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Osmotic
Regulation and the
Excretory System
Osmoregulation and Osmotic Balance
Nitrogenous Wastes
Excretion Systems
Human Osmoregulatory and Excretory Systems
Hormonal Control of Osmoregulatory Functions
Osmotic Regulation and the Excretory System
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Osmotic Regulation and the Excretory System > Osmoregulation and Osmotic Balance
Osmoregulation and Osmotic Balance
• Introduction to Osmoregulation
• Transport of Electrolytes across Cell Membranes
• Concept of Osmolality and Milliequivalent
• Osmoregulators and Osmoconformers
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Osmotic Regulation and the Excretory System > Nitrogenous Wastes
Nitrogenous Wastes
• Nitrogenous Waste in Terrestrial Animals: The Urea Cycle
• Nitrogenous Waste in Birds and Reptiles: Uric Acid
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Osmotic Regulation and the Excretory System > Excretion Systems
Excretion Systems
• Contractile Vacuoles in Microorganisms
• Flame Cells of Planaria and Nephridia of Worms
• Malpighian Tubules of Insects
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Osmotic Regulation and the Excretory System > Human Osmoregulatory and Excretory Systems
Human Osmoregulatory and Excretory Systems
• Kidney Structure
• Nephron: The Functional Unit of the Kidney
• Kidney Function and Physiology
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Osmotic Regulation and the Excretory System > Hormonal Control of Osmoregulatory Functions
Hormonal Control of Osmoregulatory Functions
• Epinephrine and Norepinephrine
• Other Hormonal Controls for Osmoregulation
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Appendix
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Osmotic Regulation and the Excretory System
Key terms
• active transport movement of a substance across a cell membrane against its concentration gradient (from low to high
concentration) facilitated by ATP conversion
• adrenergic containing or releasing adrenaline
• angiotensin any of several polypeptides that narrow blood vessels and thus regulate arterial pressure
• aquaporin any of a class of proteins that form pores in the membrane of biological cells
• arteriole one of the small branches of an artery, especially one that connects with capillaries
• catecholamine any of a class of aromatic amines derived from pyrocatechol that are hormones produced by the adrenal gland
• contractile vacuole a vacuole that removes waste or excess water
• countercurrent a current that flows against the prevailing one
• electrolyte any of the various ions (such as sodium or chloride) that regulate the electric charge on cells and the flow of water
across their membranes
• electrolyte any of the various ions (such as sodium or chloride) that regulate the electric charge on cells and the flow of water
across their membranes
• epinephrine (adrenaline) an amino acid-derived hormone secreted by the adrenal gland in response to stress
• euryhaline able to tolerate various saltwater concentrations
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Osmotic Regulation and the Excretory System
• facilitated diffusion The spontaneous passage of molecules or ions across a biological membrane passing through specific
transmembrane integral proteins.
• flame cell a specialized excretory cell found in the simplest freshwater invertebrates
• glomerulus A small intertwined group of capillaries within a kidney's nephron that filters the blood to make urine.
• guano the excrement of seabirds, cave-dwelling bats, pinnipeds, or birds more generally
• hemolymph a circulating fluid in the bodies of some invertebrates that is the equivalent of blood
• hypertonic having a greater osmotic pressure than another
• hypoxanthine an intermediate in the biosynthesis of uric acid
• loop of Henle A structure in a kidney's nephron that connects the proximal convoluted tubule to the distal convoluted tubule.
• malpighian tubule a tubule that extends from the alimentary canal to the exterior of the organism, excreting water and wastes in
the form of solid nitrogenous compounds
• molality the concentration of a substance in solution, expressed as the number of moles of solute per kilogram of solvent
• molarity the number of moles of solute per liter of solution, giving a solution's molar concentration
• mole in the International System of Units, the base unit of amount of substance
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Osmotic Regulation and the Excretory System
• nephridiopore the external opening of a nephridium, where waste is excreted from the cell
• nephridium a tubular excretory organ in some invertebrates
• nephrostome the funnel-shaped opening of a nephridium into the body cavity
• norepinephrine a neurotransmitter found in the locus coeruleus which is synthesized from dopamine
• ornithine an amino acid, which acts as an intermediate in the biosynthesis of urea
• osmoconformer a marine organism (usually an invertebrate) that maintains its internal salinity such that it is always equal to the
surrounding seawater
• osmolarity The osmotic concentration of a solution, normally expressed as osmoles of solute per litre of solution.
