Microsoft Word - Final Exam Study Guide
... stability, elimination reactions, Zaitsev’s rule, E1 mechanism, E2 mechanism, antiperiplanar, comparing substitution and elimination mechanisms, synthesis of ethers, alcohols, and epoxides, dehydration of alcohols, carbocation rearrangements, reactions of alcohols/ethers/epoxides, multistep synthesi ...
... stability, elimination reactions, Zaitsev’s rule, E1 mechanism, E2 mechanism, antiperiplanar, comparing substitution and elimination mechanisms, synthesis of ethers, alcohols, and epoxides, dehydration of alcohols, carbocation rearrangements, reactions of alcohols/ethers/epoxides, multistep synthesi ...
Organic Chemistry –Syllabus- one Semester Sackler faculty of
... double bond equivalent, alkyl group, Nomenclature (IUPAC rules), intermolecular forces( van der Waals force, Dipole–dipole interaction, Hydrogen bonds), Solubility, Conformations of alkanes(staggered-eclipsd) , Cycloalkanes, geometric isomers, The chair conformation of cyclohexane, Combustion of alk ...
... double bond equivalent, alkyl group, Nomenclature (IUPAC rules), intermolecular forces( van der Waals force, Dipole–dipole interaction, Hydrogen bonds), Solubility, Conformations of alkanes(staggered-eclipsd) , Cycloalkanes, geometric isomers, The chair conformation of cyclohexane, Combustion of alk ...
Name: Chem 22 Final exam Spring `00 What product is formed when
... a) In an organometallic compound, the carbon bonded to the metal is the nucleophile. b) An epoxide is more reactive than an ether. c) In a Hofmann elimination, a proton is removed from the beta carbon that is bonded to the greater number of hydrogens. d) Thioethers are also called sufides ...
... a) In an organometallic compound, the carbon bonded to the metal is the nucleophile. b) An epoxide is more reactive than an ether. c) In a Hofmann elimination, a proton is removed from the beta carbon that is bonded to the greater number of hydrogens. d) Thioethers are also called sufides ...
org test 1
... 2. Why is Sulphuric acid not used during reaction of alcohol with KI? 3. Why is preparation of ethers by acid catalysed dehydration of 2° and 3° alcohols not a suitable method? 4. Of benzene and phenol, which is more easily nitrated and why? 5. Ethers possess a net dipole moment even if they are sym ...
... 2. Why is Sulphuric acid not used during reaction of alcohol with KI? 3. Why is preparation of ethers by acid catalysed dehydration of 2° and 3° alcohols not a suitable method? 4. Of benzene and phenol, which is more easily nitrated and why? 5. Ethers possess a net dipole moment even if they are sym ...
review sheet
... Acetal formation (acid catalyzed) Fisher esterification (acid catalyzed) Ester hydrolysis (acid catalyzed) Nucleophilic acyl substitution (up-down-out) Example: acid chloride + alcohol to give ester Ester reaction with Grignard reagents Questions that may be on the exam: What is the proper name for ...
... Acetal formation (acid catalyzed) Fisher esterification (acid catalyzed) Ester hydrolysis (acid catalyzed) Nucleophilic acyl substitution (up-down-out) Example: acid chloride + alcohol to give ester Ester reaction with Grignard reagents Questions that may be on the exam: What is the proper name for ...
Oxacyclopropane (Epoxide) Synthesis: Epoxidation by
... Peroxycarboxylic acids deliver oxygen atoms to double bonds. Peroxycarboxylic acids have the general formula: ...
... Peroxycarboxylic acids deliver oxygen atoms to double bonds. Peroxycarboxylic acids have the general formula: ...
CHE 312 Answers in BOLD RED EXAM 1 KEY (Ch. 16
... Fischer Esterification is probably the most important lab reaction of carboxylic acids. For the alcohol and the acid shown below, give the mechanism of this reaction. DRAW THE STEPS IN THIS MECHANISM. Be sure to include all major steps and show the structures of the main intermediates that are ...
... Fischer Esterification is probably the most important lab reaction of carboxylic acids. For the alcohol and the acid shown below, give the mechanism of this reaction. DRAW THE STEPS IN THIS MECHANISM. Be sure to include all major steps and show the structures of the main intermediates that are ...
Elimination Reactions
... Draw a mechanism and energy diagram for elimination of an alcohol under acidic conditions Explain how additions of water to an alkene and elimination of an alcohol are opposite mechanisms Describe how to shift equilibrium in favor of elimination or addition Predict the major product accordin ...
