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Engineering Degrees by Distance Education
Engineering Degrees by Distance Education

... (TUOL) is the world’s leading provider of high quality flexible education to the engineering industry. For 25 years we have been creating high quality, stand alone, open learning materials. It is a realistic way to deliver necessary training and education to staff who are unable to attend convention ...
formulation, evaluation and in vitro dissolution performance of
formulation, evaluation and in vitro dissolution performance of

... was 92, 72 and 52% for 15, 30 and 45% of polymers blend, respectively. Moreover, the polymer blend retarded the drug release more efficiently than that of polymer used alone in the same corresponding ratios (15, 30 and 45%). The release rate of drug was reduced significantly when HPMC K100, HPMCK 15 ...
A Means to Address Regional Variability in Intestinal
A Means to Address Regional Variability in Intestinal

... in the intestinal epithelium. Their activity decreases longitudinally along the small intestine, with levels rising slightly from the duodenum to the jejunum and declining in the ileum and colon. This nonuniform distribution of CYP3A causes regional variability in the absorption of drugs that are su ...
an-applauded-novel-d.. - Scholars Research Library
an-applauded-novel-d.. - Scholars Research Library

... the industry experts proves right, the market for new drug delivery systems is likely to reach over US $54 billion by the year 2007 Over the past few decades, the rise of modern pharmaceutical technology and the amazing growth of the biotechnology industry have revolutionized the approach to drug di ...
Transnasal Drug Delivery
Transnasal Drug Delivery

... the stomach, excipients may need to be included during tablet formulation to ensure drug survival and to maximise the uptake of drugs into the blood circulatory system. In addition, certain drugs – such as aspirin – are often enterically coated to avoid adverse effects in the stomach until their ...
MUCOADHESIVE EFFECT OF POLYETHYLENEOXIDE ON FAMOTIDINE NANOSUSPENSION  PREPARED BY SOLVENT EVAPORATION METHOD 
MUCOADHESIVE EFFECT OF POLYETHYLENEOXIDE ON FAMOTIDINE NANOSUSPENSION  PREPARED BY SOLVENT EVAPORATION METHOD 

... break  the  adhesive  bond  between  a  model  membrane  and  the  test  formulation. The test formulation is sandwiched between two model  membranes  fixed  on  flexible  supports  in  the  assemblies  for  a  sufficient  period  of  time.  After  the  adhesive  bond  has  formed,  the  force  (wei ...
IN SITU IMPLANTS FOR PARENTERAL ADMINISTRATION    Research Article
IN SITU IMPLANTS FOR PARENTERAL ADMINISTRATION    Research Article

... The  efficiency  of  any  drug  therapy  can  be  described  by  achieving  desired  concentration  of  the  drug  in  blood  or  tissue,  which  is  therapeutically effective and  non toxic  for a  prolonged period. This  goal  can  be  achieved  on  the  basis  of  proper  design  of  the  dosage  ...
Synthesis and degradation characteristics of salicylic acid
Synthesis and degradation characteristics of salicylic acid

... 0142-9612/00/$ - see front matter  2000 Elsevier Science Ltd. All rights reserved. PII: S 0 1 4 2 - 9 6 1 2 ( 0 0 ) 0 0 0 7 3 - 9 ...
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... cumulative percentage drug release vs. time as zeroorder, Log cumulative percentage drug retained vs. time as first order release kinetics, cumulative percentage drug release vs. square root of time as Higuchi equation, and Log of fraction of drug released vs. Log time as per Korsemeyer-Peppas equat ...
Niosome and Proniosome – Vesicular Structured Dosage Form for
Niosome and Proniosome – Vesicular Structured Dosage Form for

... which is commonly expressed on the surface of many human cancers, folate-drug conjugates also bind tightly to the FR and trigger cellular uptake via endocytosis. Molecules as diverse as small radiodiagnostic imaging agents to large DNA plasmid formulations have successfully been delivered inside FR- ...
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Drugs acting on the uterus

... Vaginal pessaries Used to prime the cervix 3. Ergot alkaloids: Ergonovine, Methylergonovine I.M, oral ...
Formulation and Evaluation of Hydrogel Based Multi
Formulation and Evaluation of Hydrogel Based Multi

... evaluate in vitro release characteristics. In the present study, a series of formulations were developed with different release rates and duration using hydrophilic polymers hydroxypropyl methylcellulose (HPMC) and hydroxypropyl cellulose (HPC). The duration of rifampicin and isoniazid release could ...
Inglés
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... 10-100um diameter drug loaded microporous beads which aids in controlled delivery of drugs [3]. Rubbing, moisture, pH, friction, or ambient skin temperature are triggering factors for the controlled release of drug from microsponges by diffusion through skin. Microsponges has the facility to load wi ...
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... general anaesthesia. It is an ultra short-acting analgesic used for general anaesthesia characterized by its potent analgesic action together with its superior ability to rapidly regulate pain. ...
Chemistry in engineering curriculum Prisedsky V.V. (DonNTU
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... to meet the changing demands to engineering education. The paper outlines the role of chemistry in rapidly developing modern engineering education and necessity of restructuring its courses. Together with other natural sciences, chemistry constitutes the fundamental scientific core of engineering ed ...
Get PDF version - Bioencapsulation Research Group
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... structures, ….. Different techniques of encapsulation have been described using ultrasonic devices, microfluidic systems, (auto)emulsifications, coacervation, …. The potential of drug delivery strategies involve the use of nano- (micro) carriers for controlling, for instance, the biodistribution of ...
Important Elements in Evaluating contract Manufacturing
Important Elements in Evaluating contract Manufacturing

