IMMUNE DEFENCE - ASAB-NUST
... IFNy released by activated macrophages and NK cells. IL-6 appears to be the major cytokine of importance in enhancing production of acute phase proteins. ...
... IFNy released by activated macrophages and NK cells. IL-6 appears to be the major cytokine of importance in enhancing production of acute phase proteins. ...
Time course of immune response
... Mannan binding lectin binds to mannose MASP-1,-2 bind to bound MBL Mimics C1q Cleavage of C2 and C4 leads to C3 convertase ...
... Mannan binding lectin binds to mannose MASP-1,-2 bind to bound MBL Mimics C1q Cleavage of C2 and C4 leads to C3 convertase ...
The Complement system
... • A defensive system consisting of over 30 proteins produced by the liver and found in circulating blood serum. • Complement kills microbes in three different ways – 1. opsonization – 2. inflammation – 3. Cytolysis ...
... • A defensive system consisting of over 30 proteins produced by the liver and found in circulating blood serum. • Complement kills microbes in three different ways – 1. opsonization – 2. inflammation – 3. Cytolysis ...
The Complement system
... • A defensive system consisting of over 30 proteins produced by the liver and found in circulating blood serum. • Complement kills microbes in three different ways – 1. opsonization – 2. inflammation – 3. Cytolysis ...
... • A defensive system consisting of over 30 proteins produced by the liver and found in circulating blood serum. • Complement kills microbes in three different ways – 1. opsonization – 2. inflammation – 3. Cytolysis ...
slides - Smith Lab
... -Decay-accelerating factor (DAF) and Membrane Cofactor Protein (MCP) prevent formation of convertases by displacing C3b -MCP further acts as a cofactor to Factor I to yield inactive C3b -Other: CR1 also prevents formation of C3 convertase by displacing C2a and/or Bb and acts as cofactor to Factor I ...
... -Decay-accelerating factor (DAF) and Membrane Cofactor Protein (MCP) prevent formation of convertases by displacing C3b -MCP further acts as a cofactor to Factor I to yield inactive C3b -Other: CR1 also prevents formation of C3 convertase by displacing C2a and/or Bb and acts as cofactor to Factor I ...
Document
... Binding of Ag by IgM leads to a conformational change exposing the C1q binding sites. There are multiple sites in each IgM molecule so one IgM can bind C1q and activate the complement cascade ...
... Binding of Ag by IgM leads to a conformational change exposing the C1q binding sites. There are multiple sites in each IgM molecule so one IgM can bind C1q and activate the complement cascade ...
Complement system
... vessel walls or tissue and initiate complement activation with all the pro-inflammatory effect that are entail -Larger complexes ,composed of lattice of antibodies and antigen are more likely to become insoluble and fixed in the tissue . -The covalent binding of C3b to antibodies in a complex inhibi ...
... vessel walls or tissue and initiate complement activation with all the pro-inflammatory effect that are entail -Larger complexes ,composed of lattice of antibodies and antigen are more likely to become insoluble and fixed in the tissue . -The covalent binding of C3b to antibodies in a complex inhibi ...
7th seminar 2013 Complement system
... 4. What about the levels of the terminal components? The unregulated activation of the early components does not lead to the formation of the C3/C5 convertase, so the terminal components are not abnormally activated. 5. Despite the complement deficiency in patients with HANE, they are not unduly sus ...
... 4. What about the levels of the terminal components? The unregulated activation of the early components does not lead to the formation of the C3/C5 convertase, so the terminal components are not abnormally activated. 5. Despite the complement deficiency in patients with HANE, they are not unduly sus ...
Immune Worksheet Session 27- 4/7/11
... Iowa State University COMPLEMENT: 1) What part of the immune system (innate, adaptive) is complement a part of? 2) What are the major functions of complement? 3) Compare the two pathways in which complement is activated: Classical Pathway ...
... Iowa State University COMPLEMENT: 1) What part of the immune system (innate, adaptive) is complement a part of? 2) What are the major functions of complement? 3) Compare the two pathways in which complement is activated: Classical Pathway ...
AbD Serotec - bioNova científica sl
... C1q is a six headed molecule, attached to two molecules C1r and C1s (seen enlarged in fig 1). When two of the C1q heads bind to the pathogen, this causes a conformational change that activates the C1s enzyme. This C1s enzyme goes on to cleave C4 to produce C4b and C4a. C2 binds to C4b (which is boun ...
... C1q is a six headed molecule, attached to two molecules C1r and C1s (seen enlarged in fig 1). When two of the C1q heads bind to the pathogen, this causes a conformational change that activates the C1s enzyme. This C1s enzyme goes on to cleave C4 to produce C4b and C4a. C2 binds to C4b (which is boun ...
