Use of Secondary Metabolite Variation in Crop Improvement
... multiple aliphatic glucosinolates, this locus only controlled one metabolic trait, the accumulation of but-3-enyl glucosinolate. The SGT74B1 enzyme is not specific to the synthesis of but-3-enyl glucosinolate, as previous work has demonstrated that it has broad glucosylation activity (Grubb et al., ...
... multiple aliphatic glucosinolates, this locus only controlled one metabolic trait, the accumulation of but-3-enyl glucosinolate. The SGT74B1 enzyme is not specific to the synthesis of but-3-enyl glucosinolate, as previous work has demonstrated that it has broad glucosylation activity (Grubb et al., ...
CNS Distribution of Members of the Two-Pore
... levels in the CNS (see Discussion). The physiological similarity of these channels and their rather nondescript properties are suggestive of an invariant background role in cellular function. However, these channels appear to represent important loci for modulation of neuronal output as a result of ...
... levels in the CNS (see Discussion). The physiological similarity of these channels and their rather nondescript properties are suggestive of an invariant background role in cellular function. However, these channels appear to represent important loci for modulation of neuronal output as a result of ...
Locus coeruleus - Rice CAAM Department
... TH-expressing neurons and density of dendritic arborization surrounding the structure was shown in symptomatic Mecp2-deficient mice[12] . However, locus coeruleus cells are not dying but are more likely losing their fully mature phenotype since no apoptotic neurons in the pons were detected[12] . Re ...
... TH-expressing neurons and density of dendritic arborization surrounding the structure was shown in symptomatic Mecp2-deficient mice[12] . However, locus coeruleus cells are not dying but are more likely losing their fully mature phenotype since no apoptotic neurons in the pons were detected[12] . Re ...
- Wiley Online Library
... noninvasive (2– 4). Together with the high sensitivity of MRI for the visualization of brain lesions, fMRI can establish the relationship between the margin of the lesion and the functionally viable brain tissue. fMRI thus has the potential to predict possible deficits in cognitive, language, motor, ...
... noninvasive (2– 4). Together with the high sensitivity of MRI for the visualization of brain lesions, fMRI can establish the relationship between the margin of the lesion and the functionally viable brain tissue. fMRI thus has the potential to predict possible deficits in cognitive, language, motor, ...
Some Analogies Between Visual Cortical and Genetic Maps
... are replicas of an ancient gene for a receptor protein. 31 The genes for the red and green receptor proteins are located adjacent to each other on the X chromosome and have a 96% sequence homology.32 Many individuals have up to three slightly different versions of the gene for the green receptor pro ...
... are replicas of an ancient gene for a receptor protein. 31 The genes for the red and green receptor proteins are located adjacent to each other on the X chromosome and have a 96% sequence homology.32 Many individuals have up to three slightly different versions of the gene for the green receptor pro ...
The non-motor complications in Parkinson`s disease
... functioning [75]. At the same time, neither acute nor chronic exposure to MPTP in nonhuman primates was able to produce the sympathetic denervation of the heart [76] or induce gastrointestinal dysfunction despite a significant decrease of neurons immunoreactive for tyrosine hydroxylase in the enteri ...
... functioning [75]. At the same time, neither acute nor chronic exposure to MPTP in nonhuman primates was able to produce the sympathetic denervation of the heart [76] or induce gastrointestinal dysfunction despite a significant decrease of neurons immunoreactive for tyrosine hydroxylase in the enteri ...
Endocannabinoids and Neurodegenerative Disorders: Parkinson`s
... antioxidants (coenzyme Q10, N-acetylcysteine); and anti-inflammatory compounds (minocycline). However, their advantage is that they combine all these properties in a single molecule or in a mixture of two or more CBs. This is extremely important in neurodegenerative disorders as neuronal damage also ...
... antioxidants (coenzyme Q10, N-acetylcysteine); and anti-inflammatory compounds (minocycline). However, their advantage is that they combine all these properties in a single molecule or in a mixture of two or more CBs. This is extremely important in neurodegenerative disorders as neuronal damage also ...
Movement disorders
... Nucleus (VIM) of the thalamus has produced the greatest response in patients with severe tremor. Deep brain stimulation (DBS) of the VIM nucleus of the thalamus , has become the surgical procedure of choice ...
... Nucleus (VIM) of the thalamus has produced the greatest response in patients with severe tremor. Deep brain stimulation (DBS) of the VIM nucleus of the thalamus , has become the surgical procedure of choice ...
