Natural (Innate) Immunity
... Historical background 1798, Jenner Cowpox vaccines, induced immunity against smallpox 1885, Louis Pasteur Vaccine against rabies • Other used Inactivated diphtheria toxins as a vaccine against diphtheria (the protective effect were found to be in the serum) • Serum factor called Antibody ...
... Historical background 1798, Jenner Cowpox vaccines, induced immunity against smallpox 1885, Louis Pasteur Vaccine against rabies • Other used Inactivated diphtheria toxins as a vaccine against diphtheria (the protective effect were found to be in the serum) • Serum factor called Antibody ...
PowerPoint
... Antimicrobial substances • IFN- and IFN-: Cause cells to produce antiviral proteins that inhibit viral ...
... Antimicrobial substances • IFN- and IFN-: Cause cells to produce antiviral proteins that inhibit viral ...
Lecture 14 - Innate Defenses
... effect the behavior of other cells; “voice” Adhesion molecules - “hands” ...
... effect the behavior of other cells; “voice” Adhesion molecules - “hands” ...
Acquired immunity
... Various specialized regions in the body produce immune system components. Humoral immunity is part of acquired immunity and relies on production of antibodies to attack pathogens. A small number of “memory” cells continually patrol the blood and produce antibodies in case of later infection. Cell- ...
... Various specialized regions in the body produce immune system components. Humoral immunity is part of acquired immunity and relies on production of antibodies to attack pathogens. A small number of “memory” cells continually patrol the blood and produce antibodies in case of later infection. Cell- ...
Complement receptors
... • Pentraxin proteins such as serum amyloid and C-reactive protein • Lipid transferases • Peptidoglycan recognition proteins (PGRs) and the LRR, XA21D are all secreted proteins • One very important collectin is mannanbinding lectin (MBL), a major PRR of the innate immune system that binds to a wide r ...
... • Pentraxin proteins such as serum amyloid and C-reactive protein • Lipid transferases • Peptidoglycan recognition proteins (PGRs) and the LRR, XA21D are all secreted proteins • One very important collectin is mannanbinding lectin (MBL), a major PRR of the innate immune system that binds to a wide r ...
1. Overview of Innate Immunity The Body`s Defenses
... Cytolysis by Complement • C3b binds to outer membrane of Gram- bacteria and splits C5 into C5a & C5b • C5b on the outer membrane then recruits C6, C7, & C8 • the C5b-C8 complex triggers multiple C9 proteins to complete the circular membrane attack complex (MAC) • MAC formation produces a hole in me ...
... Cytolysis by Complement • C3b binds to outer membrane of Gram- bacteria and splits C5 into C5a & C5b • C5b on the outer membrane then recruits C6, C7, & C8 • the C5b-C8 complex triggers multiple C9 proteins to complete the circular membrane attack complex (MAC) • MAC formation produces a hole in me ...
Chapter 16: Innate Immunity
... Cytolysis by Complement • C3b binds to outer membrane of Gram- bacteria and splits C5 into C5a & C5b • C5b on the outer membrane then recruits C6, C7, & C8 • the C5b-C8 complex triggers multiple C9 proteins to complete the circular membrane attack complex (MAC) • MAC formation produces a hole in me ...
... Cytolysis by Complement • C3b binds to outer membrane of Gram- bacteria and splits C5 into C5a & C5b • C5b on the outer membrane then recruits C6, C7, & C8 • the C5b-C8 complex triggers multiple C9 proteins to complete the circular membrane attack complex (MAC) • MAC formation produces a hole in me ...
NON-SPECIFIC IMMUNE RESPONSE CHAPTER 16 Overview of the Defense
... Complement Proteins • Consists of a collection of 30 interacting proteins found in blood and tissues • These proteins promote – Opsonization: C3b coats surface/enhance phagocytosis – Inflammation – Cell lysis ...
... Complement Proteins • Consists of a collection of 30 interacting proteins found in blood and tissues • These proteins promote – Opsonization: C3b coats surface/enhance phagocytosis – Inflammation – Cell lysis ...
Reading Guide-InnateImmune (CH15)
... are many different kinds of cytokines that are important in the innate immune response. Chemokines, for example, are important in chemotaxis and promote cell migration towards areas of inflammation. Review the function of the following kinds of cytokines, colony-stimulating factors, interferons, int ...
