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Gametogenesis: Conversion of Germ Cells Into Male and Female
Gametogenesis: Conversion of Germ Cells Into Male and Female

... The ninth edition of Langman’s Medical Embryology adheres to the tradition established by the original publication—it provides a concise but thorough description of embryology and its clinical significance, an awareness of which is essential in the diagnosis and prevention of birth defects. Recent ad ...
PDF + SI - The Journal of Immunology
PDF + SI - The Journal of Immunology

... Cytokine production is regulated by intracellular signal transduction pathways that are activated following recognition of microorganisms or microbial components via receptors, such as TLRs, that exist on the cell and phagosomal membranes of phagocytes. One of the crucial signal transduction events ...
Boundless Study Slides
Boundless Study Slides

... In the excretory system of the (a) planaria, cilia of flame cells propel waste through a tubule formed by a tube cell. In (b) annelids, nephridia filter fluid from the body cavity. ...
PDF
PDF

... mouse oocytes. (A) Rate of specific glycine transport by GLYT1 in GV oocytes during meiotic progression (MI and MII) and the earliest stages of preimplantation embryogenesis (one- to eight-cell as indicated). The specific GLYT1 transport rate was calculated from the data shown in B. Bars that do not ...
Optical mapping of atrioventricular node reveals a - AJP
Optical mapping of atrioventricular node reveals a - AJP

... delivered to the coronary vessels and was adjusted to 7 ml · min21 · g wet wt21 at the beginning of each experiment and kept constant thereafter. A perfusion system with ‘‘constant coronary flow rate’’ instead of the more typical ‘‘constant aortic pressure’’ ensured that the flow of perfusate throug ...
- Wiley Online Library
- Wiley Online Library

... the p53HupKIS46A/HupKIS46A humanized protein showed defects in target gene transactivation and apoptosis [31]. Taken together, these studies suggest that Ser 46 phosphorylation on p53 is an important cell fate determinant favouring p53-dependent transcriptional activation of pro-apoptotic target gen ...
Optical mapping of atrioventricular node reveals
Optical mapping of atrioventricular node reveals

... delivered to the coronary vessels and was adjusted to 7 ml · min21 · g wet wt21 at the beginning of each experiment and kept constant thereafter. A perfusion system with ‘‘constant coronary flow rate’’ instead of the more typical ‘‘constant aortic pressure’’ ensured that the flow of perfusate throug ...
Costes et al.
Costes et al.

... interactions, which does not have the limitations of the above methods, but still requires live samples. It evaluates binding kinetics of a protein by measuring the rate of fluorescence recovery after photobleaching (McNally et al., 2000) and interpreting slow recovery as the signature of bound prot ...
What is the function of neuroglobin?
What is the function of neuroglobin?

... oxidative stress in transgenic systems, but does not appear to be strongly upregulated in response to stress. A close phylogenetic relationship with invertebrate nerve globins and its positive correlation with the oxidative metabolism and mitochondria suggest a role in O2 supply. In vitro studies an ...
aureus Staphylococcus MyD88-Dependent Responses to Are
aureus Staphylococcus MyD88-Dependent Responses to Are

... destroy engulfed material and, after pathogen encounter, are potent secretors of proinflammatory cytokines. The inflammatory response to pathogens is triggered by pattern recognition receptors (PRRs), such as the TLRs that initiate inflammatory-signaling cascades (8, 9). Although these receptors are ...
From Matula to Mass Spectrometry - Institute of Biomedical Science
From Matula to Mass Spectrometry - Institute of Biomedical Science

... A more rational and logical approach to scientific study was evident and important advances were made during this century by many famous scientists. Progress in anatomy and physiology was initially led by William Harvey (1578-1657) in his discovery of the circulation of blood in 1628. The structure ...


