PDF - Fishell Lab
... unaffected (Li et al., 1996). Previous analysis of mutant mice lacking Gsh2 demonstrated a reduction in the size of the LGE and a loss of Dlx2 expression in the LGE (Szucsik et al., 1997). The vertebrate Gsh1 and Gsh2 genes are the mammalian homologs of the Drosophila intermediate neuroblasts defect ...
... unaffected (Li et al., 1996). Previous analysis of mutant mice lacking Gsh2 demonstrated a reduction in the size of the LGE and a loss of Dlx2 expression in the LGE (Szucsik et al., 1997). The vertebrate Gsh1 and Gsh2 genes are the mammalian homologs of the Drosophila intermediate neuroblasts defect ...
Cation-Chloride Cotransporters and Neuronal Function
... Ion trafficking across biological membranes is mediated by channels and transporters, and these two types of molecules form the basis of electrical signaling in the nervous system. However, the volume of research on voltage- and ligand-gated channels is orders of magnitude higher than what has been ...
... Ion trafficking across biological membranes is mediated by channels and transporters, and these two types of molecules form the basis of electrical signaling in the nervous system. However, the volume of research on voltage- and ligand-gated channels is orders of magnitude higher than what has been ...
Development of emotional facial recognition in late
... sharply from adolescents to adults. The results provide evidence for late developmental changes in emotional expression recognition with some specificity in the time course for distinct emotions. ...
... sharply from adolescents to adults. The results provide evidence for late developmental changes in emotional expression recognition with some specificity in the time course for distinct emotions. ...
Involvement of Tumor Necrosis Factor Alpha in Hippocampal
... hippocampal morphogenesis, TNFα deficiency specifically improved performance of affected mice in behavioral tasks related to spatial memory. Moreover, lack of TNFα increased the expression of nerve growth factor (NGF), but not brain-derived neurotrophic factor (BDNF), following performance of the le ...
... hippocampal morphogenesis, TNFα deficiency specifically improved performance of affected mice in behavioral tasks related to spatial memory. Moreover, lack of TNFα increased the expression of nerve growth factor (NGF), but not brain-derived neurotrophic factor (BDNF), following performance of the le ...
skull - lms.manhattan.edu
... endothelial cells, which are packed very tightly in brain capillaries. This higher density restricts passage of substances from the bloodstream much more than endothelial cells in capillaries elsewhere in the body. Astrocyte cell projections called astrocytic feet (also known as "glial limitans") su ...
... endothelial cells, which are packed very tightly in brain capillaries. This higher density restricts passage of substances from the bloodstream much more than endothelial cells in capillaries elsewhere in the body. Astrocyte cell projections called astrocytic feet (also known as "glial limitans") su ...
PDF of article - Janelia Research Campus
... of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095 ...
... of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095 ...
Visceral sensitivity and functional dyspepsia
... so-called brain gut axis). Symptoms of functional dyspepsia can be caused by poor regulation of this axis. The most recent studies focus on the apparent alteration of the CNS in processing visceral signals that are accompanied by emotional changes and anxiety and which are very often associated with ...
... so-called brain gut axis). Symptoms of functional dyspepsia can be caused by poor regulation of this axis. The most recent studies focus on the apparent alteration of the CNS in processing visceral signals that are accompanied by emotional changes and anxiety and which are very often associated with ...
hanPNAS11
... We selected the loci of significantly differentially expressed genes based on mRNA-Seq data to which a significant enrichment of TBR1 ChIP-Seq reads mapped proximally. Analysis of these 181 loci (detailed in SI Material and Methods) revealed a binding sequence motif (Fig. S2) with similarities to the ...
... We selected the loci of significantly differentially expressed genes based on mRNA-Seq data to which a significant enrichment of TBR1 ChIP-Seq reads mapped proximally. Analysis of these 181 loci (detailed in SI Material and Methods) revealed a binding sequence motif (Fig. S2) with similarities to the ...
full program with abstracts
... The brain and spinal cord pathology of almost all MND patients is characterised by the presence the RNA/DNAbinding protein TDP-43. However, the causes and consequences of TDP-43 pathology development remain unclear, largely due to a lack of valid mammalian in vivo models of disease. We recently crea ...
