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Gastroretentive drug delivery systems: a review
Gastroretentive drug delivery systems: a review

... a long period. Because, continuous erosion of the surface allows water penetration to the inner layers maintaining surface hydration and buoyancy to dosage form [36]. Incorporation of fatty excipients gives low-density formulations reducing the erosion. Madopar LP®, based on the system was marketed ...
Polymers for Colon Targeted Drug Delivery Review Article
Polymers for Colon Targeted Drug Delivery Review Article

... Rajpurohit, et al.: Polymers for Colon Targeted Drug Delivery The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both loc ...
formulation and evaluation of release of trimetazidine
formulation and evaluation of release of trimetazidine

... HPM C, was procured fro m MJ BIOPHA RM Pvt ltd, Mumbai, Dibasic Calciu m Phosphate (Anhydrous), was procured from MJ BIOPHARM Pvt ltd, Mumbai., Polyvinyl Pyrrolidone (PVP-K30), AerosilR 200 and Magnesium Stearate, was procured fro m MJ BIOPHARM Pvt ltd, Mumbai, Isopropyl Alcohol was procured from Ra ...
International Journal of Phytopharmacology
International Journal of Phytopharmacology

... Email: [email protected] ...
development and in vitro evaluation of buccoadhesive tablets
development and in vitro evaluation of buccoadhesive tablets

... Buccoadhesion, or the attachment of a natural or synthetic polymer to a biological substrate, is a practical method of drug immobilization or localization and an important new aspect of controlled drug delivery. The unique environment of the oral (buccal) cavity offers its potential as a site for dr ...
Ethylcellulose Coated Multiparticulates
Ethylcellulose Coated Multiparticulates

... dissolution  stability  with  significant  structural  changes  observed  in  deposition  films  formed  by  aqueous  EC  dispersions.   ...
IN SITU FOR LEVOFLOXACIN HYDROCHLORIDE  Research Article  
IN SITU FOR LEVOFLOXACIN HYDROCHLORIDE  Research Article  

... of prolonging the formulation’s residence time on the surface of the  eye due to gelling 11.  Keeping  the  physiology  of  the  ocular  surface  in  mind,  three  parameters  (temperature,  pH  and  ionic  strength)  can  be  generally  exploited.  A  number  of  studies  have  already  been  perfo ...


... The formation of a cross-linked polymer network is advantageous, to control the diffusion of the hydrophilic macromolecules. Cross-linked polymer network can be found in situ by free radical reactions initiated by heat (thermosets) or absorption of photon or ionic interactions between small cation a ...
Pharmaceutical Dosage Forms
Pharmaceutical Dosage Forms

... Pharmaceutical dosage form • Pharmaceutical dosage form – Determines the physical form of the final pharmaceutical preparation – Is a drug delivery system which is formed by technological processing (drug formulation) – Must reflect therapeutic intentions, route of ...
Fabrication of Bucco-matrix tablets of Amoxicillin trihydrate on the
Fabrication of Bucco-matrix tablets of Amoxicillin trihydrate on the

... INTRODUCTION Drug release kinetics from matrix dosage form is influenced by polymer swelling, polymer erosion, and drug dissolution/diffusion and polymer ratio. For the preparation of controlled release dosage form, hydrophilic, swellable polymers in optimum combination are essential. Successful buc ...
Formulation and evaluation of ketorolac tromethamine as an anti
Formulation and evaluation of ketorolac tromethamine as an anti

... the population worldwide . Its incidence is (2-3) times greater in women than in men. The non-steroidal anti-inflammatory drugs (NSAIDs) are used as a classical treatment for several rheumatic disorders such as arthritis and rheumatoid arthritis . Ketorolac tromethamine (KT) is considered as a membe ...
Presse Release European Approval Zolmitriptan
Presse Release European Approval Zolmitriptan

... APR is an independent, international and integrated Healthcare Company headquartered in Switzerland and focused on three major areas: Delivering, Funding and Supporting Innovation in Healthcare. In particular, APR develops and licenses innovative, value added and patented healthcare products and pro ...
Why Biodegradable Polymer
Why Biodegradable Polymer

... polymers, considerable interest in being focused on the development of biodegradable polymers so that, they would mix themselves with soil after their applications being over. For ecological balance, the development of biodegradable polymers is one of the leading edges of research in polymer science ...
Better Problem Statement. Brainstorm and List all the things that
Better Problem Statement. Brainstorm and List all the things that

