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Chem Soc Rev
Chem Soc Rev

... distributed to various organs, where they are partially metabolized, excreted, or retained. The ADME processes of nanoparticles are complicated by their unique physiochemical properties. Wide variations in the chemical composition, size, shape, and surface properties of nanoparticles dictate the ADM ...
First report on Noctiluca scintillans blooms in the Red Sea off the
First report on Noctiluca scintillans blooms in the Red Sea off the

... alone. On the other hand, the non-significant difference in the physicochemical variables of Red Sea surface waters in the study region during 2004, 2005 and 2005 may have been due to the cyclic discharge of rainwater stored in ponds close to the sampling sites. The temperature (18–29◦ C) and salinity ...
Jelena Raspopovic Molecular basis for digit patterning in the vertebrate limb
Jelena Raspopovic Molecular basis for digit patterning in the vertebrate limb

... molecules that play an important role during the early digit patterning process. In this chapter I also present my two publications with the respective supplementary material. My first publication with the title “A GDF5 Point Mutation Strikes Twice - Causing BDA1 and SYNS2”, is a collaboration with ...
Graded maternal short gastrulation protein contributes to embryonic
Graded maternal short gastrulation protein contributes to embryonic

... Fig. 1. Sog is secreted into the perivitelline space. Sog protein in whole mounts (A–C) and frozen sections (D–I) of egg chambers, using the 8B (A, B, D–I) or 8A (C) antiserum. Sog is observed inside follicle cells from stages 8 to 10 and between follicle cells and oocyte beginning at stage 10 (A, a ...
View PDF - OMICS International
View PDF - OMICS International

... tuberculosis [15]. It has been validated in the M. tuberculosis, if the organisms are physiologically inactive for long time period; its storage of sugars becomes very important for survival. Various groups of scientific community has been reported that, glycan’s may regulate biochemical pathways by ...
PATELLIN1/2 interact with CVL1 and CVP2 to regulate vascular
PATELLIN1/2 interact with CVL1 and CVP2 to regulate vascular

LINGZHI or REISHI
LINGZHI or REISHI

... As pollen can be readily assimilated and utilized by chronically undernourished body cells, it helps restore the vitality of our body in a rapid manner. Only revitalized body cells can respond positively to the exceptional efficacy of Lingzhi. No nutritional program can ever work effectively when th ...
Molecular Genetic Analysis of Phototropism in
Molecular Genetic Analysis of Phototropism in

... Living plants show changes in their growth patterns in response to environmental stimuli such as light, gravity, water, temperature and touch. In 1880, Darwin outlined those various plant movements in detail in his book ‘The Power of Movement in Plants’. He also studied the phototropic response, whi ...
212-Design of Controlled Release Drug Delivery Systems (McGraw
212-Design of Controlled Release Drug Delivery Systems (McGraw

Conditional expression of Mycobacterium smegmatis
Conditional expression of Mycobacterium smegmatis

... The genus Mycobacterium includes fast-growing species, with doubling times (d.t.) of between 2 and 3 h (Mycobacterium smegmatis and Mycobacterium fortuitum) and 10 h (Mycobacterium avium–intracellulare complex), and slow-growing species, with d.t. of 24 h (Mycobacterium tuberculosis and Mycobacteriu ...
sLeX inhibits Ply hemolytic activity by blocking binding of the toxin to
sLeX inhibits Ply hemolytic activity by blocking binding of the toxin to

... Cholesterol-dependent cytolysins (CDCs) CDCs form pores in cholesterol containing membranes Intermedilysin (ILY) binds human CD59 (hCD59) as a receptor - still requires cholesterol for insertion of pre-pore complex (Giddings et al, 2004, Nat Struct Mol Biol 11:1173-1178) Proteinaceous receptors ha ...
Distinct Cellular and Molecular Mechanisms Underlie Functional
Distinct Cellular and Molecular Mechanisms Underlie Functional

... following rigorous, prolonged exercise.2 Although physiological LVH does not confer increased morbidity and mortality, pathological LVH is consistently associated with prolongation of ventricular action potentials and alterations in the dispersion of repolarization, both of which result in electric ...
iarc monographs on the evaluation of carcinogenic risks to humans
iarc monographs on the evaluation of carcinogenic risks to humans

