Dual Location of the Mitochondrial Preprotein
... both Tim23-2 and B14.7, in vitro protein uptake assays of radiolabeled proteins were performed and analyzed by BN-PAGE. The uptake of radiolabeled Tim23-2 into the Tim17:23 complexes was observed as expected, but uptake of Tim23-2 into the monomeric complex I was also distinctly observed, in a manne ...
... both Tim23-2 and B14.7, in vitro protein uptake assays of radiolabeled proteins were performed and analyzed by BN-PAGE. The uptake of radiolabeled Tim23-2 into the Tim17:23 complexes was observed as expected, but uptake of Tim23-2 into the monomeric complex I was also distinctly observed, in a manne ...
Exploring the Complement Interaction Network
... network of various soluble and membrane-bound proteins, which react with each other, with pathogenic proteins, or with surface structures (Walport 2001). For example, the complement component C3 alone is known to interact with more than 25 different molecules, making it one the most multifunctional ...
... network of various soluble and membrane-bound proteins, which react with each other, with pathogenic proteins, or with surface structures (Walport 2001). For example, the complement component C3 alone is known to interact with more than 25 different molecules, making it one the most multifunctional ...
Full Text - Labs / Projects - Fred Hutchinson Cancer Research Center
... Rpd3, impairing the ability of Hairy to repress transcription (15). It is not yet known whether Hairy is able to simultaneously recruit all of these cofactors to any promoter target. ...
... Rpd3, impairing the ability of Hairy to repress transcription (15). It is not yet known whether Hairy is able to simultaneously recruit all of these cofactors to any promoter target. ...
Hitting the Target: Emerging Technologies in the Search for Kinase
... phosphorylation of specif ic tyrosine, serine, or threonine residues on a target protein can dramatically alter its function in several ways, including activating or inhibiting enzymatic activity, creating or blocking binding sites for other proteins, altering subcellular localization, or controllin ...
... phosphorylation of specif ic tyrosine, serine, or threonine residues on a target protein can dramatically alter its function in several ways, including activating or inhibiting enzymatic activity, creating or blocking binding sites for other proteins, altering subcellular localization, or controllin ...
Population Biology of the First Replicators: On
... (10) not too much), so long as r, and rs are not r,X, BX,2 X2r2 too different. However, in view of the fact that enzyme catalyzed reactions are often many orders with X2 = XT — X,. Note that in equations of magnitude faster than their non-cata(10) it is assumed that the enzyme is already lyzed count ...
... (10) not too much), so long as r, and rs are not r,X, BX,2 X2r2 too different. However, in view of the fact that enzyme catalyzed reactions are often many orders with X2 = XT — X,. Note that in equations of magnitude faster than their non-cata(10) it is assumed that the enzyme is already lyzed count ...
Two-step and one-step secretion mechanisms in Gram
... secretion systems described above: one-step or Sec-independent compared with two-step or Sec-dependent transport mechanisms. The T2SS, T5SS and the CU systems lack an inner membrane transporter that can transfer substrates across the inner membrane in response to ATP. For the first step of transfer ...
... secretion systems described above: one-step or Sec-independent compared with two-step or Sec-dependent transport mechanisms. The T2SS, T5SS and the CU systems lack an inner membrane transporter that can transfer substrates across the inner membrane in response to ATP. For the first step of transfer ...
Microtubule and replication vesicle associations of the potyviral
... jasmonic acid and ethylene. Structural modelling of HCpro indicated that mutations in HVR altered the conformation of its whole hinge region while the fold of 4EBD remained unaffected. Together with aberrant or disrupted HIP2 interactions, the conformational changes may have triggered host defence. ...
... jasmonic acid and ethylene. Structural modelling of HCpro indicated that mutations in HVR altered the conformation of its whole hinge region while the fold of 4EBD remained unaffected. Together with aberrant or disrupted HIP2 interactions, the conformational changes may have triggered host defence. ...
The Amino-terminal Domain of the Golgi Protein Giantin Interacts
... Golgi matrix protein 130, which is involved in the reassembly of Golgi cisternae and stacks at the end of mitosis. The complex is involved in the tethering of coat protomer I vesicles to Golgi membranes and the initial stacking of reforming cisternae. Here we show that the NH2-terminal 15% of Gianti ...
... Golgi matrix protein 130, which is involved in the reassembly of Golgi cisternae and stacks at the end of mitosis. The complex is involved in the tethering of coat protomer I vesicles to Golgi membranes and the initial stacking of reforming cisternae. Here we show that the NH2-terminal 15% of Gianti ...
