Research Groups of the Department of Infectious Diseases
... study of infectious diseases at the molecular and cellular level is a rather new research area, whose origin as an independent scientific discipline can be traced back to the discovery of pathogenic microorganisms in the 19th century. Today it is common knowledge that ...
... study of infectious diseases at the molecular and cellular level is a rather new research area, whose origin as an independent scientific discipline can be traced back to the discovery of pathogenic microorganisms in the 19th century. Today it is common knowledge that ...
Job Sharing in the Endomembrane System: Vacuolar
... (Li et al., 2005). However, additional independent alleles of AVP1/ VHP1, uncovered by the analysis of fugu5 mutants that failed to support heterotrophic growth after germination, did not show auxin-related phenotypes. Importantly, vacuolar pH in the fugu5 mutants was only mildly affected, and compe ...
... (Li et al., 2005). However, additional independent alleles of AVP1/ VHP1, uncovered by the analysis of fugu5 mutants that failed to support heterotrophic growth after germination, did not show auxin-related phenotypes. Importantly, vacuolar pH in the fugu5 mutants was only mildly affected, and compe ...
Gonadotropin-Releasing Hormone Containing Neurons and
... mice reduced the total number of GnRH neurons throughout the migratory route [52]. Recent studies were performed to investigate the role of polysialic acid in the migration of GnRH neurons [73]. Mouse embryos on day 12 of gestation (E12) were treated with endoneuraminidase (endo-N), an enzyme that s ...
... mice reduced the total number of GnRH neurons throughout the migratory route [52]. Recent studies were performed to investigate the role of polysialic acid in the migration of GnRH neurons [73]. Mouse embryos on day 12 of gestation (E12) were treated with endoneuraminidase (endo-N), an enzyme that s ...
Mechanisms Shaping the Membranes of Cellular Organelles
... occurs most often by fusion or fission. During fusion two separate membranes merge into one, whereas during fission a continuous membrane is divided into two separate ones. For example, ER tubules can fuse with an existing tubule to form a three-way junction. How the characteristic shape of an organel ...
... occurs most often by fusion or fission. During fusion two separate membranes merge into one, whereas during fission a continuous membrane is divided into two separate ones. For example, ER tubules can fuse with an existing tubule to form a three-way junction. How the characteristic shape of an organel ...
Late Endosomal/Lysosomal Targeting and Lack of Recycling of the
... endothelin receptors, the mode of internalization has been analyzed only for the ETA receptor. In stably transfected Chinese hamster ovary (CHO) cells, the receptor was found to reside in caveolae and to be internalized after binding of ET1 (Chun et al., 1994). Because a significant portion of the i ...
... endothelin receptors, the mode of internalization has been analyzed only for the ETA receptor. In stably transfected Chinese hamster ovary (CHO) cells, the receptor was found to reside in caveolae and to be internalized after binding of ET1 (Chun et al., 1994). Because a significant portion of the i ...
Multidrug resistance mediated by the ATP-binding
... primary structure of the additional MSDs may be low compared with other regions of the proteins. As we learn more about the structure/function relationships of the third MSD, it may be possible to make a more educated guess. A second distinctive structural feature of MRP pertains to its NBDs. The si ...
... primary structure of the additional MSDs may be low compared with other regions of the proteins. As we learn more about the structure/function relationships of the third MSD, it may be possible to make a more educated guess. A second distinctive structural feature of MRP pertains to its NBDs. The si ...
Hairy Root Transformation Using Agrobacterium
... in cortex layers only in the meristematic zone (203). I and J, AtWERpro drives expression in the lateral root cap (I; 203) and all epidermal cells throughout the root (I and J; 203). K, SlCYCD6pro drives expression in the QC and vascular initials (203). L, SlWOX5pro drives expression in the QC and v ...
... in cortex layers only in the meristematic zone (203). I and J, AtWERpro drives expression in the lateral root cap (I; 203) and all epidermal cells throughout the root (I and J; 203). K, SlCYCD6pro drives expression in the QC and vascular initials (203). L, SlWOX5pro drives expression in the QC and v ...
Human Dendritic Cell Subsets In Vivo Colony
... work in humans (26) suggest that optimal DC expansion is seen after 10 days of FL injections. The volunteers were apheresed at days 0 and 10 to collect mononuclear cells. The mononuclear fractions from FL-treated volunteers were analyzed by flow cytometry to assess the frequencies and absolute numbe ...
