Physiological assembly and activity of human
... and cancer (Vulliamy et al., 2006). These diverse clinical presentations are just an inkling of the much greater phenotypic diversity that may be linked to telomere maintenance deficiency in the future. The spectrum of phenotypes can be much broader than currently anticipated, because mutations that ...
... and cancer (Vulliamy et al., 2006). These diverse clinical presentations are just an inkling of the much greater phenotypic diversity that may be linked to telomere maintenance deficiency in the future. The spectrum of phenotypes can be much broader than currently anticipated, because mutations that ...
Arachidonic Acid and Docosahexaenoic Acid Suppress Osteoclast Formation and Activity
... between the osteoblasts and osteoclasts is crucial in maintaining the structure of the bone tissue. Osteoclasts, the sole bone resorbing cell in the body, are multinuclear, terminally differentiated cells that are derived from haematopoietic precursors of the monocyte/macrophage lineage [3, 4, 5, 6] ...
... between the osteoblasts and osteoclasts is crucial in maintaining the structure of the bone tissue. Osteoclasts, the sole bone resorbing cell in the body, are multinuclear, terminally differentiated cells that are derived from haematopoietic precursors of the monocyte/macrophage lineage [3, 4, 5, 6] ...
Differential localization of LTA synthesis proteins and their
... 2009; Webb et al., 2009; Wörmann et al., 2011a). This is further emphasized by the observation that the B. subtilis glycosyltransferase UgtP, the homologue of the S. aureus YpfP protein, as well as LtaS and YqgS, two of the four LtaS homologues, localize to the cell division site in this organism (N ...
... 2009; Webb et al., 2009; Wörmann et al., 2011a). This is further emphasized by the observation that the B. subtilis glycosyltransferase UgtP, the homologue of the S. aureus YpfP protein, as well as LtaS and YqgS, two of the four LtaS homologues, localize to the cell division site in this organism (N ...
Cytostatic factor: an activity that puts the cell cycle on hold
... Accepted 2 February 2006 Journal of Cell Science 119, 1213-1218 Published by The Company of Biologists 2006 doi:10.1242/jcs.02919 ...
... Accepted 2 February 2006 Journal of Cell Science 119, 1213-1218 Published by The Company of Biologists 2006 doi:10.1242/jcs.02919 ...
Spatiotemporal Patterning of Reactive Oxygen Production and Ca2+
... abolished the Ca2cyt wave (Figures 4D and 4E; n 8). This raises the likelihood that the peripheral ROS increase resulted from the extracellular production of ROS by the activity of plasma membrane–associated NADPH oxidase, leading to diffusion of H 2O2 into the cell. The critical role of extracel ...
... abolished the Ca2cyt wave (Figures 4D and 4E; n 8). This raises the likelihood that the peripheral ROS increase resulted from the extracellular production of ROS by the activity of plasma membrane–associated NADPH oxidase, leading to diffusion of H 2O2 into the cell. The critical role of extracel ...
Introduced amino terminal epitopes can reduce surface expression
... α4 or β4 subunits, the V5 epitope has little effect when placed in either, while the Myc epitope reduces expression more when inserted into β4 than α4. These results indicate that the extreme amino terminal region is important for assembly of these receptors, and demonstrate that some widely used in ...
... α4 or β4 subunits, the V5 epitope has little effect when placed in either, while the Myc epitope reduces expression more when inserted into β4 than α4. These results indicate that the extreme amino terminal region is important for assembly of these receptors, and demonstrate that some widely used in ...
Comparative Cell Biology and Evolution of Annexins in Diplomonads
... have been detected in the genomes of animals (group A and B), fungi (group C), plants (group D), and some protists of the Excavata and SAR supergroups (group E) (3). Annexin diversity has been well studied in animals and plants, but comparatively little is known about the evolution, diversity, and c ...
... have been detected in the genomes of animals (group A and B), fungi (group C), plants (group D), and some protists of the Excavata and SAR supergroups (group E) (3). Annexin diversity has been well studied in animals and plants, but comparatively little is known about the evolution, diversity, and c ...
Identification of a Novel Gene, CIA6, Required for
... three strains displayed similar growth characteristics. However, in the low-CO2 environment, compared with the D66 strain, which displayed a growth pattern similar to the one under high-CO2 conditions, the cia6 mutant grew poorly, as did the CCM-defective strain cia5. The results presented here show ...
... three strains displayed similar growth characteristics. However, in the low-CO2 environment, compared with the D66 strain, which displayed a growth pattern similar to the one under high-CO2 conditions, the cia6 mutant grew poorly, as did the CCM-defective strain cia5. The results presented here show ...
