Complement
... Receptors for complement found on Red Blood Cells (RBCs), platelets, B lymphocytes, endothelial and epithelial cells Anaphylatoxins - chemicals that increase vascular permeability, contract smooth muscle, and cause the release of histamine from basophils and mast cells C3a, C4a, and C5a are anap ...
... Receptors for complement found on Red Blood Cells (RBCs), platelets, B lymphocytes, endothelial and epithelial cells Anaphylatoxins - chemicals that increase vascular permeability, contract smooth muscle, and cause the release of histamine from basophils and mast cells C3a, C4a, and C5a are anap ...
Functions of Complement
... Activation of Complement- The Lectin Pathway • A lectin is a molecule that binds to carbohydrate structures • A collectin (like C1q or Mannose Binding Protein) is a lectin with collagen like features • It is simplistic to think of each “pathway” as acting in isolation. Thus, once the classical path ...
... Activation of Complement- The Lectin Pathway • A lectin is a molecule that binds to carbohydrate structures • A collectin (like C1q or Mannose Binding Protein) is a lectin with collagen like features • It is simplistic to think of each “pathway” as acting in isolation. Thus, once the classical path ...
Discovery of Complement
... of the humoral branch of the immune system. - Although the discovery of complement and most early studies were linked to the activity of complement following Ab binding, a major role for this system is the recognition and destruction of pathogens based on recognition of pathogen-associated molecular ...
... of the humoral branch of the immune system. - Although the discovery of complement and most early studies were linked to the activity of complement following Ab binding, a major role for this system is the recognition and destruction of pathogens based on recognition of pathogen-associated molecular ...
Prezentace aplikace PowerPoint
... -main humoral mechanism of nonspecific immunity - > 40 glykoproteins - blood - on the surface of immune cells - Complement components inter-react be precise and regulated manner to eliminate microbs, foreign cells or material. -Charles Bordet 1896 - fresh serum of immunized animals agglutinate in vi ...
... -main humoral mechanism of nonspecific immunity - > 40 glykoproteins - blood - on the surface of immune cells - Complement components inter-react be precise and regulated manner to eliminate microbs, foreign cells or material. -Charles Bordet 1896 - fresh serum of immunized animals agglutinate in vi ...
Nonspecific Immunity, Complement System
... normally found in serum in constant concentration (each enzyme acts as a catalyst for the next) It interacts with antibody, and with cell membrane ...
... normally found in serum in constant concentration (each enzyme acts as a catalyst for the next) It interacts with antibody, and with cell membrane ...
Innate Immunity
... Phagocytes have evolved a system of receptors that can recognize molecular patterns on the surface of pathogen that ...
... Phagocytes have evolved a system of receptors that can recognize molecular patterns on the surface of pathogen that ...
COMPLEMENT activation - Akademik Ciamik 2010
... Opsonization, which promotes phagocytosis of particulate antigens. Regulate inflammatory and immune responses Regulate the biologic activity of cells. ...
... Opsonization, which promotes phagocytosis of particulate antigens. Regulate inflammatory and immune responses Regulate the biologic activity of cells. ...
Regulation of the complement system
... vascular permeability and smooth muscle contraction. C5b initiates the membrane attack pathway, which results in the membrane attack complex (MAC), consisting of C5b, C6, C7, C8, and polymeric C9. MAC is the cytolytic endproduct of the complement cascade; it forms a transmembrane channel, which caus ...
... vascular permeability and smooth muscle contraction. C5b initiates the membrane attack pathway, which results in the membrane attack complex (MAC), consisting of C5b, C6, C7, C8, and polymeric C9. MAC is the cytolytic endproduct of the complement cascade; it forms a transmembrane channel, which caus ...
Complement system
The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.