LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
... 6. Formation and development of WBC is called as Hematopoiesis. 7. Apoptosis leads in damage to surrounding cells. 8. All TH cells express CD4 and only recognize antigen associated with class II MHC molecule. 9. The puri potent stem cell is one of the most abundant cell types in the bone marrow. 10. ...
... 6. Formation and development of WBC is called as Hematopoiesis. 7. Apoptosis leads in damage to surrounding cells. 8. All TH cells express CD4 and only recognize antigen associated with class II MHC molecule. 9. The puri potent stem cell is one of the most abundant cell types in the bone marrow. 10. ...
Innate defense
... with C6 and C7 leads to the formation of a complex that can insert itself into a cell's lipid bylayer. When C8 associates, the complex is capable of initiating lysis, but further assoication with C9 is required for full MAC (membrane attack complex) generation. Four molecules of C9 confer full lytic ...
... with C6 and C7 leads to the formation of a complex that can insert itself into a cell's lipid bylayer. When C8 associates, the complex is capable of initiating lysis, but further assoication with C9 is required for full MAC (membrane attack complex) generation. Four molecules of C9 confer full lytic ...
Chapter 15: Nonspecific Immunity
... C3b is produced in very low levels spontaneously from C3 C3b interacts with endotoxin and other bacterial cell wall components and Factors B, D, and P to form C3bBb, which is an alternative C3 convertase, which produces more C3b, the C5 convertase This produces C5b, which results in formation ...
... C3b is produced in very low levels spontaneously from C3 C3b interacts with endotoxin and other bacterial cell wall components and Factors B, D, and P to form C3bBb, which is an alternative C3 convertase, which produces more C3b, the C5 convertase This produces C5b, which results in formation ...
AnS 214 SI Session 5 Sunday, September 13, 8pm A) Antigens and
... If you put False, justify your answer by changing the sentence to make it true. 3) What are the three organelles necessary for the extreme rates of protein synthesis found in plasma cells? 4) Write in the names of the antibody killing mechanism corresponding to the description. _________________ Ant ...
... If you put False, justify your answer by changing the sentence to make it true. 3) What are the three organelles necessary for the extreme rates of protein synthesis found in plasma cells? 4) Write in the names of the antibody killing mechanism corresponding to the description. _________________ Ant ...
Document
... osmotic lysis. The alternative complement pathway does not require antibody to initiate the lysis of bacteria. In this pathway, complement proteins from a complex known as C3 directly bind to bacteria and activate downstream components in the complement cascade, once again ending in formation of MAC ...
... osmotic lysis. The alternative complement pathway does not require antibody to initiate the lysis of bacteria. In this pathway, complement proteins from a complex known as C3 directly bind to bacteria and activate downstream components in the complement cascade, once again ending in formation of MAC ...
Immune responses to bacteria
... osmotic lysis. The alternative complement pathway does not require antibody to initiate the lysis of bacteria. In this pathway, complement proteins from a complex known as C3 directly bind to bacteria and activate downstream components in the complement cascade, once again ending in formation of MAC ...
... osmotic lysis. The alternative complement pathway does not require antibody to initiate the lysis of bacteria. In this pathway, complement proteins from a complex known as C3 directly bind to bacteria and activate downstream components in the complement cascade, once again ending in formation of MAC ...
Immunology 3 – Innate Immunity
... 1. Briefly describe the functions of the important phagocytic cells: neutrophils, monocytes/macrophages. Innate immunity is that which is “inbuilt”, present from birth. It is not antigen-specific, but is able to recognise pathogen-specific molecular patterns. It is the same at every time the body is ...
... 1. Briefly describe the functions of the important phagocytic cells: neutrophils, monocytes/macrophages. Innate immunity is that which is “inbuilt”, present from birth. It is not antigen-specific, but is able to recognise pathogen-specific molecular patterns. It is the same at every time the body is ...
Introduction to the Immune System
... (B,D,P) bind to repetitive structures on microbial surfaces, such as components of the cell wall. The complex of B, D and P forms the C3 convertase of the Alternative Pathway. Recognition is selective for microbes, but not highly specific (pattern recognition). ...
... (B,D,P) bind to repetitive structures on microbial surfaces, such as components of the cell wall. The complex of B, D and P forms the C3 convertase of the Alternative Pathway. Recognition is selective for microbes, but not highly specific (pattern recognition). ...
Foundation Block Lecture Two Natural defense mechanism
... Microbial infections initiate inflammation As bacteria possess an array of pro-inflammatory molecules: e.g. Lipopolysaccharides (LPS) ...
... Microbial infections initiate inflammation As bacteria possess an array of pro-inflammatory molecules: e.g. Lipopolysaccharides (LPS) ...
The Complement system
... The building of a C3 activation complex • Once C1 is activated, it activates 2 other complement proteins, C2 and C4 by cutting them in half • C2 is cleaved into C2a and C2b • C4 is cleaved into C4a and C4b • Both C2b and C4b bind together on the surface of the bacteria • C2a and C4a diffuse away ...
... The building of a C3 activation complex • Once C1 is activated, it activates 2 other complement proteins, C2 and C4 by cutting them in half • C2 is cleaved into C2a and C2b • C4 is cleaved into C4a and C4b • Both C2b and C4b bind together on the surface of the bacteria • C2a and C4a diffuse away ...
