Protein S-nitrosylation in photosynthetic organisms: A
... that have no unpaired electrons, but it tends to combine with other radicals and transition metals [34]. NO is also a small and lipophilic molecule that can easily cross lipid membranes and, thanks to its limited reactivity, is considered relatively long living in vivo [35]. With a half life of up t ...
... that have no unpaired electrons, but it tends to combine with other radicals and transition metals [34]. NO is also a small and lipophilic molecule that can easily cross lipid membranes and, thanks to its limited reactivity, is considered relatively long living in vivo [35]. With a half life of up t ...
Theory and practice of size exclusion chromatography for
... immunogenicity [12,13]. In recent studies, cytotoxic effects have also been observed with several biotherapeutic proteins due to significant denaturation or chemical alterations of the native protein [8,9,14]. In this context, the characterization of protein modifications requires a number of analytic ...
... immunogenicity [12,13]. In recent studies, cytotoxic effects have also been observed with several biotherapeutic proteins due to significant denaturation or chemical alterations of the native protein [8,9,14]. In this context, the characterization of protein modifications requires a number of analytic ...
(9E10): sc-40 - Santa Cruz Biotechnology
... c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas. The presence of three sequence motifs in the c-Myc COOH termi ...
... c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas. The presence of three sequence motifs in the c-Myc COOH termi ...
WW Domains Provide a Platform for the
... during 25 min with a total run time of 45 min. Data were analyzed in batch using the Mascot search engine (57), and proteins were considered “hits” if two independent peptides or a single peptide with a Mascot score of 50 or higher was found. Protein hits were converted to gene identifiers (GeneIDs) ...
... during 25 min with a total run time of 45 min. Data were analyzed in batch using the Mascot search engine (57), and proteins were considered “hits” if two independent peptides or a single peptide with a Mascot score of 50 or higher was found. Protein hits were converted to gene identifiers (GeneIDs) ...
Abstract Importance Structure of Primary Cilia A B Functional Kif3B
... Kif3B is vital in the proper functioning of the Kinesin II. Without Kinesin II, primary cilia would not be able to function in cell signaling. Some ciliopathes that are caused by malfunctioning primary cilia include Bardet-Biedl syndrome (BBS), Joubert syndrome, and MORM (mental retardation, obesity ...
... Kif3B is vital in the proper functioning of the Kinesin II. Without Kinesin II, primary cilia would not be able to function in cell signaling. Some ciliopathes that are caused by malfunctioning primary cilia include Bardet-Biedl syndrome (BBS), Joubert syndrome, and MORM (mental retardation, obesity ...
Effect of the addition of CMC on the aggregation behaviour
... Mw shift toward higher values. Also, SPI contains more tyrosine residues than WPC, 3.3% vs. 2.5%, respectively (Stuchell and Krochta, 1994). Moreover, CMC seemed to interact with the protein mixture in ...
... Mw shift toward higher values. Also, SPI contains more tyrosine residues than WPC, 3.3% vs. 2.5%, respectively (Stuchell and Krochta, 1994). Moreover, CMC seemed to interact with the protein mixture in ...
Phosphorylation of Beclin 1 by DAP
... that these residues are conserved in Bcl-2, except for the solventexposed A104 in Bcl-XL, which is replaced by the acidic D108 in Bcl-2. Therefore, the T119 binding pocket is predicted to be very similar in Bcl-XL and Bcl-2, and phosphorylation of T119 will most likely lead to similar disruption of ...
... that these residues are conserved in Bcl-2, except for the solventexposed A104 in Bcl-XL, which is replaced by the acidic D108 in Bcl-2. Therefore, the T119 binding pocket is predicted to be very similar in Bcl-XL and Bcl-2, and phosphorylation of T119 will most likely lead to similar disruption of ...
Protein structure is conceptually divided into four
... Structure of the jelly roll of hemagglutinin b strand 1 contains a long insertion, and b strand 8 contains a bulge in the corresponding position. Each of these two strands is therefore subdivided into shorter b strands. The loop region between b strands 3 and 4 contains a short a helix, which forms ...
... Structure of the jelly roll of hemagglutinin b strand 1 contains a long insertion, and b strand 8 contains a bulge in the corresponding position. Each of these two strands is therefore subdivided into shorter b strands. The loop region between b strands 3 and 4 contains a short a helix, which forms ...
