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... Proper patterning of the apical region of the globular embryo requires the activity of members of the HD-Zip III protein family (Emery et al., 2003; Prigge et al., 2005). This family consists of five genes – PHB, PHV, REV, ATHB8 and ATHB15 [also known as CORONA (CNA) and INCURVATA 4 (ICU4)] – all pr ...
... Proper patterning of the apical region of the globular embryo requires the activity of members of the HD-Zip III protein family (Emery et al., 2003; Prigge et al., 2005). This family consists of five genes – PHB, PHV, REV, ATHB8 and ATHB15 [also known as CORONA (CNA) and INCURVATA 4 (ICU4)] – all pr ...
Selection of Suitable Endogenous Reference Genes for Relative
... hybridization and microarray analysis [11] have been used to explore the gene copy number in transgenic plants. Although routinely applied and reliable, these methods are labor-intensive, time-consuming, and require considerable amounts of DNA. In addition, they produce inaccurate estimation of the ...
... hybridization and microarray analysis [11] have been used to explore the gene copy number in transgenic plants. Although routinely applied and reliable, these methods are labor-intensive, time-consuming, and require considerable amounts of DNA. In addition, they produce inaccurate estimation of the ...
A program for annotating and predicting the effects of single
... An example of a start-gained SNP is found in the 5' UTR of Ecdysone inducible protein 63E (Eip63E) gene, which is predicted to be a cyclin J dependent kinase required for oogenesis and embryonic development (Fig. 2).21 The potential start-gain SNP (A > G) in Eip63E changes 5'-ATA-3' to 5'-ATG-3' in ...
... An example of a start-gained SNP is found in the 5' UTR of Ecdysone inducible protein 63E (Eip63E) gene, which is predicted to be a cyclin J dependent kinase required for oogenesis and embryonic development (Fig. 2).21 The potential start-gain SNP (A > G) in Eip63E changes 5'-ATA-3' to 5'-ATG-3' in ...
Supplemental Tables
... also posted at the AAA site, were also used in this analysis. The FlyBase inferred cytological map locations were assigned to all of the orthologs called in the four species. These associations were then ordered and sorted according to their scaffold assignments and molecular coordinates for each sp ...
... also posted at the AAA site, were also used in this analysis. The FlyBase inferred cytological map locations were assigned to all of the orthologs called in the four species. These associations were then ordered and sorted according to their scaffold assignments and molecular coordinates for each sp ...
Detection of mutation status of IgVH genes and minimal residual
... The observation that the rate of disease progression is associated with genomic aberrations and unmutated IgVH status indicates that these factors may determine the course of the disease. The fact that overall survival was inferior for the subgroups with unmutated IgVH, 11q-, or 17p-, suggests that ...
... The observation that the rate of disease progression is associated with genomic aberrations and unmutated IgVH status indicates that these factors may determine the course of the disease. The fact that overall survival was inferior for the subgroups with unmutated IgVH, 11q-, or 17p-, suggests that ...
version pdf - Atlas of Genetics and Cytogenetics in Oncology and
... omphalocele congenital heart defects renal malformations, large bladder due to urethral obstruction, abnormal male genitalia cleft lip and palate holoprosencephaly and other brain malformations hexadactyly, radial hypo-/aplasia ...
... omphalocele congenital heart defects renal malformations, large bladder due to urethral obstruction, abnormal male genitalia cleft lip and palate holoprosencephaly and other brain malformations hexadactyly, radial hypo-/aplasia ...
Evolution at the Subgene Level: Domain Rearrangements in
... have been used to determine gene families of multidomain proteins (Enright et al. 2002; Uchiyama 2006; Song et al. 2008), mechanisms of domain deletions, shufflings, and substitutions have been proposed (Weiner and Bornberg-Bauer 2006; Weiner et al. 2006), and protein interaction maps have been gene ...
... have been used to determine gene families of multidomain proteins (Enright et al. 2002; Uchiyama 2006; Song et al. 2008), mechanisms of domain deletions, shufflings, and substitutions have been proposed (Weiner and Bornberg-Bauer 2006; Weiner et al. 2006), and protein interaction maps have been gene ...
Test Info Sheet
... et al. (2011) found that PALB2 pathogenic variant carriers are 6‐times more likely to have a family history of pancreatic cancer, 1.3‐ times more likely to have a family history of ovarian cancer and 4 times more likely to have a family history of male breast cancer. Although the association of pa ...