Humoral Immune Effector Mechanisms
... C5a is the most potent bind receptors on mast cells and basophils and cause degranulation with the release of pharmacologically active mediators which induce smoothmuscle contraction and increases in vascular permeability. C3a, C5a and C5b67 act as chemoattractants and induce monocytes and neutrophi ...
... C5a is the most potent bind receptors on mast cells and basophils and cause degranulation with the release of pharmacologically active mediators which induce smoothmuscle contraction and increases in vascular permeability. C3a, C5a and C5b67 act as chemoattractants and induce monocytes and neutrophi ...
III. Immunology and Complement
... For blood banking, an IgA deficient individual may produce anti-IgA which can cause severe, life-threatening anaphylactic reactions during transfusion. Once identified these individuals must be transfused with blood and components which lack IgA. ...
... For blood banking, an IgA deficient individual may produce anti-IgA which can cause severe, life-threatening anaphylactic reactions during transfusion. Once identified these individuals must be transfused with blood and components which lack IgA. ...
Document
... (MBL) is similar to C1 but it binds to mannose then activates C4 and C2. MB-lectin pathway is particularly important in children that do not have much antibody ...
... (MBL) is similar to C1 but it binds to mannose then activates C4 and C2. MB-lectin pathway is particularly important in children that do not have much antibody ...
投影片 1 - 國防醫學院數位學習系統
... C1s, C1r, C2, MASP 1/2,factor B, D, I • Collectins-(Collagen Stalk, Gobular Domain) C1q, MBL, Ficolin • Cytolytic-(C9/Perforin Domain) C6, C7, C8, C9 • Regulatory and Receptor (SCR Domain) DAF, MCP,C4BP,CR1 & factor H • “True” Complement Proteins C3,C4,C5 ...
... C1s, C1r, C2, MASP 1/2,factor B, D, I • Collectins-(Collagen Stalk, Gobular Domain) C1q, MBL, Ficolin • Cytolytic-(C9/Perforin Domain) C6, C7, C8, C9 • Regulatory and Receptor (SCR Domain) DAF, MCP,C4BP,CR1 & factor H • “True” Complement Proteins C3,C4,C5 ...
Almanac, Vol. 47, No. 26 March 20, 2001
... medical science, and such agents could contribute significantly to the treatment of an array of human diseases." Although the complement proteins are part of the immune system, they do not always limit themselves to potentially disease-causing invaders-complement does not discriminate between bacter ...
... medical science, and such agents could contribute significantly to the treatment of an array of human diseases." Although the complement proteins are part of the immune system, they do not always limit themselves to potentially disease-causing invaders-complement does not discriminate between bacter ...
PowerPoint Presentation - Atypical Cutaneous Leishmaniasis
... Once C1q binds to antibodies it provides site for serine proteases C1s and C1r to bind. Full C1 molecule is made of 1 C1q with 2C1r and 2 C1s molecules. ...
... Once C1q binds to antibodies it provides site for serine proteases C1s and C1r to bind. Full C1 molecule is made of 1 C1q with 2C1r and 2 C1s molecules. ...
Defence against extracellular pathogens Innate defence molecules
... antibodies bound to antigens (i.e. free antibodies cannot trigger the pathway). C1q binds to the Fc regions of these antibodies. This activates C1r and C1s that are associated with C1q, leading to the conversion of C4 and C2. The fragments C4b and C2a combine to form C4b2a, which has C3 convertase a ...
... antibodies bound to antigens (i.e. free antibodies cannot trigger the pathway). C1q binds to the Fc regions of these antibodies. This activates C1r and C1s that are associated with C1q, leading to the conversion of C4 and C2. The fragments C4b and C2a combine to form C4b2a, which has C3 convertase a ...
Complement
... proteins (nomenclature) Activated component are usually over-lined: e.g. C1qrs When enzymatically cleaved, the larger moiety, binds to the activation complex or membrane and the smaller peptide is released in the ...
... proteins (nomenclature) Activated component are usually over-lined: e.g. C1qrs When enzymatically cleaved, the larger moiety, binds to the activation complex or membrane and the smaller peptide is released in the ...
Lecture 2: Introduction to Complement
... Alternative Pathway: Phase I - Generation of C3 Convertase & C3b opsonization. A. Generation of Soluble C3 convertase: 1. C3 (soluble) spontaneous hydrolysis of thio-ester, producing iC3. 2. iC3 (soluble) binds factor B, producing iC3-B complex 3. Factor D cleaves B to give Ba + Bb, iC3Bb complex, a ...
... Alternative Pathway: Phase I - Generation of C3 Convertase & C3b opsonization. A. Generation of Soluble C3 convertase: 1. C3 (soluble) spontaneous hydrolysis of thio-ester, producing iC3. 2. iC3 (soluble) binds factor B, producing iC3-B complex 3. Factor D cleaves B to give Ba + Bb, iC3Bb complex, a ...
Lecture 9 - University of Arizona | Ecology and
... • Secreted as inactive enzymes known as zymogens (enzymes that must be modified in order to be active) • Plasma proteins that attack extra-cellular pathogens • Being coated in Complement can result in: – Phagocytosis – MAC (Membrane-Attack Complex) ...
... • Secreted as inactive enzymes known as zymogens (enzymes that must be modified in order to be active) • Plasma proteins that attack extra-cellular pathogens • Being coated in Complement can result in: – Phagocytosis – MAC (Membrane-Attack Complex) ...
Complement system
The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.