V U Z (vzw)
... and biochemical research by Kobayashi and coworkers in Japan (Kobayashi et al., 1982) and by Oliveraand coworkers in the USA (Oliveraet al., 1985, 1988, 1990, 1991, 1994) led to the concept that Conns venoms are complex mixtures of peptides and polypeptides that interact with a variety of physiolog ...
... and biochemical research by Kobayashi and coworkers in Japan (Kobayashi et al., 1982) and by Oliveraand coworkers in the USA (Oliveraet al., 1985, 1988, 1990, 1991, 1994) led to the concept that Conns venoms are complex mixtures of peptides and polypeptides that interact with a variety of physiolog ...
Shootin1 - The Journal of Cell Biology
... 14 h) and stage 3 (cultured for 62 h) hippocampal neurons. The arrows indicate the protein spot of shootin1 enriched in the stage 3 sample (stage 3/2 = 3.2; n = 12; P < 0.001). (B) Differential 2DE analysis of proteins in cell body/dendrite and axon samples. The arrows indicate the same protein spot ...
... 14 h) and stage 3 (cultured for 62 h) hippocampal neurons. The arrows indicate the protein spot of shootin1 enriched in the stage 3 sample (stage 3/2 = 3.2; n = 12; P < 0.001). (B) Differential 2DE analysis of proteins in cell body/dendrite and axon samples. The arrows indicate the same protein spot ...
Layer II/III of the Prefrontal Cortex: Inhibition by the Serotonin
... the expression of the 5-HT1A receptor in the forebrain (Gross et al., 2002) during the early postnatal period is sufficient to produce an anxiety-like phenotype in adulthood. Despite the strong association between prefrontal 5-HT1A receptors and adult psychopathology, it has yet to be established wh ...
... the expression of the 5-HT1A receptor in the forebrain (Gross et al., 2002) during the early postnatal period is sufficient to produce an anxiety-like phenotype in adulthood. Despite the strong association between prefrontal 5-HT1A receptors and adult psychopathology, it has yet to be established wh ...
Central Nervous System
... Copyright (c) 2008, 2005 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. Copyright © 2005, Elsevier, Inc. All rights reserved. ...
... Copyright (c) 2008, 2005 by Mosby, Inc., an affiliate of Elsevier Inc. All rights reserved. Copyright © 2005, Elsevier, Inc. All rights reserved. ...
Integration of Perspective and Disparity Cues in Surface
... selective (SOS) neurons in the caudal part of the lateral intraparietal sulcus (area CIP) of the monkey and found that they are sensitive to binocular disparity (Shikata et al. 1996). It was found that these neurons are sensitive to the gradients of disparity across the surface and/or those along th ...
... selective (SOS) neurons in the caudal part of the lateral intraparietal sulcus (area CIP) of the monkey and found that they are sensitive to binocular disparity (Shikata et al. 1996). It was found that these neurons are sensitive to the gradients of disparity across the surface and/or those along th ...
Filamentous contacts: the ultrastructure and three
... Since the axon terminals are often very large, it is common in such planes of section to encounter filamentous contacts extending over several micrometers (e.g. Fig. 3). One such contact, along the interface between a dendritic shaft in VB and an elongated sausage-like lemniscal terminal, was 7 µm l ...
... Since the axon terminals are often very large, it is common in such planes of section to encounter filamentous contacts extending over several micrometers (e.g. Fig. 3). One such contact, along the interface between a dendritic shaft in VB and an elongated sausage-like lemniscal terminal, was 7 µm l ...
Excitatory Postsynaptic Potentials Trigger a Plateau Potential in Rat
... structures of the basal ganglia, playing a key role in basal ganglia function. It is therefore important to understand the regulatory mechanisms for the activity of STN neurons. In the present study, we aimed to investigate how the intrinsic membrane properties of STN neurons interact with their syn ...
... structures of the basal ganglia, playing a key role in basal ganglia function. It is therefore important to understand the regulatory mechanisms for the activity of STN neurons. In the present study, we aimed to investigate how the intrinsic membrane properties of STN neurons interact with their syn ...
Neuronal Correlates for Preparatory Set Associated with Pro
... use and care of laboratory animals and approved by the Queen’s University Animal C are Committee. Surgical, electrophysiological, and data acquisition methods were described previously (Munoz and Istvan, 1998; Everling et al., 1999). Briefly, two male monkeys (Macaca mulatta) were implanted with scl ...
... use and care of laboratory animals and approved by the Queen’s University Animal C are Committee. Surgical, electrophysiological, and data acquisition methods were described previously (Munoz and Istvan, 1998; Everling et al., 1999). Briefly, two male monkeys (Macaca mulatta) were implanted with scl ...
full text pdf
... 1998b). They include fast and prolonged depolarization mediated by 5-HT3 and 5-HT1P receptors, respectively, and an indirect effect that involves the stimulation of cholinergic interneurons (supplying the SO neurons) via 5-HT3 receptor. Mawe and Kennedy (1998, 1999) have performed two experiments in ...