Protein Function and Classification (Cont.) - EMBL-EBI
... InterPro provides functional analysis of proteins by classifying them into families and predicting the presence of important domains and sites. It does this by combining predictive models known as protein signatures from a number of different databases (referred to as member databases) into a single ...
... InterPro provides functional analysis of proteins by classifying them into families and predicting the presence of important domains and sites. It does this by combining predictive models known as protein signatures from a number of different databases (referred to as member databases) into a single ...
Word - The Open University
... actin; in humans there are six principal isoforms, four of which are found in different types of muscle and the other two (β and γ) in all non-muscle cells. (The term ‘isoform’ describes variants of a protein. These may be produced by different genes, or by differential splicing of the mRNA, or be g ...
... actin; in humans there are six principal isoforms, four of which are found in different types of muscle and the other two (β and γ) in all non-muscle cells. (The term ‘isoform’ describes variants of a protein. These may be produced by different genes, or by differential splicing of the mRNA, or be g ...
Article - Andrej Sali
... between them (Figure 4C). Protein S-VIII may also interact with ES3S. In addition, some unmodeled density between the rods (see red sphere, Figure 4C) may correspond to ES1S, which forms a bulge, and some additional protein. In the large subunit, the L-XII protein density contains two long a helices ...
... between them (Figure 4C). Protein S-VIII may also interact with ES3S. In addition, some unmodeled density between the rods (see red sphere, Figure 4C) may correspond to ES1S, which forms a bulge, and some additional protein. In the large subunit, the L-XII protein density contains two long a helices ...
Correlating ribosome function with high
... Figure 1. The ribosome functional centers. (a) The two ribosomal subunits. Left: the small ribosomal subunit (T30S) [4]. The approximate positions of codon–anticodon interactions of A-, P- and E-tRNAs are shown and the main functional domains are indicated: H, head; L, latch; P, platform; S, shoulde ...
... Figure 1. The ribosome functional centers. (a) The two ribosomal subunits. Left: the small ribosomal subunit (T30S) [4]. The approximate positions of codon–anticodon interactions of A-, P- and E-tRNAs are shown and the main functional domains are indicated: H, head; L, latch; P, platform; S, shoulde ...
Renin Precursor Synthesis and Renin
... form in the kidney and the submaxillary gland, and the molecular nature of the forms in plasma were studied in the mouse. 2. Renin is synthesized as a precursor (pre-prorenin) with a molecular weight of 50 000. 3. Renin is stored in the submaxillary gland and the kidneys as fully active renin with a ...
... form in the kidney and the submaxillary gland, and the molecular nature of the forms in plasma were studied in the mouse. 2. Renin is synthesized as a precursor (pre-prorenin) with a molecular weight of 50 000. 3. Renin is stored in the submaxillary gland and the kidneys as fully active renin with a ...
Halogens: Quaternary Disinfectant Oxidizing
... References: Linton AH, Hugo WB, Russel AD. Disinfection in Veterinary and Farm Practice. 1987. Blackwell Scientific Publications; Oxford, England; Quinn PJ, Markey BK. Disinfection and Disease Prevention in Veterinary Medicine, In: Block SS, ed., Disinfection, Sterilization and Preservation. 5th edi ...
... References: Linton AH, Hugo WB, Russel AD. Disinfection in Veterinary and Farm Practice. 1987. Blackwell Scientific Publications; Oxford, England; Quinn PJ, Markey BK. Disinfection and Disease Prevention in Veterinary Medicine, In: Block SS, ed., Disinfection, Sterilization and Preservation. 5th edi ...
Molecular Definition of Distinct Cytoskeletal Structures
... It has long been known from the results of ultrastructural studies that complement- and inmmnoglobulin G (IgG)-opsonized particles are phagocytosed differently by macrophages (Kaplan, G. 1977. &and. J. bnmunol. 6:797-807). Complement-opsonized particles sink into the cell, w h e r e a s IgG-coated p ...
... It has long been known from the results of ultrastructural studies that complement- and inmmnoglobulin G (IgG)-opsonized particles are phagocytosed differently by macrophages (Kaplan, G. 1977. &and. J. bnmunol. 6:797-807). Complement-opsonized particles sink into the cell, w h e r e a s IgG-coated p ...
Molecular assembly of the period-cryptochrome circadian
... In mammals, these internal circadian rhythms are maintained by a feedback loop governed by four key proteins. Two of these proteins—CLOCK and BMAL1—work together to begin a process called transcription, whereby sections of DNA are used as a template to copy the information needed to make a protein. ...
... In mammals, these internal circadian rhythms are maintained by a feedback loop governed by four key proteins. Two of these proteins—CLOCK and BMAL1—work together to begin a process called transcription, whereby sections of DNA are used as a template to copy the information needed to make a protein. ...