... are many different kinds of cytokines that are important in the innate immune response. Chemokines, for example, are important in chemotaxis and promote cell migration towards areas of inflammation. Review the function of the following kinds of cytokines, colony-stimulating factors, interferons, int ...
1 TEMA 2. SISTEMA DE COMPLEMENTO
... the C3b to form covalent bonds with proteins and carbohydrates - the active group decays rapidly by hydrolysis, if such a bond does not form. C4 also contains a thioester bond which becomes activated similarly when C4 is split into C4a and C4b. Inmunologí Inmunología ...
... the C3b to form covalent bonds with proteins and carbohydrates - the active group decays rapidly by hydrolysis, if such a bond does not form. C4 also contains a thioester bond which becomes activated similarly when C4 is split into C4a and C4b. Inmunologí Inmunología ...
Matching – Each question is worth 0.5 pt
... Study Guide Questions - 15 pts total Below are examples of the different types of questions that will be asked on Exam 1. The only type of question not included in these examples is an essay question. ...
... Study Guide Questions - 15 pts total Below are examples of the different types of questions that will be asked on Exam 1. The only type of question not included in these examples is an essay question. ...
MICROBIO320 Short Answers – These should be typically 1
... Study Guide Questions - 15 pts total Below are examples of the different types of questions that will be asked on Exam 1. The only type of question not included in these examples is an essay question. ...
... Study Guide Questions - 15 pts total Below are examples of the different types of questions that will be asked on Exam 1. The only type of question not included in these examples is an essay question. ...
Biological therapy
... Autoimmune diseases (immunecomplex diseases) Transplant rejection Ischemia/reperfusion (stroke, myocardial infarction, etc…) Hemodialysis, on-pump cardiac operation ...
... Autoimmune diseases (immunecomplex diseases) Transplant rejection Ischemia/reperfusion (stroke, myocardial infarction, etc…) Hemodialysis, on-pump cardiac operation ...
Chapter 18 Quantitative and Thought Questions 18.1 Both would be
... 18.3 The drug may reduce but would not eliminate the action of complement, because this system destroys cells directly (via the membrane attack complex) as well as by facilitating phagocytosis. 18.4 Antibodies would bind normally to antigen but may not be able to activate complement, act as opsonins ...
... 18.3 The drug may reduce but would not eliminate the action of complement, because this system destroys cells directly (via the membrane attack complex) as well as by facilitating phagocytosis. 18.4 Antibodies would bind normally to antigen but may not be able to activate complement, act as opsonins ...
1. The barriers of the innate immune system to infection
... typical of several of the complement proteins; it is cleaved into a large (C3b) and a small (C3a) fragment. The larger fragment, C3b, takes on enzymatic activity and activates other complement components. C3b is also able to cleave any other C3 molecules in the vicinity. C3 has a tendency to break d ...
... typical of several of the complement proteins; it is cleaved into a large (C3b) and a small (C3a) fragment. The larger fragment, C3b, takes on enzymatic activity and activates other complement components. C3b is also able to cleave any other C3 molecules in the vicinity. C3 has a tendency to break d ...
ANTIBODIES - immunology.unideb.hu
... COLLABORATION OF INNATE AND ADAPTIVE IMMUNITY ANTIBODY STRUCTURE AND FUNCTION ...
... COLLABORATION OF INNATE AND ADAPTIVE IMMUNITY ANTIBODY STRUCTURE AND FUNCTION ...
Immune Mechanisms
... TH17 cells, secrete IL-17 and other cytokines to attrach Neutrophils to sites of infection… ….independent of Ag contact (activated by dendritic cells) ...
... TH17 cells, secrete IL-17 and other cytokines to attrach Neutrophils to sites of infection… ….independent of Ag contact (activated by dendritic cells) ...
Non-specific Immunity
... • Inflammation works to allow both specific and non-specific immune response to accelerate • Fever also allows for better performance in both specific and non-specific function • Specific immune response and “antigen presentation” further stimulates non-specific ...
... • Inflammation works to allow both specific and non-specific immune response to accelerate • Fever also allows for better performance in both specific and non-specific function • Specific immune response and “antigen presentation” further stimulates non-specific ...
Complement system
The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.