Neurofibromatosis type 1 - Centre for Genetics Education
... lamp. They do not affect vision. Optic pathway glioma (OPG) is a non-cancerous growth of the optic nerve that connects each eye to the brain. OPGs occur in around 15% of children usually by the age of around 7 years. They do not always cause symptoms but where they do may impair vision. OPGs that ca ...
... lamp. They do not affect vision. Optic pathway glioma (OPG) is a non-cancerous growth of the optic nerve that connects each eye to the brain. OPGs occur in around 15% of children usually by the age of around 7 years. They do not always cause symptoms but where they do may impair vision. OPGs that ca ...
Effect of Methamphetamine Neurotoxicity on Learning- Arc Efferent Neurons
... Arc/Arg3.1 is an effector immediate early gene, the protein product of which (Arc, activity regulated cytoskeleton associated protein) is thought to be critically involved in synaptic modifications subserving learning and memory (Steward et al., 1998; Guzowski et al., 2000; 2001; Steward and Worley, ...
... Arc/Arg3.1 is an effector immediate early gene, the protein product of which (Arc, activity regulated cytoskeleton associated protein) is thought to be critically involved in synaptic modifications subserving learning and memory (Steward et al., 1998; Guzowski et al., 2000; 2001; Steward and Worley, ...
19 Y-Chromosomal Rearrangements and Azoospermia
... available, the recurrent deletion of each of these intervals could be explained largely by nonallelic homologous recombination between direct repeats. However, in contrast to the conclusion from deletion mapping, AZFb deletions were found to overlap with AZFc deletions. In addition, a background lev ...
... available, the recurrent deletion of each of these intervals could be explained largely by nonallelic homologous recombination between direct repeats. However, in contrast to the conclusion from deletion mapping, AZFb deletions were found to overlap with AZFc deletions. In addition, a background lev ...
Intermittent Explosive Disorder
... this may not be true. In a chart review of 830 patients in 1983, only 1.1% were found to meet DSM-III criteria for IED.11 In a second report of 433 aggressive participants, 1.8% qualified for a diagnosis of IED by DSM-III standards.7 A 2005 study of 1300 patients seeking mental health care found tha ...
... this may not be true. In a chart review of 830 patients in 1983, only 1.1% were found to meet DSM-III criteria for IED.11 In a second report of 433 aggressive participants, 1.8% qualified for a diagnosis of IED by DSM-III standards.7 A 2005 study of 1300 patients seeking mental health care found tha ...
Postnatal microbial colonization programs HPA system for stress
... development of brain plasticity and a subsequent physiological system response. To test the idea that such microbes may affect the development of neural systems that govern the endocrine response to stress, we investigated hypothalamic–pituitary–adrenal (HPA) reaction to stress by comparing germfree ...
... development of brain plasticity and a subsequent physiological system response. To test the idea that such microbes may affect the development of neural systems that govern the endocrine response to stress, we investigated hypothalamic–pituitary–adrenal (HPA) reaction to stress by comparing germfree ...
Long-term channelrhodopsin-2 (ChR2) expression
... took two forms: elongated cylinders and large, round, calyxlike structures. Cylinders appeared earliest, were most numerous, and were found in layers 2–6, in the white matter underlying electroporated S1, and within the terminal field of callosally projecting expressing axons in contralateral S1. Th ...
... took two forms: elongated cylinders and large, round, calyxlike structures. Cylinders appeared earliest, were most numerous, and were found in layers 2–6, in the white matter underlying electroporated S1, and within the terminal field of callosally projecting expressing axons in contralateral S1. Th ...
Dopamine Deficiency in a Genetic Mouse Model of Lesch
... Ci/mmol) was obtained from DuPont-New England Nuclear (Boston, MA). Conical polypropylene tubes, rubber stoppers, and centerwells for CO1 trapping assays were obtained from Fisher/Kontes (Vineland, NJ). Animals. Mice carrying a deletion mutation in the HPRT gene (Hooper et al., 1987) were maintained ...
... Ci/mmol) was obtained from DuPont-New England Nuclear (Boston, MA). Conical polypropylene tubes, rubber stoppers, and centerwells for CO1 trapping assays were obtained from Fisher/Kontes (Vineland, NJ). Animals. Mice carrying a deletion mutation in the HPRT gene (Hooper et al., 1987) were maintained ...
Revised_BJP_MS_
... evidence from in vitro studies indicates that 2-AG induces suppressive effects on immune function by reducing inflammatory cytokines such as IL-6, IL-2 and TNF-α and mediators such as nitric oxide and prostaglandins (Chang et al., 2001; Facchinetti et al., 2003; Gallily et al., 2000; Raman et al., 2 ...