Osmotic Water Permeability of Isolated Protoplasts. Modifications
... 6037, Université de Rouen, Faculté des Sciences, 76821 Mont-Saint-Aignan cedex, France cell dimensions, induced by an osmoticum change in the external medium. Measurements of Pos by standard light microscopy have been performed on epidermal cells (Url, 1971; Stadelmann and Lee-Stadelmann, 1989) an ...
... 6037, Université de Rouen, Faculté des Sciences, 76821 Mont-Saint-Aignan cedex, France cell dimensions, induced by an osmoticum change in the external medium. Measurements of Pos by standard light microscopy have been performed on epidermal cells (Url, 1971; Stadelmann and Lee-Stadelmann, 1989) an ...
Drosophila ventral furrow morphogenesis: a
... events are driven by cell shape changes; while germband extension is driven by cell intercalation. The first morphogenetic change is ventral furrow formation, which leads to the internalization of mesodermal precursors. This process begins stochastically by a flattening of the apical membranes of a ...
... events are driven by cell shape changes; while germband extension is driven by cell intercalation. The first morphogenetic change is ventral furrow formation, which leads to the internalization of mesodermal precursors. This process begins stochastically by a flattening of the apical membranes of a ...
The Development of Radial and Biradial Symmetry: The Evolution of
... by a largely acellular mesoglea. The cnidarians generally have multiple planes of mirror symmetry which pass through the major longitudinal axis, the oral-aboral axis. A. Cross section of the benthic polyp form which attaches to the substrate via the basal discs located at the aboral pole. Numerous ...
... by a largely acellular mesoglea. The cnidarians generally have multiple planes of mirror symmetry which pass through the major longitudinal axis, the oral-aboral axis. A. Cross section of the benthic polyp form which attaches to the substrate via the basal discs located at the aboral pole. Numerous ...
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... of hepatic carcinogenesis are thought to initiate by continued viral replication and persistent attempt through a less-than-optimal immune response to eliminate HCVinfected cells (3). The genetically altered cells that have undergone malignant transformation can be cleared efficiently by the immune ...
... of hepatic carcinogenesis are thought to initiate by continued viral replication and persistent attempt through a less-than-optimal immune response to eliminate HCVinfected cells (3). The genetically altered cells that have undergone malignant transformation can be cleared efficiently by the immune ...
Testing the adaptive selection of human mtDNA haplogroups: an
... the influence of nuclear genetic effects, the authors have used a long-standing ‘friend’ of the mitochondrial geneticist, i.e. the trans-mitochondrial cytoplasmic hybrid or ‘cybrid’ cell, as their model system. Cybrids are generated by fusing donor cytoplasts (enucleated cells containing mitochondri ...
... the influence of nuclear genetic effects, the authors have used a long-standing ‘friend’ of the mitochondrial geneticist, i.e. the trans-mitochondrial cytoplasmic hybrid or ‘cybrid’ cell, as their model system. Cybrids are generated by fusing donor cytoplasts (enucleated cells containing mitochondri ...
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... spinal cord [18,19]. However, mutations in Rdh10 do not seem to affect spinal cord development, and RA signaling is still retained at the ventral neural tube [17,20], indicating that other retinol dehydrogenases could be acting in the neural tube. At least two other dehydrogenases are involved in re ...
... spinal cord [18,19]. However, mutations in Rdh10 do not seem to affect spinal cord development, and RA signaling is still retained at the ventral neural tube [17,20], indicating that other retinol dehydrogenases could be acting in the neural tube. At least two other dehydrogenases are involved in re ...
Role of glypican 4 in the regulation of convergent extension
... of the mesoendodermal and neural tissues, although they expressed normal levels of specific marker genes (Fig. 4C; data not shown). These results further suggest that both loss- and gain-of-function of Xgly4 perturb gastrulation cell movement without affecting mesodermal differentiation. Convergent ...
... of the mesoendodermal and neural tissues, although they expressed normal levels of specific marker genes (Fig. 4C; data not shown). These results further suggest that both loss- and gain-of-function of Xgly4 perturb gastrulation cell movement without affecting mesodermal differentiation. Convergent ...
ASH1 by Puf6p–Fun12p/eIF5B interaction and released by CK2 phosphorylation Yingfeng Deng,
... but not the formation of the 48S complex was affected by Puf6p. Inhibition by Puf6 was specific, as competition with cold E3 RNA led to a recovery of the 80S complex preformed by the labeled E3 (Fig. 1C, open triangles). In the presence of EDTA, RNA–ribosomal complexes were not detected, independent ...
... but not the formation of the 48S complex was affected by Puf6p. Inhibition by Puf6 was specific, as competition with cold E3 RNA led to a recovery of the 80S complex preformed by the labeled E3 (Fig. 1C, open triangles). In the presence of EDTA, RNA–ribosomal complexes were not detected, independent ...
Functional Architecture in Lateral Line Afferent Neurons.
