The Abundance of Cell Cycle Regulatory Protein Cdc4p Is
... is important for cell viability, we have sought evidence of mechanisms that modulate F-box protein regulation. Here we demonstrate that the abundance of Cdc4p is subject to control by a peptide segment that we term the R-motif (for “reduced abundance”). Furthermore, we show that binding of Skp1p to ...
... is important for cell viability, we have sought evidence of mechanisms that modulate F-box protein regulation. Here we demonstrate that the abundance of Cdc4p is subject to control by a peptide segment that we term the R-motif (for “reduced abundance”). Furthermore, we show that binding of Skp1p to ...
Review Article Hematopoietic Stem and Progenitor Cells as
... [22]. These behaviors are dictated by the microenvironment including physical and structural features, humoral, paracrine and neural signals, and metabolic factors. The HSPC niche most studied is the adult bone marrow, comprised of the osteoblastic and vascular niches. It is generally believed that ...
... [22]. These behaviors are dictated by the microenvironment including physical and structural features, humoral, paracrine and neural signals, and metabolic factors. The HSPC niche most studied is the adult bone marrow, comprised of the osteoblastic and vascular niches. It is generally believed that ...
ANISOTROPIC EXPANSION OF THE PLANT CELL WALL
... as well as apical cells in some filamentous algae and lower plants, grow by tip growth. In this mode, expansion is confined to one end of the cell, the tip, in contrast with diffuse growth in which growth occurs throughout one or more faces of the cell. For a single tip-growing cell, the stress distri ...
... as well as apical cells in some filamentous algae and lower plants, grow by tip growth. In this mode, expansion is confined to one end of the cell, the tip, in contrast with diffuse growth in which growth occurs throughout one or more faces of the cell. For a single tip-growing cell, the stress distri ...
Mutations in Actin-Related Proteins 2 and 3 Affect Cell Shape
... Based on the mutations, the protein truncations in wrm1-2, dis1-1, and dis1-2 would be predicted to occur after amino acids 14, 97, and 290, respectively (Figure 1C). The G-to-A change in wrm1-1 results in the alteration of a conserved Gly (position 151; Figure 1C) to Asp and may lead to a pivotal c ...
... Based on the mutations, the protein truncations in wrm1-2, dis1-1, and dis1-2 would be predicted to occur after amino acids 14, 97, and 290, respectively (Figure 1C). The G-to-A change in wrm1-1 results in the alteration of a conserved Gly (position 151; Figure 1C) to Asp and may lead to a pivotal c ...
Outer dense fibre protein 2 (ODF2) is a self
... Outer dense fibre protein 2 (ODF2) is a major protein of sperm tail outer dense fibres (Brohmann et al., 1997; Shao et al., 1997; Turner et al., 1997; Schalles et al., 1998). The outer dense fibres (ODF) are prominent sperm tail-specific cytoskeletal structures. They consist of nine fibres that acco ...
... Outer dense fibre protein 2 (ODF2) is a major protein of sperm tail outer dense fibres (Brohmann et al., 1997; Shao et al., 1997; Turner et al., 1997; Schalles et al., 1998). The outer dense fibres (ODF) are prominent sperm tail-specific cytoskeletal structures. They consist of nine fibres that acco ...
Shifts, Aneuploidy, and Loss of Heterozygosity Rapid Mechanisms
... ploidy variation. In both species, heterozygous cells also readily undergo loss of heterozygosity (LOH), leading to additional phenotypic changes such as altered drug resistance. Here, we examine the sexual and parasexual cycles that drive ploidy variation in human fungal pathogens and discuss ploid ...
... ploidy variation. In both species, heterozygous cells also readily undergo loss of heterozygosity (LOH), leading to additional phenotypic changes such as altered drug resistance. Here, we examine the sexual and parasexual cycles that drive ploidy variation in human fungal pathogens and discuss ploid ...
Kingdom Protista A Mixed Bag of Organisms
... cells contain __________________ of different sizes and shapes. ...
... cells contain __________________ of different sizes and shapes. ...
Chromosome Segregation in Budding Yeast: Sister Chromatid
... The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom ...
... The Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JR, United Kingdom ...
KLINEFELTER SYNDROME
... Normally, males inherit one X chromosome from their mother and one Y chromosome from their father. But those who have Klinefelter syndrome inherit an extra X chromosome. Klinefelter syndrome is typically caused by what is called nondisjunction. If a pair of sex chromosomes fails to separate during t ...