X-ray structure of functional full-length dynein motor domain - SPring-8
... X-ray structure of functional full-length dynein motor domain Dyneins are large motor complexes of 1–2 MDa that use ATP as an energy source to move toward the minus ends of microtubules [1,2]. This motor activity is crucial for a variety of cellular processes within eukaryotic cells, including the b ...
... X-ray structure of functional full-length dynein motor domain Dyneins are large motor complexes of 1–2 MDa that use ATP as an energy source to move toward the minus ends of microtubules [1,2]. This motor activity is crucial for a variety of cellular processes within eukaryotic cells, including the b ...
The Arabidopsis Rab5 Homologs Rha1 and Ara7 Localize to the
... role in vacuolar trafficking in plant cells. In this study, we investigated the localization of Rha1 and Ara7, two Arabidopsis proteins that have highly similar amino acid sequence homology to Rab5 in animal cells. Both Ara7 and Rha1 gave a punctate staining pattern and colocalized when transiently ...
... role in vacuolar trafficking in plant cells. In this study, we investigated the localization of Rha1 and Ara7, two Arabidopsis proteins that have highly similar amino acid sequence homology to Rab5 in animal cells. Both Ara7 and Rha1 gave a punctate staining pattern and colocalized when transiently ...
Lecture#5 File
... Structure of the jelly roll of hemagglutinin b strand 1 contains a long insertion, and b strand 8 contains a bulge in the corresponding position. Each of these two strands is therefore subdivided into shorter b strands. The loop region between b strands 3 and 4 contains a short a helix, which forms ...
... Structure of the jelly roll of hemagglutinin b strand 1 contains a long insertion, and b strand 8 contains a bulge in the corresponding position. Each of these two strands is therefore subdivided into shorter b strands. The loop region between b strands 3 and 4 contains a short a helix, which forms ...
Cellular Disulfide Bond Formation in Bioactive Peptides and
... enzyme and a redox cofactor [9]. Interestingly, while these enzymes have very low homology, their functional motifs differ only marginally [10]. A minimum assembly requires C–(X)n–C (where ...
... enzyme and a redox cofactor [9]. Interestingly, while these enzymes have very low homology, their functional motifs differ only marginally [10]. A minimum assembly requires C–(X)n–C (where ...
Tissue Regeneration Factor
... proteins). Thus, BMPs work to suppress major inflammatory cytokines, leading to the restoration of joint and cartilage homeostasis. In a clinical trial on Cyplexinol® PRO, its osteoinductive proteins have been reported to yield significant improvement in the reduction of joint pain and frequency of ...
... proteins). Thus, BMPs work to suppress major inflammatory cytokines, leading to the restoration of joint and cartilage homeostasis. In a clinical trial on Cyplexinol® PRO, its osteoinductive proteins have been reported to yield significant improvement in the reduction of joint pain and frequency of ...
Allosteric Modulators of Steroid Hormone Receptors: Structural
... sequence homology and DNA binding specificity, the classical SHRs are found in subfamily III, which includes estrogen receptors (ER) ␣ and  (NR3A1 and A2 respectively); the estrogen-related receptors (ERR) ␣, , and ␥ (NR3B1-3); the glucocorticoid receptor (GR; NR3C1); the mineralocorticoid recepto ...
... sequence homology and DNA binding specificity, the classical SHRs are found in subfamily III, which includes estrogen receptors (ER) ␣ and  (NR3A1 and A2 respectively); the estrogen-related receptors (ERR) ␣, , and ␥ (NR3B1-3); the glucocorticoid receptor (GR; NR3C1); the mineralocorticoid recepto ...
Diverse Effects of Mutations in the Signal Sequence on the Secretion of b-lactamase in Salmonella typhimurium.
... in that they remain trypsin-inaccessible. One of the latter mutants does produce mature protein, but at a very reduced rate. It thus appears that signalsequence mutations can affect more than one step in the secretion process, and that processing of the signal peptide is not required for the protein ...
... in that they remain trypsin-inaccessible. One of the latter mutants does produce mature protein, but at a very reduced rate. It thus appears that signalsequence mutations can affect more than one step in the secretion process, and that processing of the signal peptide is not required for the protein ...
Title: Study of the interactions between Bovine Serum Albumin (BSA
... Albumins represent the major protein content in blood plasma. When drugs are introduced into human bodies albumins usually interact with them influencing the therapeutic process. The understanding of the interactions between albumins and drugs has become a very important research branch in pharmacok ...
... Albumins represent the major protein content in blood plasma. When drugs are introduced into human bodies albumins usually interact with them influencing the therapeutic process. The understanding of the interactions between albumins and drugs has become a very important research branch in pharmacok ...
