PKCδ is Required for Survival of Cells Expressing
... of myeloid origin (18-30%, K-and N-ras) (3). In addition to its central involvement in cell proliferation, recent studies indicate that the presence of an activated p21Ras protein sensitizes transformed or malignant cells to apoptotic stimuli (4-9). Various signaling pathways have been proposed for ...
... of myeloid origin (18-30%, K-and N-ras) (3). In addition to its central involvement in cell proliferation, recent studies indicate that the presence of an activated p21Ras protein sensitizes transformed or malignant cells to apoptotic stimuli (4-9). Various signaling pathways have been proposed for ...
The role of structural disorder in cell cycle regulation, related clinical
... Mediator of DNA Damage Checkpoint 1 (MDC1) is also a large, mostly disordered protein that functions through interacting with multiple partners to participate in various aspects of DNA damage response. This protein is recruited to the site of DNA double-strand breaks (DSBs), and together with RNF8 i ...
... Mediator of DNA Damage Checkpoint 1 (MDC1) is also a large, mostly disordered protein that functions through interacting with multiple partners to participate in various aspects of DNA damage response. This protein is recruited to the site of DNA double-strand breaks (DSBs), and together with RNF8 i ...
AHD Geddes CADASIL Feb 27
... Mutations show differential Jagged1 binding and RBP/JK transcriptional activity (Joutel 2004) ...
... Mutations show differential Jagged1 binding and RBP/JK transcriptional activity (Joutel 2004) ...
Michael P. Kowalski1, Vipat Raksakulthai2
... cytometry. Maximal responses (blue boxes) correlate with imaging results for staurosporine and camptothecin but 5-fluorouracil treatment shows significant positive staining (>50% at maximal concentration). This suggests that 5-fluorouracil treated spheroids may be resistant to diffusion of the stain ...
... cytometry. Maximal responses (blue boxes) correlate with imaging results for staurosporine and camptothecin but 5-fluorouracil treatment shows significant positive staining (>50% at maximal concentration). This suggests that 5-fluorouracil treated spheroids may be resistant to diffusion of the stain ...
PowerPoint 簡報
... • Most signal molecules are water-soluble and too large to pass through the plasma membrane. • They influence cell activities by binding to receptor proteins on the plasma membrane. – Binding leads to change in the shape of the receptor or to aggregation of receptors. – These trigger changes in the ...
... • Most signal molecules are water-soluble and too large to pass through the plasma membrane. • They influence cell activities by binding to receptor proteins on the plasma membrane. – Binding leads to change in the shape of the receptor or to aggregation of receptors. – These trigger changes in the ...
P Natl Acad Sci Usa 1994 Wild
... structure and self-associated as a coiled coil. In view of the tendency of this type of structure to mediate protein association, we speculated that this region of gp4l might play a role in HIV-1 envelope oligomerization. However, later it was shown that mutations which should disrupt the structural ...
... structure and self-associated as a coiled coil. In view of the tendency of this type of structure to mediate protein association, we speculated that this region of gp4l might play a role in HIV-1 envelope oligomerization. However, later it was shown that mutations which should disrupt the structural ...
TGF-beta story - Department Of Biological Sciences Hunter
... by Arthur Pardee, is a point in G1 where cells no longer require growth factors and commit to completing the cell cycle In the absence of growth factors, cells exit the cell cycle into quiescence or G0 Zetterberg and colleagues have mapped the Restriction Point to a site ~ 3.5 hr after mitosis - whe ...
... by Arthur Pardee, is a point in G1 where cells no longer require growth factors and commit to completing the cell cycle In the absence of growth factors, cells exit the cell cycle into quiescence or G0 Zetterberg and colleagues have mapped the Restriction Point to a site ~ 3.5 hr after mitosis - whe ...
Biology of Cancer - Tunghai University
... Figure 6.24b The Biology of Cancer (© Garland Science 2007) ...
... Figure 6.24b The Biology of Cancer (© Garland Science 2007) ...
A GTPase gate for protein import into chloroplasts
... gest a possible model in which GTP-regulated dimerization of Toc34 functions as part of the molecular switch controlling the commitment of bound preproteins to translocation. In the GDP-bound dimer of Toc34, Glu 73 of the G2 motif occupies the predicted position of the γ-phosphate of a bound GTP. Fu ...