... The brain and spinal cord pathology of almost all MND patients is characterised by the presence the RNA/DNAbinding protein TDP-43. However, the causes and consequences of TDP-43 pathology development remain unclear, largely due to a lack of valid mammalian in vivo models of disease. We recently crea ...
Traditional Posters: Neuroimaging
... Metabolic profiles in the posterior cingulate cortex (PCC) have been found to be altered due to healthy aging and in many neurodegenerative diseases. The purpose of this study was to use increased spectral resolution and signal, available at higher field, to measure changes in the PCC metabolic prof ...
... Metabolic profiles in the posterior cingulate cortex (PCC) have been found to be altered due to healthy aging and in many neurodegenerative diseases. The purpose of this study was to use increased spectral resolution and signal, available at higher field, to measure changes in the PCC metabolic prof ...
The Neuroscience of Spontaneous Thought: An Evolving
... focused on a particular topic for an extended period of time. Another type of constraint is automatic in nature – as when a habitual thought pattern or salient perceptual stimulus biases one’s thoughts toward a specific topic in a bottom-up manner. This temporal variability, largely overlooked by p ...
... focused on a particular topic for an extended period of time. Another type of constraint is automatic in nature – as when a habitual thought pattern or salient perceptual stimulus biases one’s thoughts toward a specific topic in a bottom-up manner. This temporal variability, largely overlooked by p ...
A quantitative link between face discrimination deficits and neuronal
... across a range of tasks including social–emotional judgments as well as identification and discrimination. However, functional magnetic resonance imaging (fMRI) studies probing the neural bases of these behavioral differences have produced conflicting results: while some studies have reported reduced ...
... across a range of tasks including social–emotional judgments as well as identification and discrimination. However, functional magnetic resonance imaging (fMRI) studies probing the neural bases of these behavioral differences have produced conflicting results: while some studies have reported reduced ...
Chapter 2 An Integrative Approach to Psychopathology
... Life-Span and Developmental Influences Over Psychopathology Life-Span Developmental Perspective Addresses developmental changes Such changes influence and constrain What is normal and abnormal The Principle of Equifinality Concept in developmental psychopathology Several paths to a giv ...
... Life-Span and Developmental Influences Over Psychopathology Life-Span Developmental Perspective Addresses developmental changes Such changes influence and constrain What is normal and abnormal The Principle of Equifinality Concept in developmental psychopathology Several paths to a giv ...
Low-Dose Alcohol Consumption Protects against Transient Focal
... mice. Second, PPARc was upregulated in the cerebral cortex of low-dose alcohol-fed mice and low-dose alcohol-exposed CATH.a neurons. Third, treatment with PPARc-selective antagonist abolished the protective effect of low-dose alcohol on transient focal cerebral ischemia-induced brain injury and OGD/ ...
... mice. Second, PPARc was upregulated in the cerebral cortex of low-dose alcohol-fed mice and low-dose alcohol-exposed CATH.a neurons. Third, treatment with PPARc-selective antagonist abolished the protective effect of low-dose alcohol on transient focal cerebral ischemia-induced brain injury and OGD/ ...
Insulin Treatment Prevents Neuroinflammation and Neuronal Injury
... used for the ex vivo studies. An established FIV model of HAND was used for the in vivo studies. All breeders were outbred and five independent litters from different breeding animals were used for the in vivo studies to eliminate any possible litter-biased outcomes. Sample size for in vivo animal e ...
... used for the ex vivo studies. An established FIV model of HAND was used for the in vivo studies. All breeders were outbred and five independent litters from different breeding animals were used for the in vivo studies to eliminate any possible litter-biased outcomes. Sample size for in vivo animal e ...
SVPaper260111
... molecular mechanisms () in the human genome, but much less is known about SV in the mouse, currently the preeminent organism for modeling how genetic lesions give rise to disease in mammals. In this paper we use next generation sequencing to address three critical questions: what is the extent of SV ...
... molecular mechanisms () in the human genome, but much less is known about SV in the mouse, currently the preeminent organism for modeling how genetic lesions give rise to disease in mammals. In this paper we use next generation sequencing to address three critical questions: what is the extent of SV ...
Brain regions involved in heading estimation and steering control in
... them, but to have also gained their friendship. Last but most certainly not least, I would like to thank my friends and family. My friends at the Montreal Neurological Institute have shown great compassion and support during my leave of absence. They also welcomed me to the city, helped me settle in ...