... evidence from in vitro studies indicates that 2-AG induces suppressive effects on immune function by reducing inflammatory cytokines such as IL-6, IL-2 and TNF-α and mediators such as nitric oxide and prostaglandins (Chang et al., 2001; Facchinetti et al., 2003; Gallily et al., 2000; Raman et al., 2 ...
The neurophysiological correlates of motor tics following focal
... stereotyped tics similar to those observed in human disorders. This focal disruption of GABA transmission in the putamen led to motor tics confined to a single or a few muscles. The temporal and structural properties of the tics were identified using electromyogram and frame-by-frame analysis of mul ...
... stereotyped tics similar to those observed in human disorders. This focal disruption of GABA transmission in the putamen led to motor tics confined to a single or a few muscles. The temporal and structural properties of the tics were identified using electromyogram and frame-by-frame analysis of mul ...
Reflections on the Field of Human Genetics: A Call for Increased
... truly associated/linked with complex diseases (Sabbagh and Darlu, 2006; Roychowdhury and Chinnaiyan, 2013; Bottini and Peterson, 2014; Kavanaugh et al., 2014; Everett et al., 2015; Lueck et al., 2015), we are currently in the infancy of understanding disease genetics where prediction of any common, ...
... truly associated/linked with complex diseases (Sabbagh and Darlu, 2006; Roychowdhury and Chinnaiyan, 2013; Bottini and Peterson, 2014; Kavanaugh et al., 2014; Everett et al., 2015; Lueck et al., 2015), we are currently in the infancy of understanding disease genetics where prediction of any common, ...
Mutations in sodium-channel gene SCN9A cause a spectrum of
... recurrent pain remains challenging, in part because the therapeutic armamentarium is incomplete. Hopefully, this will change as a result of increased understanding of the molecular basis of pain. Over the past several years, elucidation of the genetic defects underlying three monogenic pain disorder ...
... recurrent pain remains challenging, in part because the therapeutic armamentarium is incomplete. Hopefully, this will change as a result of increased understanding of the molecular basis of pain. Over the past several years, elucidation of the genetic defects underlying three monogenic pain disorder ...
Mirror Neurons: Findings and Functions
... After the first experiment, a great amount of research has provided evidence for the location of the MNS and its properties. This research has shown that there appear to be other areas with mirror properties. Besides the premotor area, one of its important input areas, the rostral inferior parietal ...
... After the first experiment, a great amount of research has provided evidence for the location of the MNS and its properties. This research has shown that there appear to be other areas with mirror properties. Besides the premotor area, one of its important input areas, the rostral inferior parietal ...
The Teen Brain on Marijuana
... determine whether symptoms of mental illness were present BEFORE marijuana use initiation, and perhaps contributed to individuals becoming marijuana users. Even after controlling for the confounding effect of mental illness symptoms preceding marijuana use, these studies showed an increased risk of ...
... determine whether symptoms of mental illness were present BEFORE marijuana use initiation, and perhaps contributed to individuals becoming marijuana users. Even after controlling for the confounding effect of mental illness symptoms preceding marijuana use, these studies showed an increased risk of ...
ChennWalshCeCortexJu..
... and may regulate cerebral cortical size by controlling the generation of neural precursor cells. Mice expressing high levels of a stabilized β-catenin transgene in neural precursors develop enlarged brains with expanded precursor populations, increased cerebral cortical surface area, and folds resem ...
... and may regulate cerebral cortical size by controlling the generation of neural precursor cells. Mice expressing high levels of a stabilized β-catenin transgene in neural precursors develop enlarged brains with expanded precursor populations, increased cerebral cortical surface area, and folds resem ...
Can the Psycho-Emotional State be Optimized by Regular Use of
... impact of training. Therefore, here we explored the effect of selfguided emotion-centered imagery, trying to answer not only the question “whether”, according to the subjects, there was an effect on their state of emotional well-being, but also “how” functioning of the brain was affected by training ...
... impact of training. Therefore, here we explored the effect of selfguided emotion-centered imagery, trying to answer not only the question “whether”, according to the subjects, there was an effect on their state of emotional well-being, but also “how” functioning of the brain was affected by training ...
IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque
... has an unexpected negative effect on Ab proteostasis and cognition in APP mouse models demonstrate the complex interplay between innate immunity and proteostasis in neurodegenerative diseases, an interaction we call immunoproteostasis. ...
... has an unexpected negative effect on Ab proteostasis and cognition in APP mouse models demonstrate the complex interplay between innate immunity and proteostasis in neurodegenerative diseases, an interaction we call immunoproteostasis. ...
Controlling gene expression with the Q repressible binary
... Q system functions effectively with single-copy transgenes Standard transgenic technique in C. elegans involves microinjection of exogenous DNA into the gonad, which results in complex extrachromosomal arrays containing high-copy-number transgenes. Although this method is convenient and frequently u ...
