Caudo‐rostral brain spreading of α‐synuclein through vagal
... Brain accumulation, aggregation and spreading of a‐synuclein (a‐syn) are hallmarks of Parkinson’s (PD) and other neurodegenerative diseases (Spillantini et al, 1997). Although the exact mechanisms triggering this a‐syn pathology are yet to be fully elucidated, both clinical and experimental evidence ...
... Brain accumulation, aggregation and spreading of a‐synuclein (a‐syn) are hallmarks of Parkinson’s (PD) and other neurodegenerative diseases (Spillantini et al, 1997). Although the exact mechanisms triggering this a‐syn pathology are yet to be fully elucidated, both clinical and experimental evidence ...
8129402
... complexes of various innate potentials that are developed one way or another depending upon the training. ...
... complexes of various innate potentials that are developed one way or another depending upon the training. ...
Neuron
... 2001) and lateral intraparietal areas in macaques (Andersen et al., 1997; Colby and Goldberg, 1999), but functional correspondences among them also remain elusive. These diversities emphasize the importance of direct comparison of the functional architecture of the frontal and parietal eye fields be ...
... 2001) and lateral intraparietal areas in macaques (Andersen et al., 1997; Colby and Goldberg, 1999), but functional correspondences among them also remain elusive. These diversities emphasize the importance of direct comparison of the functional architecture of the frontal and parietal eye fields be ...
Six novel CC - DIGITAL.CSIC, el repositorio institucional
... Chemokines are key regulators of migration and consequent activation of migrating leucocytes. CC chemokines constitute the largest chemokine group with 2428 members in mammalian species, and even more in teleost fish, with up to 81 members in zebrafish Danio rerio. Further studies concerning fish ch ...
... Chemokines are key regulators of migration and consequent activation of migrating leucocytes. CC chemokines constitute the largest chemokine group with 2428 members in mammalian species, and even more in teleost fish, with up to 81 members in zebrafish Danio rerio. Further studies concerning fish ch ...
Amelioration of Delayed Neuronal Death in the Hippocampus by
... and 2, eventhoughthe cell somawas still present.After 1 week,all the pyramidal cellstogetherwith dendrites disappeared without NGF treatment. Treatment with NGF preventedthe early destructionof dendritic structures. ...
... and 2, eventhoughthe cell somawas still present.After 1 week,all the pyramidal cellstogetherwith dendrites disappeared without NGF treatment. Treatment with NGF preventedthe early destructionof dendritic structures. ...
The Neuroscientist
... Birbaumer and others 1990). Several studies also provided solid evidence that controlling brain activation can modify behavior and have a therapeutic effect in particular in patients with otherwise pharmacologically intractable epilepsy and attention-deficit hyperactivity disorder, but only a few in ...
... Birbaumer and others 1990). Several studies also provided solid evidence that controlling brain activation can modify behavior and have a therapeutic effect in particular in patients with otherwise pharmacologically intractable epilepsy and attention-deficit hyperactivity disorder, but only a few in ...
The major symptom dimensions of obsessive
... Obsessive–compulsive disorder (OCD) is a clinically heterogeneous disorder characterized by multiple, temporally stable symptom dimensions. Preliminary functional neuroimaging studies suggest that these symptom dimensions may have distinct neural substrates. Whole-brain voxel-based morphometry was u ...
... Obsessive–compulsive disorder (OCD) is a clinically heterogeneous disorder characterized by multiple, temporally stable symptom dimensions. Preliminary functional neuroimaging studies suggest that these symptom dimensions may have distinct neural substrates. Whole-brain voxel-based morphometry was u ...
Aerobic Glycolysis in the Frontal Cortex Correlates with Memory
... generate lactate as a metabolic intermediate, which is subsequently used as a primary fuel source for neurons (for review, see Magistretti and Allaman, 2015). Aerobic glycolysis can be described as the reliance on glycolysis, even when oxygen is not rate-limiting, with the concomitant production of ...
... generate lactate as a metabolic intermediate, which is subsequently used as a primary fuel source for neurons (for review, see Magistretti and Allaman, 2015). Aerobic glycolysis can be described as the reliance on glycolysis, even when oxygen is not rate-limiting, with the concomitant production of ...