CRB1 Gene Mutations Are Associated with
... retina and the cornea; (3) multifactorial or polygenetic causes where different genes cause each disorder but there is some form of linkage present; and (4) a casual but not necessarily a causal link between the two disorders. Keratoconus has a prevalence of between 50 and 230 per 100,000.7 LCA has ...
... retina and the cornea; (3) multifactorial or polygenetic causes where different genes cause each disorder but there is some form of linkage present; and (4) a casual but not necessarily a causal link between the two disorders. Keratoconus has a prevalence of between 50 and 230 per 100,000.7 LCA has ...
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... divided into three regions. Each body cavity or coelom, shaded in blue, is lined by mesoderm (So, somatopleura or outer lining; Sp, splanchnopleura or inner lining). The most anterior region is the proboscis or protosome (Pr) whose coelomic cavity, the protocoel, is shown in light blue. Immediately ...
... divided into three regions. Each body cavity or coelom, shaded in blue, is lined by mesoderm (So, somatopleura or outer lining; Sp, splanchnopleura or inner lining). The most anterior region is the proboscis or protosome (Pr) whose coelomic cavity, the protocoel, is shown in light blue. Immediately ...
Predicting Activation Across Individuals with Resting
... Contribution. In this paper we extend the functional connectivity alignment proposed in [10] to “resting state” data and multi-atlas label fusion. First, we establish correspondence between cortical surface points across individuals by functional connectivity alignment. Then, we predict task activat ...
... Contribution. In this paper we extend the functional connectivity alignment proposed in [10] to “resting state” data and multi-atlas label fusion. First, we establish correspondence between cortical surface points across individuals by functional connectivity alignment. Then, we predict task activat ...
Molecular and functional analysis of Drosophila single
... (Pielage et al., 2002). The role of sim in the optic lobes was functionally investigated and shown to play a role in the differentiation of laminar precursor cells into mature neurons (Umetsu et al., 2006). Mammals have two sim genes, Sim1 and Sim2 (reviewed in Fan et al. (1996)). Sim1 is expressed ...
... (Pielage et al., 2002). The role of sim in the optic lobes was functionally investigated and shown to play a role in the differentiation of laminar precursor cells into mature neurons (Umetsu et al., 2006). Mammals have two sim genes, Sim1 and Sim2 (reviewed in Fan et al. (1996)). Sim1 is expressed ...
Localization of Glycine Neurotransmitter Transporter (GLYT2
... noradrenaline transporter that clearly stained the locus ceruleus neurons (Jursky et al ., 1994) . In contrast to the immunostaining with GLYT2 antibodies, the antinoradrenaline transporter stained not only processes but also cell bodies . Western analysis using protein extracts from different parts ...
... noradrenaline transporter that clearly stained the locus ceruleus neurons (Jursky et al ., 1994) . In contrast to the immunostaining with GLYT2 antibodies, the antinoradrenaline transporter stained not only processes but also cell bodies . Western analysis using protein extracts from different parts ...
Statistical Methods for Detecting and Interpreting
... Sequence entire genomic region All genetic variants are uncovered Variants are directly tested for their associations with the ...
... Sequence entire genomic region All genetic variants are uncovered Variants are directly tested for their associations with the ...
cerebral and gastric histamine system is altered after portocaval shunt
... in response to feeding or injection of pentagastrin and insulin. Portocavally shunted rats are a suitable animal model of hepatic encephalopathy (HE) (5) and in our studies on neurochemical alterations in the CNS triggered by chronic liver dysfunction we have found that an enhanced histamine synthes ...
... in response to feeding or injection of pentagastrin and insulin. Portocavally shunted rats are a suitable animal model of hepatic encephalopathy (HE) (5) and in our studies on neurochemical alterations in the CNS triggered by chronic liver dysfunction we have found that an enhanced histamine synthes ...
5-28-2007
... diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also cell groups underneath the globus pallidus that bridge the centromedial amygdala to the bed nucleus of the stria terminalis. Among the cell populations, the magnocellular, cholinergic corticopetal projection neurons ...
... diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also cell groups underneath the globus pallidus that bridge the centromedial amygdala to the bed nucleus of the stria terminalis. Among the cell populations, the magnocellular, cholinergic corticopetal projection neurons ...
Exploration of Variability of Arkypallidal and Prototypical Projections
... Patients suffering from neuropsychiatric disorders, such as depression, schizophrenia, autism, Parkinson’s disease and bipolar disorders, are today treated with psychotherapeutic drugs developed from findings brought to light before 1960 in conjunction with clinical observation. Researchers are curr ...