... Draw a mechanism and energy diagram for elimination of an alcohol under acidic conditions Explain how additions of water to an alkene and elimination of an alcohol are opposite mechanisms Describe how to shift equilibrium in favor of elimination or addition Predict the major product accordin ...
Alcohol Worksheet Key
... groups at position 3 and 5 will have very little effect on the acidity of the phenol. ...
... groups at position 3 and 5 will have very little effect on the acidity of the phenol. ...
Mechanistic Assignment
... CH3CH2SH is a good Lewis base. Why doesn’t it just react with the Lewis acid (BF3)? You will likely want to refer to your mechanism to explain why that is a better reaction path. ...
... CH3CH2SH is a good Lewis base. Why doesn’t it just react with the Lewis acid (BF3)? You will likely want to refer to your mechanism to explain why that is a better reaction path. ...
Biehl PPT Part2
... From ethyl benzene? Side-chain oxidation!!!! Appears as if we could start with benzoic acid and introduce ethyl group by EtLi. ...
... From ethyl benzene? Side-chain oxidation!!!! Appears as if we could start with benzoic acid and introduce ethyl group by EtLi. ...
Annexure `CD-01` L T P/S SW/FW TOTAL CREDIT UNITS 3 1 2 0 5
... derivatives. Physical properties, interconversion of acid derivatives by nucleophilic acyl substitution. Preparation of carboxylic acid derivatives, chemical reactions, Mechanisms of esterification and hydrolysis (acidic and basic) Dicarboxylic acids; methods of formation and effect of heat and de ...
... derivatives. Physical properties, interconversion of acid derivatives by nucleophilic acyl substitution. Preparation of carboxylic acid derivatives, chemical reactions, Mechanisms of esterification and hydrolysis (acidic and basic) Dicarboxylic acids; methods of formation and effect of heat and de ...
Exam 1
... As mentioned in the text, diethyl ether, pentane, and 1-butanol have similar molar masses, but different physical properties. Boiling points are 35oC, 36oC, and 117oC, respectively. Their respective solubilities in water are 7.5g/100mL, insoluble, and 9g/100mL. (i) Draw structures for each of these ...
... As mentioned in the text, diethyl ether, pentane, and 1-butanol have similar molar masses, but different physical properties. Boiling points are 35oC, 36oC, and 117oC, respectively. Their respective solubilities in water are 7.5g/100mL, insoluble, and 9g/100mL. (i) Draw structures for each of these ...
Chap Thirteen: Alcohols
... iii. reaction with acid chlorides or esters (double addition) iv. reaction with epoxides (Anti stereoselective; SN2-like regioselectivity) v. Side reactions with acidic compounds d. Via reduction of carbonyls or epoxides with Hydride Reducing reagents i. Reduction of Ketones, Aldehydes and Epoxides ...
... iii. reaction with acid chlorides or esters (double addition) iv. reaction with epoxides (Anti stereoselective; SN2-like regioselectivity) v. Side reactions with acidic compounds d. Via reduction of carbonyls or epoxides with Hydride Reducing reagents i. Reduction of Ketones, Aldehydes and Epoxides ...
Properties of , -Unsaturated Aldehydes and Ketones
... 18-11 Conjugate Additions of Enolate Ions: Michael Addition and Robinson Annulation Enolate ions undergo conjugate additions to ,-unsaturated aldehydes and ketones in a reaction called the Michael addition. ...
... 18-11 Conjugate Additions of Enolate Ions: Michael Addition and Robinson Annulation Enolate ions undergo conjugate additions to ,-unsaturated aldehydes and ketones in a reaction called the Michael addition. ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
... b) How will you prepare isobutyl alcohol using a Grignard reagent? 15. An amide(A) having molecular formula C3H7ON on hydrolysis gives an acid C3H6O2(B) which upon chlorination in the presence of red phosphorus produces a chloroacid(C).The latter on boiling with aqueous NaOH and subsequent acidifica ...
... b) How will you prepare isobutyl alcohol using a Grignard reagent? 15. An amide(A) having molecular formula C3H7ON on hydrolysis gives an acid C3H6O2(B) which upon chlorination in the presence of red phosphorus produces a chloroacid(C).The latter on boiling with aqueous NaOH and subsequent acidifica ...
REVISED Review 3 - Bonham Chemistry
... * 34. The drugs Prilosec and Nexium both contain the same active ingredient. Nexium contains a single enantiomer but Prilosec is a racemic mixture. Which drug will be more effective if you receive a 20 mg dose of each? How much more effective? ...
