MITOSIS SEQUENCE DETECTION USING HIDDEN CONDITIONAL
... classify each candidate sequence as mitosis or not. The proposed detection method achieved 95% precision and 85% recall in very challenging image sequences of multipolar-shaped C3H10T1/2 mesenchymal stem cells. The superiority of the method was further demonstrated by comparisons with conditional ra ...
... classify each candidate sequence as mitosis or not. The proposed detection method achieved 95% precision and 85% recall in very challenging image sequences of multipolar-shaped C3H10T1/2 mesenchymal stem cells. The superiority of the method was further demonstrated by comparisons with conditional ra ...
Lethality of radioisotopes in early mouse embryos
... Experiments to examine the synthesis of stage-specific embryonic proteins revealed that exposure to [35S]methionine prevented further division of the embryos. To investigate this effect of [35S]methionine on development, 2 to 4-cell embryos were incubated for 2 days in M16 containing different conce ...
... Experiments to examine the synthesis of stage-specific embryonic proteins revealed that exposure to [35S]methionine prevented further division of the embryos. To investigate this effect of [35S]methionine on development, 2 to 4-cell embryos were incubated for 2 days in M16 containing different conce ...
The Gram Reaction and Cell Composition: Nucleic
... low LP in the analyses of the whole cells. The work of Newton (1953)and our own recent unpublished observations show that Gram-negative organisms lose significant amounts of the acidsoluble components when washed in distilled water, whereas Gram-positive organisms generally do not. Since all the org ...
... low LP in the analyses of the whole cells. The work of Newton (1953)and our own recent unpublished observations show that Gram-negative organisms lose significant amounts of the acidsoluble components when washed in distilled water, whereas Gram-positive organisms generally do not. Since all the org ...
Organelle communication - Repositorio Académico
... serving as a platform that anchors molecular complexes to subcellular regions. Fact 3. Organelle interfaces serve as nucleation sites for pathways such as stress signals, mitochondrial dynamics and autophagy. Fact 4. Organelle communication regulates important cellular processes such as metabolism, ...
... serving as a platform that anchors molecular complexes to subcellular regions. Fact 3. Organelle interfaces serve as nucleation sites for pathways such as stress signals, mitochondrial dynamics and autophagy. Fact 4. Organelle communication regulates important cellular processes such as metabolism, ...
Lipid transfer and metabolism across the endolysosomal
... Ca2+ microdomain, responsible for the activation of the protein phosphatase calcineurin, which in turn dephosphorylates TFEB and promotes its nuclear translocation [24]. Once in nucleus, TFEB stimulates its own transcription, as well as the expression of target genes, including the peroxisome prolif ...
... Ca2+ microdomain, responsible for the activation of the protein phosphatase calcineurin, which in turn dephosphorylates TFEB and promotes its nuclear translocation [24]. Once in nucleus, TFEB stimulates its own transcription, as well as the expression of target genes, including the peroxisome prolif ...
PDF
... and in cholesterol itself at concentrations up to 100yMg/ml (the highest concentration tested). However when embryos were treated with a variety of sterol synthesis inhibitors (Brown & Goldstein, 1974) a dose-related inhibition of compaction and blastocyst formation was observed. 7-ketocholesterol a ...
... and in cholesterol itself at concentrations up to 100yMg/ml (the highest concentration tested). However when embryos were treated with a variety of sterol synthesis inhibitors (Brown & Goldstein, 1974) a dose-related inhibition of compaction and blastocyst formation was observed. 7-ketocholesterol a ...
Measuring forces and stresses in situ in living tissues
... Stress. A coarse-grained description of the forces within a tissue. When a piece of tissue experiences a force from a neighboring tissue region (A), mechanical stress (σ) is defined as the ratio of the force (F ) to the area of contact (A) with that region (B, top equation). Tension and compression ...
... Stress. A coarse-grained description of the forces within a tissue. When a piece of tissue experiences a force from a neighboring tissue region (A), mechanical stress (σ) is defined as the ratio of the force (F ) to the area of contact (A) with that region (B, top equation). Tension and compression ...
Autophagy in Tobacco BY-2 Cells Cultured under
... pathway and as contributing to some of the regulation pathways in cellular homeostasis (Klionsky and Emr 2000). It is generally accepted that all eukaryotic cells have a lytic compartment: the lysosome in animal cells, the lysosome/ vacuole in yeast cells and the vacuole in plant cells. By macroauto ...
... pathway and as contributing to some of the regulation pathways in cellular homeostasis (Klionsky and Emr 2000). It is generally accepted that all eukaryotic cells have a lytic compartment: the lysosome in animal cells, the lysosome/ vacuole in yeast cells and the vacuole in plant cells. By macroauto ...