... work in humans (26) suggest that optimal DC expansion is seen after 10 days of FL injections. The volunteers were apheresed at days 0 and 10 to collect mononuclear cells. The mononuclear fractions from FL-treated volunteers were analyzed by flow cytometry to assess the frequencies and absolute numbe ...
Mechanistic Modeling of Cancer Tumor Growth Using a Porous
... Evading growth suppressors: The genetics of normal cells include genes called tumor suppressors that function to prevent the excessive growth that causes tumor formation. One or more of these growth controls are inactivated cancer cells. Inducing angiogenesis: Malignant cells have triggered the grow ...
... Evading growth suppressors: The genetics of normal cells include genes called tumor suppressors that function to prevent the excessive growth that causes tumor formation. One or more of these growth controls are inactivated cancer cells. Inducing angiogenesis: Malignant cells have triggered the grow ...
Study of the role of estrogen receptor variant, ER36, in non genomic
... Farida Nasri for all your solutions and buffers, as well as your constant good humor and your delicious pastries. Thanks for all the plasmids you prepared for me. I also wish to thank Cecile Languilaire, our lab technician, for all her technical help and hygiene and security advice. I wish to thank ...
... Farida Nasri for all your solutions and buffers, as well as your constant good humor and your delicious pastries. Thanks for all the plasmids you prepared for me. I also wish to thank Cecile Languilaire, our lab technician, for all her technical help and hygiene and security advice. I wish to thank ...
The Wnt signaling pathway mechanisms
... which modifies histone deacetylases (Hdac) and as such influences gene expression (Karamboulas et al., 2006; Kuhl and Pandur, 2008) (figure 1D). ...
... which modifies histone deacetylases (Hdac) and as such influences gene expression (Karamboulas et al., 2006; Kuhl and Pandur, 2008) (figure 1D). ...
File
... – MTOCs control the number of microtubules, their polarity, the number of protofilaments, and the time and location of their assembly. – The protein -tubulin is found in all MTOCs and is critical for microtubule nucleation. ...
... – MTOCs control the number of microtubules, their polarity, the number of protofilaments, and the time and location of their assembly. – The protein -tubulin is found in all MTOCs and is critical for microtubule nucleation. ...
Protective effects of sphingosine-1
... control) (Figure 3B). Fifty nanomolar FTY720 did not attenuate the rise in LVEDP. Neither 50 nor 500 nM FTY720 showed a significant effect on coronary flow (Figure 3C) or heart rate (data not shown) during reperfusion. In contrast to FTY720, the selective S1P1 receptor agonist SEW2871 was neither ab ...
... control) (Figure 3B). Fifty nanomolar FTY720 did not attenuate the rise in LVEDP. Neither 50 nor 500 nM FTY720 showed a significant effect on coronary flow (Figure 3C) or heart rate (data not shown) during reperfusion. In contrast to FTY720, the selective S1P1 receptor agonist SEW2871 was neither ab ...
Bacterial Outer Membrane Vesicles as a Delivery System for
... OMVs are spherical structures that pinch off from the cell surface and enclose a broad range of molecules such as lipoproteins, phospholipids, and LPS, which are distributed in the outer membrane. Therefore, in principle, the outer membrane becomes dissociated from the underlying peptidoglycans and ...
... OMVs are spherical structures that pinch off from the cell surface and enclose a broad range of molecules such as lipoproteins, phospholipids, and LPS, which are distributed in the outer membrane. Therefore, in principle, the outer membrane becomes dissociated from the underlying peptidoglycans and ...
The consequences of Rad51 overexpression for normal and tumor
... The RAD51 promoter of mammalian cells contains a p53 response element that acts through AP2 and p53 binding, resulting in decreased RAD51 mRNA and Rad51 protein levels [28,29]. p53 also regulates Rad51 function as it inhibits the formation of Rad51 nuclear foci after the induction of DSBs. The p53 c ...
... The RAD51 promoter of mammalian cells contains a p53 response element that acts through AP2 and p53 binding, resulting in decreased RAD51 mRNA and Rad51 protein levels [28,29]. p53 also regulates Rad51 function as it inhibits the formation of Rad51 nuclear foci after the induction of DSBs. The p53 c ...