The complement system
... • The complement is activated in a cascading manner (= each protein activates that following) and it has widespread physiologic and pathophysiologic effects • Complement proteins are synthesized mainly in the liver, but tissue macrophages and fibroblasts can synthesize some complement proteins as we ...
... • The complement is activated in a cascading manner (= each protein activates that following) and it has widespread physiologic and pathophysiologic effects • Complement proteins are synthesized mainly in the liver, but tissue macrophages and fibroblasts can synthesize some complement proteins as we ...
Document
... • The complement is activated in a cascading manner (= each protein activates that following) and it has widespread physiologic and pathophysiologic effects • Complement proteins are synthesized mainly in the liver, but tissue macrophages and fibroblasts can synthesize some complement proteins as we ...
... • The complement is activated in a cascading manner (= each protein activates that following) and it has widespread physiologic and pathophysiologic effects • Complement proteins are synthesized mainly in the liver, but tissue macrophages and fibroblasts can synthesize some complement proteins as we ...
IMMUNITY MEDIATED BY B LYMPHOCYTES AND ANTIBODIES
... DIRECT KILLING OF PATHOGENS BY COMPLEMENT SYSTEM * Terminal complement proteins form “membrane attack complex” * Mechanism of attack by classic pathway * C3b binds to C3 convertase (C4b,2b) / (C4b,2a) results in * C5 convertase (C4b,2b,3b) / (C4b,2a, 3b) ...
... DIRECT KILLING OF PATHOGENS BY COMPLEMENT SYSTEM * Terminal complement proteins form “membrane attack complex” * Mechanism of attack by classic pathway * C3b binds to C3 convertase (C4b,2b) / (C4b,2a) results in * C5 convertase (C4b,2b,3b) / (C4b,2a, 3b) ...
IMMUNITY MEDIATED BY B LYMPHOCYTES AND ANTIBODIES
... * Proteins of classic pathway named with capital “C” followed by a numeral (C1, C2, C3…..C9) * Cleavage fragments named as parent followed by lower case letter * “a” for smaller fragment (C3a) * “b” for larger fragment (C3b) ...
... * Proteins of classic pathway named with capital “C” followed by a numeral (C1, C2, C3…..C9) * Cleavage fragments named as parent followed by lower case letter * “a” for smaller fragment (C3a) * “b” for larger fragment (C3b) ...
Innate Immune System
... 7. What are phagocytes and what are their functions? What groups of bacteria can avoid their actions? Phagocytes include macrophages, neutrophils, NK cells, eosinophils and basophils. They all ingest foreign pathogens through phagocytosis, a process that is facilitated by opsonisation. The ingested ...
... 7. What are phagocytes and what are their functions? What groups of bacteria can avoid their actions? Phagocytes include macrophages, neutrophils, NK cells, eosinophils and basophils. They all ingest foreign pathogens through phagocytosis, a process that is facilitated by opsonisation. The ingested ...
THE ROLE OF COMPLEMENT
... surface – then interacts with associated Serine Proteases – MASP1 and 2 (homologous to C1r and C1s). – Antibody independent activation of classical ...
... surface – then interacts with associated Serine Proteases – MASP1 and 2 (homologous to C1r and C1s). – Antibody independent activation of classical ...
Document
... C. ClO- found in lysosomes of macrophages D. the respiratory burst 6. For macrophages, identify… Two oxygen-dependent killing mechanisms ...
... C. ClO- found in lysosomes of macrophages D. the respiratory burst 6. For macrophages, identify… Two oxygen-dependent killing mechanisms ...
Tan1
... The complement system is a set of plasma proteins that act together to attack extracellular forms of pathogens. It was first discovered as an effector arm of the antibody response, but complement can also be activated early in infection in the absence of antibodies; complement first evolved as part ...
... The complement system is a set of plasma proteins that act together to attack extracellular forms of pathogens. It was first discovered as an effector arm of the antibody response, but complement can also be activated early in infection in the absence of antibodies; complement first evolved as part ...
PowerPoint to accompany
... • The lectin pathway is homologous to the classical pathway, but with the opsonin, mannose-binding lectin (MBL), and ficolins, instead of C1q • Ficolins are homologous to MBL and function via MASP in a similar way. In vertebrates without an adaptive immune system, ficolins are expanded and their bin ...
... • The lectin pathway is homologous to the classical pathway, but with the opsonin, mannose-binding lectin (MBL), and ficolins, instead of C1q • Ficolins are homologous to MBL and function via MASP in a similar way. In vertebrates without an adaptive immune system, ficolins are expanded and their bin ...
PG2003 Lecutre 14 The Complement Cascade
... Initiation of an inflammatory response Recruitment of phagocytes to site of infection Direct destruction of gram negative bacteria ...
... Initiation of an inflammatory response Recruitment of phagocytes to site of infection Direct destruction of gram negative bacteria ...
Complement system
The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.