... gest a possible model in which GTP-regulated dimerization of Toc34 functions as part of the molecular switch controlling the commitment of bound preproteins to translocation. In the GDP-bound dimer of Toc34, Glu 73 of the G2 motif occupies the predicted position of the γ-phosphate of a bound GTP. Fu ...
Gene Section CSNK1A1 (casein kinase 1, alpha 1) in Oncology and Haematology
... although it seems as if CK1 delta is the most important kinase in the regulation of p53 activity and interacts with several cellular proteins including the oncoprotein Mdm2. ...
... although it seems as if CK1 delta is the most important kinase in the regulation of p53 activity and interacts with several cellular proteins including the oncoprotein Mdm2. ...
Supplementary data
... functions as the ATPase subunit of this complex which is strongly related to the yeast SWI/SNF nucleosome remodeling complex. The TrxG proteins Ash1 and TRX exist in the other two distinct multiprotein complexes. Both are SET-domain proteins and function as histone methyltarnsferase. Ash1 selectivel ...
... functions as the ATPase subunit of this complex which is strongly related to the yeast SWI/SNF nucleosome remodeling complex. The TrxG proteins Ash1 and TRX exist in the other two distinct multiprotein complexes. Both are SET-domain proteins and function as histone methyltarnsferase. Ash1 selectivel ...
Cell communication
... 1. Describe the nature of a ligand-receptor interaction and state how such interactions initiate a signal-transduction system 2. Compare and contrast G protein-coupled receptors, tyrosine kinase receptors, and ligandgated ion channels 3. List two advantages of a multistep pathway in the transduction ...
... 1. Describe the nature of a ligand-receptor interaction and state how such interactions initiate a signal-transduction system 2. Compare and contrast G protein-coupled receptors, tyrosine kinase receptors, and ligandgated ion channels 3. List two advantages of a multistep pathway in the transduction ...
2002 Workplan Results
... Microarray analysis software (Two yearly licenses of Spotfire and one free yearly license of GeneSpring 4.2) One server computer with Oracle Database Accomplishments and future direction: Since all the proposed equipment have been purchased and set up, customized cDNA chips spotted with 350 genes of ...
... Microarray analysis software (Two yearly licenses of Spotfire and one free yearly license of GeneSpring 4.2) One server computer with Oracle Database Accomplishments and future direction: Since all the proposed equipment have been purchased and set up, customized cDNA chips spotted with 350 genes of ...
File
... Alpha1A – contraction of smooth muscle – high density in prostate gland; also found on arteries and veins Alpha1B – most abundant type in heart (function??), may be involved with alpha 1A in cardiac growth and structure, may be more abundant on blood vessels as we get older; Alpha1C was discovered a ...
... Alpha1A – contraction of smooth muscle – high density in prostate gland; also found on arteries and veins Alpha1B – most abundant type in heart (function??), may be involved with alpha 1A in cardiac growth and structure, may be more abundant on blood vessels as we get older; Alpha1C was discovered a ...
Plantae - Stotts 5th Biology
... Fungi are heterotrophs. Most fungi feed on dead or decaying organic matter by secreting digestive enzymes into it and absorbing small food molecules into their bodies. They can be either multicellular (mushrooms) or unicellular (yeasts). ...
... Fungi are heterotrophs. Most fungi feed on dead or decaying organic matter by secreting digestive enzymes into it and absorbing small food molecules into their bodies. They can be either multicellular (mushrooms) or unicellular (yeasts). ...
Consulta: subjectFacets:"Alternative oxidase" Registros
... protists. The uncoupling protein (UCP) is much more widespread than previously believed, not only in tissues of higher animals but also in plants and in an amoeboid protozoan. The redox energy-dissipating pathway (AOX) and the proton electrochemical gradient energy-dissipating pathway (UCP) lead to ...
... protists. The uncoupling protein (UCP) is much more widespread than previously believed, not only in tissues of higher animals but also in plants and in an amoeboid protozoan. The redox energy-dissipating pathway (AOX) and the proton electrochemical gradient energy-dissipating pathway (UCP) lead to ...
Structure analysis of FAAP24 reveals single-stranded DNA
... to damaged DNA or stalled replication forks. However, the DNA-binding activity of this complex was not clearly defined. We investigated how FAAP24 contributes to the DNA-interacting functions of the FANCM/FAAP24 complex by acquiring the N-terminal and C-terminal solution structures of human FAAP24. ...
