Brain Stem Involvement in Immune and Aversive Challenge Jakob Paues
... anorexia and hyperalgesia. An often used model to study sickness behaviour is the intravenous injection of the gram negative bacterial endotoxin lipopolysaccharide (LPS). LPS induces the production of inflammatory mediators, such as cytokines and prostaglandins, which in turn can interact with the c ...
... anorexia and hyperalgesia. An often used model to study sickness behaviour is the intravenous injection of the gram negative bacterial endotoxin lipopolysaccharide (LPS). LPS induces the production of inflammatory mediators, such as cytokines and prostaglandins, which in turn can interact with the c ...
Mapping synaptic pathology within cerebral cortical circuits in
... Primary auditory cortex offers another example of a cortical region in which convergent evidence implicates synaptic disruptions in the pathology of schizophrenia. In subjects with schizophrenia, the processing of sensory information within AI is impaired, manifest as the reduced ability to discrimi ...
... Primary auditory cortex offers another example of a cortical region in which convergent evidence implicates synaptic disruptions in the pathology of schizophrenia. In subjects with schizophrenia, the processing of sensory information within AI is impaired, manifest as the reduced ability to discrimi ...
- Journal of Clinical Investigation
... More than 30 yr after the first description of central pontine myelinolysis (CPM)' by Adams et al. (1), the pathogenesis of this disease is still not fully understood. CPM is characterized by a loss of oligodendrocytes and myelin with relatively wellpreserved neuronal cell bodies and axons in the ce ...
... More than 30 yr after the first description of central pontine myelinolysis (CPM)' by Adams et al. (1), the pathogenesis of this disease is still not fully understood. CPM is characterized by a loss of oligodendrocytes and myelin with relatively wellpreserved neuronal cell bodies and axons in the ce ...
Synaptogenesis in the human cortex occurs between - UvA-DARE
... reveals a paradox; as experiences cause more pruning and at the same time a better network how it is possible then, that EE results in more synapses, which also has a positive effect on the organism‟s behavior? At this moment it is not yet clear whether pruning actually occurs in CA1. The variety o ...
... reveals a paradox; as experiences cause more pruning and at the same time a better network how it is possible then, that EE results in more synapses, which also has a positive effect on the organism‟s behavior? At this moment it is not yet clear whether pruning actually occurs in CA1. The variety o ...
“Genome-wide association study identifies 74 loci associated with
... that the College phenotype is for all intents and purposes merely a coarsening of the EduYears phenotype. Hence, we reasoned in light of this new evidence that attempts to detect associations with EduYears are likely to be better powered, regardless of whether or not the effect is stronger at the up ...
... that the College phenotype is for all intents and purposes merely a coarsening of the EduYears phenotype. Hence, we reasoned in light of this new evidence that attempts to detect associations with EduYears are likely to be better powered, regardless of whether or not the effect is stronger at the up ...
Cerebellar Abnormalities Based on Chemical Neuroanatomy
... endoplasmic reticulum (ER), and play a role in Ca2+ mobilization from the ER [22]. Three types of RyRs (RyR1, RyR2 and RyR3) have been identified, and all of them are known to be expressed in the mouse cerebellum [15,19,25]. In the rolling mouse cerebellum, RyR1 expression in Purkinje cells was unif ...
... endoplasmic reticulum (ER), and play a role in Ca2+ mobilization from the ER [22]. Three types of RyRs (RyR1, RyR2 and RyR3) have been identified, and all of them are known to be expressed in the mouse cerebellum [15,19,25]. In the rolling mouse cerebellum, RyR1 expression in Purkinje cells was unif ...
uncorrected page page page proofs
... to the naked eye. You cannot see that it is densely packed with structures, systems, functions, connections and interconnections, many of which are still not fully understood. Within the brain’s tissue are roughly 86 billion individual nerve cells called neurons. Each neuron is connected to between ...
... to the naked eye. You cannot see that it is densely packed with structures, systems, functions, connections and interconnections, many of which are still not fully understood. Within the brain’s tissue are roughly 86 billion individual nerve cells called neurons. Each neuron is connected to between ...
cHaPter 3
... to the naked eye. You cannot see that it is densely packed with structures, systems, functions, connections and interconnections, many of which are still not fully understood. Within the brain’s tissue are roughly 86 billion individual nerve cells called neurons. Each neuron is connected to between ...
