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Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival
Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival

... purified from late embryonic chick eye tissue (Barbin et al. 1984). The adult rat sciatic nerve was subsequently identified as the most abundant source of CNTF (Manthorpe et al. 1986) wherefrom it was purified to homogeneity as a basis for microsequencing and finally molecular cloning (Stöckli et al ...
Guanylate cyclase in Dictyostelium discoideum with the topology of
Guanylate cyclase in Dictyostelium discoideum with the topology of

... Both cAMP and folic acid bind to G-protein-coupled receptors. The activation of these receptors leads to dissociation of heterotrimeric G-proteins into Gα and Gβγ subunits. Gβγ is thought to mediate the activation of the adenylate cyclase, DdACA [1]. This activation also requires a cytosolic regulat ...
Cytological Fixation by Chromic Acid and Dichromates By W. G.
Cytological Fixation by Chromic Acid and Dichromates By W. G.

... Various mixtures were prepared such that from 0-15 to 8o-o per cent, of the solute was chromic acid, the remainder being potassium dichromate. The 0-17 M series was the most extensive, fewer mixtures being prepared with concentrations of 0-07 M or 0-34 M. All volumetric measurements were made with w ...
“J” TABLE OF CONTENTS Page 1 of 1 #17//04 SPECIAL
“J” TABLE OF CONTENTS Page 1 of 1 #17//04 SPECIAL

... In reviewing whether an inmate shall be removed from or remain in a safety cell, the watch commander will consult with an authorized Sheriff’s mental health provider to determine whether the inmate, if removed from the safety cell, is likely to pose a threat to himself/herself or others. However, wh ...
Cationic albumin-conjugated pegylated nanoparticles as novel drug
Cationic albumin-conjugated pegylated nanoparticles as novel drug

... Besides liposomes, as the drug container, nanoparticles have certain advantages over liposomes for their function to prolong drug release [13], be freeze-dried for long-term storage and be more chemically and physically stable [14]. They also can be loaded with small molecules, proteins or plasmid D ...
schoeneich_oxidants
schoeneich_oxidants

... from smokers compared to non-smokers [29]. The sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) plays a critical role in regulating calcium homeostasis by transporting cytosolic Ca2+ into the sarco/endoplasmic reticulum, thus lowering intracellular Ca2+ levels. Through this process of Ca2+ sequestrat ...
Dynamics of a=Tubulin Deacetylation in Intact Neurons
Dynamics of a=Tubulin Deacetylation in Intact Neurons

... However, there is no corresponding increase in soluble acetylated tubulin. Because the total levels of a-tubulin remain unchanged during drug treatment, the decrease in levels of acetylated a-tubulin during depolymerization must reflect its rapid conversion to nonacetylated a-tubulin. These findings ...
Functional unit of RNA polymerase II
Functional unit of RNA polymerase II

... The C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II (RNAP II) comprises a set of tandemly repeated heptapeptides (Y1S2P3 T4S5P6S7) that are essential for viability in both animals and yeast (1, 2). The CTD functions throughout the RNAP II transcription cycle; ...
Localization of retinitis pigmentosa 2 to cilia is regulated by Importin 2
Localization of retinitis pigmentosa 2 to cilia is regulated by Importin 2

... trafficking of retinitis pigmentosa 2 (RP2, also known as protein XRP2) to the cilia. RP2 is an X-linked gene that, when mutated, gives rise to retinitis pigmentosa (Hardcastle et al., 1999). The RP2 gene encodes a 350 residue polypeptide that appears to be ubiquitously expressed. Previous work has ...
Fibronectin and Other Adhesive Glycoproteins
Fibronectin and Other Adhesive Glycoproteins

... 2009) (see Chap. 1). It has been noted that the N-terminal sub-domain of the VWF type C module of a2 procollagen shows a structural similarity with the fibronectin FN1 module (O’Leary et al. 2004) and suggested that the VWF type C module, which has been found in a large number of proteins of flies a ...
Name…………………………………………………
Name…………………………………………………

... a) Account for the loss in dry weight of cotyledons in a germinating bean seed. (1mk) *BND* b) State three effects of gibberellins on shoots of plants. (3mks) *BND* Which one of the cell organelles would be more numerous in; a) An enzyme secreting cell. (1mk) *BND* b) A rapidly respiring cell in com ...
Thermogenesis in Muscle
Thermogenesis in Muscle

... not as clearly defined. Heat liberation resulting from contractile activity is well understood, actively studied, and has been carefully measuredby muscle energeticists. Heat production during periods of nonshivering thermogenesis (NST) is not as well defined, and its existence is controversial in m ...
Theranostic Value of Multimers: Lessons Learned from Trimerization
Theranostic Value of Multimers: Lessons Learned from Trimerization

