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Name: Shania Puspasari 0177 Exercise 6
Name: Shania Puspasari 0177 Exercise 6

... You scored 100% by answering 4 out of 4 questions correctly. 1. The amplitude of the ventricular systole did not change with the more frequent stimulation because You correctly answered: a. a new contraction could not begin until the relaxation phase 2. Which of the following do you think contribute ...
Synopsis of Management on Ventricular arrhythmias
Synopsis of Management on Ventricular arrhythmias

... In patients with a prior myocardial infarction who are at high risk for ventricular tachyarrhythmia, prophylactic therapy with an implanted defibrillator leads to improved survival as compared with conventional medical therapy. ...
First clinical trial with etomoxir in patients with
First clinical trial with etomoxir in patients with

... levels of contractile proteins have been observed, which may be responsible for reduced contractility as well as diastolic dysfunction. In addition, levels of a key protein in calcium cycling, i.e. the sarcoplasmic reticulum Ca2+-ATPase, and of the α-myosin heavy chain have been shown to be enhanced ...
Pericardium, Myocardium and Endocardium
Pericardium, Myocardium and Endocardium

... lungs within the chest. It is made up of the visceral pericardium, which is actually the outer epicardial layer of the heart, and the parietal pericardium. At times, the pericardium can become inflamed, which is a ...
Gene Therapy for Common Acquired Diseases of the Heart
Gene Therapy for Common Acquired Diseases of the Heart

... thinking that we can readily translate our accomplishments to the clinic. The notion that ectopically expressed V2 receptors might be helpful in heart failure is plausible, but it has yet to be tested in a relevant disease model. Even if the results of such studies looked promising in the short term ...
GASTROENTEROLOGY AND HEPATOLOGY 1. Presence of triad of
GASTROENTEROLOGY AND HEPATOLOGY 1. Presence of triad of

... 2) disturbances of heart rhythm and conductivity 3) arterial hypotension without hypotensive therapy 4) pathological Q-wave on ECG 25. Instable angina may develop into: 1) myocardial infarction ...
Sympathetic denervation in the treatment of fatal arrhythmias in long
Sympathetic denervation in the treatment of fatal arrhythmias in long

... Following the application of medical treatment (high-dose beta-blocker therapy) and ICD implantation, polymorphic ventricular extrasystoles, which may induce fibrillation, were ablated to reduce the corresponding ICD shocks. A decrease in the corresponding ICD shocks was achieved through ablation, a ...
5.9.2006 Dear Mrs Selz, I hereby include a summary taken from my
5.9.2006 Dear Mrs Selz, I hereby include a summary taken from my

... stiffening and myocardial infarction (MI), combination of the two considered as a novel cardiovascular research model for diseased hearts pumping against an aged, stiffened arterial tree. The stiffened arterial tree yields isolated systolic hypertension and is obtained by administration of vitamin D ...
How can we know if treatment for heart failure is effective?
How can we know if treatment for heart failure is effective?

... not the prescription of drugs(13). The prescription of higher doses of vasodilators, or the addition of hydralazine and nitrate, led to better compensation of these patients and better outcome after discharge(13). CHAMPION study showed that the use of an implanted device to assess the pulmonary capi ...
Answer Sheet
Answer Sheet

... 1. Explain why the circulatory system is called a closed system. There is no entry or exit. 2. How does our body offer the heart protection? The heart is nestled in the chest cavity, cushioned by soft, spongy lungs and surrounded by a sac called the pericardium. 3. What are vessels that carry blood ...
acute heart failure syndrome - Rajiv Gandhi University of Health
acute heart failure syndrome - Rajiv Gandhi University of Health

... than 1 million patients present to hospitals with acute decompensated heart failure (ADHF) every year. Approximately one-third of the ADHF patients develop AKI as defined by an increase in serum creatinine of ≥0.3 mg/dl. In patients with cardiogenic shock, the incidence of AKI can exceed 70%. Furthe ...
LBBB - EDExam
LBBB - EDExam

... Additional features frequently seen in LBBB include: 1) The QRS complexes in some leads may be notched (leads I, aVL, V5 and V6). 2) The QRS complexes in V5, V6, I and aVL tend to have rsR’, "M" pattern or broad monophasic R waves. 3) Secondary ST depression and possibly T wave inversion may be seen ...
Cardiac Impairment Due To Hypocalcemia In A Multitransfused
Cardiac Impairment Due To Hypocalcemia In A Multitransfused

... supplementation suggests that the hypocalcemia was due to hypoparathyroidism and/or vitamin D3 deficiency. The response to calcitriol also indicates that iron overload was not responsible since cardiac impairment due to iron overload would be refractory to calcitriol treatment. Cardiac failure in mu ...
SHORTNESS OF BREATH WITHOUT CHEST PAIN - Cedars
SHORTNESS OF BREATH WITHOUT CHEST PAIN - Cedars

... study and the Director of Cardiac Imaging at Cedars-Sinai Medical Center. “If we can identify patients with coronary disease before an event occurs, then the vast majority of the cardiac events could be prevented by modern therapies. The problem is identifying the patient at risk,” he added. In the ...
ECG Rhythm Study Guide for CORE Advanced
ECG Rhythm Study Guide for CORE Advanced

... P Wave ‐ Visible before each QRS complex P‐R Interval ‐ Normal (<5 small Squares. Anything above and this would be 1st degree block) Indicates that the electrical signal is generated by the sinus node and travelling in a normal fashion in the heart ...
Randomized Trial of Cardiac Resynchronization in Mildly
Randomized Trial of Cardiac Resynchronization in Mildly

... was measured as the absolute change between baseline and 12 months for comparison between the 2 randomized groups. The 12-month echocardiographic measurements were made with CRT programmed off, irrespective of the treatment assignment, with the same parameters in the full echocardiographic protocol ...
Dr. M. Wilhelm
Dr. M. Wilhelm

... Case 1: The fragile patient with heart failure H.K., male, 72 years, NYHA class III ...
Successful use of a percutaneous miniaturized extracorporeal life
Successful use of a percutaneous miniaturized extracorporeal life

... which can result in bleeding, arrhythmias, thromboembolism, neurological disorders, and organ dysfunction4. LVAD implantation without CPB has been advocated for small axial pumps, as well as for paracorporeal devices, but did not get wide-spread acceptance as hemodynamic instability may occur and vi ...
Cardiac marker - Lab Test Consult
Cardiac marker - Lab Test Consult

... for early detection. 2. Long interval of increase, replaced LD in detecting late-presenting patient. Although can not differentiate new and recurrent MI. 3. Cardiac tissue specificity ...
Enhanced External Counterpulsation (EECP): A Non-Invasive
Enhanced External Counterpulsation (EECP): A Non-Invasive

... buttocks. Patients wear special pants during the sessions to minimize the possibility of skin irritation. Inflation and deflation of the cuffs is triggered by the patient’s EKG signal. At the onset of diastole, the cuffs inflate rapidly and sequentially, starting from the calves and proceeding upwar ...
Guidelines for Postoperative Care of Tetralogy of Fallot Hala Agha, MD
Guidelines for Postoperative Care of Tetralogy of Fallot Hala Agha, MD

... A hemodynamically significant leak will result in elevated heart rate, left atrial equal to or exceeding RA pressure, and PA saturation (>80%). Findings such as these warrant investigation with echocardiography and early reoperation is required. ...
Introduction to Heart Failure
Introduction to Heart Failure

... How is systolic heart failure treated? The body’s response to heart failure to maintain blood pressure acutely improves the situation but chronically are maladaptive. Medical treatment for heart failure involves blocking hormonal responses to prevent remodeling of the heart and diuretic medications ...
living a fuller life
living a fuller life

... to the equipment. It was not a problem at all.” –Harald ...
diuretics - Caangay.com
diuretics - Caangay.com

... – Increase demand of the body with insufficient cardiac output – Hyperthyroidism, beri-beri, anemia, AV shunts – Treatment is correction of underlying cause ...
Cardiac Physiology Relation to Cardiac Anatomy
Cardiac Physiology Relation to Cardiac Anatomy

... of the heart, the left bundle branch bifurcates into the left anterior and left posterior bundle branches • Impulses travel through bundle branches to reach terminal point in the conduction system called the purkinjie fiber this is the point at which myocardial cell at stimulated causing ventricular ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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