... with the use of opioids of the 19th century and steroid hormones of the mid-20th century. Over time, however, several definitions have arisen in the industry, including the following: 1. A pharmacologically active ingredient or intermediate with biological activity at approximately 150 micrograms pe ...
FORMULATION AND EVALUATION OF SINTERED GASTRO RETENTIVE TABLETS OF GLIPIZIDE
FORMULATION AND EVALUATION OF SINTERED GASTRO RETENTIVE TABLETS OF GLIPIZIDE

... Hydrodynamically Balanced Systems (HBS) with sintering technique is an approach to increase the gastric residence time of drugs in stomach. This system is designed for site specific oral drugs with low bulk density than gastric fluids so as to buoyant the dosage form in stomach to increase the resid ...
DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET OF TRAMADOL HYDROCHLORIDE  Research Article
DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET OF TRAMADOL HYDROCHLORIDE Research Article

... has the same skeleton, α-1, 4 D-glucan, as cellulose and therefore is not digested by human digestive enzymes (it acts as dietary fiber)14. Isolation of xyloglucan the polysaccharide from tamarind kernel powder was carried out by aqueous extraction-non aqueous precipitation method15. Polysaccharide ...
preparation and in-vitro characterization of sustained release
preparation and in-vitro characterization of sustained release

... Patil et al., have investigated sustained release matrix tablets of furosemide using natural polymers such as pectin, guar gum, and xanthan gum. Various preformulation and post formulation studies were performed and were found to be within the limits. In-vitro dissolution studies were also evaluated ...
Temperature and pH stimuli-responsive polymers
Temperature and pH stimuli-responsive polymers

... increasing momentum especially in the fields of controlled and self-regulated drug delivery. Stimuliresponsive or “smart“ polymers are macromolecules that display a significant physiochemical change in response to small changes in their environment such as temperature, pH, light, magnetic field, ion ...
PREPARATION OF MICROSPHERES OF DICLOFENAC SODIUM BY IONOTROPIC GELATION TECHNIQUE Research Article
PREPARATION OF MICROSPHERES OF DICLOFENAC SODIUM BY IONOTROPIC GELATION TECHNIQUE Research Article

... Diclofenac sodium is a non-steroidal anti-inflammatory drug used in the treatment of arthritis. Treatment with NSAIDs is observed to have gastro intestinal side effects and the formulation of Diclofenac sodium using biodegradable and biocompatible polymer in the form of microspheres is expected to d ...
THE ESSENTIALS OF CHRONOPHARMACOTHERAPEUTICS  Review Article VIKRAM S. CHHABRA
THE ESSENTIALS OF CHRONOPHARMACOTHERAPEUTICS Review Article VIKRAM S. CHHABRA

... flow depends on several regulatory factors including sympathetic and parasympathetic systems which activities are known to be circadian time dependent with a predominant diurnal effect of the sympathetic system. Thus, diurnal increase and nocturnal decrease of blood flow may explain a possible diffe ...
DESIGN AND DEVELOPMENT OF RILUZOLE LOADED CHITOSAN NANOPARTICLES BY EMULSIFICATION CROSSLINKING
DESIGN AND DEVELOPMENT OF RILUZOLE LOADED CHITOSAN NANOPARTICLES BY EMULSIFICATION CROSSLINKING

... The major difficulty in treating most of the central nervous disorder was designing a formulation that overcoming the blood brain barrier and reaching the intended targeted site. In that case nanopariculate drug delivery is a successful dosage form to break the impasse In present study nanoparticles ...
USE OF NATURAL GUMS IN FORMULATION OF CONTROL RELEASED THEOPHYLLINE... Research Article *CLEMENT JACKSON, MUSILIU ADEDOKUN AND EKAETTE AKPABIO
USE OF NATURAL GUMS IN FORMULATION OF CONTROL RELEASED THEOPHYLLINE... Research Article *CLEMENT JACKSON, MUSILIU ADEDOKUN AND EKAETTE AKPABIO

... Matrix tablets were prepared using blends of xanthan gum (XG) and Guar gum (GG). Theophyline was used as the model drug. Theophylline controlled release (CR) powder mixtures were prepared and evaluated for the angle of repose, bulk density, tapped density, compressibility index and hausners ratio. A ...
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Nicholas A. Peppas



Nicholas (Nikolaos) A. Peppas (Greek: Νικόλαος Α. Πέππας; born in Athens, Greece on August 25, 1948) is a chemical and biomedical engineer whose leadership in biomaterials science and engineering, drug delivery, bionanotechnology, pharmaceutical sciences, chemical and polymer engineering has led to numerous biomedical products or devices.
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