5. Sample Size, Power & Thresholds
... QTL RNA1 RNA2 – class of possible models – best model = putative biochemical pathway ...
... QTL RNA1 RNA2 – class of possible models – best model = putative biochemical pathway ...
Comparative Study of c-Fos Expression in Rat Dorsal Vagal
... and close correlation in function, so that they constitute the dorsal vagal complex (DVC) (4). Thus, DVC and NA are the primary nerve centres that regulate gastric functions. Nevertheless, whether the neurons of DMV, NTS, AP and NA are excited, and characterization of the temporal-spatial pattern of ...
... and close correlation in function, so that they constitute the dorsal vagal complex (DVC) (4). Thus, DVC and NA are the primary nerve centres that regulate gastric functions. Nevertheless, whether the neurons of DMV, NTS, AP and NA are excited, and characterization of the temporal-spatial pattern of ...
Negative mood-induction modulates default mode network resting
... mood-induction might require more cognitive effort from their healthy participants whereas neutral recall might require less cognitive effort. Given previous findings of task induced deactivation of the DMN they expected that the sad vs neutral mood induction would lead to reduced DMN connectivity [10] ...
... mood-induction might require more cognitive effort from their healthy participants whereas neutral recall might require less cognitive effort. Given previous findings of task induced deactivation of the DMN they expected that the sad vs neutral mood induction would lead to reduced DMN connectivity [10] ...
donepezil dose-dependently inhibits acetylcholinesterase activity in
... Donepezil (R,S-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2yl]methylpiperidine hydrochloride) (E2020) is a centralacting second-generation cholinesterase inhibitor that is used in the treatment of Alzheimer’s disease (AD). 12,45,57,65,73 Neuropathologically, the affected brain is characterized by the pre ...
... Donepezil (R,S-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2yl]methylpiperidine hydrochloride) (E2020) is a centralacting second-generation cholinesterase inhibitor that is used in the treatment of Alzheimer’s disease (AD). 12,45,57,65,73 Neuropathologically, the affected brain is characterized by the pre ...
The GABAergic system in schizophrenia
... further hypofunctioning of the glutamatergic system through feedback mechanisms. Several classes of compounds, including benzodiazepines (BZD), muscurinic receptor antagonist and haloperidol, blocked NMDAinduced neurotoxicity in the posterior cingulate and retrospenial regions of experimental animal ...
... further hypofunctioning of the glutamatergic system through feedback mechanisms. Several classes of compounds, including benzodiazepines (BZD), muscurinic receptor antagonist and haloperidol, blocked NMDAinduced neurotoxicity in the posterior cingulate and retrospenial regions of experimental animal ...
Deep Brain stimulation in the Treatment of Dystonia – The
... extreme cases they can become fixed.1 Deep brain stimulation(DBS) is a neurosurgical procedure for movement disorders and this essay intends to assess its role in the treatment of dystonia. ...
... extreme cases they can become fixed.1 Deep brain stimulation(DBS) is a neurosurgical procedure for movement disorders and this essay intends to assess its role in the treatment of dystonia. ...
A Master Key to Assess Stroke Consequences Across Species: The
... showed to be promising as a predictor of post-stroke functional outcome (Rose et al., 1994). In the way of improving the functional assessment in experimental stroke models, adhesive removal test has been first adapted to rats about a quarter of century ago (Schallert et al., 1982). The stimulus emp ...
... showed to be promising as a predictor of post-stroke functional outcome (Rose et al., 1994). In the way of improving the functional assessment in experimental stroke models, adhesive removal test has been first adapted to rats about a quarter of century ago (Schallert et al., 1982). The stimulus emp ...
Transcranial Magnetic Stimulation: A Neuroscientific Probe of
... currents and result in scalp burn, unless appropriate electrode materials (e.g., plastic) or shapes (e.g., slotted) are used (14). A particularly appealing aspect of combining TMS with other imaging techniques is that it becomes possible to obtain physiological, objective measures of TMS effects, ra ...
... currents and result in scalp burn, unless appropriate electrode materials (e.g., plastic) or shapes (e.g., slotted) are used (14). A particularly appealing aspect of combining TMS with other imaging techniques is that it becomes possible to obtain physiological, objective measures of TMS effects, ra ...
Delayed Puberty but Normal Fertility in Mice With Selective Deletion
... plays a pivotal role in the regulation of reproduction. Indeed, insulin has been shown to activate GnRH and LH secretion in vitro (8, 9). Mice that lack insulin signaling in brain neurons (NIRKO mice) exhibit hypothalamic hypogonadism (10) and a delay in puberty (11). Moreover, diabetic rats display ...