... * 34. The drugs Prilosec and Nexium both contain the same active ingredient. Nexium contains a single enantiomer but Prilosec is a racemic mixture. Which drug will be more effective if you receive a 20 mg dose of each? How much more effective? ...
Exam 3 Review Sheet
... You should feel comfortable with the following topics: Ch. 16 and 17: Aromatic Compounds • Concepts of aromaticity: MO diagrams, Hückel Rules for Aromaticity, resonance structures • Reactions at the benzylic position: o Addition of Br or Cl with NBS/NCS in the presence of peroxide. o Oxidation of a ...
... You should feel comfortable with the following topics: Ch. 16 and 17: Aromatic Compounds • Concepts of aromaticity: MO diagrams, Hückel Rules for Aromaticity, resonance structures • Reactions at the benzylic position: o Addition of Br or Cl with NBS/NCS in the presence of peroxide. o Oxidation of a ...
Pre Ch15 HW
... unsaturated hydrocarbon (628) geometric (cis-trans) isomers (628) alkyne (CnH2n–2) (630) aromatic hydrocarbon (631) nuclear magnetic resonance (NMR) spectroscopy (633) Section 15.3 alkyl group (635) addition reaction (635) elimination reaction (635) substitution reaction (636) Section 15.4 alcohol ( ...
... unsaturated hydrocarbon (628) geometric (cis-trans) isomers (628) alkyne (CnH2n–2) (630) aromatic hydrocarbon (631) nuclear magnetic resonance (NMR) spectroscopy (633) Section 15.3 alkyl group (635) addition reaction (635) elimination reaction (635) substitution reaction (636) Section 15.4 alcohol ( ...
Carboxylic Acid Derivatives
... Above are two sets of resonance structures. In each set, the right-hand structure reflects the positive polarization of the carbon atom which undergoes attack by nucleophiles. In the protonated structures, both are charged and the right hand structure has an electron deficient carbon atom. In the no ...
... Above are two sets of resonance structures. In each set, the right-hand structure reflects the positive polarization of the carbon atom which undergoes attack by nucleophiles. In the protonated structures, both are charged and the right hand structure has an electron deficient carbon atom. In the no ...
CHE 312 Exam III Review Sheet - Saint Leo University Faculty
... Explain why an aromatic molecule like benzene reacts differently than the corresponding alkene (actually a –triene)? ...
... Explain why an aromatic molecule like benzene reacts differently than the corresponding alkene (actually a –triene)? ...
CHEM 201 Name Quiz 10 (Ch 17) ID Q1. Which of the following
... Q3. Which of the following reactions would not normally yield an alcohol? a) Oxymercuration/ demercuraction of ...
... Q3. Which of the following reactions would not normally yield an alcohol? a) Oxymercuration/ demercuraction of ...
Wolff rearrangement
The Wolff rearrangement is a reaction in organic chemistry in which an α-diazocarbonyl compound is converted into a ketene by loss of dinitrogen with accompanying 1,2-rearrangement. The Wolff rearrangement yields a ketene as an intermediate product, which can undergo nucleophilic attack with weakly acidic nucleophiles such as water, alcohols, and amines, to generate carboxylic acid derivatives or undergo [2+2] cycloaddition reactions to form four-membered rings. The mechanism of the Wolff rearrangement has been the subject of debate since its first use. No single mechanism sufficiently describes the reaction, and there are often competing concerted and carbene-mediated pathways; for simplicity, only the textbook, concerted mechanism is shown below. The reaction was discovered by Ludwig Wolff in 1902. The Wolff rearrangement has great synthetic utility due to the accessibility of α-diazocarbonyl compounds, variety of reactions from the ketene intermediate, and stereochemical retention of the migrating group. However, the Wolff rearrangement has limitations due to the highly reactive nature of α-diazocarbonyl compounds, which can undergo a variety of competing reactions.The Wolff rearrangement can be induced via thermolysis, photolysis, or transition metal catalysis. In this last case, the reaction is sensitive to the transition metal; silver (I) oxide or other Ag(I) catalysts work well and are generally used. The Wolff rearrangement has been used in many total syntheses; the most common use is trapping the ketene intermediate with nucleophiles to form carboxylic acid derivatives. The Arndt-Eistert homologation is a specific example of this use, wherein a carboxylic acid may be elongated by a methylene unit. Another common use is in ring-contraction methods; if the α-diazo ketone is cyclic, the Wolff rearrangement results in a ring-contracted product. The Wolff rearrangement works well in generating ring-strained systems, where other reactions may fail.