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MTG Digest - Arrhythmia Alliance
MTG Digest - Arrhythmia Alliance

... If you suspect you're having a heart attack, dial 999 immediately and if you have aspirin handy, chew one. The drug has a blood thinning effect and chewing rather than swallowing will get it into your system quicker. Studies show that if it's taken during or shortly after a heart attack and daily af ...
Ventricular Septal Defect PDF
Ventricular Septal Defect PDF

... The defect can be small or large. The VSD may be termed muscular, perimembranous, inlet, outlet, apical or doublycommitted depending on its position and the surrounding substance of the heart. Where the VSD is small, there is no elevation of the low pressures found in the right ventricle (pumping ch ...
The Mid-term Results of Ventricular Containment (ACORN WRAP
The Mid-term Results of Ventricular Containment (ACORN WRAP

... MR presumably decreased partly due to stabilization of the cardiac base. The ACSD is a permanent implant that has been successful in preventing the continual dilation of the left ventricle in two heart failure animal models.8) Pervaiz and colleagues9) also reported in an animal model that the ACSD s ...
Drug therapy for rate control Beta
Drug therapy for rate control Beta

... blockers. These are effective rate controllers, and may be superior to beta-blockers for rate control during exercise.43 They are particularly useful in patients with contraindications to, or intolerant of, beta-blockers. The main side-effects are relative hypotension, and occasionally ankle swellin ...
Arrythmias presentation by Prof Celia Marr
Arrythmias presentation by Prof Celia Marr

... • Atrial fibrillation requires treatment if it is affecting the horse's role as a performance animal ...
Hypertensive crisis
Hypertensive crisis

... new category designated prehypertension has been added, and stages 2 and 3 hypertension have been combined. Patients with prehypertension are at increased risk for progression to hypertension; those in the 130/80 to 139/89 mm Hg BP range are at twice the risk to develop hypertension as those with lo ...
Infections in Patients with Diabetes Mellitus
Infections in Patients with Diabetes Mellitus

... These medications have potential for significant adverse effects. ...
The achievement of the congress of European Society of Cardiology
The achievement of the congress of European Society of Cardiology

... The main key messages of this paper are: prevention of CVD, either by implementation of lifestyle changes or use of medication, is cost effective in many scenarios, including population-based approaches and actions directed at high-risk individuals; cost-effectiveness depends on several factors, inc ...
Cardiovascular Pharmacology
Cardiovascular Pharmacology

... 20% die within 1 year of diagnosis & 50% within 5 years Increases with age- more men and more risk if high BP. Decline in death from other CV diseases since 1980 – but not heart failure ? ...
Chapter 20
Chapter 20

... SA node begins the action potential Stimulus spreads to the AV node Impulse is delayed at AV node Impulse then travels through ventricular conducting cells Then distributed by Purkinje fibers ...
Depression Modulates Autonomic Cardiac Control
Depression Modulates Autonomic Cardiac Control

... Depression Inventory; BDI), it seems to affect the prognosis after acute myocardial infarctions (Bush et al., 2001). However, it still remains unclear what the underlying mechanisms are. In patients with coronary heart disease or chronic heart failure, heart rate variability (HRV) is reduced, which ...
Medtronic-Supported Clinical Trial Shows ICD Patients Less
Medtronic-Supported Clinical Trial Shows ICD Patients Less

... Marshall Stanton, M.D., vice president of clinical research for the Cardiac Rhythm Disease Management business at Medtronic. “The analysis presented today shows that MVP reduces the development of the need for pacing in some ICD patients, but there is no evidence to show atrial pacing improves outco ...
GUIDELINES IMPLEMENTATION Practical Application of the
GUIDELINES IMPLEMENTATION Practical Application of the

... supporting the use of TC/HDL ratio as a treatment target is mostly derived from retrospective patient ...
Echocardiographic Evaluation of left ventricular diastolic function
Echocardiographic Evaluation of left ventricular diastolic function