... plays a pivotal role in the regulation of reproduction. Indeed, insulin has been shown to activate GnRH and LH secretion in vitro (8, 9). Mice that lack insulin signaling in brain neurons (NIRKO mice) exhibit hypothalamic hypogonadism (10) and a delay in puberty (11). Moreover, diabetic rats display ...
A zebrafish model of CLN2 disease is deficient in
... epilepsy and cognitive defects, with MRI indicating widespread brain atrophy, and profound neuron loss is evident within the retina and brain. Currently there are no effective therapies for this disease, which causes premature death in adolescence. Zebrafish have been successfully used to model a ra ...
... epilepsy and cognitive defects, with MRI indicating widespread brain atrophy, and profound neuron loss is evident within the retina and brain. Currently there are no effective therapies for this disease, which causes premature death in adolescence. Zebrafish have been successfully used to model a ra ...
Temporal reproduction and its neuroanatomical correlates in adults
... Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neuropsychiatric disorders in childhood and adolescence (Kieling et al., 2010) and is one of the most underdiagnosed psychiatric disorders in adults (Faraone, 2007). It is defined with age inappropriate symptoms of hyperactivi ...
... Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neuropsychiatric disorders in childhood and adolescence (Kieling et al., 2010) and is one of the most underdiagnosed psychiatric disorders in adults (Faraone, 2007). It is defined with age inappropriate symptoms of hyperactivi ...
Natural Genetic Variation Shapes Root System Responses
... the plant, its architecture determines which parts of the soil are foraged for water and nutrients, ...
... the plant, its architecture determines which parts of the soil are foraged for water and nutrients, ...
thyroid hormones in brain development and
... Thyroid hormones are essential for brain developat through specific time windows influencing neurogenesis, neuronal migration, neuronal and glial cell differentiation, myelination, and synaptogenesis. The actions of thyroid hormones are mostly due to interaction of the active hormone T3 with nuclear ...
... Thyroid hormones are essential for brain developat through specific time windows influencing neurogenesis, neuronal migration, neuronal and glial cell differentiation, myelination, and synaptogenesis. The actions of thyroid hormones are mostly due to interaction of the active hormone T3 with nuclear ...
FREE Sample Here - Find the cheapest test bank for your
... speed up the transmission of neural impulses; mimic the action of neurotransmitters e) speed up the transmission of neural impulses; increase the effectiveness of neurotransmitters ANS: c TOP: MOD: 2.1 REF: Neurons: The Body’s Wiring MSC: conceptual OBJ: 4-Explain difference between agonists and ant ...
... speed up the transmission of neural impulses; mimic the action of neurotransmitters e) speed up the transmission of neural impulses; increase the effectiveness of neurotransmitters ANS: c TOP: MOD: 2.1 REF: Neurons: The Body’s Wiring MSC: conceptual OBJ: 4-Explain difference between agonists and ant ...
PDF Document
... The spinal cord and periphery are rich with excitable cells that are targets for therapeutic modulation. These include motor neurons, sensory neurons, interneurons, visceral afferents and efferents, various types of muscle, and a variety of other nonneural targets (Fig. 3). Modulating activity in th ...
... The spinal cord and periphery are rich with excitable cells that are targets for therapeutic modulation. These include motor neurons, sensory neurons, interneurons, visceral afferents and efferents, various types of muscle, and a variety of other nonneural targets (Fig. 3). Modulating activity in th ...
Rethinking Mammalian Brain Evolution1
... the most basic functional anatomy of the brain has at last become available for study. We are still far from possessing a complete connectional characterization for even the best studied of mammalian brains, yet already the scattered details from comparative studies have begun to provide a remarkabl ...
... the most basic functional anatomy of the brain has at last become available for study. We are still far from possessing a complete connectional characterization for even the best studied of mammalian brains, yet already the scattered details from comparative studies have begun to provide a remarkabl ...
Development of replication-defective herpes simplex viral vectors for
... silencing in dorsal root ganglia (DRG) using replication-defective herpes simplex viral (HSV1) vectors by identifying and evaluating various approaches to induce RNAi, i.e. expression of individual short-hairpin RNAs (shRNAs), artificial microRNAs (miRNAs) and multiple tandem miRNAs. Following the d ...
... silencing in dorsal root ganglia (DRG) using replication-defective herpes simplex viral (HSV1) vectors by identifying and evaluating various approaches to induce RNAi, i.e. expression of individual short-hairpin RNAs (shRNAs), artificial microRNAs (miRNAs) and multiple tandem miRNAs. Following the d ...