... carcinogens may also be considered, even in the absence of data on a possible carcinogenic effect in humans or experimental animals. The scientific literature is surveyed for published data relevant to an assessment of carcinogenicity. The IARC information bulletins on agents being tested for carcin ...
NUBBIN and JAGGED define stamen and carpel
NUBBIN and JAGGED define stamen and carpel

... to promote the differentiation of adaxial cell types in the carpel walls, and in the establishment of the correct number of cell layers. The important role these two factors play in regulating organ growth is further demonstrated by gain-of-function experiments showing that ectopic NUB expression is ...
A Guide to Aerosol Delivery Devices for Respiratory Therapists
A Guide to Aerosol Delivery Devices for Respiratory Therapists

... Aerosol therapy is considered to be one of the cornerstones of respiratory therapy that exemplifies the nuances of both the art and science of 21st century medicine. As respiratory therapists are the only health care providers who receive extensive formal education and who are tested for competency ...
Characterization of the Visceral Endoderm Components in Early
Characterization of the Visceral Endoderm Components in Early

... Early mouse development The course of normal mouse development up to the implantation stage is shown in Figure. 1.1 (Hogan, 1994; Tam and Behringer, 1997; Beddington and Robertson, 1999). The first few cleavage stages after fertilization are very slow, taking approximately 48 hours to reach the 8-ce ...
2-3-8 Lung cancer
2-3-8 Lung cancer

... None small cell lung cancer National lung screening trial American lung association Chronic obstructive pulmonary disease ...
Binding of Thrombin to Subendothelial Extracellular Matrix
Binding of Thrombin to Subendothelial Extracellular Matrix

... their underlying extracellular cell matrix (ECM)' (23). Moreover, thrombin may also be accessible to the vascular subendothelium even at postclotting events because upon fibrinolysis, it can be released from a fibrin clot, intact and functionally active (24, 25). In view of thrombin accessibility to ...
Self-Aligned Cu Etch Mask for Individually-Addressable Metallic and Semiconducting Carbon Nanotubes
Self-Aligned Cu Etch Mask for Individually-Addressable Metallic and Semiconducting Carbon Nanotubes

... provide single CNT devices and also allows control over the average number of CNTs per channel. The second and a more deterministic approach uses self-aligned Cu-filled trenches formed in a photoresist (after Joule heating of the underlying CNT) to protect and obtain a large number of single CNT devi ...
Oxidative-stress-induced nuclear to cytoplasmic relocalization is
Oxidative-stress-induced nuclear to cytoplasmic relocalization is

... several post-transcriptional mechanisms. For example, stressinduced mRNA decay is accelerated in specialized compartments termed P-bodies. In P-bodies, mRNAs are subjected to decapping and deadenylation by Dcp1p–Dcp2p and Ccr4p, respectively (reviewed by Eulalio et al., 2007; Parker and Sheth, 2007) ...
Stochastic and reversible aggregation of mRNA with expanded CUG
Stochastic and reversible aggregation of mRNA with expanded CUG

... To analyze the dynamics of the CUG-rich RNA foci in living cells, the lacZ–MS2–5CUG and lacZ–MS2–145CUG cell lines were infected with retroviral vector expressing MS2–GFP, and live-cell microscopy was performed at a rate of three images per second using a spinning disk confocal microscope, to visual ...
THE ROLE OF NODAL SIGNALING IN PATTERNING THE
THE ROLE OF NODAL SIGNALING IN PATTERNING THE

... comprise the adult body plan. Cells differentiate according to their position in the embryo in a highly reproducible fashion. Patterning is fundamental to establishing the spatial organization of the developing embryo (Heasman, 1997), ensuring that all the parts of the body are generated and that th ...
Document
Document

... (b) removal of toxic macromolecular aggregates too large for handling by smaller capacity or single-molecule-handling proteolytic systems of the cell (e.g. proteasome); ...
Titanium oxide antibacterial surfaces in biomedical devices
Titanium oxide antibacterial surfaces in biomedical devices

... of the host organism (1), thus making reoperation of infected implants mandatory. Specific guideline practices have been designed with the aim of minimizing the risks of infection on biomedical devices (1-3). However, implantation procedures are increasingly performed in a population that comprises ...
PicoPure RNA Isolation Kit
PicoPure RNA Isolation Kit

... and CapSure Macro LCM Caps but can be used with various cell samples to isolate total cellular RNA. Researchers can obtain high recoveries of total cellular RNA from as little as a single cell to samples with up to 100 µg of RNA. Total cellular RNA isolated using the PicoPure RNA Isolation Kit prod ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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