... them, but to have also gained their friendship. Last but most certainly not least, I would like to thank my friends and family. My friends at the Montreal Neurological Institute have shown great compassion and support during my leave of absence. They also welcomed me to the city, helped me settle in ...
Roles of Multiple Globus Pallidus Territories of Monkeys and
... et al., 1998; Kita et al., 1999; Bolam et al., 2000). Therefore, the GPe is a key node involved in the control of information flow through the BG, whereas the GPi integrates converging signals from cortical areas (via the striatum), the STN and the GPe to give rise to output signals to the cerebral ...
... et al., 1998; Kita et al., 1999; Bolam et al., 2000). Therefore, the GPe is a key node involved in the control of information flow through the BG, whereas the GPi integrates converging signals from cortical areas (via the striatum), the STN and the GPe to give rise to output signals to the cerebral ...
avian brain nomenclature forum
... caudal and lateroventral part of the telencephalon, showing a topological position and developmental origin identical to that of the amygdala (Striedter, 1997; Puelles et al., 2000); note that this is the first and most important condition for homology; (2) Like the mammalian amygdala, the avian arc ...
... caudal and lateroventral part of the telencephalon, showing a topological position and developmental origin identical to that of the amygdala (Striedter, 1997; Puelles et al., 2000); note that this is the first and most important condition for homology; (2) Like the mammalian amygdala, the avian arc ...
SVPaper2803111
... impact5,6 and the responsible molecular mechanisms7,8 in the human genome, but much less is known about structural variants (SVs) in the mouse, the preeminent organism for modeling how genetic lesions give rise to disease in mammals. In this paper we use next generation sequencing to address three c ...
... impact5,6 and the responsible molecular mechanisms7,8 in the human genome, but much less is known about structural variants (SVs) in the mouse, the preeminent organism for modeling how genetic lesions give rise to disease in mammals. In this paper we use next generation sequencing to address three c ...
Differential functional connectivity of rostral
... ¼ 4.06) were recruited based on questionnaire screening of 1099 college students. Participants completed the Penn State Worry Questionnaire (PSWQ; Meyer et al., 1990; Molina and Borkovec, 1994), which measures AP, and the Mood and Anxiety Symptom Questionnaire (MASQ; Watson et al., 1995a,b), which m ...
... ¼ 4.06) were recruited based on questionnaire screening of 1099 college students. Participants completed the Penn State Worry Questionnaire (PSWQ; Meyer et al., 1990; Molina and Borkovec, 1994), which measures AP, and the Mood and Anxiety Symptom Questionnaire (MASQ; Watson et al., 1995a,b), which m ...
Enhanced Perceptual Functioning in Autism
... cognitive tasks; atypically high involvement of perception in the accomplishment of complex cognitive tasks; and the centrality of perception-related behaviors in typical every day situations. Superior performance in laboratory situations and superior importance in ecological situations were both at ...
... cognitive tasks; atypically high involvement of perception in the accomplishment of complex cognitive tasks; and the centrality of perception-related behaviors in typical every day situations. Superior performance in laboratory situations and superior importance in ecological situations were both at ...
View PDF - e-Science Central
... events. Individuals were not enrolled in TRACTS if they had a history of the following illnesses: seizures; cerebrovascular accident; myocardial infarction; diabetes; current active suicidal, and/or homicidal ideation, intent or plan requiring crisis intervention, current DSM-IV-TR [40] diagnosis of ...
... events. Individuals were not enrolled in TRACTS if they had a history of the following illnesses: seizures; cerebrovascular accident; myocardial infarction; diabetes; current active suicidal, and/or homicidal ideation, intent or plan requiring crisis intervention, current DSM-IV-TR [40] diagnosis of ...
Impaired insulin and insulin-like growth factor expression
... are sporadic and do not exhibit clear familial or genetic clustering. Recent exploration of biochemical, molecular, and cellular abnormalities that precede or accompany classic AD demonstrated that cell loss was associated with increased activation of pro-death genes and signaling pathways, impaired ...
... are sporadic and do not exhibit clear familial or genetic clustering. Recent exploration of biochemical, molecular, and cellular abnormalities that precede or accompany classic AD demonstrated that cell loss was associated with increased activation of pro-death genes and signaling pathways, impaired ...