Cortical evolution and development: Conserved
... In addition to the predictability of brain component scaling from brain size, a second important feature was disproportionality – different brain components enlarge with markedly different slopes, such that the mammalian brain comes to be dominated in volume by different structures as it enlarges, n ...
... In addition to the predictability of brain component scaling from brain size, a second important feature was disproportionality – different brain components enlarge with markedly different slopes, such that the mammalian brain comes to be dominated in volume by different structures as it enlarges, n ...
View PDF - Genetics
... to mapping structural variants that segregate in a population sequenced at low coverage. We avoid calling structural variants directly. Instead, the evidence for a potential structural variant at a locus is indicated by variation in the counts of short-reads that map anomalously to that locus. These ...
... to mapping structural variants that segregate in a population sequenced at low coverage. We avoid calling structural variants directly. Instead, the evidence for a potential structural variant at a locus is indicated by variation in the counts of short-reads that map anomalously to that locus. These ...
Title Modulation of Conditioned Fear, Fear
... Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA administration of the GABA A receptor agonist, muscimol, on the expression of con ...
... Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA administration of the GABA A receptor agonist, muscimol, on the expression of con ...
Combining electroencephalographic activity and
... mediated regulation of physiological, affective and cognitive processes. As a general approach, previous studies have tried to link the EEG power in specific bands to HRV measures. Although significant correlations were found for the α (8–12 Hz) [48–52], β (13–30 Hz) [49,50,53] and γ (>30 Hz) bands ...
... mediated regulation of physiological, affective and cognitive processes. As a general approach, previous studies have tried to link the EEG power in specific bands to HRV measures. Although significant correlations were found for the α (8–12 Hz) [48–52], β (13–30 Hz) [49,50,53] and γ (>30 Hz) bands ...
Alzheimer-like neurodegeneration in aged antinerve growth factor
... ameliorates lesion-induced abnormalities in these cells (6), and reverses atrophy of BFCNs (7) and spatial memory impairments in aged rats (8–10). A decline in the integrity of the central cholinergic function in aged human brain has been postulated (11) to be responsible for the neuropathological c ...
... ameliorates lesion-induced abnormalities in these cells (6), and reverses atrophy of BFCNs (7) and spatial memory impairments in aged rats (8–10). A decline in the integrity of the central cholinergic function in aged human brain has been postulated (11) to be responsible for the neuropathological c ...
32 MaxPlanckResearch 3 | 09 Small but mighty: In mice, around ten
... to be attractive. There is hardly anything more repellent to us than a bad smell. Biologists, physicians and psychologists are well aware of just how loaded natural smells are with information – for humans and, to an even greater extent, for other mammals. When a dog sniffs the urine of another memb ...
... to be attractive. There is hardly anything more repellent to us than a bad smell. Biologists, physicians and psychologists are well aware of just how loaded natural smells are with information – for humans and, to an even greater extent, for other mammals. When a dog sniffs the urine of another memb ...
Cerebral blood flow and gray matter volume covariance patterns of
... Abstract: Advancing age results in altered cognitive and neuroimaging-derived markers of neural integrity. Whether cognitive changes are the result of variations in brain measures remains unclear and relating the two across the lifespan poses a unique set of problems. It must be determined whether s ...
... Abstract: Advancing age results in altered cognitive and neuroimaging-derived markers of neural integrity. Whether cognitive changes are the result of variations in brain measures remains unclear and relating the two across the lifespan poses a unique set of problems. It must be determined whether s ...
Cat Health Network Feline SNP Chip Studies Final Accomplishments
... some cats with PKD live long lives, while others die very quickly, even though all share the same genetic mutation. Funded by the Cat Health Network, researchers from University of California–Davis sought to identify a genomic region that may influence disease progression in cats. Specifically, the ...
... some cats with PKD live long lives, while others die very quickly, even though all share the same genetic mutation. Funded by the Cat Health Network, researchers from University of California–Davis sought to identify a genomic region that may influence disease progression in cats. Specifically, the ...
The role of nicotinic acetylcholine receptors and GABAergic
... frontal lobe epilepsy (ADNFLE). ADNFLE is a rare idiopathic epilepsy, which has been diagnosed in over a hundred families worldwide. This form of familial partial epilepsy had not been described until 1994, and is characterized by brief motor seizures during sleep. The exclusive occurrence of attack ...