... Background: Mitral stenosis is frequent valvular complication of rheumatic heart disease, leading to reduced LV filling during diastole, causing diastolic dysfunction. The aim of this study is 2D Echocardiographic Evaluation of left ventricular diastolic function after closed mitral valvotomy in rhe ...
Sudden Cardiac Death Caused by an Uncommon Disease
Sudden Cardiac Death Caused by an Uncommon Disease

... CS at autopsy ever showing clinical signs before death. Just recently, the first expert committee was convened to write a consensus statement on the diagnosis and management of CS, from which two diagnostic pathways were developed (Table 1). The authors also suggested a screening protocol for those ...
parasympathomimetic stimulation provokes vagally
parasympathomimetic stimulation provokes vagally

... During electrophysiologic study (EPS) and radiofrequency (RF) ablation of mainly vagally mediated, symptomatic premature ventricular contractions (PVC), ectopy may be absent due to stress induced sympathetic stimulation or sedative drugs. We hypothesized that pharmacological stimulation of the paras ...
Rate Limiting Calcium Channel Blockers
Rate Limiting Calcium Channel Blockers

... Heart Failure: Due to their effect on the strength on heart muscle contraction the rate limiting calcium channel blockers should not be used in patients who have problems with the strength of their heart beat. These patients are classed as having heart failure also referred to as left ventricular im ...
AFFIRM Trial
AFFIRM Trial

... (HR 1.49), which was due to non-cardiovascular causes, while the presence of SR was associated with a significant reduction in mortality (HR 0.53). A similar benefit from being in sinus rhythm (relative risk 0.44) was noted in the DIAMOND trial that compared dofetilide to placebo in patients with re ...
Straight from the Heart F Francis LaBossière Profile WRHA Cardiac Sciences Program Newsletter
Straight from the Heart F Francis LaBossière Profile WRHA Cardiac Sciences Program Newsletter

... • Mark your calendars for ...
Pulmonary Atresia and intact ventricular septum:
Pulmonary Atresia and intact ventricular septum:

...  After the shunt is open, low diastolic pressure with decreased coronary perfusion may persist  Patients who are hypoxic after RVOT patch/dilation might need a BTS  Development of pulmonary regurgitation can cause a retrograde circular shunt (RV-RA-LA-LV-Ao-BTS-PARV) ...
as a PDF
as a PDF

... to reach the ventricles and actual ventricular beats are skipped. This can progress to complete heart block, cardiac standstill, and death. Because the TCAs can cause severe arrhythmia in overdose, it has been widely assumed that their use would be contra-indicated in patients with pre-existing arrh ...
Heart Anatomy and Physiology Presentation
Heart Anatomy and Physiology Presentation

... • composed of vessels that lead from the heart to all body parts (except the lungs) and back to the heart • includes the aorta and its branches • includes the system of veins that return blood to the right atrium ...
The Cardiovascular System - Pearson Schools and FE Colleges
The Cardiovascular System - Pearson Schools and FE Colleges

... It is possible to summarise the cardiac cycle into It was stated earlier that the heart is myogenic – it four stages: generates its own impulses from its own intrinsic Stage 1 Atrial diastole pacemaker, the sinoatrial node (SA node). However, 0.5 seconds the rate at which cardiac impulses are fired ...
Pacemaker Malfunction
Pacemaker Malfunction

... The appropriate chambers are captured. b. If no pacing stimulus can be seen, native depolarisation should be adequate. c. Evaluate whether native beats are appropriately sensed in relation to paced complexes. FOLLOW-UP Patients with permanent pacemakers require follow-up by a pacemaker clinic (CTC) ...
Applied Exercise Physiology: The Cardiovascular System
Applied Exercise Physiology: The Cardiovascular System

... It is possible to summarise the cardiac cycle into It was stated earlier that the heart is myogenic – it four stages: generates its own impulses from its own intrinsic Stage 1 Atrial diastole pacemaker, the sinoatrial node (SA node). However, 0.5 seconds the rate at which cardiac impulses are fired ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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