9/12
... Lophotrichous = tuft at one or both ends Peritrichous = spread evenly over the entire surface Arrangement can be useful in identification ...
... Lophotrichous = tuft at one or both ends Peritrichous = spread evenly over the entire surface Arrangement can be useful in identification ...
Document
... B. The process of transport between all parts of the pathway is identical, vesicular transport, Fig. 13-2. C. Experimental Methods for studying vesicular transport 1. Cell free systems 2. Genetic 3. GFP fusion proteins D Specificity of transport- Coat formation, Fig13-5. 1. Clathrin, Fig. 13-6, Fig. ...
... B. The process of transport between all parts of the pathway is identical, vesicular transport, Fig. 13-2. C. Experimental Methods for studying vesicular transport 1. Cell free systems 2. Genetic 3. GFP fusion proteins D Specificity of transport- Coat formation, Fig13-5. 1. Clathrin, Fig. 13-6, Fig. ...
Dynamic properties of a reconstituted myelin sheath
... often polyanionic in nature [2]. Due to its high charge and low overall hydrophobicity, there is significant intramolecular electrostatic repulsion in MBP; this results in MBP being an extended, intrinsically unstructured protein in solution [12,21]. P2 is a small folded protein with a high homology ...
... often polyanionic in nature [2]. Due to its high charge and low overall hydrophobicity, there is significant intramolecular electrostatic repulsion in MBP; this results in MBP being an extended, intrinsically unstructured protein in solution [12,21]. P2 is a small folded protein with a high homology ...
Ribosomal proteins L5 and L15 Ivailo Simoff in vivo
... proteins show high sequence homology across the species borders. Furthermore, both L5 and L15 are connected to various human diseases which makes it important to elucidate their role in ribosome biogenesis and ribosome function. By applying random- and site-directed mutagenesis, coupled with functio ...
... proteins show high sequence homology across the species borders. Furthermore, both L5 and L15 are connected to various human diseases which makes it important to elucidate their role in ribosome biogenesis and ribosome function. By applying random- and site-directed mutagenesis, coupled with functio ...
hotspots
... for binding of proteins and stabilizing complexes need to be identified i.e. the interface residues • Prediction methods have mainly focused on entire interfaces of 2 interacting proteins ...
... for binding of proteins and stabilizing complexes need to be identified i.e. the interface residues • Prediction methods have mainly focused on entire interfaces of 2 interacting proteins ...
Transcription factor IIIA (TFIIIA) in the second decade
... of binding two kinds of structurally different nucleic acids through its unusual structural features. It contains nine consecutive zinc finger domains (Miller et al., 1985), with each domain consisting of about 30 amino acids. The zinc metal is coordinated by pairs of highly conserved cysteine and h ...
... of binding two kinds of structurally different nucleic acids through its unusual structural features. It contains nine consecutive zinc finger domains (Miller et al., 1985), with each domain consisting of about 30 amino acids. The zinc metal is coordinated by pairs of highly conserved cysteine and h ...
Poster
... Structure of GNNQQNY molecule: Nelson, R., Sawaya, MR., Balbirnie, M., Madsen, AO., Riekel, C., Grothe, R. & Eisenberg, D. (2005). Structure of the crossβ-spine of amyloid-like fibrils. Nature. 435, 773-778. Brain images: Aguzzi, A., Glatzel, M., Montrasio, F., Prinz, M & Heppner FL. (2001). Interve ...
... Structure of GNNQQNY molecule: Nelson, R., Sawaya, MR., Balbirnie, M., Madsen, AO., Riekel, C., Grothe, R. & Eisenberg, D. (2005). Structure of the crossβ-spine of amyloid-like fibrils. Nature. 435, 773-778. Brain images: Aguzzi, A., Glatzel, M., Montrasio, F., Prinz, M & Heppner FL. (2001). Interve ...
Regulation of microtubule dynamics by microtubule
... However the molecular mechanisms responsible tor the MAPstimulated microtubule stabilization are still unclear. One possibility is that the binding of MAPs to the microtubule lattice would simply diminish the rate of loss of tubulin from the polymer. Additionally, the binding of MAPs may increase th ...
... However the molecular mechanisms responsible tor the MAPstimulated microtubule stabilization are still unclear. One possibility is that the binding of MAPs to the microtubule lattice would simply diminish the rate of loss of tubulin from the polymer. Additionally, the binding of MAPs may increase th ...
Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.