A guide to studying human hair follicle cycling in vivo
... In HFs-XG, anagen VI progresses into catagen unusually rapidly so that on day two postgrafting, follicles that closely correspond to murine catagen stage IV can already be found (Müller-Röver et al., 2001) (Figure 1d-h). In catagen HFs-XG, the matrix is reduced down to just two-three cell layers, ye ...
... In HFs-XG, anagen VI progresses into catagen unusually rapidly so that on day two postgrafting, follicles that closely correspond to murine catagen stage IV can already be found (Müller-Röver et al., 2001) (Figure 1d-h). In catagen HFs-XG, the matrix is reduced down to just two-three cell layers, ye ...
Academic paper: The free-living amoeba Willaertia magna, is
... the bacteria displayed the ability to grow within H. vermiformis and A. castellanii with a respective increase of 1.3 and 1.4 log in CFU/ml after 3 days of infection (Fig. 1). Surprisingly, and at the opposite of these two amoebas, W. magna did not favour bacterial yield and even reduced it signific ...
... the bacteria displayed the ability to grow within H. vermiformis and A. castellanii with a respective increase of 1.3 and 1.4 log in CFU/ml after 3 days of infection (Fig. 1). Surprisingly, and at the opposite of these two amoebas, W. magna did not favour bacterial yield and even reduced it signific ...
Core-specific adaptive regulatory T-cells in
... responses [2]. Although the mechanisms of impaired antiviral immunity in patients with chronic hepatitis C are only incompletely understood, it has been proposed that CD4+ Treg -cells (regulatory T-cells) might contribute to T-cell dysfunctions during ongoing HCV infection. Several studies have demo ...
... responses [2]. Although the mechanisms of impaired antiviral immunity in patients with chronic hepatitis C are only incompletely understood, it has been proposed that CD4+ Treg -cells (regulatory T-cells) might contribute to T-cell dysfunctions during ongoing HCV infection. Several studies have demo ...
Requirements for autosomal gene activity during
... * For translocations, 'Early Phenotype' refers to the phenotype in the distally deficient embryos obtained when translocation males are crossed with compound females. 'Slow phase block' refers to the failure to cellularize during the first 40min of cycle 14. The early cycle 14 defects in 3L~ and 3R~ ...
... * For translocations, 'Early Phenotype' refers to the phenotype in the distally deficient embryos obtained when translocation males are crossed with compound females. 'Slow phase block' refers to the failure to cellularize during the first 40min of cycle 14. The early cycle 14 defects in 3L~ and 3R~ ...
Mitochondrial dysfunction in Parkinson`s disease
... A plethora of studies established that mitochondria are an important source of reactive oxygen species (ROS) (rev. in refs. [64–66]). Increased formation of mitochondrial ROS and/or defective ROS removal by mitochondrial defence systems results in oxidative damage to mtDNA, proteins and lipids and p ...
... A plethora of studies established that mitochondria are an important source of reactive oxygen species (ROS) (rev. in refs. [64–66]). Increased formation of mitochondrial ROS and/or defective ROS removal by mitochondrial defence systems results in oxidative damage to mtDNA, proteins and lipids and p ...
Adeno-Associated Virus Vectors for Gene Therapy - diss.fu
... 1.1.1 Genome Structure and Expression of the Viral Proteins The genomes of the different AAV serotypes consist of linear, single-stranded DNA molecules with a length of approximately 4700 nucleotides. Generally, the genome structures are mostly identical for all AAV serotypes. However, most research ...
... 1.1.1 Genome Structure and Expression of the Viral Proteins The genomes of the different AAV serotypes consist of linear, single-stranded DNA molecules with a length of approximately 4700 nucleotides. Generally, the genome structures are mostly identical for all AAV serotypes. However, most research ...
Direct Interaction between Survivin and Smac/DIABLO Is Essential
... Survivin (Surv-BIR) lacking its C-terminal and Smac/DIABLO were also cloned into pEGFP-C1 plasmid, respectively. In addition, the gene fragments (reacted by PCR for primer pairs P12/P1) was used to generated pTRE2/A-Surv (coding for antisense Survivin). The DNA fragment coding for mature Smac/DIABLO ...
... Survivin (Surv-BIR) lacking its C-terminal and Smac/DIABLO were also cloned into pEGFP-C1 plasmid, respectively. In addition, the gene fragments (reacted by PCR for primer pairs P12/P1) was used to generated pTRE2/A-Surv (coding for antisense Survivin). The DNA fragment coding for mature Smac/DIABLO ...