... Q system functions effectively with single-copy transgenes Standard transgenic technique in C. elegans involves microinjection of exogenous DNA into the gonad, which results in complex extrachromosomal arrays containing high-copy-number transgenes. Although this method is convenient and frequently u ...
Human genetics and genomics a decade after the release of the
... These developments are vital for the emergence of genome-wide association studies in the investigation of complex diseases and traits. In parallel, the advent of high-throughput sequencing technologies has ushered in the ‘personal genome sequencing’ era for both normal and cancer genomes, and made p ...
... These developments are vital for the emergence of genome-wide association studies in the investigation of complex diseases and traits. In parallel, the advent of high-throughput sequencing technologies has ushered in the ‘personal genome sequencing’ era for both normal and cancer genomes, and made p ...
Fluorescent in situ hybridization technique for cell type identification
... Central nervous system consists of a myriad of cell types, including neurons, glias, endothelial cells, etc. On top of it, each cell type can be further subdivided into many different subtypes [4,27]. Considering that the neuronal circuit is an assembly of various neuronal types, the identification ...
... Central nervous system consists of a myriad of cell types, including neurons, glias, endothelial cells, etc. On top of it, each cell type can be further subdivided into many different subtypes [4,27]. Considering that the neuronal circuit is an assembly of various neuronal types, the identification ...
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... of the circuitry underlying these models remains incomplete. Prior studies of the habenula, a poorly understood nucleus in the dorsal diencephalon, suggest that projections to the medial habenula (MHb) regulate fear and anxiety responses, whereas the lateral habenula (LHb) is involved in the express ...
... of the circuitry underlying these models remains incomplete. Prior studies of the habenula, a poorly understood nucleus in the dorsal diencephalon, suggest that projections to the medial habenula (MHb) regulate fear and anxiety responses, whereas the lateral habenula (LHb) is involved in the express ...
Sample
... neurotransmitter dopamine. b) major depression Incorrect. L-Dopa would have no clinical application for major depressive disorder. c) Alzheimer’s disease d) generalized anxiety disorder ANS: A, p. 49, A, (2) Section: Brain Circuits: Making Connections 42. Which of the following is the most accurate ...
... neurotransmitter dopamine. b) major depression Incorrect. L-Dopa would have no clinical application for major depressive disorder. c) Alzheimer’s disease d) generalized anxiety disorder ANS: A, p. 49, A, (2) Section: Brain Circuits: Making Connections 42. Which of the following is the most accurate ...
PubMed Central CANADA
... task). For these tasks we also used trait descriptors to ensure similar input and output characteristics, varying only the specific task demands. Our analysis also differed in an important way from previous studies because we opted not to specify a priori the brain areas that make up the DN, as othe ...
... task). For these tasks we also used trait descriptors to ensure similar input and output characteristics, varying only the specific task demands. Our analysis also differed in an important way from previous studies because we opted not to specify a priori the brain areas that make up the DN, as othe ...
VIP in Neurological Diseases: More Than A Neuropeptide
... Besides of the crucial role of VIP during development of the CNS, alterations on VIP levels in nervous tissues of adults seem to be crucial in the onset and progression of different neurodegenerative diseases such as multiple sclerosis (MS), Parkinson’s and Alzheimer´s disease (PD and AD, respective ...
... Besides of the crucial role of VIP during development of the CNS, alterations on VIP levels in nervous tissues of adults seem to be crucial in the onset and progression of different neurodegenerative diseases such as multiple sclerosis (MS), Parkinson’s and Alzheimer´s disease (PD and AD, respective ...
Genome-Wide Association Study of Generalized Vitiligo in an
... Family clusters of vitiligo cases are not uncommon, occurring in a non-Mendelian pattern suggestive of polygenic, multifactorial inheritance (Spritz, 2007, 2008). Genetic linkage and association studies have implicated a number of genes in vitiligo pathogenesis, especially genes involved in immune f ...
... Family clusters of vitiligo cases are not uncommon, occurring in a non-Mendelian pattern suggestive of polygenic, multifactorial inheritance (Spritz, 2007, 2008). Genetic linkage and association studies have implicated a number of genes in vitiligo pathogenesis, especially genes involved in immune f ...
Open interconnected model of basal ganglia
... symptoms as a result of damage to only one station in one of the circuits. Thus, whereas the closed segregated organization provides a framework whereby damage to different stations of an individual circuit results in selective disturbances of motor, cognitive, or emotional behaviors, the open inter ...
... symptoms as a result of damage to only one station in one of the circuits. Thus, whereas the closed segregated organization provides a framework whereby damage to different stations of an individual circuit results in selective disturbances of motor, cognitive, or emotional behaviors, the open inter ...