PDF - Blood Journal
... attack complex. A similar defense mechanism has been described for platelets,10 neutrophils,11 and oligodendrocytes.12 The clinical ...
... attack complex. A similar defense mechanism has been described for platelets,10 neutrophils,11 and oligodendrocytes.12 The clinical ...
Metabolic Incorporation of Stable Isotope Labels into Glycans
... during their existence1,3 and virtually all membrane and secreted proteins are glycosylated.2 Glycoprotein glycans often play crucial roles in physiological events such as cell-cell recognition,4-6 signal transduction,7 inflammation8 and tumorigenesis.9-13 Given the important physiological roles of ...
... during their existence1,3 and virtually all membrane and secreted proteins are glycosylated.2 Glycoprotein glycans often play crucial roles in physiological events such as cell-cell recognition,4-6 signal transduction,7 inflammation8 and tumorigenesis.9-13 Given the important physiological roles of ...
The Sec34/35 Golgi Transport Complex Is Related to the Exocyst
... Sec34p and Sec35p, the two known components of the Sec34/35 complex previously proposed to tether vesicles to the Golgi. Of the six previously uncharacterized components, four have homologs in higher eukaryotes, including a subunit of a mammalian Golgi transport complex. Furthermore, several of the ...
... Sec34p and Sec35p, the two known components of the Sec34/35 complex previously proposed to tether vesicles to the Golgi. Of the six previously uncharacterized components, four have homologs in higher eukaryotes, including a subunit of a mammalian Golgi transport complex. Furthermore, several of the ...
public exam_photosynthesis
... In 1883, a German scientist, Engelmann, used a green alga to study the effect of light on photosynthesis. This alga has long ribbon-like chloroplasts. He placed the alga on a slide with a suspension of bacteria which would migrate to regions with high oxygen concentration. He observed the distributi ...
... In 1883, a German scientist, Engelmann, used a green alga to study the effect of light on photosynthesis. This alga has long ribbon-like chloroplasts. He placed the alga on a slide with a suspension of bacteria which would migrate to regions with high oxygen concentration. He observed the distributi ...
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[PDF]
... cells (MDCK), Lgl homologs regulate docking and fusion of post-Golgi vesicles with the plasma membrane through the SNARE complex (Larsson et al., 1998; Lehman et al., 1999). In summary, Lgl is believed to contribute to cellular asymmetry via its association with (1) cell junctional complexes and (2) ...
... cells (MDCK), Lgl homologs regulate docking and fusion of post-Golgi vesicles with the plasma membrane through the SNARE complex (Larsson et al., 1998; Lehman et al., 1999). In summary, Lgl is believed to contribute to cellular asymmetry via its association with (1) cell junctional complexes and (2) ...
Chromatin meets the cell cycle
... type of cell cycle may be concomitant with the deposition of epigenetic marks required for the specification of cell identity. The molecular bases of epigenetics have been described extensively, even though the connections between individual chromatin modifications and their functions are not always ...
... type of cell cycle may be concomitant with the deposition of epigenetic marks required for the specification of cell identity. The molecular bases of epigenetics have been described extensively, even though the connections between individual chromatin modifications and their functions are not always ...
Leukaemia Section Anaplastic large cell lymphoma (ALCL) Atlas of Genetics and Cytogenetics
... - The common type, characterized by large lymphoid cells with horseshoe shaped nuclei with many nucleoli, and large cytoplasm; may be ALK + or - ALCL, - The small cell type, together with the above described cells, show small and medium sized cells; almost exclusively ALK+ cases, - The lymphohistioc ...
... - The common type, characterized by large lymphoid cells with horseshoe shaped nuclei with many nucleoli, and large cytoplasm; may be ALK + or - ALCL, - The small cell type, together with the above described cells, show small and medium sized cells; almost exclusively ALK+ cases, - The lymphohistioc ...
The Development of the Cnidoblasts of Hydra
... within the same cluster of early cnidoblasts are presumed to be united by intercellular bridges, as has been shown to be the case in the spermatid clusters in the germinal epithelium of the testis (3). The origin, fine structure, and significance of these protoplasmic connections are considered in g ...
... within the same cluster of early cnidoblasts are presumed to be united by intercellular bridges, as has been shown to be the case in the spermatid clusters in the germinal epithelium of the testis (3). The origin, fine structure, and significance of these protoplasmic connections are considered in g ...
Autotroph or Heterotroph
... Protists are a diverse group of eukaryotic microorganisms. They do not have much in common except that they are relatively simple eukaryotes. They are either unicellular or multicellular without reaching the specialized tissue level of organization. Protists include organisms such as algae, amoebae ...