... Normally, males inherit one X chromosome from their mother and one Y chromosome from their father. But those who have Klinefelter syndrome inherit an extra X chromosome. Klinefelter syndrome is typically caused by what is called nondisjunction. If a pair of sex chromosomes fails to separate during t ...
Telomerase activity and differential expression of telomerase genes
... studied in chicken embryonic stem (chES) cells, chicken embryo fibroblasts (CEFs), and DT40 cells using quantitative real-time polymerase chain reaction. Our results establish that, relative to transcription levels in telomerase-negative CEFs, chTERT and chTR are up-regulated in telomerase-positive c ...
... studied in chicken embryonic stem (chES) cells, chicken embryo fibroblasts (CEFs), and DT40 cells using quantitative real-time polymerase chain reaction. Our results establish that, relative to transcription levels in telomerase-negative CEFs, chTERT and chTR are up-regulated in telomerase-positive c ...
The Plant Host–Pathogen Interface Cell Wall and Membrane
... factors.2,3 In the absence of the cognate resistance (R) proteins, effectors can function to disable host basal defenses and to release nutrients from host cells, rendering the host susceptible to pathogen proliferation. However, if these effectors are recognized by plant surveillance systems, usual ...
... factors.2,3 In the absence of the cognate resistance (R) proteins, effectors can function to disable host basal defenses and to release nutrients from host cells, rendering the host susceptible to pathogen proliferation. However, if these effectors are recognized by plant surveillance systems, usual ...
Involvement of the Vacuoles of the Endodermis in
... gravity with similar kinetics to wild-type plants, although the parental zig-1 plants showed little response even after 24 hr. In addition, their lateral stems, which in the parental zig-1 mutant curl downward, grew upward (Figure 2B). Interestingly, however, pSCR::ZIG could not complement the morph ...
... gravity with similar kinetics to wild-type plants, although the parental zig-1 plants showed little response even after 24 hr. In addition, their lateral stems, which in the parental zig-1 mutant curl downward, grew upward (Figure 2B). Interestingly, however, pSCR::ZIG could not complement the morph ...
Tissue and Cell Pertinent cell population to characterize periodontal
... presence of immunoglobulin producing plasma cells in the gingival tissues of patients with periodontal disease. This was the first evidence which demonstrated that adaptive immune mechanisms play a role in the pathogenesis of periodontal inflammation. In 1970, Ivanyi and Lehner (1970) using peripheral ...
... presence of immunoglobulin producing plasma cells in the gingival tissues of patients with periodontal disease. This was the first evidence which demonstrated that adaptive immune mechanisms play a role in the pathogenesis of periodontal inflammation. In 1970, Ivanyi and Lehner (1970) using peripheral ...
Unlinked Noncomplementation: Isolation of New Conditional-Lethal Mutations in Each of the Tubulin Genes of Saccharomyces cerevisiae .
... were sought by screening for unlinked mutations that fail to complement mutations in the single P-tubulin-encoding gene (TUBZ). Among the first three noncomplementing mutations examined, two are linked to TUB2 while one is unlinked. The unlinked mutation was shown to be a conditionallethal allele of ...
... were sought by screening for unlinked mutations that fail to complement mutations in the single P-tubulin-encoding gene (TUBZ). Among the first three noncomplementing mutations examined, two are linked to TUB2 while one is unlinked. The unlinked mutation was shown to be a conditionallethal allele of ...
mechanotransduction in lymphatic endothelial cells
... dilatation of approximately 30% was obtained ...
... dilatation of approximately 30% was obtained ...
Journal of Cell Biology - Institute of Cancer Research Repository
... caspase-mediated cleavage of ROCK I results in constitutive activation and consequent myosin light chain (MLC) phosphorylation leading to contraction and membrane blebbing (Coleman et al., 2001; Sebbagh et al., 2001). Inhibition of ROCK activity with the small molecule inhibitor Y-27632 attenuated b ...
... caspase-mediated cleavage of ROCK I results in constitutive activation and consequent myosin light chain (MLC) phosphorylation leading to contraction and membrane blebbing (Coleman et al., 2001; Sebbagh et al., 2001). Inhibition of ROCK activity with the small molecule inhibitor Y-27632 attenuated b ...
PDF
... that is highly conserved among leeches and oligochaetes (clitellate annelids; (Sandig and Dohle, 1988; Dohle, 1999; Bissen and Weisblat, 1989; Shimizu, 1982; Storey, 1989) and to a lesser extent among more distantly related annelids (Dohle, 1999). Three rounds of division in the A, B and C quadrants ...