... frontal lobe epilepsy (ADNFLE). ADNFLE is a rare idiopathic epilepsy, which has been diagnosed in over a hundred families worldwide. This form of familial partial epilepsy had not been described until 1994, and is characterized by brief motor seizures during sleep. The exclusive occurrence of attack ...
Role of Slitrk Family Members in
... 3.7.2. Slitrks and their CNS functions 3.7.2.1. Early experiments with cell lines and primary neurons ..................... 60 3.7.2.2. Interaction between Slitrk1 and the 14-3-3 proteins ......................... 60 3.7.2.3. Characterization of Slitrks knockout mice ................................ ...
... 3.7.2. Slitrks and their CNS functions 3.7.2.1. Early experiments with cell lines and primary neurons ..................... 60 3.7.2.2. Interaction between Slitrk1 and the 14-3-3 proteins ......................... 60 3.7.2.3. Characterization of Slitrks knockout mice ................................ ...
Dorsoventral Patterning in Hemichordates
... anal tail [22]. Even for the diffuse nervous system, there are dorsoventral differences in neuronal cell types. The two axon tracts on the opposite midlines differ functionally (the ventral one more associated with motor function). The dorsal tract is internalized in the collar region by a neurulati ...
... anal tail [22]. Even for the diffuse nervous system, there are dorsoventral differences in neuronal cell types. The two axon tracts on the opposite midlines differ functionally (the ventral one more associated with motor function). The dorsal tract is internalized in the collar region by a neurulati ...
NIH Public Access - Medicinal Genomics
... unprovoked seizures that are the manifestation of abnormal electrical activity in the central nervous system (CNS), and they represent one of the most common neurological diseases, with a lifetime incidence of up to 3% in the general population (Hauser et al., 1993). Although many epilepsies are sec ...
... unprovoked seizures that are the manifestation of abnormal electrical activity in the central nervous system (CNS), and they represent one of the most common neurological diseases, with a lifetime incidence of up to 3% in the general population (Hauser et al., 1993). Although many epilepsies are sec ...
Emotion Dysregulation
... as negative rather than approach it or vice versa, depending on the bias in information-processing style). Once a stimulus has been processed, the individual generates an emotional response, attaching valence to stimuli (i.e., deciding if it is positive or negative). This complex step involves aspec ...
... as negative rather than approach it or vice versa, depending on the bias in information-processing style). Once a stimulus has been processed, the individual generates an emotional response, attaching valence to stimuli (i.e., deciding if it is positive or negative). This complex step involves aspec ...
What is Nervous System Fatigue and How do I Prevent it
... What is Nervous System Fatigue and How do I Prevent it? Young – Elitetrack.com Nervous system fatigue can be grouped into 2 categories, peripheral and central. Central nervous system (CNS) fatigue is neural fatigue originating in the brain, brain stem, spinal cord, or spinal nerves. The exact mechan ...
... What is Nervous System Fatigue and How do I Prevent it? Young – Elitetrack.com Nervous system fatigue can be grouped into 2 categories, peripheral and central. Central nervous system (CNS) fatigue is neural fatigue originating in the brain, brain stem, spinal cord, or spinal nerves. The exact mechan ...
Ontogeny, Compartmentation, and Turnover of Spectrin lsoforms in
... compartmentation comes from its ontogeny. Membrane-associated cuyspectrin is present at birth at its adult levels, but cytoplasmic a&spectrin is expressed only following the second postnatal week. Similarly, the 4-fold difference in cytoplasmic ay-spectrin content across brain regions develops durin ...
... compartmentation comes from its ontogeny. Membrane-associated cuyspectrin is present at birth at its adult levels, but cytoplasmic a&spectrin is expressed only following the second postnatal week. Similarly, the 4-fold difference in cytoplasmic ay-spectrin content across brain regions develops durin ...
Connectivity of the human pedunculopontine nucleus region and
... of the principal direction of diffusion it is possible to reconstruct estimated fiber pathways.9,25,37 Conventional approaches to tract tracing, however, can typically only trace pathways in areas of high anisotropy—that is, within white matter bundles—where the estimate of fiber direction is more c ...
... of the principal direction of diffusion it is possible to reconstruct estimated fiber pathways.9,25,37 Conventional approaches to tract tracing, however, can typically only trace pathways in areas of high anisotropy—that is, within white matter bundles—where the estimate of fiber direction is more c ...