Physical and chemical interactions between aphids and plants
... most likely candidates for fast plugging events. There is a variety of protein forms in the sieve tubes. Presumably most of the phloem-specific proteins are in a soluble form in the phloem sap, a few are present as insoluble deposits along the SE plasma membrane of dicotyledons, while again others a ...
... most likely candidates for fast plugging events. There is a variety of protein forms in the sieve tubes. Presumably most of the phloem-specific proteins are in a soluble form in the phloem sap, a few are present as insoluble deposits along the SE plasma membrane of dicotyledons, while again others a ...
Tyrosine phosphorylation of the BRI1 receptor kinase occurs via a
... development and response to the environment. The receptor kinases in plants and animals are structurally similar but evolutionarily distinct and thus while most animal receptor kinases are tyrosine kinases the plant receptor kinases are classified as serine/threonine kinases. One of the best studied ...
... development and response to the environment. The receptor kinases in plants and animals are structurally similar but evolutionarily distinct and thus while most animal receptor kinases are tyrosine kinases the plant receptor kinases are classified as serine/threonine kinases. One of the best studied ...
Molecular organization of the cell wall of Candida albicans and its
... Fig. 2. Chemical structures of chitin (a), b-1,3/1,6-glucan (b), a glycosyl phosphatidylinositol (GPI) protein (c) and CaPir1 (d). GPI proteins are rich in Ser/ Thr, indicating that the protein could be highly glycosylated, with one or more potential N-glycosylation sites (NST). The hydrophobic N- ( ...
... Fig. 2. Chemical structures of chitin (a), b-1,3/1,6-glucan (b), a glycosyl phosphatidylinositol (GPI) protein (c) and CaPir1 (d). GPI proteins are rich in Ser/ Thr, indicating that the protein could be highly glycosylated, with one or more potential N-glycosylation sites (NST). The hydrophobic N- ( ...
Recent Advances in Target Characterization and Identification by
... available functionalized benzophenone derivatives to the probe. Otherwise, the benzophenone motif can be synthesized from a suitable precursor bearing the desired linking unit. The utilization of benzophenone-derived affinity probes has been widely explored, revealing both its advantages and disadva ...
... available functionalized benzophenone derivatives to the probe. Otherwise, the benzophenone motif can be synthesized from a suitable precursor bearing the desired linking unit. The utilization of benzophenone-derived affinity probes has been widely explored, revealing both its advantages and disadva ...
Personal details Current position Name: Lilah Glazer, PhD E-mail:
... conservation. Over the past several years there has been increased recognition that the earlylife environment can strongly influence the trajectory of developmental pathways, and that perturbations at critical stages of development can have persistent or delayed functional consequences in later life ...
... conservation. Over the past several years there has been increased recognition that the earlylife environment can strongly influence the trajectory of developmental pathways, and that perturbations at critical stages of development can have persistent or delayed functional consequences in later life ...
Acquisition, Conservation, and Loss of Dual
... The dual-targeting ability of a variety of proteins from Physcomitrella patens, rice (Oryza sativa), and Arabidopsis (Arabidopsis thaliana) was tested to determine when dual targeting arose and to what extent it was conserved in land plants. Overall, the targeting ability of over 80 different protei ...
... The dual-targeting ability of a variety of proteins from Physcomitrella patens, rice (Oryza sativa), and Arabidopsis (Arabidopsis thaliana) was tested to determine when dual targeting arose and to what extent it was conserved in land plants. Overall, the targeting ability of over 80 different protei ...
Chimie de l`H érédité.
... As yet we have no idea why the ribosome structure is so complex. The fact, however, that so many different proteins are used, strongly hints that virtually all parts of the ribosome participate in protein synthesis. Eventually it should be possible to test the functional role of the various proteins ...
... As yet we have no idea why the ribosome structure is so complex. The fact, however, that so many different proteins are used, strongly hints that virtually all parts of the ribosome participate in protein synthesis. Eventually it should be possible to test the functional role of the various proteins ...
2.7. Future of plant-based protein sources
... laborious or time-consuming to prepare. They often think that beans and soy products need hours of soaking or that the products need germinating. Even some vegetarians were frustrated with the long time that some vegetarian foods take to prepare. Unfamiliarity of the products is a problem for vegeta ...
... laborious or time-consuming to prepare. They often think that beans and soy products need hours of soaking or that the products need germinating. Even some vegetarians were frustrated with the long time that some vegetarian foods take to prepare. Unfamiliarity of the products is a problem for vegeta ...
Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.