Lecture 06, case study - Taxol - Cal State LA
... Caplow, M., Shanks, J. & Ruhlen, R. (1994) How Taxol modulates microtubule disassembly. J. Biol. Chem. 269, 23399-23402. Downing, K.H. (2000) Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu. Rev. Cell Devel. Biol. 16, 89-111. Giannakakou ...
... Caplow, M., Shanks, J. & Ruhlen, R. (1994) How Taxol modulates microtubule disassembly. J. Biol. Chem. 269, 23399-23402. Downing, K.H. (2000) Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu. Rev. Cell Devel. Biol. 16, 89-111. Giannakakou ...
Role of hsp90 and the hsp90-binding immunophilins in signalling
... binding site on hsp90. Using several intracellular receptors and the tumor suppressor p53 as examples, we review evidence that dynamic assembly of heterocomplexes with hsp90 is required for rapid movement through the cytoplasm to the nucleus along microtubular tracks. The role of the immunophilin in ...
... binding site on hsp90. Using several intracellular receptors and the tumor suppressor p53 as examples, we review evidence that dynamic assembly of heterocomplexes with hsp90 is required for rapid movement through the cytoplasm to the nucleus along microtubular tracks. The role of the immunophilin in ...
FOXO1 Plays an Essential Role in Apoptosis of Retinal
... threefold increase in apoptosis (Figure 3C). Preincubation with FOXO1 siRNA-A reduced the level of apoptosis in response to CML-collagen by 60% (p<0.05). Transfection per se was not responsible for the reduced apoptosis since scrambled siRNA had no effect (Figure 3C). To gain insight into how TNF-α ...
... threefold increase in apoptosis (Figure 3C). Preincubation with FOXO1 siRNA-A reduced the level of apoptosis in response to CML-collagen by 60% (p<0.05). Transfection per se was not responsible for the reduced apoptosis since scrambled siRNA had no effect (Figure 3C). To gain insight into how TNF-α ...
Chapter 06 (Urinalyisis
... 1. Usually larger than granulocytes, contain a large round or oval nucleus and normally slough into the urine in small numbers 2. In nephrotic syndrome and in conditions leading to tubular degeneration, the number sloughed is increased 3. When lipiduria occurs, these cells contain endogenous fats. W ...
... 1. Usually larger than granulocytes, contain a large round or oval nucleus and normally slough into the urine in small numbers 2. In nephrotic syndrome and in conditions leading to tubular degeneration, the number sloughed is increased 3. When lipiduria occurs, these cells contain endogenous fats. W ...
Microbial Bioremediation of Uranium: an Overview
... Microbial cells are able to interact with uranium in multiple ways due to diversity in their metabolism and cell surface structures. The latter provide a highly efficient matrix for metal complexation. The metal binding with surfaces of microbial cells is even more efficient than that with inorganic ...
... Microbial cells are able to interact with uranium in multiple ways due to diversity in their metabolism and cell surface structures. The latter provide a highly efficient matrix for metal complexation. The metal binding with surfaces of microbial cells is even more efficient than that with inorganic ...
A Monoclonal Antibody against a Laminin
... and pathways of migration The role of the ECM in the outgrowth and regeneration of peripheral neurites has been the subject of many recent studies in tissue culture (1, 17, 21, 30). When plated on the ECM deposited by a variety of different cultured cell lines, neurons respond rapidly with extensive ...
... and pathways of migration The role of the ECM in the outgrowth and regeneration of peripheral neurites has been the subject of many recent studies in tissue culture (1, 17, 21, 30). When plated on the ECM deposited by a variety of different cultured cell lines, neurons respond rapidly with extensive ...
Molecular organization of the cell wall of Candida albicans and its
... Synthesis of chitin involves a transglycosylation reaction of GlcNAc residues from the universal substrate UDP-Nacetylglucosamine to the growing chain of the polysaccharide. The reaction (catalyzed by ill-known enzymes called chitin synthases, Chsps) requires a divalent metal, generally Mg21, but do ...
... Synthesis of chitin involves a transglycosylation reaction of GlcNAc residues from the universal substrate UDP-Nacetylglucosamine to the growing chain of the polysaccharide. The reaction (catalyzed by ill-known enzymes called chitin synthases, Chsps) requires a divalent metal, generally Mg21, but do ...
