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gland - Sinoe Medical Association
gland - Sinoe Medical Association

... Glandular tissues Danil Hammoudi.MD ...
Tolerance of CD8 + T Cells Developing in Parent
Tolerance of CD8 + T Cells Developing in Parent

... with supralethal irradiation; host class I expression in the chimeras was limited to non-BMderived cells. In terms of helper-independent proliferative responses in vitro and induction of graft-vs.-host disease on adoptive transfer, CD8 + cells from long-term chimeras showed profound tolerance to hos ...
mast cells and basophils
mast cells and basophils

... the complement peptides. Whilst skin mast cells are able to release histamine in response to a range of polycationic stimuli [87, 88], possibly via direct interaction with the G protein [89], lung mast cells fail to respond to any of these agents. Despite IL-3 being a potent growth factor for murine ...
cilia regeneration in tetrahymena and its inhibition
cilia regeneration in tetrahymena and its inhibition

... The cilia of Tetrahymena were amputated by the use of a procedure in which the cells remained viable and regenerated cilia. Deciliated cells were nonmotile, and cilia regeneration was assessed by scoring the percentage of motile cells at intervals following deciliation. After a 30-min lag, the decil ...
Phospholipase D promotes Arcanobacterium haemolyticum
Phospholipase D promotes Arcanobacterium haemolyticum

... mammalian plasma membrane [17]. SM, with cholesterol and GPI-anchored proteins, predominantly partitions to lipid rafts, which are tightly packed, membrane micro-domains that act to compartmentalize cellular processes on the outer leaflet of the plasma membrane [18]. Lipid rafts are also implicated ...
G α 12/13 regulate epiboly by inhibiting E
G α 12/13 regulate epiboly by inhibiting E

... defect was observed in E-cadherin–deficient embryos, with cells bulging and detaching from the embryonic surface (Babb and Marrs, 2004; Kane et al., 2005; McFarland et al., 2005; Shimizu et al., 2005). E-cadherin is a plasma membrane glycoprotein that is indirectly linked to the actin cytoskeleton t ...
Converting nonsense codons into sense codons by targeted
Converting nonsense codons into sense codons by targeted

... isolated from cells expressing snR81-1C produced a spot corresponding to Y (Fig. 2C, compare panel c with panel d). Quantification indicated that approximately 5% of the cup1-PTC transcript was pseudouridylated. Thus, our in vivo pseudouridylation results would predict that, upon expression of snR81 ...
Grade 3 Health Unit 3_master copy
Grade 3 Health Unit 3_master copy

... How Muscles Help You Move Muscles can move bones because muscle cells can change their shape. Move your fist to your shoulder. The muscle in your upper arm changes. Muscle cells contracted, or got shorter, to make movement. Muscles cannot push bones. Muscles can only pull. That is why muscles work i ...
Transient Exposure to Ethylene Stimulates Cell Division and Alters
Transient Exposure to Ethylene Stimulates Cell Division and Alters

... Because ethylene’s formative effects should include changes in cell division control, we are especially interested in the effects of ethylene on those cells that remain competent for cell division, such as the progenitors of trichomes and stomata. In this study, we examined how ethylene treatments a ...
Culm strenth of a rice brittle mutant
Culm strenth of a rice brittle mutant

... that affect the formation of the secondary cell walls usually grow relatively normally (Taylor et al., 1999; 2000), for example, the bc1 with mutation which affect the formation of the secondary cell wall, it only altered in mechanical strengthen. The plant morphology of fp2 was different to the wil ...
Characterization of Value Nutrition’s 5-Androstenediol
Characterization of Value Nutrition’s 5-Androstenediol

... stimulated, and HepG2 metabolism of the 5Adiol product increased LNCaP mitogenicity, although significant differences were unattainable primarily due to the LNCaP cells reduced adhesion properties. Because reverse-phase HPLC was unable to detect compounds within 5Adiol even at high concentrations, t ...
Suppressing cardiac arrhythmia by targeting the
Suppressing cardiac arrhythmia by targeting the

... HS E1, Lecture Hall Centre Auenbruggerplatz 15 Abstract Abnormal Ca2+ handling in cardiac muscle cells is associated with a wide range of human cardiac diseases, including heart failure and cardiac arrhythmia. Animal models suitable for large-scale screening techniques are potent tools to identify n ...
Expression Sequences and Distribution of Two Primary Cell
Expression Sequences and Distribution of Two Primary Cell