... et al. (2011) found that PALB2 pathogenic variant carriers are 6‐times more likely to have a family history of pancreatic cancer, 1.3‐ times more likely to have a family history of ovarian cancer and 4 times more likely to have a family history of male breast cancer. Although the association of pa ...
Set 2: Mutations
... The Effects of Mutations Harmful Mutations: There are many examples of harmful mutations that result from alterations to the DNA base sequence. Examples include: – Sickle-cell disease – Cystic fibrosis – Thalassemias These mutations are harmful because they alter the DNA sequence, thereby upsetting ...
... The Effects of Mutations Harmful Mutations: There are many examples of harmful mutations that result from alterations to the DNA base sequence. Examples include: – Sickle-cell disease – Cystic fibrosis – Thalassemias These mutations are harmful because they alter the DNA sequence, thereby upsetting ...
Linköping University Post Print Segment-specific generation of Drosophila
... A common feature of most nervous systems is the appearance of unique neuronal subtypes only within certain segments. Studies have shown that this may result from several developmental mechanisms, the first of which is the segment-specific generation of unique sets of progenitor cells – for example, ...
... A common feature of most nervous systems is the appearance of unique neuronal subtypes only within certain segments. Studies have shown that this may result from several developmental mechanisms, the first of which is the segment-specific generation of unique sets of progenitor cells – for example, ...
Two Classes of sir3 Mutants Enhance the sir1
... Immunoblot analysis: Preparation of protein extracts, SDSPAGE electrophoresis, and immunoblotting for Sir3p detection were performed as described (Stone and Pillus 1996). High-copy 2 plasmids were used to facilitate detection of Sir3p from wild-type and mutant strains. For all parameters tested pre ...
... Immunoblot analysis: Preparation of protein extracts, SDSPAGE electrophoresis, and immunoblotting for Sir3p detection were performed as described (Stone and Pillus 1996). High-copy 2 plasmids were used to facilitate detection of Sir3p from wild-type and mutant strains. For all parameters tested pre ...
Peter Kunzmann Metaphors in the Language of Darwinism
... subtheories. Genes are discrete, unitary and stable enough. Not only to serve for natu ral selection, but to be dealt with as proper entities. So what about the analogy, the isomorphism between these very dissimilar spheres? At the end of the day I find the whole comparison of memes and genes widel ...
... subtheories. Genes are discrete, unitary and stable enough. Not only to serve for natu ral selection, but to be dealt with as proper entities. So what about the analogy, the isomorphism between these very dissimilar spheres? At the end of the day I find the whole comparison of memes and genes widel ...
Cancer Prone Disease Section Hereditary multiple exostoses (HME) in Oncology and Haematology
... EXT2 Location: 11p11-p12 Note HME is a genetically heterogeneous disorder for which at present, two genes, EXT1 and EXT2 located respectively on 8q24 and 11p11-p12, have been isolated; the EXT1 gene was reported to show linkage in 44%-66% of the HME families, whereas EXT2 would be involved in 27%; a ...
... EXT2 Location: 11p11-p12 Note HME is a genetically heterogeneous disorder for which at present, two genes, EXT1 and EXT2 located respectively on 8q24 and 11p11-p12, have been isolated; the EXT1 gene was reported to show linkage in 44%-66% of the HME families, whereas EXT2 would be involved in 27%; a ...
SPT3 interacts with TFIID to allow normal transcription in
... spt3 sup alleles were used: one strong allele, spt3-401, and three weak alleles, spt3-417, spt3-426, and spt3-445. For each case examined, the spt3 ~up m u t a t i o n s suppressed the transcriptional defects caused by sptl5-21 (Fig. 2). For his4-9176, previous work demonstrated that sptl 521 suppre ...
... spt3 sup alleles were used: one strong allele, spt3-401, and three weak alleles, spt3-417, spt3-426, and spt3-445. For each case examined, the spt3 ~up m u t a t i o n s suppressed the transcriptional defects caused by sptl5-21 (Fig. 2). For his4-9176, previous work demonstrated that sptl 521 suppre ...
MOLECULAR CYTOGENETIC ANALYSES IN WHEAT AND
... make detailed studies on the degree of relationship between the various plant species and varieties and on their genome structures. In recent decades many results have been achieved in this field. Basic breeding material with more favourable agronomic properties have been developed carrying genes or ...
... make detailed studies on the degree of relationship between the various plant species and varieties and on their genome structures. In recent decades many results have been achieved in this field. Basic breeding material with more favourable agronomic properties have been developed carrying genes or ...