• osmoregulation the homeostatic regulation of osmotic pressure in the body in order to maintain a constant water content
• osmosis The net movement of solvent molecules from a region of high solvent potential to a region of lower solvent potential
through a partially permeable membrane
• osmotic pressure the hydrostatic pressure exerted by a solution across a semipermeable membrane from a pure solvent
• osmotic pressure the hydrostatic pressure exerted by a solution across a semipermeable membrane from a pure solvent
• passive diffusion movement of water and other molecules across membranes along a concentration gradient
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Osmotic Regulation and the Excretory System
• purine any of a class of organic heterocyclic base containing fused pyrimidine and imidazole rings; they are components of
nucleic acids
• renal pertaining to the kidneys
• renin a circulating enzyme released by mammalian kidneys that converts angiotensinogen to angiotensin-I that plays a role in
maintaining blood pressure
• stenohaline tolerant of only a narrow range of saltwater concentrations
• urea a water-soluble organic compound, CO(NH2)2, formed by the metabolism of proteins and excreted in the urine
• urea a water-soluble organic compound, CO(NH2)2, formed by the metabolism of proteins and excreted in the urine
• ureotelic animals that secrete urea as the primary nitrogenous waste material
• uric acid a bicyclic heterocyclic phenolic compound, formed in the body by the metabolism of protein and excreted in the urine
• uric acid a bicyclic heterocyclic phenolic compound, formed in the body by the metabolism of protein and excreted in the urine
• xanthine a precursor of uric acid found in many organs of the body
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Osmotic Regulation and the Excretory System
Renin-angiotensin-aldosterone system
The renin-angiotensin-aldosterone system increases blood pressure and volume. The hormone ANP has antagonistic effects.
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OpenStax CNX. "OpenStax College, Hormonal Control of Osmoregulatory Functions. October 17, 2013." CC BY 3.0
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Osmotic Regulation and the Excretory System
Kidneys' location and function
Kidneys filter the blood, producing urine that is stored in the bladder prior to elimination through the urethra. They are located in the peritoneal cavity.
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OpenStax CNX. "OpenStax College, The Kidneys and Osmoregulatory Organs. October 17, 2013." CC BY 3.0
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Osmotic Regulation and the Excretory System
Diagram of a nephron
The nephron is the functional unit of the kidney. The glomerulus and convoluted tubules of the nephron are located in the cortex of the kidney, while the
collecting ducts are located in the pyramids of the kidney's medulla.
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OpenStax CNX. "The Kidneys and Osmoregulatory Organs Source: Boundless. “Kidney Structure.” Boundless Biology. Boundless, 08 Jan. 2016. Retrieved 19
Feb. 2016 from https://www.boundless.com/biology/textbooks/boundless-biology-textbook/osmotic-regulation-and-the-excretory-system-41/human-osmoregulatory-
Osmotic Regulation and the Excretory System
Salmon physiology responds to freshwater and seawater to maintain osmotic balance
Fish are osmoregulators, but must use different mechanisms to survive in (a) freshwater or (b) saltwater environments.
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OpenStax CNX. "OpenStax College, Osmoregulation and Osmotic Balance. October 17, 2013." CC BY 3.0
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Osmotic Regulation and the Excretory System
Nephron structure
Each part of the nephron performs a different function in filtering waste and maintaining homeostatic balance.
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Osmotic Regulation and the Excretory System
Urea Cycle
The urea cycle converts ammonia to urea in five steps that include the catalyzation of five different enzymes.
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OpenStax CNX. "OpenStax College, Nitrogenous Wastes. October 17, 2013." CC BY 3.0 http://cnx.org/content/m44811/latest/Figure_41_04_01.jpg View on
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Osmotic Regulation and the Excretory System
Nitrogen excretion
Nitrogenous waste is excreted in different forms by different species. These include (a) ammonia, (b) urea, and (c) uric acid.
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Osmotic Regulation and the Excretory System
Response of red blood cells in hypertonic, hypotonic, and isotonic solutions
Cells placed in a hypertonic environment tend to shrink due to loss of water. In a hypotonic environment, cells tend to swell due to intake of water. The
blood maintains an isotonic environment so that cells neither shrink nor swell.
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Osmotic Regulation and the Excretory System
Adrenal gland
The adrenal medulla, located toward the bottom of this image, is responsible for the release of epinephrine and norepinephrine.
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Wikipedia. "Gray1185." Public domain http://en.wikipedia.org/wiki/File:Gray1185.png View on Boundless.com
Osmotic Regulation and the Excretory System
Concentration of solutions; part 2; moles, millimoles & milliequivalents by Professor Fink
Professor Fink reviews the use of moles, millimoles & milliquivalents in expressing concentration and dosage. Example problems are presented
explaining how to prepare molar solutions and convert to percent concentration. In addition, Professor Fink explains how to convert from millimoles to
milliequivalents, or convert milliequivalents back to millimoles.