... 1998b). They include fast and prolonged depolarization mediated by 5-HT3 and 5-HT1P receptors, respectively, and an indirect effect that involves the stimulation of cholinergic interneurons (supplying the SO neurons) via 5-HT3 receptor. Mawe and Kennedy (1998, 1999) have performed two experiments in ...
Dynamics and Synchronization of Motifs of Neuronal Populations in the Presence
... This mixture distinctly prevails in the brain structure and its function. ...
... This mixture distinctly prevails in the brain structure and its function. ...
a full bladder is sometimes a boon
... increasingly triggers inhibitory responses (Griffiths & Tadic, 2008). People increasingly have to inhibit their (motor) impulse to void. The inhibition of this motor response is present while people engage in other behaviors, making these simultaneously occurring behaviors susceptible for inhibitory ...
... increasingly triggers inhibitory responses (Griffiths & Tadic, 2008). People increasingly have to inhibit their (motor) impulse to void. The inhibition of this motor response is present while people engage in other behaviors, making these simultaneously occurring behaviors susceptible for inhibitory ...
Electrophysiological and Pharmacological Evidence for the Role of
... mediated in part by NMDA and non-NMDA glutamate receptors (Uchimura et al., 1989; Pennartz et al., 1991). These excitatory responses are modulated by catecholamines, as indicated by the effects of stimulation of VTA or locus coeruleus, the major source of dopaminergic and noradrenergic inputs, respe ...
... mediated in part by NMDA and non-NMDA glutamate receptors (Uchimura et al., 1989; Pennartz et al., 1991). These excitatory responses are modulated by catecholamines, as indicated by the effects of stimulation of VTA or locus coeruleus, the major source of dopaminergic and noradrenergic inputs, respe ...
- Valiente Lab
... Schizophrenia is a complex disorder that interferes with the function of several brain systems required for cognition and normal social behaviour. Although the most notable clinical aspects of the disease only become apparent during late adolescence or early adulthood, many lines of evidence suggest ...
... Schizophrenia is a complex disorder that interferes with the function of several brain systems required for cognition and normal social behaviour. Although the most notable clinical aspects of the disease only become apparent during late adolescence or early adulthood, many lines of evidence suggest ...
JAMA SIDS
... [1.25] fmol/mg, respectively; P=.001). Male SIDS cases had significantly lower 5-HT1A binding density in the raphé obscurus compared with female cases (mean [SD], 16.2 [2.0] vs 29.6 [16.5] fmol/mg, respectively; P=.04) or with male and female controls combined (mean [SD], 53.9 [19.8] fmol/mg; P=.00 ...
... [1.25] fmol/mg, respectively; P=.001). Male SIDS cases had significantly lower 5-HT1A binding density in the raphé obscurus compared with female cases (mean [SD], 16.2 [2.0] vs 29.6 [16.5] fmol/mg, respectively; P=.04) or with male and female controls combined (mean [SD], 53.9 [19.8] fmol/mg; P=.00 ...
Where do mirror neurons come from?
... – the closer the two events occur in time, the stronger the association – and ‘contingency’ – there needs to be a correlation or predictive relationship between them. For example, the probability of the second event occurring must be higher when the first event has occurred than when the first event h ...
... – the closer the two events occur in time, the stronger the association – and ‘contingency’ – there needs to be a correlation or predictive relationship between them. For example, the probability of the second event occurring must be higher when the first event has occurred than when the first event h ...
PDF
... (L5 and L6) and subplate (SP; see Glossary, Box 1) neurons, whereas upper-layer (L2-L4) neurons project within the cortex, either intra-hemispherically or contralaterally, mostly via the corpus callosum (see Glossary, Box 1). In addition to projection neurons, interneurons of distinct lineages and m ...
... (L5 and L6) and subplate (SP; see Glossary, Box 1) neurons, whereas upper-layer (L2-L4) neurons project within the cortex, either intra-hemispherically or contralaterally, mostly via the corpus callosum (see Glossary, Box 1). In addition to projection neurons, interneurons of distinct lineages and m ...
A chemogenomic analysis of the transmembrane binding cavity of
... (3) no TM domain at all could be detected (e.g., CRCP_HUMAN). The TM cavity-derived phylogenetic tree obtained from 369 human nonredundant nonolfactory GPCRs is shown in Figure 2. A total of 22 clusters were defined in order to encompass the maximum number of related entries within a branch character ...
... (3) no TM domain at all could be detected (e.g., CRCP_HUMAN). The TM cavity-derived phylogenetic tree obtained from 369 human nonredundant nonolfactory GPCRs is shown in Figure 2. A total of 22 clusters were defined in order to encompass the maximum number of related entries within a branch character ...