... Protists are a diverse group of eukaryotic microorganisms. They do not have much in common except that they are relatively simple eukaryotes. They are either unicellular or multicellular without reaching the specialized tissue level of organization. Protists include organisms such as algae, amoebae ...
PROTEIN DEPHOSPHORYLATION AND THE INTRACELLULAR
... was quickly suggested that PP1 and PP2A might be tumor suppressors in their own right (6). These exciting discoveries occurred a short time after we learned that many oncogenes encode protein kinases, and, more specifically, that the enzyme responsible for triggering entry into mitosis, p34cdc2/CDC2 ...
... was quickly suggested that PP1 and PP2A might be tumor suppressors in their own right (6). These exciting discoveries occurred a short time after we learned that many oncogenes encode protein kinases, and, more specifically, that the enzyme responsible for triggering entry into mitosis, p34cdc2/CDC2 ...
Mechanisms of cell positioning during C. elegans gastrulation
... a gap between these ingressing cells and the eggshell. Six neighboring cells converge under the endodermal precursors, filling this gap. Using an in vitro system, we observed that these movements occurred consistently in the absence of the eggshell and the vitelline envelope. We found that movement ...
... a gap between these ingressing cells and the eggshell. Six neighboring cells converge under the endodermal precursors, filling this gap. Using an in vitro system, we observed that these movements occurred consistently in the absence of the eggshell and the vitelline envelope. We found that movement ...
The C-terminal end of R-Ras contains a focal adhesion targeting
... R-Ras uses the endomembrane transport route To investigate the targeting of R-Ras, we constructed constitutive active (38V) and dominant-negative (43N) mutants of R-Ras and tagged them to EGFP. Western blot analysis of Hela cell extracts harbouring these constructs showed the presence of a 55 kDa pr ...
... R-Ras uses the endomembrane transport route To investigate the targeting of R-Ras, we constructed constitutive active (38V) and dominant-negative (43N) mutants of R-Ras and tagged them to EGFP. Western blot analysis of Hela cell extracts harbouring these constructs showed the presence of a 55 kDa pr ...
The regulation and function of Class III PI3Ks: novel roles for Vps34
... a null allele of Vps34 means that additional sources of PtdIns3P must exist in C. elegans. Consistent with this, siRNA knockdown of the C. elegans Class II PI3K, F39B1.1, reduces the rescue of let-512 mutants by the myotubularin knockdown. The enzymatic activity of recombinant Vps34 is readily assay ...
... a null allele of Vps34 means that additional sources of PtdIns3P must exist in C. elegans. Consistent with this, siRNA knockdown of the C. elegans Class II PI3K, F39B1.1, reduces the rescue of let-512 mutants by the myotubularin knockdown. The enzymatic activity of recombinant Vps34 is readily assay ...
Supplementary Table VI. List of Deletions/Hypomorphic Alleles
... Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; ...
... Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; ...
II-Expressing Microvesicles at Their Surface Follicular Dendritic
... MHC class II compartments (MIICs) (10), which are the subcellular site of peptide loading onto MHC class II molecules (11). MIICs are part of the endosomal/lysosomal pathway in APC and often have a multivesicular phenotype (12, 13). The internal vesicles of multivesicular MIICs are probably formed b ...
... MHC class II compartments (MIICs) (10), which are the subcellular site of peptide loading onto MHC class II molecules (11). MIICs are part of the endosomal/lysosomal pathway in APC and often have a multivesicular phenotype (12, 13). The internal vesicles of multivesicular MIICs are probably formed b ...
Cytokinesis
Cytokinesis (cyto- + kinesis) is the process during cell division in which the cytoplasm of a single eukaryotic cell is divided to form two daughter cells. It usually initiates during the early stages of mitosis, and sometimes meiosis, splitting a mitotic cell in two, to ensure that chromosome number is maintained from one generation to the next. After cytokinesis two (daughter) cells will be formed that are exact copies of the (parent) original cell. After cytokinesis, each daughter cell is in the interphase portion of the cell cycle. In animal cells, one notable exception to the normal process of cytokinesis is oogenesis (the creation of an ovum in the ovarian follicle of the ovary), where the ovum takes almost all the cytoplasm and organelles, leaving very little for the resulting polar bodies, which then die. Another form of mitosis without cytokinesis occurs in the liver, yielding multinucleate cells. In plant cells, a dividing structure known as the cell plate forms within the centre of the cytoplasm and a new cell wall forms between the two daughter cells.Cytokinesis is distinguished from the prokaryotic process of binary fission.