Rapidly progressive Alzheimer`s disease features
... investigation and prion protein gene sequencing, was concluded to be rapidly progressive Alzheimer’s disease (Chitravas et al., 2011). Data from all of the cases with rapidly progressive Alzheimer’s disease collected independently at prion centres in Germany, Japan, Spain and France have uniformly c ...
... investigation and prion protein gene sequencing, was concluded to be rapidly progressive Alzheimer’s disease (Chitravas et al., 2011). Data from all of the cases with rapidly progressive Alzheimer’s disease collected independently at prion centres in Germany, Japan, Spain and France have uniformly c ...
hoofdstuk 8 - VU-dare
... A total of 150 participants (17.6 yrs., SD 1.7) were recruited from a cohort of 364 adolescents who were first arrested by the police before the age of 12 and had already participated in three previous waves of this longitudinal study: mean age at study entrance was 10.8 (SD 1.5) and at wave three 1 ...
... A total of 150 participants (17.6 yrs., SD 1.7) were recruited from a cohort of 364 adolescents who were first arrested by the police before the age of 12 and had already participated in three previous waves of this longitudinal study: mean age at study entrance was 10.8 (SD 1.5) and at wave three 1 ...
Cell type-specific activation of p38 MAPK in the brain regions of
... The phosphorylation and protein expression levels of p38 MAPK were analyzed by Western blot as reported previously (Long et al., 2006; Niu et al., 2005). Briefly, 50 mg of protein from the whole tissue homogenate of each sample was loaded in 10% SDS–PAGE gel. Then, the proteins were transferred onto ...
... The phosphorylation and protein expression levels of p38 MAPK were analyzed by Western blot as reported previously (Long et al., 2006; Niu et al., 2005). Briefly, 50 mg of protein from the whole tissue homogenate of each sample was loaded in 10% SDS–PAGE gel. Then, the proteins were transferred onto ...
GABA transporters in the mammalian cerebral cortex - LIRA-Lab
... GAT-2, GAT-3, and BGT-1 have been identified using molecular cloning. Of these, GAT-1 and -3 are expressed in the cerebral cortex. Studies of the cortical distribution, cellular localization, ontogeny and relationships of GATs with GABA-releasing elements using a variety of light and electron micros ...
... GAT-2, GAT-3, and BGT-1 have been identified using molecular cloning. Of these, GAT-1 and -3 are expressed in the cerebral cortex. Studies of the cortical distribution, cellular localization, ontogeny and relationships of GATs with GABA-releasing elements using a variety of light and electron micros ...
- Reppert Lab
... The central complex is present in all insects examined and is characterized by its regular, almost crystalline appearance, owing to its repetitive composition of layers and columns. It is one of the highest centers for sensory integration, and it is also involved in motor control (Strauss, 2002; Hom ...
... The central complex is present in all insects examined and is characterized by its regular, almost crystalline appearance, owing to its repetitive composition of layers and columns. It is one of the highest centers for sensory integration, and it is also involved in motor control (Strauss, 2002; Hom ...
Lillienfeld: Chapter 3 lecture PowerPoint
... • During learning, long-term potentiation occurs and makes synapses perform better. • There is only limited recovery following brain injury or serious illness. ...
... • During learning, long-term potentiation occurs and makes synapses perform better. • There is only limited recovery following brain injury or serious illness. ...
University of Groningen The hearing brain in males and
... auditory regions has also been found in other species of primates. They are called the core, belt and parabelt, resembling BA 41, 42 and 22 respectively in humans. In these animal studies, extensive connections between the three auditory regions have been demonstrated (e.g. Kaas and Hackett, 1998). ...
... auditory regions has also been found in other species of primates. They are called the core, belt and parabelt, resembling BA 41, 42 and 22 respectively in humans. In these animal studies, extensive connections between the three auditory regions have been demonstrated (e.g. Kaas and Hackett, 1998). ...
Mietzsch U, McKenna J 3rd, Reith RM, Way SW, Gambello MJ. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants. J Comp Neurol. 2013 Nov. 521(16):3817-31.
... 2007). We cannot yet account for these genotype– phenotype data, but different molecular effects from the loss of hamartin versus tuberin might explain the differences in disease severity. Several brain-specific mouse models of TSC have made it possible to study the roles of hamartin and tuberin in ...
... 2007). We cannot yet account for these genotype– phenotype data, but different molecular effects from the loss of hamartin versus tuberin might explain the differences in disease severity. Several brain-specific mouse models of TSC have made it possible to study the roles of hamartin and tuberin in ...
Gene Dosage in the Dysbindin Schizophrenia Susceptibility
... Neurodevelopmental disorders arise from single or multiple gene defects. However, the way multiple loci interact to modify phenotypic outcomes remains poorly understood. Here, we studied phenotypes associated with mutations in the schizophrenia susceptibility gene dysbindin (dysb), in isolation or i ...