... to the naked eye. You cannot see that it is densely packed with structures, systems, functions, connections and interconnections, many of which are still not fully understood. Within the brain’s tissue are roughly 86 billion individual nerve cells called neurons. Each neuron is connected to between ...
online age page age page proofs proofs
... to the naked eye. You cannot see that it is densely packed with structures, systems, functions, connections and interconnections, many of which are still not fully understood. Within the brain’s tissue are roughly 86 billion individual nerve cells called neurons. Each neuron is connected to between ...
... to the naked eye. You cannot see that it is densely packed with structures, systems, functions, connections and interconnections, many of which are still not fully understood. Within the brain’s tissue are roughly 86 billion individual nerve cells called neurons. Each neuron is connected to between ...
Stereologic analysis of the lateral geniculate nucleus of the
... Reduction of volume and neuronal number has been found in several association nuclei of the thalamus in schizophrenic subjects. Recent evidence suggests that schizophrenic patients exhibit abnormalities in early visual processing and that many of the observed perceptual deficits are consistent with ...
... Reduction of volume and neuronal number has been found in several association nuclei of the thalamus in schizophrenic subjects. Recent evidence suggests that schizophrenic patients exhibit abnormalities in early visual processing and that many of the observed perceptual deficits are consistent with ...
Comprehensive imaging of cortical networks
... Neural computations are implemented by activity in spatially distributed neural circuits. Cellular imaging fills a unique niche in linking activity of specific types of neurons to behavior, over spatial scales spanning single neurons to entire brain regions, and temporal scales from milliseconds to ...
... Neural computations are implemented by activity in spatially distributed neural circuits. Cellular imaging fills a unique niche in linking activity of specific types of neurons to behavior, over spatial scales spanning single neurons to entire brain regions, and temporal scales from milliseconds to ...
Life: The Science of Biology, 8e
... Nervous System - Can higher functions be understood in cellular terms? Patterns of electrical activity in the cerebral cortex characterize stages of sleep ...
... Nervous System - Can higher functions be understood in cellular terms? Patterns of electrical activity in the cerebral cortex characterize stages of sleep ...
Efficient gene transduction of neurons by lentivirus with
... IIF between CMV and all the hybrid promoters by one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test. E/Ta1 promoter displayed higher intensity than CMV promoter in the neostriatum, whereas E/CaMKII and E/PDGF promoters exhibited lower intensities than CMV promoter in the thalamu ...
... IIF between CMV and all the hybrid promoters by one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test. E/Ta1 promoter displayed higher intensity than CMV promoter in the neostriatum, whereas E/CaMKII and E/PDGF promoters exhibited lower intensities than CMV promoter in the thalamu ...
Genetic mechanisms behind cell specification Drosophila Magnus Baumgardt
... neurobiology Developmental biology is the study of the processes by which a multicellular organism develops from one cell, into an adult. However, most multicellular organisms continue development, in a sense, even as adults, as old or injured cells constantly need to be replaced by new ones, making ...
... neurobiology Developmental biology is the study of the processes by which a multicellular organism develops from one cell, into an adult. However, most multicellular organisms continue development, in a sense, even as adults, as old or injured cells constantly need to be replaced by new ones, making ...
HUMAN BRAIN EVOLUTION IN AN ECOLOGICAL CONTEXT^
... However, caution must be exercised when relationships are determined for fossil forms. As pointed out previously (Martin, 1980), description of an allometric relationship for a time series of fossil ...
... However, caution must be exercised when relationships are determined for fossil forms. As pointed out previously (Martin, 1980), description of an allometric relationship for a time series of fossil ...
Ascorbic acid treatment, similarly to fluoxetine, reverses depressive
... behavioral and biochemical alterations induced by CUS in mice, suggesting that this vitamin may be an alternative approach for the management of depressive symptoms. Ó 2011 Elsevier Ltd. All rights reserved. ...
... behavioral and biochemical alterations induced by CUS in mice, suggesting that this vitamin may be an alternative approach for the management of depressive symptoms. Ó 2011 Elsevier Ltd. All rights reserved. ...
fMRI sample and movement - Open Research Exeter
... remission which was defined as the absence of any significant symptom for two weeks or longer. Full remission was defined as the absence of any clinically significant depressive symptoms (i.e., a score of three on any KSADS-PL MDD item was exclusionary, whereas a two - indicative of a subthreshold s ...