... as shown by immunoblot analysis. The functional reactivity of this antibody in Xenopus was established by its ability (Gallin et al., 1983) to inhibit the aggregation of tadpole skin ceils in the presence of calcium. Skin cells were prepared by immersing stage 32 or 38 tadpoles in Hepes-buffered, Ca ...
Natural sequence variants of yeast environmental sensors confer
Natural sequence variants of yeast environmental sensors confer

... this response is the Met4p transcriptional activator (complexed with Cbf1p and Met28p) that promotes gene activation but only at low intracellular concentrations of S-adenosyl methionine (AdoMet) when it is not degraded by the action of the SCF(Met30) ubiquitin ligase complex (Rouillon et al, 2000). ...
- Wiley Online Library
- Wiley Online Library

... The failure of these studies was largely due to the fact that cells rarely moved from the point of injection and did not display the requisite whole muscle dispersal. Using time-lapse microscopy, we and others examined the movement of satellite cells localized on muscle fibers and have shown a number ...
Goblet Cells Contribute to Ocular Surface Immune Tolerance
Goblet Cells Contribute to Ocular Surface Immune Tolerance

... and increased expression of inflammatory cytokines in the conjunctiva [8]. Spdef has been found to have immunomodulatory functions. Overexpression of Spdef in airway epithelium of neonatal mice promoted inflammatory cell infiltration and increased expression of chemokines and cytokines that mediate ...
Stem Cell - Active Motif
Stem Cell - Active Motif

... a pre-implantation embryo called the inner cell mass that can differentiate into any cell type derivative of the three germ layers (endoderm, mesoderm and ectoderm). Adult stem cells can be found throughout the post-embryonic and adult organism, and function primarily in the maintenance, repair and ...
05 Keim
05 Keim

... space between the cell and outer membranes that contains the peptidoglycan layer [5]. Additionally, several prokaryotes form specialized intracellular inclusions [8,35], some of which are restricted to specific bacterial groups and thus are used to describe them. For example, magnetosomes, which are ...
Flatworms and Roundworms
Flatworms and Roundworms

... long, tubular body, such as an earthworm. You might be less familiar with flatworms and roundworms. The flatworms are the largest group of acoelomate worms. Although the flatworm body plan is relatively simple, it is a great deal more complex than that of a sponge or cnidarian. Flatworms have a midd ...
Chapter 3 - PKDiet.com
Chapter 3 - PKDiet.com

... calcium and protein. These nutrients are also vital to the generation and utilization of hemoglobin, the energy courier of animal blood. The similarities between chlorophyll and heme are not limited to appearance and function. Chemists89 report that the synthesis of heme by animals can occur in much ...
Oocyte Development in Hydra Involves Selection from Competent
Oocyte Development in Hydra Involves Selection from Competent

... with phagocytosis, nurse cells develop morphological features of apoptosis and condense (Honegger et al., 1989). Stage 5. During stage 5, the oocyte begins retracting its pseudopods and initiates a massive morphological change (Fig. 1, A5 and B5). The distal ends of the pseudopods thicken relative t ...
A1982PM90100001
A1982PM90100001

... periments showed that distilled water was preferable to buffers for release of folate from red cells. As with the serum folate assay, it was necessary to add ascorbic acid to protect the folate from oxidative destruction in subsequent autoclaving. We showed that one in ten dilution of whole blàod in ...
Genetic Block of Outer Plaque Morphogenesis at the Second Meiotic
Genetic Block of Outer Plaque Morphogenesis at the Second Meiotic

... Strains. For electron microscopy, an hfdl-I mutant, SOS4 (hfdl-Ilhfdl-I), and its parent, MT13 (HFDI + / H F D l +), were used. The former produces about 87 % two-spored asci and the latter produces about 72% four-spored asci when sporulation is induced in SPOL at 29 "C (Okamoto & Iino, 1981). The g ...
Cell-wall carbohydrates and their modification as a resource for
Cell-wall carbohydrates and their modification as a resource for

... exploit this resource for the production of biofuels. As a result, cell walls are naturally resistant to breakdown by mechanical and microbial forces, which are precisely the processes needed for the cost-effective and efficient production of monosaccharides. Hence, one major objective is to make wa ...
06Gastrulationtxt
06Gastrulationtxt

... Gastrulation - The point in embryogenesis where the basic organization of the organism is established. ...
< 1 ... 161 162 163 164 165 166 167 168 169 ... 1638 >

Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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