... that is highly conserved among leeches and oligochaetes (clitellate annelids; (Sandig and Dohle, 1988; Dohle, 1999; Bissen and Weisblat, 1989; Shimizu, 1982; Storey, 1989) and to a lesser extent among more distantly related annelids (Dohle, 1999). Three rounds of division in the A, B and C quadrants ...
Storage of Quinolizidine Alkaloids in Epidermal Tissues
... thesize these compounds but also to accumulate and store them. While we have rather extensive know ledge on the biosynthetic pathways, our information on the conditions required to accumulate and store the products is comparably scanty. We observe as a general rule that the site of synthesis is dif ...
... thesize these compounds but also to accumulate and store them. While we have rather extensive know ledge on the biosynthetic pathways, our information on the conditions required to accumulate and store the products is comparably scanty. We observe as a general rule that the site of synthesis is dif ...
Active transport - Teachit Science
... Active transport is often the 'poor relation' in students' understanding of the movement of substances in and out of cells. These short match-up activities make useful starters, plenaries or revision tasks. Give students the first set of questions (Task 1). Tasks 2-7 are for those who struggle to an ...
... Active transport is often the 'poor relation' in students' understanding of the movement of substances in and out of cells. These short match-up activities make useful starters, plenaries or revision tasks. Give students the first set of questions (Task 1). Tasks 2-7 are for those who struggle to an ...
Relationship between the timing of DNA replication and the
... cells progress through a cell cycle in which DNA replication takes place immediately and exclusively after completion of mitosis. In D cells, however, DNA synthesis takes place not only after nuclear division but also before division. Despite the occurrence of premitotic DNA synthesis in D cells, th ...
... cells progress through a cell cycle in which DNA replication takes place immediately and exclusively after completion of mitosis. In D cells, however, DNA synthesis takes place not only after nuclear division but also before division. Despite the occurrence of premitotic DNA synthesis in D cells, th ...
Keratin, Low Molecular Weight Ab-1
... For concentrated antibodies, the antibody must be diluted before using. Use Lab Vision Antibody Diluent (catalog # TA-125-UD). Refer to diluent product instructions for use. Refer to the “General Protocol” instructions. Refer to the “General Protocol” instructions. ...
... For concentrated antibodies, the antibody must be diluted before using. Use Lab Vision Antibody Diluent (catalog # TA-125-UD). Refer to diluent product instructions for use. Refer to the “General Protocol” instructions. Refer to the “General Protocol” instructions. ...
Understanding the role of cholesterol in cellular biomechanics and
... to the oxidized form of LDL (oxLDL) particles also led to reorganization of the actin cytoskeleton. LDL particles are complex structures formed of different lipids and the proteins ApoB [49]. Oxidation of these particles leads to changes such as loss of antioxidant molecules, formation of shiff’s ba ...
... to the oxidized form of LDL (oxLDL) particles also led to reorganization of the actin cytoskeleton. LDL particles are complex structures formed of different lipids and the proteins ApoB [49]. Oxidation of these particles leads to changes such as loss of antioxidant molecules, formation of shiff’s ba ...
Mitosis
Mitosis is a part of the cell cycle in which chromosomes in a cell nucleus are separated into two identical sets of chromosomes, each in its own nucleus. In general, mitosis (division of the nucleus) is often followed by cytokinesis, which divides the cytoplasm, organelles and cell membrane into two new cells containing roughly equal shares of these cellular components. Mitosis and cytokinesis together define the mitotic (M) phase of an animal cell cycle—the division of the mother cell into two daughter cells, genetically identical to each other and to their parent cell.The process of mitosis is divided into stages corresponding to the completion of one set of activities and the start of the next. These stages are prophase, prometaphase, metaphase, anaphase, and telophase. During mitosis, the chromosomes, which have already duplicated, condense and attach to fibers that pull one copy of each chromosome to opposite sides of the cell. The result is two genetically identical daughter nuclei. The cell may then divide by cytokinesis to produce two daughter cells. Producing three or more daughter cells instead of normal two is a mitotic error called tripolar mitosis or multipolar mitosis (direct cell triplication / multiplication). Other errors during mitosis can induce apoptosis (programmed cell death) or cause mutations. Certain types of cancer can arise from such mutations.Mitosis occurs only in eukaryotic cells and the process varies in different organisms. For example, animals undergo an ""open"" mitosis, where the nuclear envelope breaks down before the chromosomes separate, while fungi undergo a ""closed"" mitosis, where chromosomes divide within an intact cell nucleus. Furthermore, most animal cells undergo a shape change, known as mitotic cell rounding, to adopt a near spherical morphology at the start of mitosis. Prokaryotic cells, which lack a nucleus, divide by a different process called binary fission.