... Patients suffering from neuropsychiatric disorders, such as depression, schizophrenia, autism, Parkinson’s disease and bipolar disorders, are today treated with psychotherapeutic drugs developed from findings brought to light before 1960 in conjunction with clinical observation. Researchers are curr ...
Cyclooxygenase-2 (COX-2) in Inflammatory and Degenerative Brain
... COX-2 expression should be more correctly regarded as ‘‘dynamically’’ regulated since it is dependent on normal synaptic activity, is rapidly increased during seizures or ischemia, and is downregulated by glucocorticoids (6). The dependence of COX-2 expression on natural excitatory synaptic activity ...
... COX-2 expression should be more correctly regarded as ‘‘dynamically’’ regulated since it is dependent on normal synaptic activity, is rapidly increased during seizures or ischemia, and is downregulated by glucocorticoids (6). The dependence of COX-2 expression on natural excitatory synaptic activity ...
Full Text - Digital Access to Scholarship at Harvard
... significance of gene expression differences between neuronal subtypes was determined by pairwise comparisons at each age using statistical analysis of microarrays (SAM) (Tusher et al., 2001). Using a SAM D score cutoff of more than 2 or less than "2, we selected significantly differentially expresse ...
... significance of gene expression differences between neuronal subtypes was determined by pairwise comparisons at each age using statistical analysis of microarrays (SAM) (Tusher et al., 2001). Using a SAM D score cutoff of more than 2 or less than "2, we selected significantly differentially expresse ...
A forward genetic screen with a thalamocortical emx2
... repeated observation of a specific phenotype in independent litters, followed by faithful transmission after further outcrosses, indicated a high likelihood the abnormality was caused by a monogenic mutation [30]. We screened 57 G1 lines, each representing an independently mutagenized haploid autoso ...
... repeated observation of a specific phenotype in independent litters, followed by faithful transmission after further outcrosses, indicated a high likelihood the abnormality was caused by a monogenic mutation [30]. We screened 57 G1 lines, each representing an independently mutagenized haploid autoso ...
Molecular Analysis of Developmental Plasticity in Neocortex
... seems unaffected, a-CaMKII may not be required for activity-dependent development of somatosensory cortex, while it is necessary for some aspects, albeit noncrucial ones, of activity-dependent development of visual cortex. Another study testing for the role of a plasticity molecule, nitric oxide (NO ...
... seems unaffected, a-CaMKII may not be required for activity-dependent development of somatosensory cortex, while it is necessary for some aspects, albeit noncrucial ones, of activity-dependent development of visual cortex. Another study testing for the role of a plasticity molecule, nitric oxide (NO ...
... the disruption of the large networks of neurons that are associated with understanding and producing language. People with Alzheimer’s disease also have abnormal lesions called beta-amyloid plaques and neurofibrillary tangles. Beta-amyloid plaques are sticky pieces of protein and other matter than s ...
Basal Ganglia Functional Connectivity Based on
... a specific set of motor or cognitive tasks, depending on the cortical area that belongs to it. Modifications of this model and further subdivisions of specific loops have been proposed (Fig. 1B) (Lawrence and others 1998; Nakano and others 2000). Other investigators have divided the striatum into 3 fun ...
... a specific set of motor or cognitive tasks, depending on the cortical area that belongs to it. Modifications of this model and further subdivisions of specific loops have been proposed (Fig. 1B) (Lawrence and others 1998; Nakano and others 2000). Other investigators have divided the striatum into 3 fun ...
Grade 7 ELA Module 4A, Unit 1, Lesson 2
... indicates that they struggled, whereas a “five” indicates that it was easy. It’s likely that many students identified that the science information was important but were less sure how the Jensen’s story fit into the main idea. Acknowledge the difficulty of this assignment. • If time permits, have st ...
... indicates that they struggled, whereas a “five” indicates that it was easy. It’s likely that many students identified that the science information was important but were less sure how the Jensen’s story fit into the main idea. Acknowledge the difficulty of this assignment. • If time permits, have st ...
Corticosteroid–serotonin interactions in the
... irritability and a feeling of being unable to cope which may ultimately result in depression. Depression is probably the most common stress-related disorder. However, repeated stress per se is not sufficient to cause depression. Interactions between a genetic predisposition and some environmental str ...
... irritability and a feeling of being unable to cope which may ultimately result in depression. Depression is probably the most common stress-related disorder. However, repeated stress per se is not sufficient to cause depression. Interactions between a genetic predisposition and some environmental str ...