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... development occurs as a result of the inhibition of BMP signalling in the embryonic ectoderm, and that in the absence of cell-cell signalling, ectodermal cells will adopt a neural fate (Munoz-Sanjuan and Brivanlou, 2002; Weinstein and Hemmati-Brivanlou, 1997). There is compelling evidence that BMP s ...
... development occurs as a result of the inhibition of BMP signalling in the embryonic ectoderm, and that in the absence of cell-cell signalling, ectodermal cells will adopt a neural fate (Munoz-Sanjuan and Brivanlou, 2002; Weinstein and Hemmati-Brivanlou, 1997). There is compelling evidence that BMP s ...
The TSC1–TSC2 complex: a molecular switchboard controlling cell
... regarding the regulation and function of TORC2. Although it has been shown to regulate aspects of the actin cytoskeleton [32,33], the only direct target of mTORC2 (mammalian TORC2) identified to date is Akt. mTORC2 phosphorylates Akt on a residue (Ser473 ) within a hydrophobic motif C-terminal to it ...
... regarding the regulation and function of TORC2. Although it has been shown to regulate aspects of the actin cytoskeleton [32,33], the only direct target of mTORC2 (mammalian TORC2) identified to date is Akt. mTORC2 phosphorylates Akt on a residue (Ser473 ) within a hydrophobic motif C-terminal to it ...
Decrease in Reactive Amino Groups during Oxidation or Endothelial
... changes in the physicochemical properties of LDL including increased electrophoretic mobility, increased density, decreased content of esterified cholesterol, hydrolysis of phosphatidylcholine, and fragmentation of apolipoprotein B. Under conditions highly favorable to oxidation, a similar modificat ...
... changes in the physicochemical properties of LDL including increased electrophoretic mobility, increased density, decreased content of esterified cholesterol, hydrolysis of phosphatidylcholine, and fragmentation of apolipoprotein B. Under conditions highly favorable to oxidation, a similar modificat ...
Cytological Fixation by Chromic Acid and Dichromates By W. G.
... acid and its salts is well established (Neuss and Riemann, 1934; Dole, 1941). The same instrument was used for the oxidation potential measurements with a gold electrode and the saturated-potassium chloride calomel reference electrode. The determinations were also made in triplicate, at room tempera ...
... acid and its salts is well established (Neuss and Riemann, 1934; Dole, 1941). The same instrument was used for the oxidation potential measurements with a gold electrode and the saturated-potassium chloride calomel reference electrode. The determinations were also made in triplicate, at room tempera ...
Monoclonal Antibodies Distinguish Titins from Heart and Skeletal
... protein have yielded similar results (15). Current hypothesis based on the immunofluorescence data assume that titin stretches throughout the myofibril from the M-line to the Zline or the N2-1ine within the I-band. Proteolytic degradation with subsequent redistribution of the molecule within the myo ...
... protein have yielded similar results (15). Current hypothesis based on the immunofluorescence data assume that titin stretches throughout the myofibril from the M-line to the Zline or the N2-1ine within the I-band. Proteolytic degradation with subsequent redistribution of the molecule within the myo ...
Actin-Dependent and -Independent Functions of
... Corda et al., 2006; Stern et al., 2007; Bai et al., 2010). Apart from this correlative evidence that the cortical microtubule collar seen in young trichome stalks is required for branching (Folkers et al., 2002), we have little understanding of the microtubule configurations of the exact branch point ...
... Corda et al., 2006; Stern et al., 2007; Bai et al., 2010). Apart from this correlative evidence that the cortical microtubule collar seen in young trichome stalks is required for branching (Folkers et al., 2002), we have little understanding of the microtubule configurations of the exact branch point ...
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... Origin licensing can begin as early as telophase, as soon as nuclear envelopes have formed around the segregated mitotic chromosomes, though it is not clear if licensing begins this early in all species or cell types [37–39]. Licensing continues throughout G1 and ceases at the G1/S phase transition. ...
... Origin licensing can begin as early as telophase, as soon as nuclear envelopes have formed around the segregated mitotic chromosomes, though it is not clear if licensing begins this early in all species or cell types [37–39]. Licensing continues throughout G1 and ceases at the G1/S phase transition. ...
