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sustained and controlled drug delivery system - as a part
sustained and controlled drug delivery system - as a part

... In order to overcome the drawbacks of conventional drug delivery systems, several technical advancements have led to the development of controlled drug delivery system that could revolutionize method of medication and provide a number of therapeutic benefits like multiple dosing and single doses of ...
CHALLENGES AND KEY CONSIDERATIONS FOR THE
CHALLENGES AND KEY CONSIDERATIONS FOR THE

... counterparts, as devices are normally manufactured using plastics, metals or other materials that are easily adapted to terminal sterilisation. Sterility assurance is obviously still critical for this market and standards have been developed and unified over the last 30 years, which clearly outline ...
Polymer Science -1
Polymer Science -1

... within the formulation as well as the polymer mesh size, enabling the drug to diffuse through the swollen network into the external environment. ...
A Review on Fast Dissolving Sublingual Film
A Review on Fast Dissolving Sublingual Film

... Sublingual route is a useful when rapidonset of action is desired with better patient compliance. The portion of drug absorbed through the sublingual blood vessels bypasses the hepatic first pass metabolism processes giving acceptable bioavailability. Fast dissolving drug delivery is rapidly gaining ...
Generating Qualitative Causal Graph using Modeling Constructs of
Generating Qualitative Causal Graph using Modeling Constructs of

... World Academy of Science, Engineering and Technology International Journal of Chemical, Molecular, Nuclear, Materials and Metallurgical Engineering Vol:3, No:11, 2009 ...
Nasal Drug Delivery in EMS
Nasal Drug Delivery in EMS

...  Occupational Exposure and Bloodborne Pathogens Standard ...


... higher doses for therapy. Consequently, such drugs need to be delivered in a presolubized form, or formulation should be targeted for proximal colon, which has more fluid than in the distal colon34. PHARMACEUTICAL APPROACHES FOR COLON SPECIFIC DRUG DELIVERY (CDDS) pH sensitive polymer coated drug de ...
Controlled Release of Naproxen Sodium from
Controlled Release of Naproxen Sodium from

... 1. Faculty of Science, Anadolu University, Eskişehir 26470, Turkey 2. Faculty of Pharmacy, Anadolu University, Eskişehir 26470, Turkey 3. Plant, Drug and Scientific Research Center (BİBAM), Anadolu University, Eskişehir 26470, Turkey 4. Graduate School of Health, Department of Pharmacology Anadolu U ...
Preparation, Optimization and In Vivo Evaluation of Eletriptan Hbr
Preparation, Optimization and In Vivo Evaluation of Eletriptan Hbr

... The present investigation was aimed with the objective of developing fast dissolving oral films of Eletriptan HBr in order to attain quick onset of action for the better management of migraine attack. Twenty five formulations were prepared by solvent casting method using different polymer types, pla ...
Pilot Bioavailability Study
Pilot Bioavailability Study

... Dr. Thierry Breul*, Stephanie Silva-Lejmi*, Dr Simona Rizea Savu**, Dr. Luigi Silvestro** * Institut Nord Sud de Cooperation Biopharmaceutique, INSCB - CNRS, Montpellier, France - ** 3S Pharmacological Consultation & Research, GmbH, Harpsedt, Germany ...
Phyto-phospholipid complex vesicles for phytoconstituents and
Phyto-phospholipid complex vesicles for phytoconstituents and

... overviews recent advance in phytosome technology, their application for various standardized herbal extracts and aims to provide complete scientific information about phytosomes as promising drug delivery system. Keywords: Phytosomes, Phyto-phospholipid complex, Phospholipid, Herbal Extract ...
FORMULATION AND EVALUATION OF FLURBIPROFEN SOLID DISPERSION Research Article  AHMED LAITH
FORMULATION AND EVALUATION OF FLURBIPROFEN SOLID DISPERSION Research Article AHMED LAITH

... components, usually a hydrophilic carrier and a hydrophobic drug in a solid state, prepared by melting dissolution in solvent or melting solvent method. Solid dispersion is a good method for enhancing bioavailability of poor water-soluble drugs. When the solid dispersion is exposed to aqueous media, ...
2017 Pre-Filled Syringes Forum
2017 Pre-Filled Syringes Forum

... Jakob Lange, PhD, Director Delivery Systems, Ypsomed The pharmaceutical market is constantly changing and pharma companies around the world have to adjust to the pace of changes to be successful. The last decades have been characterized by the development of reusable pens as well as disposable pens ...
design and evaluation of controlled release tablets of
design and evaluation of controlled release tablets of

... Extensive literature review was made for understanding the study and there has been number of reports concerning sustained release matrix tablets of various drugs like diclofenac sodium, diltiazem, stavudine, tramadol hydrochloride, etc. Literature review made by referring to various National and In ...
Engineering
Engineering