... Neurodevelopmental disorders arise from single or multiple gene defects. However, the way multiple loci interact to modify phenotypic outcomes remains poorly understood. Here, we studied phenotypes associated with mutations in the schizophrenia susceptibility gene dysbindin (dysb), in isolation or i ...
Tese final so frentes - Repositório da Universidade de Lisboa
... Figure 2. Clinical features of muscle wasting in patients with ALS. ......................................... 4 Figure 3. Mutations causing ALS. ............................................................................................ 6 Figure 4. Time course of clinical and neuropathological even ...
... Figure 2. Clinical features of muscle wasting in patients with ALS. ......................................... 4 Figure 3. Mutations causing ALS. ............................................................................................ 6 Figure 4. Time course of clinical and neuropathological even ...
Early Neuronal Loss and Axonal/Presynaptic Damage is Associated
... review, see [31]). In AD patients, the subiculum is among the earliest regions displaying severe atrophy and pathology [1, 16, 18, 32–37]. Loss of the subicular neurons has been reported to be associated with clinical AD [19, 21]. Thus, damaged hippocampal–cortical and hippocampal–subcortical commun ...
... review, see [31]). In AD patients, the subiculum is among the earliest regions displaying severe atrophy and pathology [1, 16, 18, 32–37]. Loss of the subicular neurons has been reported to be associated with clinical AD [19, 21]. Thus, damaged hippocampal–cortical and hippocampal–subcortical commun ...
The neurobiology of Meditation and its clinical effectiveness in
... neurophysiological systems, and on behavioural symptoms in psychiatric disorders. With the increasing growth of well designed and well-controlled Meditation studies, however, future studies will be needed that compare between different Meditation techniques in order to shape out the technique-specifi ...
... neurophysiological systems, and on behavioural symptoms in psychiatric disorders. With the increasing growth of well designed and well-controlled Meditation studies, however, future studies will be needed that compare between different Meditation techniques in order to shape out the technique-specifi ...
The Ventral Striatopallidum and Extended Amygdala in
... aversion (Goodson & Wang, 2006) via Vasotoxin-positive neurons. The intraamygdaloid bed nucleus of the stria terminalis contains only a few cells bordering the dorsal part of the medial nucleus laterally. It is interspersed by fibers projecting to the stria terminalis. The medial sublenticular EA is ...
... aversion (Goodson & Wang, 2006) via Vasotoxin-positive neurons. The intraamygdaloid bed nucleus of the stria terminalis contains only a few cells bordering the dorsal part of the medial nucleus laterally. It is interspersed by fibers projecting to the stria terminalis. The medial sublenticular EA is ...
Lessons from Founder Populations - Digital Commons @ RU
... I want to express my deep gratitude to the many people who have helped get to where I am today. First and foremost, I would like to thank my two advisors: Jan Breslow and Itsik Pe’er. It has been a true pleasure to spend time in both of their labs and I am very grateful for the training they have gi ...
... I want to express my deep gratitude to the many people who have helped get to where I am today. First and foremost, I would like to thank my two advisors: Jan Breslow and Itsik Pe’er. It has been a true pleasure to spend time in both of their labs and I am very grateful for the training they have gi ...
View PDF - CiteSeerX
... ataxia of gait and incoordination of the lower extremities without prominent involvement of arm movements, speech, or eye movements [1-81. The disease usually evolves slowly for weeks or months, but it may occur abruptly [2-9}. The symptoms may improve or even completely clear with cessation of alco ...
... ataxia of gait and incoordination of the lower extremities without prominent involvement of arm movements, speech, or eye movements [1-81. The disease usually evolves slowly for weeks or months, but it may occur abruptly [2-9}. The symptoms may improve or even completely clear with cessation of alco ...
- Journal of Adolescent Health
... they relate to learning from previous experience. Animal research has shown that one potential mechanism of damage to the hippocampus is through corticosterone, the animal analog to cortisol in humans, which can be neurotoxic if secreted in high levels [11]. In studies involving rodents, the number ...
... they relate to learning from previous experience. Animal research has shown that one potential mechanism of damage to the hippocampus is through corticosterone, the animal analog to cortisol in humans, which can be neurotoxic if secreted in high levels [11]. In studies involving rodents, the number ...
Aberrant changes of somatostatin and neuropeptide Y in brain of a
... following manufacturer’s instructions. The concentration of RNA was measured by spectrophotometer to make sure a A260/A280 ratio close to 1.8–2.0. Equal amount of RNA (500 ng) from each sample was used for cDNA synthesis in a volume of 10 µl according to the guideline in Takara RT reagent kit (Takar ...