DNA Methylation Analysis
... Database9 (Genome Build 36). Additional markers provide increased resolution focused on 144 established cancer genes that have shown differential methylation patterns. To ensure the most important loci were represented, Illumina designed markers to cover nearly 1,000 cancer-related genes described i ...
... Database9 (Genome Build 36). Additional markers provide increased resolution focused on 144 established cancer genes that have shown differential methylation patterns. To ensure the most important loci were represented, Illumina designed markers to cover nearly 1,000 cancer-related genes described i ...
Creating conditional dual fluorescence labelled transgenic animals
... In addition to messenger RNA that encodes proteins, non-coding RNAs, including microRNA (miRNA) and long non-coding RNA (lncRNA) have been shown to be involved in gene regulation at post-transcriptional and translational levels. For example, microRNAs, about 22 nucleotide long, are among the largest ...
... In addition to messenger RNA that encodes proteins, non-coding RNAs, including microRNA (miRNA) and long non-coding RNA (lncRNA) have been shown to be involved in gene regulation at post-transcriptional and translational levels. For example, microRNAs, about 22 nucleotide long, are among the largest ...
An SMN-Dependent U12 Splicing Event Essential for Motor
... (Figures S1A and S1B available online) and reduction of SMN protein levels (Figure 1A) compared to untreated cells. SMN deficiency severely decreased snRNP assembly of snRNAs in vitro and caused a profound alteration of their expression in NIH 3T3 cells (Figures 1B and S1C–S1E), including a reductio ...
... (Figures S1A and S1B available online) and reduction of SMN protein levels (Figure 1A) compared to untreated cells. SMN deficiency severely decreased snRNP assembly of snRNAs in vitro and caused a profound alteration of their expression in NIH 3T3 cells (Figures 1B and S1C–S1E), including a reductio ...
2q13 microduplications
... When the sperm and egg cells join they form a single cell and this cell must continuously make copies of itself (and all its genetic material) in order to produce the billions of cells that are necessary for human growth and development. Sometimes during the formation of the egg or sperm cells or du ...
... When the sperm and egg cells join they form a single cell and this cell must continuously make copies of itself (and all its genetic material) in order to produce the billions of cells that are necessary for human growth and development. Sometimes during the formation of the egg or sperm cells or du ...
Leaf shape: genetic controls and environmental factors
... and is represented by leaves of most model plants, including Arabidopsis, Antirrhinum majus L. and Zea mays L. Simple leaves show more or less serration in the margin but are not separated into several units. On the other hand, tomato, rose and white clover are typical species with compound leaves, ...
... and is represented by leaves of most model plants, including Arabidopsis, Antirrhinum majus L. and Zea mays L. Simple leaves show more or less serration in the margin but are not separated into several units. On the other hand, tomato, rose and white clover are typical species with compound leaves, ...
Physical map of the aromatic amine and m-toluate
... pTDN1. Additionally, UCC2 retained the ability to grow on m-toluate and coupled with aromatic amine degradation this was termed the Tdn+ phenotype (McClure & Venables, 1986). Data from oxygen uptake experiments, release of ammonia by UCC2 incubated with aniline or m- or p-toluidine, identification o ...
... pTDN1. Additionally, UCC2 retained the ability to grow on m-toluate and coupled with aromatic amine degradation this was termed the Tdn+ phenotype (McClure & Venables, 1986). Data from oxygen uptake experiments, release of ammonia by UCC2 incubated with aniline or m- or p-toluidine, identification o ...
Misregulation of pre-mRNA splicing that causes human diseases
... diseases are caused by mutations in sequences that regulate pre-mRNA processing. Their molecular characterization indicates that contributions of pre-mRNA splicing defects to human diseases have been underestimated and could account for pleiotropic phenotypes. The understanding o f the molecular mec ...
... diseases are caused by mutations in sequences that regulate pre-mRNA processing. Their molecular characterization indicates that contributions of pre-mRNA splicing defects to human diseases have been underestimated and could account for pleiotropic phenotypes. The understanding o f the molecular mec ...
Testing hypotheses for the functions of APC family
... signaling, it did not substantially alter cell viability, cadherin-based adhesion, spindle morphology, orientation or selection of division plane, as predicted from previous studies. We also tested the hypothesis that truncated APC proteins found in tumors are dominant negative. Two mutant proteins ...
... signaling, it did not substantially alter cell viability, cadherin-based adhesion, spindle morphology, orientation or selection of division plane, as predicted from previous studies. We also tested the hypothesis that truncated APC proteins found in tumors are dominant negative. Two mutant proteins ...