Control of Leaf and Vein Development by Auxin
... leaf, and mesophyll cells for photosynthesis. Although the cellular proliferation, differentiation, and expansion stages of leaf development cannot be rigidly separated in time, evidence has increasingly been accumulating that suggests that the temporal regulation of the transition from one stage to ...
... leaf, and mesophyll cells for photosynthesis. Although the cellular proliferation, differentiation, and expansion stages of leaf development cannot be rigidly separated in time, evidence has increasingly been accumulating that suggests that the temporal regulation of the transition from one stage to ...
Cytoplasmic and cortical reorganizations of the ascidian zygote
... A definition of the myoplasm as a cytoplasmic domain The myoplasm has been loosely defined as a cortical/subcortical region of the egg and zygote which when relocalized and/or transferred is associated with the differentiation of muscle cells. It presumably contains a muscle determinant which can be ...
... A definition of the myoplasm as a cytoplasmic domain The myoplasm has been loosely defined as a cortical/subcortical region of the egg and zygote which when relocalized and/or transferred is associated with the differentiation of muscle cells. It presumably contains a muscle determinant which can be ...
Pathology of The Parathyroid Glands
... appears to be an equal sex predilection. Patients with parathyroid carcinoma are younger than those with adenoma, and usually present with profound hypercalcemia, and/or its clinical consequences. The initial clinical presentation of parathyroid carcinoma may be that of palpable neck mass, which can ...
... appears to be an equal sex predilection. Patients with parathyroid carcinoma are younger than those with adenoma, and usually present with profound hypercalcemia, and/or its clinical consequences. The initial clinical presentation of parathyroid carcinoma may be that of palpable neck mass, which can ...
1 MCM10 MEDIATES THE INTERACTION BETWEEN DNA
... Large regions of eukaryotic genomes are packaged into transcriptionally silent heterochromatin. Yeast heterochromatic silencing is established and maintained by the action of a group of factors called silent information regulators (SIRs) (RUSCHE et al. 2003). Sir2, Sir3 and Sir4 are recruited to chr ...
... Large regions of eukaryotic genomes are packaged into transcriptionally silent heterochromatin. Yeast heterochromatic silencing is established and maintained by the action of a group of factors called silent information regulators (SIRs) (RUSCHE et al. 2003). Sir2, Sir3 and Sir4 are recruited to chr ...
Roles of maltodextrin and glycogen phosphorylases in maltose
... completely lacked MalP activity and showed reduced intracellular glycogen degradation, confirming the proposed pathway for glycogen degradation in C. glutamicum via GlgP, GlgX and MalP. Surprisingly, the DmalP mutant showed impaired growth, reduced viability and altered cell morphology on maltose an ...
... completely lacked MalP activity and showed reduced intracellular glycogen degradation, confirming the proposed pathway for glycogen degradation in C. glutamicum via GlgP, GlgX and MalP. Surprisingly, the DmalP mutant showed impaired growth, reduced viability and altered cell morphology on maltose an ...
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... mechanisms similar to those used by vertebrates (Jiang et al., 2005; Munro and Odell, 2002b), and require an intact extracellular matrix (Veeman et al., 2008). Formation of intercellular lumens similar to vacuoles also contributes to notochord elongation (Dong et al., 2009; Miyamoto and Crowther, 19 ...
... mechanisms similar to those used by vertebrates (Jiang et al., 2005; Munro and Odell, 2002b), and require an intact extracellular matrix (Veeman et al., 2008). Formation of intercellular lumens similar to vacuoles also contributes to notochord elongation (Dong et al., 2009; Miyamoto and Crowther, 19 ...
... EDS spectrum, up to the detection limit of EDS instrument and thus, again confirms that the synthesized products are pure HAP made of Ca, P and O. Semiquantitative analysis indicates that the Ca/P molar ratio is about 1.66 and it is closer to the theoretical value of 1.66, confirming that the nanopa ...
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... CD34 may have roles in both adhesion and differentiation. In a myeloid leukemia cell line we demonstrated that forced expression impaired terminal differentiation.12 To address how CD34 transduces signals during adhesion, we sought to identify proteins that physically associated with the intracellul ...
... CD34 may have roles in both adhesion and differentiation. In a myeloid leukemia cell line we demonstrated that forced expression impaired terminal differentiation.12 To address how CD34 transduces signals during adhesion, we sought to identify proteins that physically associated with the intracellul ...