THE AREA POSTREMA: A POTENTIAL SITE FOR CIRCADIAN REGULATION BY
... driving circadian signalling pass through the subparaventricular zone and dorsomedial hypothalamus, major relay centres in the brain, to synapse with nuclei controlling sleep, arousal, and autonomic function (Saper et al., 2005). A major limitation to our current understanding of the proposed circad ...
... driving circadian signalling pass through the subparaventricular zone and dorsomedial hypothalamus, major relay centres in the brain, to synapse with nuclei controlling sleep, arousal, and autonomic function (Saper et al., 2005). A major limitation to our current understanding of the proposed circad ...
Quick Quiz 1 - child-development-2011
... c. synaptic pruning. b. synaptic gap. d. neural axons. 3. Infants raised in severely restricted environments show structural brain differences. At least some of these differences, in particular facets of development, may be linked to a specific, but limited time period. These time periods are known ...
... c. synaptic pruning. b. synaptic gap. d. neural axons. 3. Infants raised in severely restricted environments show structural brain differences. At least some of these differences, in particular facets of development, may be linked to a specific, but limited time period. These time periods are known ...
hanPNAS11
... In the postnatal day (P) 0 Tbr1−/− neocortex, the number of neurons highly expressing Fezf2-Gfp, which did not migrate normally (18), increased significantly from 21.8% in Tbr1+/+ to 33.3% in Tbr1−/− (P = 0.0058) (Fig. 2C). This significant increase in the total number of Fezf2-Gfp–expressing neurons ...
... In the postnatal day (P) 0 Tbr1−/− neocortex, the number of neurons highly expressing Fezf2-Gfp, which did not migrate normally (18), increased significantly from 21.8% in Tbr1+/+ to 33.3% in Tbr1−/− (P = 0.0058) (Fig. 2C). This significant increase in the total number of Fezf2-Gfp–expressing neurons ...
Uncovering the Forgotten Effect of Superior Cervical Ganglia on
... Figure 2: A schematic drawing of cervical ganglia and related anatomical structures of a rabbit in the right upper corner (SSG: Superior cervical sympathetic ganglion, MSG: Middle cervical sympathetic ganglion, ISG: Inferior cervical sympathetic ganglion, STG: Stellate ganglion). At the base, histol ...
... Figure 2: A schematic drawing of cervical ganglia and related anatomical structures of a rabbit in the right upper corner (SSG: Superior cervical sympathetic ganglion, MSG: Middle cervical sympathetic ganglion, ISG: Inferior cervical sympathetic ganglion, STG: Stellate ganglion). At the base, histol ...
Galanin in Alzheimer s disease: Neuroinhibitory or neuroprotective?
... perforant path-dentate gyrus and Schaffer collateralCA1 synapses [9, 11, 13, 30]. GAL may impact glutamatergic transmission in the hippocampus by reducing evoked glutamate release [11, 83 – 85]. However, while GAL inhibits LTP at CA1 synapses, it has no effect on ionotropic AMPA or NMDA glutamate re ...
... perforant path-dentate gyrus and Schaffer collateralCA1 synapses [9, 11, 13, 30]. GAL may impact glutamatergic transmission in the hippocampus by reducing evoked glutamate release [11, 83 – 85]. However, while GAL inhibits LTP at CA1 synapses, it has no effect on ionotropic AMPA or NMDA glutamate re ...
computational and in vitro studies of persistent activity
... a trial. The network consists of one pool of inhibitory neurons (upper rasters, labeled I) and six pools of excitatory neurons, five of them selective to different stimuli (rasters labeled 1 through 5) and one of unselective neurons (unlabeled rasters). Within selective populations, neurons are coup ...
... a trial. The network consists of one pool of inhibitory neurons (upper rasters, labeled I) and six pools of excitatory neurons, five of them selective to different stimuli (rasters labeled 1 through 5) and one of unselective neurons (unlabeled rasters). Within selective populations, neurons are coup ...
Two Types of Neurons in the Primate Globus
... (baseline period); (2) the 250-ms period after the target onset (target onset period); and (3) the 150-ms period starting from 100 ms before saccades (saccade period). We used a relatively long target onset period to compare neuronal activities during antisaccades with those during NoGo trials, beca ...
... (baseline period); (2) the 250-ms period after the target onset (target onset period); and (3) the 150-ms period starting from 100 ms before saccades (saccade period). We used a relatively long target onset period to compare neuronal activities during antisaccades with those during NoGo trials, beca ...
Vol 431 No 7010 pp723-882
... Neuromodulators such as dopamine have a central role in cognitive disorders. In the past decade, biological findings on dopamine function have been infused with concepts taken from computational theories of reinforcement learning. These more abstract approaches have now been applied to describe the ...
... Neuromodulators such as dopamine have a central role in cognitive disorders. In the past decade, biological findings on dopamine function have been infused with concepts taken from computational theories of reinforcement learning. These more abstract approaches have now been applied to describe the ...