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Osmotic Regulation and the Excretory System
Transport across cell membranes
Paul Andersen describes how cells move materials across the cell membrane. All movement can be classified as passive or active. Passive transport,
such as diffusion, requires no energy as particles move along their gradient. Active transport requires additional energy as particles move against their
gradient. Specific examples, such as GLUT and the Na/K, pump are included.
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Osmotic Regulation and the Excretory System
Flame cells and nephridia
In the excretory system of the (a) planaria, cilia of flame cells propel waste through a tubule formed by a tube cell. In (b) annelids, nephridia filter fluid
from the body cavity.
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OpenStax CNX. "OpenStax College, Excretion Systems. October 17, 2013." CC BY 3.0 http://cnx.org/content/m44810/latest/Figure_41_02_02.jpg View on
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Osmotic Regulation and the Excretory System
Contractile vacuole of Euglena
Structure of Euglena: 1 - Flagellum; 2 - Eye spot / Pigment spot / Stigma; 3 - Photoreceptor; 4 - Short second flagellum; 5 - Reservoir; 6 - Basal body; 7 Contractile vacuole; 8 - Paramylon granule; 9 - Chloroplasts; 10 - Nucleus; 11 - Nucleolus; 12 - Pellicle
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Osmotic Regulation and the Excretory System
Malpighian tubules in bees
Malpighian tubules of insects and other terrestrial arthropods remove nitrogenous wastes and other solutes from the hemolymph.
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Osmotic Regulation and the Excretory System
Loop of Henle
The loop of Henle acts as a countercurrent multiplier that uses energy to create concentration gradients. The descending limb is water permeable. Water
flows from the filtrate to the interstitial fluid, so osmolality inside the limb increases as it descends into the renal medulla. At the bottom, the osmolality is
higher inside the loop than in the interstitial fluid. Thus, as filtrate enters the ascending limb, Na+ and Cl- ions exit through ion channels present in the
cell membrane. Further up, Na+ is actively transported out of the filtrate and Cl- follows. Osmolarity is given in units of milliosmoles per liter (mOsm/L).
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OpenStax CNX. "OpenStax College, The Kidneys and Osmoregulatory Organs. October 17, 2013." CC BY 3.0
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Osmotic Regulation and the Excretory System
Structure of the kidney
Externally, the kidney is surrounded by the renal fascia, the perirenal fat capsule, and the renal capsule. Internally, the kidney is most importantly filled
with nephrons that filter blood and generate urine.
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Osmotic Regulation and the Excretory System
Nephrons perform the main function of the kidney
The nephron is the functional unit of the kidney. The glomerulus and convoluted tubules of the nephron are located in the cortex of the kidney, while
collecting ducts are located in the pyramids of the kidney's medulla.
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OpenStax CNX. "OpenStax College, The Kidneys and Osmoregulatory Organs. October 17, 2013." CC BY 3.0
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Osmotic Regulation and the Excretory System
Attribution
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• Wiktionary. "osmosis." CC BY-SA 3.0 http://en.wiktionary.org/wiki/osmosis
• Wiktionary. "electrolyte." CC BY-SA 3.0 http://en.wiktionary.org/wiki/electrolyte
• Wikipedia. "Osmoconformer." CC BY-SA 3.0 http://en.wikipedia.org/wiki/Osmoconformer
• OpenStax CNX. "OpenStax College, Biology. October 23, 2013." CC BY 3.0
http://cnx.org/content/m44807/latest/?collection=col11448/latest
• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44808/latest/?collection=col11448/latest
• Wikipedia. "facilitated diffusion." CC BY-SA 3.0 http://en.wikipedia.org/wiki/facilitated%20diffusion
• Wikipedia. "active transport." CC BY-SA 3.0 http://en.wikipedia.org/wiki/active%20transport
• Wikipedia. "passive diffusion." CC BY-SA 3.0 http://en.wikipedia.org/wiki/passive%20diffusion
• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44808/latest/?collection=col11448/latest
• Wiktionary. "osmotic pressure." CC BY-SA 3.0 http://en.wiktionary.org/wiki/osmotic_pressure
• Wiktionary. "mole." CC BY-SA 3.0 http://en.wiktionary.org/wiki/mole
• Wiktionary. "molality." CC BY-SA 3.0 http://en.wiktionary.org/wiki/molality