... These pathways have been created to provide guidance for Bachelor of Engineering (Honours) students wishing to specialise in a study area with their elective courses. Each course has been selected to complement the content of the Bachelor of Engineering (Honours) degrees with consideration of pre-re ...
Formulation and Evaluation of Almotriptan Malate Nasal Drops
Formulation and Evaluation of Almotriptan Malate Nasal Drops

... is a need for alternate form of delivery to tablets. Nasal drug delivery is attractive since the large surface area of nasal mucosa affords a rapid onset of therapeutic effect and the potential for direct nose to brain delivery. Liquid delivery either as drops or sprays are very popular with patient ...
PRELIMINARY SCREENING AND DEVELOPMENT OF FORMULATION DESIGN SPACE FOR  Research Article
PRELIMINARY SCREENING AND DEVELOPMENT OF FORMULATION DESIGN SPACE FOR Research Article

... Jagadeesh Induru*, Afreen Firdous, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, AP, India. *Email: [email protected] Received: 11 Oct 2011, Revised and Accepted: 6 Jan 2012 ABSTRACT The drugs which are susceptible to acid hydrolysis in the stomach or extensively metab ...
FABRICATION AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF TRAMADOL HYDROCHLORIDE
FABRICATION AND EVALUATION OF EXTENDED RELEASE MATRIX TABLETS OF TRAMADOL HYDROCHLORIDE

... suffer from osteoarthritis [1]. It is an opiod analgesic used to treat moderate to moderately severe pains. It is a centrally acting drug which acts by blocking the transmission of pain signals sent by the nerves to the brain [2]. Tramadol Hydrochloride is a very weak opioid receptor agonist which i ...
Journal Club Seminar
Journal Club Seminar

... Multiparticulate Drug Delivery Systems There are many reasons for formulating a drug as a multiparticulate system for example, to facilitate disintegration in the stomach, or to provide a convenient, fast disintegrating tablet that dissolves in water before swallowing which can aid compliance in ol ...
EFFECT OF POLYMERS AS MATRIX SYSTEM IN FORMULATION OF SUSTAINED... THEOPHYLLINE MATRIX TABLET Research Article
EFFECT OF POLYMERS AS MATRIX SYSTEM IN FORMULATION OF SUSTAINED... THEOPHYLLINE MATRIX TABLET Research Article

... variation, thickness, diameter, friability and drug content. Tablet hardness was determined for six tablets using a Monsanto hardness tester (Campbell electronics, Mumbai)5. The weight variation was evaluated on 20 tablets using an electronic balance and the test was performed according to the offic ...
A c a d
A c a d

... more easily than anionic compounds, which are repelled by the negative charge of the mucin layer on the ocular surface as well as the negatively charged pores present in the corneal epithelium10. Finally, the molecular size of the drug has an effect on the corneal absorption. The normal pH of the te ...
Formulation and In Vitro Evaluation of Minoxidil Topical Gel
Formulation and In Vitro Evaluation of Minoxidil Topical Gel

... The objective of the present investigation is to develop topical gel of minoxidil using model polymers such as hydroxypropyl methylcellulose K4M (HPMC K4M) and hydroxypropyl cellulose (HPC) at different concentrations (1, 2 and 3%) individually and in combination. The drug and polymers compatibility ...
floating bilayer tablet: a review - international journal of advances in
floating bilayer tablet: a review - international journal of advances in

... released. Floatation mechanism can be achieved by incorporating floating chamber filled with vacuum, air or inert gas from the system. After release of drug, the remaining system is emptied from the stomach. This results in an increased GRT and a better control of fluctuations in plasma drug concen ...
FORMULATION AND IN VITRO EVALUATION OF NIOSOMAL POVIDONE –IODINE CARRIERS
FORMULATION AND IN VITRO EVALUATION OF NIOSOMAL POVIDONE –IODINE CARRIERS

... intervals of time and serially diluted 10-fold. Surface spread technique was performed using Saboraud’s agar. The number of colony-forming units was then calculated from appropriate dilutions. All microbiological experiments were done in triplicate and repeated three times. Mean values have been rep ...
Relation Extraction for Drug-Drug Interactions using Ensemble Learning
Relation Extraction for Drug-Drug Interactions using Ensemble Learning

... of single nucleotide polymorphisms [3, 11]. A recent trend is the extraction of simple or complex relations between entities [7]. In this work, we describe our approach for the extraction of drug-drug interactions (DDI) from text that was also the core task of the DDI Extraction 2011 challenge1 . DD ...
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Nicholas A. Peppas



Nicholas (Nikolaos) A. Peppas (Greek: Νικόλαος Α. Πέππας; born in Athens, Greece on August 25, 1948) is a chemical and biomedical engineer whose leadership in biomaterials science and engineering, drug delivery, bionanotechnology, pharmaceutical sciences, chemical and polymer engineering has led to numerous biomedical products or devices.
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