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35.2 Defenses against Infection
35.2 Defenses against Infection

... antibodies that circulate in the blood and lymph •  The response is activated when antibodies on B cells bind to antigens on a pathogen. •  Antibodies have two antigen binding sites on the prongs of the “Y” •  These bind to specific antigens ...
Chapter 35- Infectious Diseases
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...  Epithelial barriers offering physical and mechanical barriers  Chemical factors: in response to microbes, macrophages and other cells secrete cytokines that mediate many of the cellular reactions of innate immunity (i.e.: inflammatory cytokines  IL1, IL6, IL8, IL12, TNF-a). These activate vascul ...
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... It has two important characteristics: Immune response is highly specific for the antigen that triggered it and has memory to the antigen. Exposure to antigen creates an immunologic “memory.”(3’) 2.Complement: The complement system is an important component of innate immunity(2’). Complement was 1st ...
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... from their surfaces. One of the remarkable things about the immune system is its ability to recognize many millions of distinctive non-self molecules, and to respond by producing molecules such as these antibodies—and also cells—that can match and counteract each one of the non-self molecules. Any s ...
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... (1) From the word bank, assign each term to the immunity heading with which it is associated. Some terms may fit more than one category and should be placed in all categories that apply. antibodies in breast milk lymphocytes stomach acid, saliva, tears complement first line of defense ...
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... 1. Physical barriers (skin, mucus lining of gastrointestinal, respiratory and genitourinary tracts) 2. Phagocytic cells – neutrophils, macrophages 3. Protective chemicals – acid pH of stomach, lipids on skin surface 4. Enzymes – lysozyme in saliva, intestinal secretions; digests cell walls of bacter ...
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... debris, and produce inflammatory molecules which regulate other components of the immune system. They express a wide range of surface receptors that allow them to identify microorganisms. Also, phagocytosis can be enhanced by antibodies, complement and acute phase proteins (all called opsonins and a ...
01_innate - WordPress.com
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... • Infected or altered self (transformed) cell downregulated MHC • NK does not receive inhibitory signal • Signals kill infected cell ...
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Presentation
Presentation

... Sources and Impacts of Emerging Contaminants Nancy Denslow, Ph.D. Center for Environmental and Human Toxicology, UF ...
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Complement system



The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.
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