... transgenic line HuC:Kaede, larvae express a UV light-sensitive, photo-convertible protein under the control of a pan-neuronal promoter (Sato et al. 2006). This allows the ability to time-stamp afferent neurons to determine their relative stage of development. To do this, HuC:Kaede larvae are flashed ...
... transgenic line HuC:Kaede, larvae express a UV light-sensitive, photo-convertible protein under the control of a pan-neuronal promoter (Sato et al. 2006). This allows the ability to time-stamp afferent neurons to determine their relative stage of development. To do this, HuC:Kaede larvae are flashed ...
Arterial-venous endothelial plasticity
... neuropilin-1 (NRP1) and TIE2. TIE2 is known as an ECspecific receptor for growth factors of the angiopoietin family, which play a role in angiogenesis and the assembly of the vascular wall (Gale and Yancopoulos, 1999; Yancopoulos et al., 2000, for reviews). NRP1 is a receptor for members of the sema ...
... neuropilin-1 (NRP1) and TIE2. TIE2 is known as an ECspecific receptor for growth factors of the angiopoietin family, which play a role in angiogenesis and the assembly of the vascular wall (Gale and Yancopoulos, 1999; Yancopoulos et al., 2000, for reviews). NRP1 is a receptor for members of the sema ...
Chemotaxis Movement and Attachment of Agrobacterium
... away from chemicals in response to a gradient of attractant or repellent, respectively (Mao et al. 2003). In Agrobacterium, chemotaxis plays an important role during the early events of plant-microbe interaction since without it, the cellcell contact, which is required for DNA transfer, could not be ...
... away from chemicals in response to a gradient of attractant or repellent, respectively (Mao et al. 2003). In Agrobacterium, chemotaxis plays an important role during the early events of plant-microbe interaction since without it, the cellcell contact, which is required for DNA transfer, could not be ...
The Iron-Sulfur Cluster Proteins Isa1 and Isa2 Are Required for the
... on glycerol-containing plates (Fig. 1B) by transformation with single-copy or multicopy genomic libraries. When we used the same libraries to complement the desthiobiotin defect of the dtb1 mutant on glucose, however, transformations were immediately successful and produced 30 colonies that were cap ...
... on glycerol-containing plates (Fig. 1B) by transformation with single-copy or multicopy genomic libraries. When we used the same libraries to complement the desthiobiotin defect of the dtb1 mutant on glucose, however, transformations were immediately successful and produced 30 colonies that were cap ...
Signals and Structural Features Involved in Integral Membrane
... are located at the junctures between the three nuclear envelope membrane domains, they may play an important role in establishing and maintaining the nonrandom segregation of integral proteins between these membranes. Several integral membrane proteins that are nonrandomly localized in the membrane ...
... are located at the junctures between the three nuclear envelope membrane domains, they may play an important role in establishing and maintaining the nonrandom segregation of integral proteins between these membranes. Several integral membrane proteins that are nonrandomly localized in the membrane ...
"Pompeii worms" and their epibiotic bacteria - Archimer
... by the presence of dorsal expansions associatcd with filamentous bacteria. The underlying cell epidermis aspects are qui te different as far as bacteria association types are concerned, espccially in the notopod part of Alvinella caudata. These results permit an overview of the possible functioning ...
... by the presence of dorsal expansions associatcd with filamentous bacteria. The underlying cell epidermis aspects are qui te different as far as bacteria association types are concerned, espccially in the notopod part of Alvinella caudata. These results permit an overview of the possible functioning ...
Expression of and Cytokine Activation by Eschevichia coli Curi
... Reprints or correspondence: Dr. Zhao Bian, Microbiology and Tumorbiology Center, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden ...
... Reprints or correspondence: Dr. Zhao Bian, Microbiology and Tumorbiology Center, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden ...
Cdc6 in S phase in human cells - Journal of Cell Science
... We first asked whether Cdc6 enters the nucleus under in vitro replication conditions. We chose to use purified recombinant Xenopus Cdc6 protein in these studies for three reasons. Firstly, because we know it stimulates replication in mammalian nuclei in vitro (Stoeber et al., 1998), secondly because ...
... We first asked whether Cdc6 enters the nucleus under in vitro replication conditions. We chose to use purified recombinant Xenopus Cdc6 protein in these studies for three reasons. Firstly, because we know it stimulates replication in mammalian nuclei in vitro (Stoeber et al., 1998), secondly because ...
viruses
... A typical consequence of DDR activation is the triggering of cell cycle arrest that prevents replication of potentially mutagenic lesions and provides opportunity for DNA repair [31]. Three major checkpoints are involved in monitoring the integrity of the genome under normal circumstances. The G1/S ...
... A typical consequence of DDR activation is the triggering of cell cycle arrest that prevents replication of potentially mutagenic lesions and provides opportunity for DNA repair [31]. Three major checkpoints are involved in monitoring the integrity of the genome under normal circumstances. The G1/S ...