... and precautions may lead to serious consequences or injury to the patient. The Powerlink System for AAA should only be used by physicians and teams trained in vascular interventional techniques and in the use of this device. Specific training expectations are described in Section 10.1, Physician Tra ...
Evolutionarily conserved recognition and innate immunity to fungal
Evolutionarily conserved recognition and innate immunity to fungal

... To determine if CED-1 is also involved in the host response to other pathogens, we infected WT and CED-1 mutant worms with the common human pathogens Salmonella typhimurium, Staphylococcus aureus, and Enterococcus faecalis. By 144 h, ⵑ56% of CED-1 mutants died in response to Salmonella infection as ...
Encapsulation of Plasmid DNA in Stabilized Plasmid – Lipid
Encapsulation of Plasmid DNA in Stabilized Plasmid – Lipid

... lipid at a 1 : 1 lipid ratio. The objective of this study was to construct SPLPs with increased cationic lipid contents that result in maximum transfection levels. A phosphate buffer detergent dialysis technique is described resulting in formation of SPLP containing 7-42.5mol% DODAC with reproducibl ...
interactions between the glycosylated gag protein of a murine
interactions between the glycosylated gag protein of a murine

... newly synthesized proviral DNA. Other deaminase-independent mechanisms of inhibition have been identified, such as directly inhibiting reverse transcription. Both HIV and murine leukemia viruses (MuLVs) have evolved mechanisms to evade the action of the APOBEC proteins. HIV encodes the Vif protein w ...
Thermogenesis in Muscle - Tag-A
Thermogenesis in Muscle - Tag-A

... not as clearly defined. Heat liberation resulting from contractile activity is well understood, actively studied, and has been carefully measured by muscle energeticists. Heat production during periods of nonshivering thermogenesis (NST) is not as well defined, and its existence is controversial in ...
HIV-1 Replication by Distinct Mechanisms Monocyte
HIV-1 Replication by Distinct Mechanisms Monocyte

1 review 1 article
1 review 1 article

... far-red light for 30 min during the dark period (Nagy e t al., 1988). In S_ynechococcm RF-1, however, the rhythmicity was not affected by a 30 min pulse of 730 nm far-red light applied at various intervals during the dark treatment (Chen e t al., 1993). The overt rhythms in Synechococcaf RF-1 can al ...
Mathematical Biology
Mathematical Biology

... Fluorescence photoactivation experiments reveal a roughly uniform rate of turnover across the lamellipodium, difficult to reconcile with pointed ends concentrated at one place (Theriot and Mitchison, 1991). Similar studies have been used (Theriot, 1994) to argue that the gradient of filamentous acti ...
Micromechanical studies of mitotic chromosomes
Micromechanical studies of mitotic chromosomes

... techniques. These experiments reveal that chromosomes have well-behaved elastic response over a fivefold range of stretching, with an elastic modulus similar to that of a loosely tethered polymer network. Perturbation by microfluidic ‘spraying’ of various ions reveals that the mitotic chromosome can b ...
GFR estimation: The key to assessment of kidney disease
GFR estimation: The key to assessment of kidney disease

... • Glomerular Filtration Rate is the volume of fluid passing through the glomerulus in a given period of time. • Influenced by renal perfusion pressure, renal vascular resistance, glomerular damage, postglomerular resistance. • “Normal Range” approx 90 - 150 mL/min – Approx 170 L per day ...
A Lectin with Highly Potent Inhibitory Activity toward Breast
A Lectin with Highly Potent Inhibitory Activity toward Breast

... them exert immuno-modulatory activities [11,12], while others elicit anti-tumor, anti-bacterial, anti-fungal, anti-viral and antiinsect effects [13,14]. The physiological functions and mechanisms of various animal lectins have been studied precisely [15–18]. However, those of plant lectins have not ...
Pericentriolar material structure and dynamics
Pericentriolar material structure and dynamics

... The resolution required to distinguish subdomains within the PCM would not be achieved until the implementation of EM tomography. Using this approach, in combination with immunolabelling, Moritz et al. [3] could discern gamma-tubulin-containing ring structures 25–30 nm in diameter within PCM from is ...
ISIS 2302 - Journal of Pharmacology and Experimental Therapeutics
ISIS 2302 - Journal of Pharmacology and Experimental Therapeutics

... Electrocardiogram, supine blood pressure and pulse were unaffected by dosing. No serious adverse events were reported nor was any particular adverse event seen occurring with disproportionate frequency after active drug with the exception of headache (seven ISIS 2302, one placebo; expected ratio 3:1 ...
Biofilms  are  described  as  surface ... et al.,
Biofilms are described as surface ... et al.,

... resulting in efficient heat transfer, energy loss, increased fluid frictional resistance and accelerated corrosion and also deteriorates the quality of various chemicals and process additives (Xiong and Liu, 2010). For example, in the paper industry, biofilms cause deterioration of chemicals like st ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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