• Wiktionary. "molarity." CC BY-SA 3.0 http://en.wiktionary.org/wiki/molarity
• Wikipedia. "Plasma osmolality." CC BY-SA 3.0 https://en.wikipedia.org/wiki/Plasma_osmolality
• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44808/latest/?collection=col11448/latest
• Wiktionary. "osmoconformer." CC BY-SA 3.0 http://en.wiktionary.org/wiki/osmoconformer
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Osmotic Regulation and the Excretory System
• Wiktionary. "stenohaline." CC BY-SA 3.0 http://en.wiktionary.org/wiki/stenohaline
• Wiktionary. "euryhaline." CC BY-SA 3.0 http://en.wiktionary.org/wiki/euryhaline
• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44808/latest/?collection=col11448/latest
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• Wikibooks. "Human Physiology/The Urinary System." CC BY-SA 3.0
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http://cnx.org/content/m44809/latest/?collection=col11448/latest
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http://cnx.org/content/m44809/latest/?collection=col11448/latest
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• Wiktionary. "hypertonic." CC BY-SA 3.0 http://en.wiktionary.org/wiki/hypertonic
• Wiktionary. "osmolarity." CC BY-SA 3.0 http://en.wiktionary.org/wiki/osmolarity
• Wiktionary. "osmoregulation." CC BY-SA 3.0 http://en.wiktionary.org/wiki/osmoregulation
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• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44810/latest/?collection=col11448/latest
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• Wiktionary. "nephridiopore." CC BY-SA 3.0 http://en.wiktionary.org/wiki/nephridiopore
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• Wiktionary. "nephridium." CC BY-SA 3.0 http://en.wiktionary.org/wiki/nephridium
Osmotic Regulation and the Excretory System
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• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44810/latest/?collection=col11448/latest
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• Wiktionary. "hemolymph." CC BY-SA 3.0 http://en.wiktionary.org/wiki/hemolymph
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• Wikipedia. "Malpighian tubules." CC BY-SA 3.0 http://en.wikipedia.org/wiki/Malpighian_tubules
• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
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• Wiktionary. "ornithine." CC BY-SA 3.0 http://en.wiktionary.org/wiki/ornithine
• Boundless Learning. "Boundless." CC BY-SA 3.0 http://www.boundless.com//biology/definition/ureotelic
• Wikipedia. "Urea." CC BY-SA 3.0 http://en.wikipedia.org/wiki/Urea
• OpenStax CNX. "OpenStax College, Biology. December 2, 2013." CC BY 3.0
http://cnx.org/content/m44811/latest/?collection=col11448/latest
• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44811/latest/?collection=col11448/latest
• Wiktionary. "uric acid." CC BY-SA 3.0 http://en.wiktionary.org/wiki/uric_acid
• Wiktionary. "hypoxanthine." CC BY-SA 3.0 http://en.wiktionary.org/wiki/hypoxanthine
• Wiktionary. "xanthine." CC BY-SA 3.0 http://en.wiktionary.org/wiki/xanthine
• Wiktionary. "purine." CC BY-SA 3.0 http://en.wiktionary.org/wiki/purine
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Osmotic Regulation and the Excretory System
• Wikipedia. "guano." CC BY-SA 3.0 http://en.wikipedia.org/wiki/guano
• Wiktionary. "urea." CC BY-SA 3.0 http://en.wiktionary.org/wiki/urea
• Wikipedia. "Uric acid." CC BY-SA 3.0 http://en.wikipedia.org/wiki/Uric_acid
• Wikipedia. "Metabolic waste." CC BY-SA 3.0 http://en.wikipedia.org/wiki/Metabolic_waste
• OpenStax CNX. "OpenStax College, Biology. December 2, 2013." CC BY 3.0
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• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44811/latest/?collection=col11448/latest
• Wiktionary. "catecholamine." CC BY-SA 3.0 http://en.wiktionary.org/wiki/catecholamine
• Wiktionary. "norepinephrine." CC BY-SA 3.0 http://en.wiktionary.org/wiki/norepinephrine
• Wiktionary. "epinephrine." CC BY-SA 3.0 http://en.wiktionary.org/wiki/epinephrine
• Wiktionary. "adrenergic." CC BY-SA 3.0 http://en.wiktionary.org/wiki/adrenergic
• Wikipedia. "Norepinephrine." CC BY-SA 3.0 http://en.wikipedia.org/wiki/Norepinephrine%23Mechanism
• Wikipedia. "Epinephrine." CC BY-SA 3.0 http://en.wikipedia.org/wiki/Epinephrine%23Mechanism_of_action
• OpenStax CNX. "OpenStax College, Biology. October 17, 2013." CC BY 3.0
http://cnx.org/content/m44828/latest/?collection=col11448/latest
• Wiktionary. "angiotensin." CC BY-SA 3.0 http://en.wiktionary.org/wiki/angiotensin
• Wiktionary. "aquaporin." CC BY-SA 3.0 http://en.wiktionary.org/wiki/aquaporin
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