... a biological half-life of only a few minutes, or even less [8–10]. Consequently, great efforts were taken regarding stabilization of this peptide sequence. It was found that the cleavage sites are located between Arg8 -Arg9 , Pro10 -Tyr11 and Tyr11 -Ile12 . Hence, NT analogs developed for in vivo ap ...
Microengineering Aerospace Systems
Microengineering Aerospace Systems

... piezoresistivity of semiconductors and published the first paper on the piezoresistive effect in Ge and Si in 1954.2 The piezoresistive effect is the change in the resistivity of certain materials due to applied mechanical strain. The measured piezoresistive coefficients indicated that the gauge fac ...
1409 Lab Manual - Austin Community College
1409 Lab Manual - Austin Community College

... loosely structured to begin with a short introduction to the exercise that highlights the activities of the day, what materials are available for use and any changes in procedures. After that you will work independently to learn the material. There is never enough time in lab to go over each and eve ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
Mitochondrial dynamics, mitophagy and cardiovascular disease

... and fission are highly expressed in the adult heart (Delettre et al. 2001; Santel et al. 2003). Ultrastructural analysis of murine left ventricle subjected to physical training reveals the presence of giant mitochondria, thought to be the result of multiple fusion events (Coleman et al. 1987). More ...
PC_Biology_Macomb_April08
PC_Biology_Macomb_April08

... organisms on environmental resources and the interdependence of organisms in ecosystems. Photosynthesis and Respiration Organisms acquire their energy directly or indirectly from sunlight. Plants capture the Sun’s energy and use it to convert carbon dioxide and water to sugar and oxygen through the ...
Percutaneous Coronary Interventions
Percutaneous Coronary Interventions

... A diagnostic cardiac catheterization to assess the nature of the lesion(s) prior to the intervention is a covered service. The diagnostic cardiac catheterization may be performed at any time prior to the PCI, including the same day as the PCI. Performance of a diagnostic cardiac catheterization and ...
science - Christian Schools International
science - Christian Schools International

... to become actively involved in scientific discovery. The curriculum is designed to give teachers as much flexibility as possible. Most units are independent, so they can be used in whatever order is most convenient for teachers, students, and cross-curricular activities planning. Teachers can choose ...
Regulation 1591 Medicines and Medical Devices (Ear Implant Devices)
Regulation 1591 Medicines and Medical Devices (Ear Implant Devices)

... not they are permanently implanted. A non-returnable, nonreusable needle fused or prethreaded to a suture is regarded as part of the suture. Implantable articles that do not qualify as "permanently" implanted medicines include, but are not limited to, Chemoport implantable fluid systems; Port-a-Cath ...
Survival in Animal Cells Requires ppGpp for Internalization and
Survival in Animal Cells Requires ppGpp for Internalization and

... an alternative route independent of SPI-1 is responsible for the uptake of serovar Gallinarum into animal cells. Here, we demonstrate that among various serovar Gallinarum mutants, only ppGpp-defective serovar Gallinarum showed significantly reduced entry into several types of animal cells, suggesti ...
Glutamate 83 and arginine 85 of helix H3 bend are key residues for
Glutamate 83 and arginine 85 of helix H3 bend are key residues for

... Background: FtsZ is an essential cell division protein, which localizes at the middle of the bacterial cell to mediate cytokinesis. In vitro, FtsZ polymerizes and induces GTPase activity through longitudinal interactions to form the protofilaments, whilst lateral interactions result within formation ...
The actin cytoskeleton is a target of the self
The actin cytoskeleton is a target of the self

... prior to the formation of punctate foci of actin at the cell cortex. Although the SI response can be reproduced in pollen tubes that have been grown for several hours, this is not what generally happens in vivo, where inhibition normally occurs in pollen grains, either before or soon after germinati ...
Gametogenesis: Conversion of Germ Cells Into Male and Female
Gametogenesis: Conversion of Germ Cells Into Male and Female

... The ninth edition of Langman’s Medical Embryology adheres to the tradition established by the original publication—it provides a concise but thorough description of embryology and its clinical significance, an awareness of which is essential in the diagnosis and prevention of birth defects. Recent ad ...
CPT Code: 35500 - HCProfessor.com
CPT Code: 35500 - HCProfessor.com

... Description of Procedure: This code describes the harvest of a single vein segment from the upper extremity that is later used in a lower extremity bypass procedure. Lower extremity bypasses, especially bypasses traversing the knee are best performed with autogenous vein tissue. The best choice is t ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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