Circadian and histaminergic regulation of the sleep
... of high θ-, and γ-waves and strengthened the phase-amplitude coupling between these frequencies. The 24-hour rhythms of production and release of histamine and its metabolite, 1-methylhistamine were detected, whereas activities of the enzymes had no detectable diurnal rhythm. In addition, histamine ...
... of high θ-, and γ-waves and strengthened the phase-amplitude coupling between these frequencies. The 24-hour rhythms of production and release of histamine and its metabolite, 1-methylhistamine were detected, whereas activities of the enzymes had no detectable diurnal rhythm. In addition, histamine ...
Divergent sorting of a balanced ancestral polymorphism underlies
... peciation proceeds by the establishment of barriers to gene-flow between different populations, ultimately resulting in reproductive isolation1. Gene-flow barriers can act at the prezygotic stage, for example, by restricting the temporal overlap of the reproductive periods, or at the post-zygotic stag ...
... peciation proceeds by the establishment of barriers to gene-flow between different populations, ultimately resulting in reproductive isolation1. Gene-flow barriers can act at the prezygotic stage, for example, by restricting the temporal overlap of the reproductive periods, or at the post-zygotic stag ...
Document
... BIN1 is the second most significant Alzheimer’s disease (AD) risk factor gene identified through genome-wide association studies. BIN1 is an adaptor protein that can bind to several proteins including c-Myc, clathrin, adaptor protein-2 and dynamin. BIN1 is widely expressed in the brain and periphera ...
... BIN1 is the second most significant Alzheimer’s disease (AD) risk factor gene identified through genome-wide association studies. BIN1 is an adaptor protein that can bind to several proteins including c-Myc, clathrin, adaptor protein-2 and dynamin. BIN1 is widely expressed in the brain and periphera ...
Canty, J Neurosci 2009 - Carlos Ibanez Lab @ KI
... indicated that cis-only mice recapitulate the deficits in GABAergic neurons observed in the cortex of null mutants at birth. Unexpectedly, neither Gfra1 TLZ/TLZ or cis-only mice showed any loss of Cb ⫹ cells in more rostromedial and caudomedial areas, corresponding to prospective motor and retrosple ...
... indicated that cis-only mice recapitulate the deficits in GABAergic neurons observed in the cortex of null mutants at birth. Unexpectedly, neither Gfra1 TLZ/TLZ or cis-only mice showed any loss of Cb ⫹ cells in more rostromedial and caudomedial areas, corresponding to prospective motor and retrosple ...
Molecular mechanisms of floor plate formation and neural patterning
... Midkine-a (Mdka) in zebrafish. In higher vertebrates, mdk and the related factor pleiotrophin (ptn) are widely expressed during embryogenesis and are implicated in a variety of processes. The in-vivo function of both factors, however, is unclear, as knock-out mice show no embryonic phenotype. We hav ...
... Midkine-a (Mdka) in zebrafish. In higher vertebrates, mdk and the related factor pleiotrophin (ptn) are widely expressed during embryogenesis and are implicated in a variety of processes. The in-vivo function of both factors, however, is unclear, as knock-out mice show no embryonic phenotype. We hav ...
A magnetic resonance spectroscopy investigation of obsessive
... caudate in adult OCD. Second, we sampled the OFWM since, despite frequent findings of abnormalities in the orbital gyrus using other imaging techniques (Saxena et al., 2001), only one study has used MRS to examine the prefrontal cortex in pediatric OCD (Russell et al., 2003). To our knowledge, no st ...
... caudate in adult OCD. Second, we sampled the OFWM since, despite frequent findings of abnormalities in the orbital gyrus using other imaging techniques (Saxena et al., 2001), only one study has used MRS to examine the prefrontal cortex in pediatric OCD (Russell et al., 2003). To our knowledge, no st ...
Material and methods - HAL
... significantly enhances t-MeHA levels in various mouse brain regions [7, 8]. Furthermore the effect of PCP is mimicked by MK-801, another NMDA open-channel blocker displaying higher potency and selectivity [9]. In addition, histidine decarboxylase mRNA expression is increased by PCP administration in ...
... significantly enhances t-MeHA levels in various mouse brain regions [7, 8]. Furthermore the effect of PCP is mimicked by MK-801, another NMDA open-channel blocker displaying higher potency and selectivity [9]. In addition, histidine decarboxylase mRNA expression is increased by PCP administration in ...
PROGRAMME and ABSTRACTS
... Growth factor gene delivery for Alzheimer’s disease: From animal models to clinical trials Introduced by: Julita Czarkowska-Bauch ...
... Growth factor gene delivery for Alzheimer’s disease: From animal models to clinical trials Introduced by: Julita Czarkowska-Bauch ...