... following manufacturer’s instructions. The concentration of RNA was measured by spectrophotometer to make sure a A260/A280 ratio close to 1.8–2.0. Equal amount of RNA (500 ng) from each sample was used for cDNA synthesis in a volume of 10 µl according to the guideline in Takara RT reagent kit (Takar ...
Hes1 and Hes3 regulate maintenance of the isthmic organizer and
... expression is restricted to the midbrain±hindbrain boundary region. The isthmic organizer is indicated by arrowheads. (B) In situ hybridization of Hes1. At E9.5, Hes1 is also expressed in the midbrain±hindbrain boundary region (arrowhead). (C±G) In situ hybridization (C±E) and immunohistochemistry ( ...
... expression is restricted to the midbrain±hindbrain boundary region. The isthmic organizer is indicated by arrowheads. (B) In situ hybridization of Hes1. At E9.5, Hes1 is also expressed in the midbrain±hindbrain boundary region (arrowhead). (C±G) In situ hybridization (C±E) and immunohistochemistry ( ...
Bipolar Disorder
... The nature and location of the neuroanatomical dysfunction in bipolar patients often correlates with the resulting symptoms. Abnormalities in the frontosubcortical circuit, especially in the hippocampus and the prefrontal cortex, may explain the attention impairment observed in manic patients (Sax e ...
... The nature and location of the neuroanatomical dysfunction in bipolar patients often correlates with the resulting symptoms. Abnormalities in the frontosubcortical circuit, especially in the hippocampus and the prefrontal cortex, may explain the attention impairment observed in manic patients (Sax e ...
Optogenetic Brain Interfaces
... The work of R. Pashaie was supported in part by the University of Wisconsin research growth initiative; grants 101X172, 101X213, and 101X254. The work of P. Anikeeva was supported by the National Science Foundation (NSF, MRSEC DMR-0819762, and NSF CAREER CBET-1253890) and by the Defense Advanced Res ...
... The work of R. Pashaie was supported in part by the University of Wisconsin research growth initiative; grants 101X172, 101X213, and 101X254. The work of P. Anikeeva was supported by the National Science Foundation (NSF, MRSEC DMR-0819762, and NSF CAREER CBET-1253890) and by the Defense Advanced Res ...
Insular cortex – review
... cognitive processes including integration of perception, gustation, regulation of food intake, social interactions, empathy, pain processing and even takes part in pathogenesis of some neuropsychiatric disorders including anxiety, obsessive compulsive disorder and schizophrenia. All these findings o ...
... cognitive processes including integration of perception, gustation, regulation of food intake, social interactions, empathy, pain processing and even takes part in pathogenesis of some neuropsychiatric disorders including anxiety, obsessive compulsive disorder and schizophrenia. All these findings o ...
MR Imaging–Detectable Metabolic Alterations in Attention Deficit
... Based on MR imaging, there have been findings of volumetric and functional brain abnormalities in subjects with ADHD reported in the literature.8 The volumetric abnormalities involve the frontostriatal network, also with a widespread reduction in the volume of the total cerebrum and cerebellum, in p ...
... Based on MR imaging, there have been findings of volumetric and functional brain abnormalities in subjects with ADHD reported in the literature.8 The volumetric abnormalities involve the frontostriatal network, also with a widespread reduction in the volume of the total cerebrum and cerebellum, in p ...
(Nurr1, Nur77 and Nor-1) by Typical and Atypical Antipsychotics in
... neurons of the substantia nigra and ventral tegmental area. This nuclear receptor is essential for the development and maintenance of mesencephalic dopamine neurons (Zetterström et al., 1997). However, its role in fully mature dopamine neurons remains uncertain. Nur77 (also known as Nerve-Growth Fac ...
... neurons of the substantia nigra and ventral tegmental area. This nuclear receptor is essential for the development and maintenance of mesencephalic dopamine neurons (Zetterström et al., 1997). However, its role in fully mature dopamine neurons remains uncertain. Nur77 (also known as Nerve-Growth Fac ...
The Effect of Ischemia on Biogenic Amine Concentrations in
... such methods, the results are subject to criticism because the distribution of damage is not reliably reproducible in any of the currently known cerebral stroke models. Since the brain is so complex morphologically and neurotransmitter concentrations differ substantially from region to region, compa ...
... such methods, the results are subject to criticism because the distribution of damage is not reliably reproducible in any of the currently known cerebral stroke models. Since the brain is so complex morphologically and neurotransmitter concentrations differ substantially from region to region, compa ...
Preview the material
... developmental screenings performed at well-child check-ups; these screenings should always be performed, although parents should also be encouraged to voice concerns about their child’s development at other times as well. The cause of CDD is not known, but a link to the brain and nervous system has ...
... developmental screenings performed at well-child check-ups; these screenings should always be performed, although parents should also be encouraged to voice concerns about their child’s development at other times as well. The cause of CDD is not known, but a link to the brain and nervous system has ...