... to damaged DNA or stalled replication forks. However, the DNA-binding activity of this complex was not clearly defined. We investigated how FAAP24 contributes to the DNA-interacting functions of the FANCM/FAAP24 complex by acquiring the N-terminal and C-terminal solution structures of human FAAP24. ...
Autophagy and Immunity
... Cell swelling and rupture Release in intracellular components Activation of inflammatory response Can be regulated Can occur in concert with or instead of apoptosis (e.g. if apoptosis is blocked) ...
... Cell swelling and rupture Release in intracellular components Activation of inflammatory response Can be regulated Can occur in concert with or instead of apoptosis (e.g. if apoptosis is blocked) ...
Gene Section SEMA3F (sema domain, immunoglobulin domain 3F)
... between somites in which they are expressed. However, Sema3A and Sema3F-induced ERK1 / ERK2 inhibition is unrelated to the ability of VEGF to induce phosphorylation of VEGFR2, suggesting that while antagonistic the semaphorin effects may not be directly competitive in terms of binding. A major conse ...
... between somites in which they are expressed. However, Sema3A and Sema3F-induced ERK1 / ERK2 inhibition is unrelated to the ability of VEGF to induce phosphorylation of VEGFR2, suggesting that while antagonistic the semaphorin effects may not be directly competitive in terms of binding. A major conse ...
Document
... enzyme activities contained in three proteins: (1) 3β-hydroxysteroid dehydrogenase (3β-HSD) and ∆5,4-isomerase; (2) 17α-hydroxylase and C17-20 Lyase and (3) 17β-hydroxysteroid dehydrogenase (17β-OHSD). The ∆5 route appears to be most used in human testes. ...
... enzyme activities contained in three proteins: (1) 3β-hydroxysteroid dehydrogenase (3β-HSD) and ∆5,4-isomerase; (2) 17α-hydroxylase and C17-20 Lyase and (3) 17β-hydroxysteroid dehydrogenase (17β-OHSD). The ∆5 route appears to be most used in human testes. ...
Mycotoxins reveal connections between plants and animals
... of reactive oxygen intermediates (ROIs). In several studies of inducible host responses to infection by incompatible strains of bacterial and fungal pathogens exhibiting the HR phenotype, the affected host cells show dramatic changes in calcium influx that precede an oxidative burst. Both hydrogen p ...
... of reactive oxygen intermediates (ROIs). In several studies of inducible host responses to infection by incompatible strains of bacterial and fungal pathogens exhibiting the HR phenotype, the affected host cells show dramatic changes in calcium influx that precede an oxidative burst. Both hydrogen p ...
Studies of focal adhesion assembly
... Src and FAK (focal adhesion kinase), and adaptors that facilitate intracellular complex formation, such as paxillin. Focal adhesions are dynamic, but are formed by multiple specific protein–protein interactions. Some general structural features of the component proteins can be discerned: (i) they ar ...
... Src and FAK (focal adhesion kinase), and adaptors that facilitate intracellular complex formation, such as paxillin. Focal adhesions are dynamic, but are formed by multiple specific protein–protein interactions. Some general structural features of the component proteins can be discerned: (i) they ar ...
Laboratory 7
... • Measure diameter of zone of inhibition (mm) • The larger the zone, the more effective an antibiotic will be. ...
... • Measure diameter of zone of inhibition (mm) • The larger the zone, the more effective an antibiotic will be. ...
Apoptosome
The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leading to the degradation of a tadpole's tail.In mammalian cells, once cytochrome c is released, it binds to the cytosolic protein Apaf-1 to facilitate the formation of apoptosome. An early biochemical study suggests a two-to-one ratio of cytochrome c to apaf-1 for apoptosome formation. However, recent structural studies suggest the cytochrome c to apaf-1 ratio is one-to-one. It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. The mammalian apoptosome had never been crystallized, but a human APAF-1/cytochrome-c apoptosome has been imaged at lower (2 nm) resolution by cryogenic transmission electron microscopy 10 years ago, revealing a wheel-like particle with 7-fold symmetry. Recently, a medium resolution (9.5 Ångström) structure of human apoptosome was also solved by cryo-electron microscopy, which allows unambiguous inference for positions of all the APAF-1 domains (CARD, NBARC and WD40) and cytochrome c. There is also now a crystal structure of the monomeric, inactive Apaf-1 subunit (PDB 3SFZ). Once formed, the apoptosome can then recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis.