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File S1 - Digital Commons@Becker
File S1 - Digital Commons@Becker

... In order to establish a connection between identified miRNAs and target genes that could lead to the HCM phenotype and arrhythmias, the 3′ untranslated regions (UTRs) from the human genome were scanned for potential target sites, with an emphasis on genes affecting fibrosis, hypertrophy, apoptosis, ...
Shone`s Syndrome - Children`s Heart Clinic
Shone`s Syndrome - Children`s Heart Clinic

... cardiac anomalies including parachute mitral valve, supravalvar ring, coarctation (narrowing) of the aorta, and subaortic obstruction. The mitral valve leaflets are abnormal, often thickened or immobile with fused commissures and thick, shortened cords, giving the valve a “parachute” shape. Mitral r ...
Shone`s Syndrome - The Children`s Heart Clinic, PA
Shone`s Syndrome - The Children`s Heart Clinic, PA

... cardiac anomalies including parachute mitral valve, supravalvar ring, coarctation (narrowing) of the aorta, and subaortic obstruction. The mitral valve leaflets are abnormal, often thickened or immobile with fused commissures and thick, shortened cords, giving the valve a “parachute” shape. Mitral r ...
Cardiac Clearance and Sudden Cardiac Death in
Cardiac Clearance and Sudden Cardiac Death in

... – Sporatic or inherited (autosomal-dominant) – Can predispose to malignant ventricular arrhythmias leading to syncope or sudden death – S/S: • Dyspnea (initially exertional in onset), Angina, Exertional syncope, exertional presyncope, fatigue, palpitations ...
Double right ventricle outflow tract repair icd 10
Double right ventricle outflow tract repair icd 10

... the. Pulmonary valve stenosis (PVS) is a heart valve disorder in which outflow of blood from the right ventricle of the heart is obstructed at the level of the pulmonic valve. Pulmonary artery banding (PAB) is a technique of palliative surgical therapy used by congenital heart surgeons as a staged a ...
Cardiology Diagnostic Tools
Cardiology Diagnostic Tools

... d. Perfusion Scanning Cardiac Catheterization and Selective Angiography a. Right and Left Heart used for Dx and Assessment of Congenital/Acquired Heart Disease i. Pressure and Oxygen Saturation in heart chambers ii. Selective angiography of chambers iii. Selective coronary cineangiography – motion p ...
Congenital Heart Defects
Congenital Heart Defects

... Small VSD’s have no problems and heal on their own  Larger VSD’s can cause the left ventricle to work too hard and may result in heart failure.  Open heart surgery is used to repair. ...
VALVULAR HEART DISEASE
VALVULAR HEART DISEASE

... Aortic valve stenosis produces a pressure over load on the left ventricle due to the greater pressure that must be generated to force blood past the stenotic ...
A1990EJ37400001
A1990EJ37400001

... widely used, though other titles such as muscular subaortic stenosis and idiopathic hypertrophic subaortic stenosis have been used. But these titles miss the point that hypertrophic cardiomyopathy is a generalised (though patchy) form of hypertrophic heart muscle disease and not a localised outflow ...
Slide ()
Slide ()

... backflow into left atrium, left atrial enlargement, left ventricular enlargement (hypertrophy in acute lesions), prominent v wave caused by filling from both the pulmonary veins and the regurgitant jet, and holosystolic murmur. (3, third heart sound; SM, systolic murmur; A, aortic; P, pulmonary.) (R ...
Slide ()
Slide ()

... backflow into left atrium, left atrial enlargement, left ventricular enlargement (hypertrophy in acute lesions), prominent v wave caused by filling from both the pulmonary veins and the regurgitant jet, and holosystolic murmur. (3, third heart sound; SM, systolic murmur; A, aortic; P, pulmonary.) (R ...
HYPERTROPHIC CARDIOMYOPATHY
HYPERTROPHIC CARDIOMYOPATHY

... HYPERTROPHIC CARDIOMYOPATHY Hypertrophic cardiomyopathy (HCM) is a relatively common condition affecting the heart muscle that can present at any age. HCM is usually detected by echocardiogram and/or electrocardiogram. Symptoms range from mild shortness of breath on exertion to sudden cardiac death, ...
The Befores and Afters of Arrhythmias and Hypertrophic
The Befores and Afters of Arrhythmias and Hypertrophic

... Children experience slow growth because the body uses up all of its calories compensating for the heart’s hard work. ...
Cardio GR - WordPress.com
Cardio GR - WordPress.com