... Department of Chemical Engineering, University of Michigan, Ann Arbor ...
Lipid Excipients in Self Emulsifying Drug
Lipid Excipients in Self Emulsifying Drug

... improvement of bio-availability of drugs with such properties presents one of the greatest challenges in drug formulations. In recent years, there has been increasing interest in the use of formulations containing lipid based excipients that comprise combinations of synthetic or semisynthetic lipids ...
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF DILTIAZEM HYDROCHLORIDE
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF DILTIAZEM HYDROCHLORIDE

... Keywords: Calcium channel blocker, Diltiazem hydrochloride, Matrix tablet, Sustain release, Control release. INTRODUCTION Sustained release technology is relatively new field and as a consequence, research in the field has been extremely fertile and has produced many discoveries. With many drugs, th ...
Lack of Dose Flexibility in Solid Oral Controlled
Lack of Dose Flexibility in Solid Oral Controlled

... clinical and convenience advantages for patients as compared to immediate-release (IR) formulations. Among these are reductions of fluctuations in drug concentration and adverse side effects, increased compliance and a more convenient dosing regimen. The drawback however is the lack of dose flexibil ...
Biomaterials Week 7
Biomaterials Week 7

... Biodegradable Biodegradable polymer: water-insoluble polymer that is converted under physiological condition into water-soluble materials without regard to specific mechanism involve in the erosion process  Bioerosion: include both physical processes (dissolution) and chemical processes (backbone ...
ijlbpr_23
ijlbpr_23

... a prolonged period of time and the microbial flora present in the colon can initiate the drug release from the delivery system containing polysaccharides. The colonic bacteria are predominantly anaerobic in nature and secrete enzymes that are capable of metabolizing both endogenous and exogenous sub ...
FUNCTIONAL NANO- AND MICROPARTICLES FOR DRUG, NUTRITION, AGRO AND ENVIRONMENTAL APPLICATIONS
FUNCTIONAL NANO- AND MICROPARTICLES FOR DRUG, NUTRITION, AGRO AND ENVIRONMENTAL APPLICATIONS

... a safer environment through the application of functional, tailor-made nanoparticles to water treatment processes and ...
Blister Packaging of Oral Solids - Challenges for the Pharma
Blister Packaging of Oral Solids - Challenges for the Pharma

... become common practice within many pharmaceutical companies. Key selection criteria for primary packaging materials include the capability to offer stability in all climatic zones and to meet the needs of both marketing and packaging operations stakeholders. Additionally, there are ongoing efforts t ...
Volume 30 • Number 6 • 2013 - Controlled Release Society
Volume 30 • Number 6 • 2013 - Controlled Release Society

... future, but the complexity of possible interactions between scientific disciplines and collaborators means we don’t have a road map. It is more a compass direction. Or, it is like Adam Smith’s “invisible hand of the market,” where the efforts and interplay of individuals, driven not necessarily by s ...
Encapsulation of Hydrophobic Drugs in a Copolymer:
Encapsulation of Hydrophobic Drugs in a Copolymer:

... and Engineering, and Center for Advanced Research and Technology (CART), University of North Texas, Denton, Texas 76203-5017 ...
review - International Research Journal of Pharmacy
review - International Research Journal of Pharmacy

... Vishvakarama Prabhakar*, Agarwal Shivendra, Sharma Ritika, Saurabh Sharma Vivek College of Technical Education, Bijnor, U.P., India Article Received on: 11/04/12 Revised on: 09/05/12 Approved for publication: 17/05/12 ...
“Formulation, Development and Evaluation of Controlled and
“Formulation, Development and Evaluation of Controlled and

... Otilia M. Koo, Israel Rubinstein, and Hayat Onyuksel (2006) have reviewed the role of nanotech in the targeted drug delivery and imaging. The emphases of this review are on biophysical attributes of the drug delivery and imaging platforms as well as the biological aspects that enable targeting of th ...
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Nicholas A. Peppas



Nicholas (Nikolaos) A. Peppas (Greek: Νικόλαος Α. Πέππας; born in Athens, Greece on August 25, 1948) is a chemical and biomedical engineer whose leadership in biomaterials science and engineering, drug delivery, bionanotechnology, pharmaceutical sciences, chemical and polymer engineering has led to numerous biomedical products or devices.
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