... remission which was defined as the absence of any significant symptom for two weeks or longer. Full remission was defined as the absence of any clinically significant depressive symptoms (i.e., a score of three on any KSADS-PL MDD item was exclusionary, whereas a two - indicative of a subthreshold s ...
Hereditary Pick’s disease with the G272V tau mutation shows predominant three-repeat
... Frontotemporal dementia and parkinsonism linked to chromosome 17 have been associated with mutations in the microtubule associated protein tau (MAPT or tau) gene. This disorder is characterized by a large spectrum of neuronal and glial tau lesions in different brain regions. Pick bodies were found i ...
... Frontotemporal dementia and parkinsonism linked to chromosome 17 have been associated with mutations in the microtubule associated protein tau (MAPT or tau) gene. This disorder is characterized by a large spectrum of neuronal and glial tau lesions in different brain regions. Pick bodies were found i ...
Neuronal and microglial cathepsins in aging and age
... Besides functions inside the endosomal/lysosomal system, there is evidence that some members of cathepsins are also involved in extracellular proteolysis resulting in pathological conditions. Leakage of cathepsins into the cytoplasm is often achieved by the endocytosis of oxidizable substrates that ...
... Besides functions inside the endosomal/lysosomal system, there is evidence that some members of cathepsins are also involved in extracellular proteolysis resulting in pathological conditions. Leakage of cathepsins into the cytoplasm is often achieved by the endocytosis of oxidizable substrates that ...
Introduction to Psychology
... become neuroscientists? To make music of exquisite beauty? To seek a cure for cancer? To fall in love? Or to read a book like this one? Each of the billions of neurons—or nerve cells—in your brain is linked to thousands of others. The resulting network allows you to process immense amounts of inform ...
... become neuroscientists? To make music of exquisite beauty? To seek a cure for cancer? To fall in love? Or to read a book like this one? Each of the billions of neurons—or nerve cells—in your brain is linked to thousands of others. The resulting network allows you to process immense amounts of inform ...
Human nasal olfactory epithelium as a dynamic marker for CNS
... Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been re ...
... Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been re ...
NIH Public Access
... Serotonergic neurons within the raphe, especially the dorsal raphe, project to diverse forebrain regions, including the key corticolimbic structures involved in the regulation of stress, such as the mPFC, septum, extended amygdala, and hippocampus. Within the DRN, further topological organization su ...
... Serotonergic neurons within the raphe, especially the dorsal raphe, project to diverse forebrain regions, including the key corticolimbic structures involved in the regulation of stress, such as the mPFC, septum, extended amygdala, and hippocampus. Within the DRN, further topological organization su ...
Module 1 - Doral Academy Preparatory
... • Biological approach – focuses on how our genes, hormones, and nervous system interact with our environments to influence learning, personality, memory, motivation, emotions, and coping techniques – Examples: • Autism • Autism runs in families; supported by the findings in identical twins • If one ...
... • Biological approach – focuses on how our genes, hormones, and nervous system interact with our environments to influence learning, personality, memory, motivation, emotions, and coping techniques – Examples: • Autism • Autism runs in families; supported by the findings in identical twins • If one ...
Genetic Diversity of Principal Neurons in the Hippocampus
... especially slow-wave sleep (Marshall et al., 2006). It has been hypothesized that this improvement is due to interactions between the hippocampus and neocortex during sleep, leading to a transfer of newly acquired representations from the hippocampus to neocortex to form long-term memories. Recent s ...
... especially slow-wave sleep (Marshall et al., 2006). It has been hypothesized that this improvement is due to interactions between the hippocampus and neocortex during sleep, leading to a transfer of newly acquired representations from the hippocampus to neocortex to form long-term memories. Recent s ...
Use of Secondary Metabolite Variation in Crop Improvement
... multiple aliphatic glucosinolates, this locus only controlled one metabolic trait, the accumulation of but-3-enyl glucosinolate. The SGT74B1 enzyme is not specific to the synthesis of but-3-enyl glucosinolate, as previous work has demonstrated that it has broad glucosylation activity (Grubb et al., ...
... multiple aliphatic glucosinolates, this locus only controlled one metabolic trait, the accumulation of but-3-enyl glucosinolate. The SGT74B1 enzyme is not specific to the synthesis of but-3-enyl glucosinolate, as previous work has demonstrated that it has broad glucosylation activity (Grubb et al., ...