most often seen through the lens of two interrelated theories: mutation accumulation theory and antagonistic pleiotropy. Articulated by Medawar in 1952, mutation accumulation theory proposes that aging results from a decline in selection power against deleterious ...
Cell Wall, Cytoskeleton, and Cell Expansion in Higher Plants
... from cell wall self-assembly. Although these findings did not take several factors into account, including the incorporation of other wall polymers, turgor-driven expansion, and other biophysical forces, it is clear that microtubules play a primary role in determining the overall pattern of wall arc ...
... from cell wall self-assembly. Although these findings did not take several factors into account, including the incorporation of other wall polymers, turgor-driven expansion, and other biophysical forces, it is clear that microtubules play a primary role in determining the overall pattern of wall arc ...
The Dynamic Changes of Tonoplasts in Guard
... Many vesicle-like structures (named as bulb by Saito et al. [2002]) with diameters of 0.5 to 1.5 mm were found in spherical vacuole lumen (Fig. 5, A and B), bound with the single or double layer membrane. To study the full-view structure of the vesicle-like structures, we performed Z-axis optical se ...
... Many vesicle-like structures (named as bulb by Saito et al. [2002]) with diameters of 0.5 to 1.5 mm were found in spherical vacuole lumen (Fig. 5, A and B), bound with the single or double layer membrane. To study the full-view structure of the vesicle-like structures, we performed Z-axis optical se ...
The P2Y12 receptor regulates microglial activation by extracellular
... P2Y12 is expressed on microglia but not macrophages We, and others, have previously shown that P2Y12 transcripts are expressed by glial cells of the spinal cord and brain, specifically microglia7,12. To determine whether receptor protein is located on the microglial cell surface, we generated an ant ...
... P2Y12 is expressed on microglia but not macrophages We, and others, have previously shown that P2Y12 transcripts are expressed by glial cells of the spinal cord and brain, specifically microglia7,12. To determine whether receptor protein is located on the microglial cell surface, we generated an ant ...
Scrapie infected tissues
... most experimental models, PrPres is a reliable indicator of infectivity. Light microscopic studies have suggested that both PrPsen and disease specific accumulations of PrP are associated with follicular dendritic cells (FDCs). Using immunogold electron microscopy, we have demonstrated disease speci ...
... most experimental models, PrPres is a reliable indicator of infectivity. Light microscopic studies have suggested that both PrPsen and disease specific accumulations of PrP are associated with follicular dendritic cells (FDCs). Using immunogold electron microscopy, we have demonstrated disease speci ...
A novel type 2A von Willebrand factor mutation located at the last
... VWF is the largest soluble plasma protein. The VWF gene encompasses 178 kb of genomic DNA and is comprised of 52 exons. Based on the number of exons that have to be spliced together, it is not surprising that several splicing mutations resulting in various types of VWD have previously been described ...
... VWF is the largest soluble plasma protein. The VWF gene encompasses 178 kb of genomic DNA and is comprised of 52 exons. Based on the number of exons that have to be spliced together, it is not surprising that several splicing mutations resulting in various types of VWD have previously been described ...