... • Internal: SA and AV nodes; keeps the heartbeat regular • External: Medulla Oblongata can alter cardiac cycle with sympathetic and parasympathetic – Epinephrine & Norepinephrine stimulates the heart ...
Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy

... • Slow decrease in LV function over time • No correlation of cardiac abnormalities with GAA repeats or ambulatory status ...
Chapter 20
Chapter 20

... fatigued more easily with the same amount of effort. He notes that his ankles are swollen and have not gone down over night as they usually do and that his abdomen has increased in size to the point he cannot fasten his trousers. Last night he was unable to lie down in bed because he could not breat ...
Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy

... Martin is the most appropriate person to refer for expert evaluation. All HCM surveillance recommendations are for first-degree relatives. There are none for second-degree relatives ...
Hypertrophic Cardiomyopathy - GEC-KO
Hypertrophic Cardiomyopathy - GEC-KO

... Martin is the most appropriate person to refer for expert evaluation. All HCM surveillance recommendations are for first-degree relatives. There are none for second-degree relatives ...
Slide ()
Slide ()

... Anatomy of the heart. A: Anterior view of the heart. B: View of the right heart with the right atrial wall reflected to show the right atrium. C: Anterior view of the heart with the anterior wall removed to show the right ventricular cavity. D: View of the left heart with the left ventricular wall t ...
Arrhythmogenic Right Ventricular Cardiomyopathy Arrhythmogenic
Arrhythmogenic Right Ventricular Cardiomyopathy Arrhythmogenic

... Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), also called Boxer Cardiomyopathy, is a disease of the lower chamber of the heart called the ventricle. The right ventricle is primarily affected in most cases, but it can sometimes affect both ventricles. In ARVC, the normal heart muscle tissue ...
this PDF file - The Tamil Nadu Dr. MGR Medical
this PDF file - The Tamil Nadu Dr. MGR Medical

... valvular click differentiate it from pulmonary valve stenosis while the inspiratory increase in the systolic murmur differentiates it from ventricular septal defect. Echocardiography with colour flow imaging excludes other possibilities and shows hypertrophy of right ventricular outflow tract muscle ...
Murmurs - stjpap 2011
Murmurs - stjpap 2011

... Electrocardiogram (EKG) ...
USMLE Step 1 Web Prep — Heart Muscle Mechanics: Part 3
USMLE Step 1 Web Prep — Heart Muscle Mechanics: Part 3

... The correct answer is E. The various points on the volume-pressure diagram correspond to specific events of the cardiac cycle as follows: Choice A: Marks the beginning of systole. The mitral valve closes and S1 can be heard. The end diastolic pressure (5 mmHg) and end diastolic volume (125 mL) can b ...
Valvular Heart Disease Aortic Stenosis
Valvular Heart Disease Aortic Stenosis

... Aortic Stenosis ...
Valvular Heart Disease Aortic Stenosis
Valvular Heart Disease Aortic Stenosis

... Aortic Stenosis ...
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Hypertrophic cardiomyopathy



Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is hypertrophied (thickened) without any obvious cause, creating functional impairment of the cardiac muscle. It is a leading cause of sudden cardiac death in young athletes.The occurrence of hypertrophic cardiomyopathy is a significant cause of sudden unexpected cardiac death in any age group and as a cause of disabling cardiac symptoms. Younger people are likely to have a more severe form of hypertrophic cardiomyopathy.HCM is frequently asymptomatic until sudden cardiac death, and for this reason some suggest routinely screening certain populations for this disease.A cardiomyopathy is a disease that affects the muscle of the heart. With HCM, the myocytes (cardiac contractile cells) in the heart increase in size, which results in the thickening of the heart muscle. In addition, the normal alignment of muscle cells is disrupted, a phenomenon known as myocardial disarray. HCM also causes disruptions of the electrical functions of the heart. HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte (the muscle cell of the heart). These are predominantly single-point missense mutations in the genes for beta-myosin heavy chain (MHC), myosin-binding protein C, cardiac troponinT, or tropomyosin. These mutations cause myofibril and myocyte structural abnormalities and possible deficiencies in force generation. Not to be confused with dilated cardiomyopathy or any other cardiomyopathy.While most literature so far focuses on European, American, and Japanese populations, HCM appears in all ethnic groups. The prevalence of HCM is about 0.2% to 0.5% of the general population.
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