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Ch. 18 Class PowerPoint
Ch. 18 Class PowerPoint

... • But theoretically, every reaction can proceed in two directions, forward and reverse. • Essentially all chemical reactions are considered to be reversible under suitable conditions. • A chemical reaction in which the products can react to re-form the reactants is called a reversible reaction. ...
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... (VDOE) Curriculum Framework, Enhanced Scope and Sequence, and Released Test items. In addition to VDOE information, Glencoe Textbook Series and resources have been used. Finally, information from various websites is included. The websites are listed with the information as it appears in the document ...
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Equilibrium - AP Chemistry

... yields, and the many reasons actual yields may be lower. Another critical reason actual yields may be lower is the reversibility of chemical reactions: some reactions may produce only 70% of the product you may calculate they ought to produce. Equilibrium looks at the extent of a chemical reaction. ...
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... Notice that in a combination reaction, the number of reactants is greater than the number of products (Figure 4.1.2). In a typical decomposition reaction (Interactive Figure 4.1.3), the number of products is greater than the number of reactants. The reaction is essentially the reverse of a combinati ...
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Bioorthogonal chemistry



The term bioorthogonal chemistry refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes. The term was coined by Carolyn R. Bertozzi in 2003. Since its introduction, the concept of the bioorthogonal reaction has enabled the study of biomolecules such as glycans, proteins, and lipids in real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality, including the 1,3-dipolar cycloaddition between azides and cyclooctynes (also termed copper-free click chemistry), between nitrones and cyclooctynes, oxime/hydrazone formation from aldehydes and ketones, the tetrazine ligation, the isocyanide-based click reaction, and most recently, the quadricyclane ligation.The use of bioorthogonal chemistry typically proceeds in two steps. First, a cellular substrate is modified with a bioorthogonal functional group (chemical reporter) and introduced to the cell; substrates include metabolites, enzyme inhibitors, etc. The chemical reporter must not alter the structure of the substrate dramatically to avoid affecting its bioactivity. Secondly, a probe containing the complementary functional group is introduced to react and label the substrate.Although effective bioorthogonal reactions such as copper-free click chemistry have been developed, development of new reactions continues to generate orthogonal methods for labeling to allow multiple methods of labeling to be used in the same biosystems.
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